| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jean Girar. Glucagon, a key factor in the pathophysiology of type 2 diabetes. Biochimie. vol 143. 2018-10-02. PMID:29024725. |
the hyperglucagonemia of diabetes results from an excessive secretion of the hormone secondary from a deficit in insulin secretion and/or a dysfunction of various cells within the islets of langerhans (somatostatin) leading to the notion of "paracrinopathy". |
2018-10-02 |
2023-08-13 |
Not clear |
| H Suzuki, T Yamamot. Localization of amylin-like immunoreactivity in the striped velvet gecko pancreas. Anatomia, histologia, embryologia. vol 47. issue 2. 2018-08-28. PMID:29315753. |
four types of endocrine cells were distinguished: insulin immunoreactive (b cells), pancreatic polypeptide immunoreactive (pp cells), glucagon and pancreatic polypeptide immunoreactive (a/pp cells) and somatostatin immunoreactive cells (d cells). |
2018-08-28 |
2023-08-13 |
Not clear |
| Sho Tanaka, Akira Haketa, Shun Yamamuro, Toshiko Suzuki, Hiroki Kobayashi, Yoshinari Hatanaka, Takahiro Ueno, Noboru Fukuda, Masanori Abe, Atsuo Yoshino, Masayoshi Som. Marked alteration of glycemic profile surrounding lanreotide administration in acromegaly: A case report. Journal of diabetes investigation. vol 9. issue 1. 2018-08-15. PMID:28390105. |
an 80-year-old japanese female diabetes patient treated with insulin therapy was diagnosed with acromegaly, and the somatostatin analog, lanreotide, was given. |
2018-08-15 |
2023-08-13 |
Not clear |
| Evelyn H Schlenke. Sexual dimorphism of cardiopulmonary regulation in the arcuate nucleus of the hypothalamus. Respiratory physiology & neurobiology. vol 245. 2018-07-23. PMID:27756648. |
importantly, the anh exhibits structural and functional sexually dimorphic characteristics and contains numerous neuroactive substances and receptors including leptin, neuropeptide y, glutamate, acetylcholine, endorphins, orexin, kisspeptin, insulin, agouti-related protein, cocaine and amphetamine-regulated transcript, dopamine, somatostatin, components of renin-angiotensin system and gamma amino butyric acid that modulate physiological functions. |
2018-07-23 |
2023-08-13 |
Not clear |
| Daniel Neiman, Joshua Moss, Merav Hecht, Judith Magenheim, Sheina Piyanzin, A M James Shapiro, Eelco J P de Koning, Aharon Razin, Howard Cedar, Ruth Shemer, Yuval Do. Islet cells share promoter hypomethylation independently of expression, but exhibit cell-type-specific methylation in enhancers. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 51. 2018-06-28. PMID:29203669. |
here we show that islet cells expressing insulin, glucagon, or somatostatin share a lack of methylation at the promoters of the insulin and glucagon genes. |
2018-06-28 |
2023-08-13 |
Not clear |
| Rishi K Somvanshi, Amrit Jhajj, Michael Heer, Ujendra Kuma. Characterization of somatostatin receptors and associated signaling pathways in pancreas of R6/2 transgenic mice. Biochimica et biophysica acta. Molecular basis of disease. vol 1864. issue 2. 2018-05-22. PMID:29104117. |
the present study describes the status of somatostatin receptors (sstrs) and their colocalization with insulin (β), glucagon (α) and somatostatin (δ) producing cells in the pancreatic islets of 11weeks old r6/2 huntington's disease transgenic (hd tg) and age-matched wild type (wt) mice. |
2018-05-22 |
2023-08-13 |
mouse |
| Rishi K Somvanshi, Amrit Jhajj, Michael Heer, Ujendra Kuma. Characterization of somatostatin receptors and associated signaling pathways in pancreas of R6/2 transgenic mice. Biochimica et biophysica acta. Molecular basis of disease. vol 1864. issue 2. 2018-05-22. PMID:29104117. |
