| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Patrik Rorsman, Mark O Huisin. The somatostatin-secreting pancreatic δ-cell in health and disease. Nature reviews. Endocrinology. vol 14. issue 7. 2019-07-16. PMID:29773871. |
somatostatin antagonists or agents that suppress somatostatin secretion have been proposed as an adjunct to insulin therapy. |
2019-07-16 |
2023-08-13 |
Not clear |
| K J Olstad, T Kasantikul, M Kiupel, J R Reade. Mixed Malignant Pancreatic Tumour in a Rhesus Macaque (Macaca mullata). Journal of comparative pathology. vol 167. 2019-07-15. PMID:30898297. |
expression of multiple hormones such as gastrin, insulin, pancreatic polypeptide and somatostatin was also observed throughout the neoplastic cell population, while the endocrine component of the neoplasm was predominantly positive for glucagon. |
2019-07-15 |
2023-08-13 |
monkey |
| Catherine M Dewaal, Eric McGillis, Matt Mink, Scott Lucy. Octreotide for the treatment of intentional insulin aspart overdose in a non-diabetic patient. CJEM. vol 20. issue 4. 2019-06-20. PMID:29202888. |
octreotide, a somatostatin analogue, may help prevent dextrose-induced hypoglycemia and improve the management in select insulin overdose patients; large infusion volumes resulted in significant peripheral edema. |
2019-06-20 |
2023-08-13 |
Not clear |
| Jean-Claude Henquin, Majeed M Ibrahim, Jacques Rahie. Insulin, glucagon and somatostatin stores in the pancreas of subjects with type-2 diabetes and their lean and obese non-diabetic controls. Scientific reports. vol 7. issue 1. 2019-06-04. PMID:28887444. |
insulin, glucagon and somatostatin stores in the pancreas of subjects with type-2 diabetes and their lean and obese non-diabetic controls. |
2019-06-04 |
2023-08-13 |
human |
| Jean-Claude Henquin, Majeed M Ibrahim, Jacques Rahie. Insulin, glucagon and somatostatin stores in the pancreas of subjects with type-2 diabetes and their lean and obese non-diabetic controls. Scientific reports. vol 7. issue 1. 2019-06-04. PMID:28887444. |
we compared insulin, glucagon and somatostatin stores in pancreas obtained at autopsy of 20 lean and 19 obese non-diabetic (nd), and 18 type-2 diabetic (t2d) subjects. |
2019-06-04 |
2023-08-13 |
human |
| Bo Hellman, Heléne Dansk, Eva Grapengiesse. Somatostatin promotes glucose generation of Ca Cell calcium. vol 74. 2019-05-10. PMID:29883894. |
somatostatin promotes glucose generation of ca many cellular processes, including pulsatile release of insulin, are triggered by increase of cytoplasmic ca |
2019-05-10 |
2023-08-13 |
Not clear |
| Xi-Nuo Li, Tai Rao, Yang-Fan Xu, Kang-Rui Hu, Zhang-Pei Zhu, Hao-Feng Li, Dian Kang, Yu-Hao Shao, Bo-Yu Shen, Xiao-Xi Yin, Lin Xie, Guang-Ji Wang, Yan Lian. Pharmacokinetic and pharmacodynamic evidence for developing an oral formulation of octreotide against gastric mucosal injury. Acta pharmacologica Sinica. vol 39. issue 8. 2019-04-11. PMID:29188801. |
among the somatostatin analogues, octreotide (oct) is the most commonly used in clinic via intravenous or subcutaneous injection to treat various diseases caused by increased secretion of growth hormone, gastrin or insulin. |
2019-04-11 |
2023-08-13 |
mouse |
| J Malik, N Rooh. GLP-1, a powerful physiological incretin: an update. Journal of biological regulators and homeostatic agents. vol 32. issue 5. 2019-03-15. PMID:30334409. |