in r6/2 mice, islets are relatively smaller in size, exhibit enhanced expression and nuclear inclusion of mhtt along with the loss of insulin, glucagon and somatostatin expression. |
2018-05-22 |
2023-08-13 |
mouse |
| Casey J A Smith-Anttila, Sophie Bensing, Mohammad Alimohammadi, Frida Dalin, Mikael Oscarson, Ming-Dong Zhang, Jaakko Perheentupa, Eystein S Husebye, Jan Gustafsson, Peyman Björklund, Anette Fransson, Gunnel Nordmark, Lars Rönnblom, Antonella Meloni, Rodney J Scott, Tomas Hökfelt, Patricia A Crock, Olle Kämp. Identification of endothelin-converting enzyme-2 as an autoantigen in autoimmune polyendocrine syndrome type 1. Autoimmunity. vol 50. issue 4. 2018-05-11. PMID:28557628. |
in the pancreas ece-2 was co-expressed with insulin or somatostatin, but not glucagon and was widely expressed in gh producing cells in the guinea pig pituitary. |
2018-05-11 |
2023-08-13 |
Not clear |
| György Csab. Is there a hormonal regulation of phagocytosis at unicellular and multicellular levels? A critical review. Acta microbiologica et immunologica Hungarica. vol 64. issue 4. 2018-05-09. PMID:28859501. |
macrophage phagocytosis of multicellulars is also stimulated by amino acid hormones, such as histamine, epinephrine, melatonin, and thyroid hormones, however, the effect of peptide hormones is not uniform: prolactin, insulin, glucagon, somatostatin, and leptin have positive effects, whereas acth, human chorionic gonadotropin, opioids, and ghrelin have negative ones. |
2018-05-09 |
2023-08-13 |
human |
| Kim M Newkirk, Gordon Ehrensing, Agricola Odoi, Raymond C Boston, Nicholas Fran. Immunohistochemical expression of insulin, glucagon, and somatostatin in pancreatic islets of horses with and without insulin resistance. American journal of veterinary research. vol 79. issue 2. 2018-05-01. PMID:29359971. |
immunohistochemical expression of insulin, glucagon, and somatostatin in pancreatic islets of horses with and without insulin resistance. |
2018-05-01 |
2023-08-13 |
Not clear |
| Kim M Newkirk, Gordon Ehrensing, Agricola Odoi, Raymond C Boston, Nicholas Fran. Immunohistochemical expression of insulin, glucagon, and somatostatin in pancreatic islets of horses with and without insulin resistance. American journal of veterinary research. vol 79. issue 2. 2018-05-01. PMID:29359971. |
objective to assess insulin, glucagon, and somatostatin expression within pancreatic islets of horses with and without insulin resistance. |
2018-05-01 |
2023-08-13 |
Not clear |
| Youngjin Kim, Hyeongseok Kim, Ung Hyun Ko, Youjin Oh, Ajin Lim, Jong-Woo Sohn, Jennifer H Shin, Hail Kim, Yong-Mahn Ha. Islet-like organoids derived from human pluripotent stem cells efficiently function in the glucose responsiveness in vitro and in vivo. Scientific reports. vol 6. 2018-04-24. PMID:27731367. |
the hesc-derived ecs expressed pancreatic endocrine hormones, such as insulin, somatostatin, and pancreatic polypeptide. |
2018-04-24 |
2023-08-13 |
mouse |
| Emmanouil Saloustros, Paraskevi Salpea, Matthew Starost, Sissi Liu, Fabio R Faucz, Edra London, Eva Szarek, Woo-Jin Song, Mehboob Hussain, Constantine A Strataki. Prkar1a gene knockout in the pancreas leads to neuroendocrine tumorigenesis. Endocrine-related cancer. vol 24. issue 1. 2018-02-13. PMID:27803029. |
negative immunohistochemical staining for the most commonly produced peptides (insulin, c-peptide, glucagon, gastrin and somatostatin) suggested that these tumors were non-functioning. |
2018-02-13 |
2023-08-13 |
mouse |
| R Gostelow, C Scudder, S Keyte, Y Forcada, R C Fowkes, H A Schmid, D B Church, S J M Niesse. Pasireotide Long-Acting Release Treatment for Diabetic Cats with Underlying Hypersomatotropism. Journal of veterinary internal medicine. vol 31. issue 2. 2018-01-15. PMID:28145031. |