the secretions of many enzymes and hormones, such as trypsin, lipase and glucagon, inhibited significantly while the increase in levels of insulin and somatostatin was reported in many studies. |
2019-03-15 |
2023-08-13 |
human |
| Rosane A Ribeiro, Maria L Bonfleur, Thiago M Batista, Patricia C Borck, Everardo M Carneir. Regulation of glucose and lipid metabolism by the pancreatic and extra-pancreatic actions of taurine. Amino acids. vol 50. issue 11. 2019-02-25. PMID:30206707. |
importantly, there are several lines of evidence that indicate a direct action of tau on the endocrine pancreas to regulate the secretion and paracrine actions of insulin, glucagon, and somatostatin. |
2019-02-25 |
2023-08-13 |
Not clear |
| F Rafael Castiello, Maryam Tabrizia. Multiplex Surface Plasmon Resonance Imaging-Based Biosensor for Human Pancreatic Islets Hormones Quantification. Analytical chemistry. vol 90. issue 5. 2019-02-11. PMID:29378126. |
recent studies indicated that furthering our understanding of the paracrine effect of somatostatin on glucose-induced insulin secretion could represent a novel therapeutic avenue for diabetes. |
2019-02-11 |
2023-08-13 |
human |
| F Rafael Castiello, Maryam Tabrizia. Multiplex Surface Plasmon Resonance Imaging-Based Biosensor for Human Pancreatic Islets Hormones Quantification. Analytical chemistry. vol 90. issue 5. 2019-02-11. PMID:29378126. |
in this study, we introduced a multiplex surface plasmon resonance imaging-based biosensor for simultaneous quantification of insulin, glucagon, and somatostatin. |
2019-02-11 |
2023-08-13 |
human |
| Elisa Vergari, Jakob G Knudsen, Reshma Ramracheya, Albert Salehi, Quan Zhang, Julie Adam, Ingrid Wernstedt Asterholm, Anna Benrick, Linford J B Briant, Margarita V Chibalina, Fiona M Gribble, Alexander Hamilton, Benoit Hastoy, Frank Reimann, Nils J G Rorsman, Ioannis I Spiliotis, Andrei Tarasov, Yanling Wu, Frances M Ashcroft, Patrik Rorsma. Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion. Nature communications. vol 10. issue 1. 2019-02-08. PMID:30635569. |
insulin inhibits glucagon release by sglt2-induced stimulation of somatostatin secretion. |
2019-02-08 |
2023-08-13 |
mouse |
| Elisa Vergari, Jakob G Knudsen, Reshma Ramracheya, Albert Salehi, Quan Zhang, Julie Adam, Ingrid Wernstedt Asterholm, Anna Benrick, Linford J B Briant, Margarita V Chibalina, Fiona M Gribble, Alexander Hamilton, Benoit Hastoy, Frank Reimann, Nils J G Rorsman, Ioannis I Spiliotis, Andrei Tarasov, Yanling Wu, Frances M Ashcroft, Patrik Rorsma. Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion. Nature communications. vol 10. issue 1. 2019-02-08. PMID:30635569. |
here we show in mice that therapeutic concentrations of insulin inhibit glucagon secretion by an indirect (paracrine) mechanism mediated by stimulation of intra-islet somatostatin release. |
2019-02-08 |
2023-08-13 |
mouse |
| Elisa Vergari, Jakob G Knudsen, Reshma Ramracheya, Albert Salehi, Quan Zhang, Julie Adam, Ingrid Wernstedt Asterholm, Anna Benrick, Linford J B Briant, Margarita V Chibalina, Fiona M Gribble, Alexander Hamilton, Benoit Hastoy, Frank Reimann, Nils J G Rorsman, Ioannis I Spiliotis, Andrei Tarasov, Yanling Wu, Frances M Ashcroft, Patrik Rorsma. Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion. Nature communications. vol 10. issue 1. 2019-02-08. PMID:30635569. |