pasireotide, a novel somatostatin analogue, decreases serum insulin-like growth factor 1 (igf-1) and improves insulin sensitivity in cats with hs when administered as a short-acting preparation. |
2018-01-15 |
2023-08-13 |
Not clear |
| N Frank, P Hermida, A Sanchez-Londoño, R Singh, C M Gradil, C K Uricchi. Blood Glucose and Insulin Concentrations after Octreotide Administration in Horses With Insulin Dysregulation. Journal of veterinary internal medicine. vol 31. issue 4. 2018-01-03. PMID:28503791. |
octreotide is a somatostatin analog that suppresses insulin secretion. |
2018-01-03 |
2023-08-13 |
Not clear |
| Thomas B Farb, Marta Adeva, Thomas J Beauchamp, Over Cabrera, David A Coates, Tamika DeShea Meredith, Brian A Droz, Alexander Efanov, James V Ficorilli, Susan L Gackenheimer, Maria A Martinez-Grau, Victoriano Molero, Gema Ruano, Michael A Statnick, Todd M Suter, Samreen K Syed, Miguel A Toledo, Francis S Willard, Xin Zhou, Krister B Bokvist, David G Barret. Regulation of Endogenous (Male) Rodent GLP-1 Secretion and Human Islet Insulin Secretion by Antagonism of Somatostatin Receptor 5. Endocrinology. vol 158. issue 11. 2017-12-12. PMID:28938487. |
regulation of endogenous (male) rodent glp-1 secretion and human islet insulin secretion by antagonism of somatostatin receptor 5. |
2017-12-12 |
2023-08-13 |
mouse |
| Bhawna Chandravanshi, Ramesh Bhond. Reprogramming mouse embryo fibroblasts to functional islets without genetic manipulation. Journal of cellular physiology. vol 233. issue 2. 2017-11-21. PMID:28657136. |
the transcriptional analysis of the icas at different day points exhibited up-regulation of islet markers (insulin, pdx1, hnf3, glucagon, and somatostatin) and down-regulation of msc-markers (vimentin and nestin). |
2017-11-21 |
2023-08-13 |
mouse |
| Bhawna Chandravanshi, Ramesh Bhond. Reprogramming mouse embryo fibroblasts to functional islets without genetic manipulation. Journal of cellular physiology. vol 233. issue 2. 2017-11-21. PMID:28657136. |
they positively stained for dithizone, c-peptide, insulin, glucagon, and somatostatin indicating intact insulin producing machinery. |
2017-11-21 |
2023-08-13 |
mouse |
| Qing Li, Min Cui, Fan Yang, Na Li, Baichun Jiang, Zhen Yu, Daolai Zhang, Yijing Wang, Xibin Zhu, Huili Hu, Pei-Shan Li, Shang-Lei Ning, Si Wang, Haibo Qi, Hechen Song, Dongfang He, Amy Lin, Jingjing Zhang, Feng Liu, Jiajun Zhao, Ling Gao, Fan Yi, Tian Xue, Jin-Peng Sun, Yaoqin Gong, Xiao Y. A cullin 4B-RING E3 ligase complex fine-tunes pancreatic δ cell paracrine interactions. The Journal of clinical investigation. vol 127. issue 7. 2017-09-14. PMID:28604389. |
somatostatin secreted by pancreatic δ cells mediates important paracrine interactions in langerhans islets, including maintenance of glucose metabolism through the control of reciprocal insulin and glucagon secretion. |
2017-09-14 |
2023-08-13 |
Not clear |
| Qing Li, Min Cui, Fan Yang, Na Li, Baichun Jiang, Zhen Yu, Daolai Zhang, Yijing Wang, Xibin Zhu, Huili Hu, Pei-Shan Li, Shang-Lei Ning, Si Wang, Haibo Qi, Hechen Song, Dongfang He, Amy Lin, Jingjing Zhang, Feng Liu, Jiajun Zhao, Ling Gao, Fan Yi, Tian Xue, Jin-Peng Sun, Yaoqin Gong, Xiao Y. A cullin 4B-RING E3 ligase complex fine-tunes pancreatic δ cell paracrine interactions. The Journal of clinical investigation. vol 127. issue 7. 2017-09-14. PMID:28604389. |
constitutive ablation of cul4b, the core component of the crl4b-prc2 complex, in δ cells impaired glucose tolerance and decreased insulin secretion through enhanced somatostatin release. |
2017-09-14 |
2023-08-13 |
Not clear |