insulin's capacity to inhibit glucagon secretion is lost following genetic ablation of insulin receptors in the somatostatin-secreting δ-cells, when insulin-induced somatostatin secretion is suppressed by dapagliflozin (an inhibitor of sodium-glucose co-tranporter-2; sglt2) or when the action of secreted somatostatin is prevented by somatostatin receptor (sstr) antagonists. |
2019-02-08 |
2023-08-13 |
mouse |
| H Kristinsson, E Sargsyan, H Manell, D M Smith, S O Göpel, P Bergste. Basal hypersecretion of glucagon and insulin from palmitate-exposed human islets depends on FFAR1 but not decreased somatostatin secretion. Scientific reports. vol 7. issue 1. 2019-01-28. PMID:28680093. |
basal hypersecretion of glucagon and insulin from palmitate-exposed human islets depends on ffar1 but not decreased somatostatin secretion. |
2019-01-28 |
2023-08-13 |
human |
| H Kristinsson, E Sargsyan, H Manell, D M Smith, S O Göpel, P Bergste. Basal hypersecretion of glucagon and insulin from palmitate-exposed human islets depends on FFAR1 but not decreased somatostatin secretion. Scientific reports. vol 7. issue 1. 2019-01-28. PMID:28680093. |
in addition, we hypothesized that concomitant hypersecretion of glucagon and insulin was also contributed by reduced somatostatin secretion. |
2019-01-28 |
2023-08-13 |
human |
| H Kristinsson, E Sargsyan, H Manell, D M Smith, S O Göpel, P Bergste. Basal hypersecretion of glucagon and insulin from palmitate-exposed human islets depends on FFAR1 but not decreased somatostatin secretion. Scientific reports. vol 7. issue 1. 2019-01-28. PMID:28680093. |
we found basal glucagon, insulin and somatostatin secretion and respiration from human islets, to be enhanced during palmitate treatment at normoglycemia. |
2019-01-28 |
2023-08-13 |
human |
| H Kristinsson, E Sargsyan, H Manell, D M Smith, S O Göpel, P Bergste. Basal hypersecretion of glucagon and insulin from palmitate-exposed human islets depends on FFAR1 but not decreased somatostatin secretion. Scientific reports. vol 7. issue 1. 2019-01-28. PMID:28680093. |
we conclude that fatty acids enhance both glucagon and insulin secretion at fasting glucose concentrations and that ffar1 and enhanced mitochondrial metabolism but not lowered somatostatin secretion are crucial in this effect. |
2019-01-28 |
2023-08-13 |
human |
| Alexandre Kazuo Kuniyoshi, Roberto Tadashi Kodama, Luis Henrique Ferreira Moraes, Bruno Duzzi, Leo Kei Iwai, Ismael Feitosa Lima, Daniela Cajado-Carvalho, Fernanda Vieira Portar. In vitro cleavage of bioactive peptides by peptidases from Bothrops jararaca venom and its neutralization by bothropic antivenom produced by Butantan Institute: Major contribution of serine peptidases. Toxicon : official journal of the International Society on Toxinology. vol 137. 2018-12-20. PMID:28759785. |
in this study, we used a set of bioactive peptides (insulin b chain, met-enkephalin, leu-enkephalin, neuropeptide y, peptide yy, pancreatic polypeptide, substance p and somatostatin) to identify new peptide substrates for the metallopeptidases and serine peptidases from the b. jararaca venom. |
2018-12-20 |
2023-08-13 |
Not clear |
| Dawood Khan, Charlotte R Moffet, Peter R Flatt, Catriona Kell. Role of islet peptides in beta cell regulation and type 2 diabetes therapy. Peptides. vol 100. 2018-12-11. PMID:29412821. |
a great deal of attention has focused on classical islet peptides, namely insulin, glucagon and somatostatin. |
2018-12-11 |
2023-08-13 |
Not clear |