| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D W O'Brien, R V Rajotte, G D Molnar, K Toth, T D Peterse. Somatostatin increases hepatic insulin extraction. Diabetes research (Edinburgh, Scotland). vol 7. issue 4. 1988-09-22. PMID:2900090. |
eleven anesthetized dogs were used to assess the effect of somatostatin on hepatic insulin extraction (hie) and hepatic glucose production (hgp). |
1988-09-22 |
2023-08-11 |
Not clear |
| D W O'Brien, R V Rajotte, G D Molnar, K Toth, T D Peterse. Somatostatin increases hepatic insulin extraction. Diabetes research (Edinburgh, Scotland). vol 7. issue 4. 1988-09-22. PMID:2900090. |
hie was increased in the presence of insulin plus somatostatin infusion. |
1988-09-22 |
2023-08-11 |
Not clear |
| D W O'Brien, R V Rajotte, G D Molnar, K Toth, T D Peterse. Somatostatin increases hepatic insulin extraction. Diabetes research (Edinburgh, Scotland). vol 7. issue 4. 1988-09-22. PMID:2900090. |
hgp was decreased in the presence of insulin and somatostatin infusion compared to insulin infusion alone both in series i and ii (1.71 +/- 0.25 to 3.72 +/- 4.0%, combined results, p less than 0.01). |
1988-09-22 |
2023-08-11 |
Not clear |
| D W O'Brien, R V Rajotte, G D Molnar, K Toth, T D Peterse. Somatostatin increases hepatic insulin extraction. Diabetes research (Edinburgh, Scotland). vol 7. issue 4. 1988-09-22. PMID:2900090. |
however, a decrease in hepatic glucose production is consistent with increased insulin extraction during somatostatin observed in the present study. |
1988-09-22 |
2023-08-11 |
Not clear |
| D W O'Brien, R V Rajotte, G D Molnar, K Toth, T D Peterse. Somatostatin increases hepatic insulin extraction. Diabetes research (Edinburgh, Scotland). vol 7. issue 4. 1988-09-22. PMID:2900090. |
we conclude that somatostatin increases the hepatic extraction of exogenous insulin. |
1988-09-22 |
2023-08-11 |
Not clear |
| V A Mirza-Zade, A A Mamedov, M K Atakishiev. [Physiological role of pancreatic D-cells (mathematical study)]. Biulleten' eksperimental'noi biologii i meditsiny. vol 106. issue 7. 1988-09-21. PMID:2900029. |
the suppression of insulin secretion by pancreatic somatostatin is substantial at lower glucose concentration and is insignificant at higher glucose concentration. |
1988-09-21 |
2023-08-11 |
Not clear |
| F Laurent, C Hindelang, M T Strosser, P Mialh. The ultrastructure of A, B and D pancreatic cells in normal and in diabetic ducks. Biological structures and morphogenesis. vol 1. issue 1. 1988-09-21. PMID:3042030. |
the morphological data correlate well with the previously reported evolution of plasma and pancreatic hormone concentration after surgery, and suggest that the normal inhibitory control of glucagon and insulin secretion by the local release of somatostatin might be reduced or suppressed during transient diabetes in subtotally depancreatized ducks. |
1988-09-21 |
2023-08-11 |
Not clear |
| P J Boyle, S B Liggett, S D Shah, P E Crye. Direct muscarinic cholinergic inhibition of hepatic glucose production in humans. The Journal of clinical investigation. vol 82. issue 2. 1988-09-20. PMID:2900252. |
to test the hypothesis that direct muscarinic inhibition of glucose production was offset by an indirect action of the agonist, specifically increased glucagon secretion with consequent stimulation of glucose production, bethanechol was administered while glucagon levels were held constant with the islet clamp technique (somatostatin infusion with insulin, glucagon and growth hormone replacement at fixed rates). |
1988-09-20 |
2023-08-11 |
human |
| V Schusdziarr. Physiological significance of gastrointestinal somatostatin. Hormone research. vol 29. issue 2-3. 1988-09-16. PMID:2900200. |
neutralization of endogenous circulating somatostatin with specific antiserum is followed by increases in gh and enteroglucagon, augmenting also the postprandial rise of gastrin, insulin and pancreatic polypeptide. |
1988-09-16 |
2023-08-11 |
human |
| V Schusdziarr. Physiological significance of gastrointestinal somatostatin. Hormone research. vol 29. issue 2-3. 1988-09-16. PMID:2900200. |
concomitant elevation of insulin and gastrin levels can be antagonized by exogenous somatostatin. |
1988-09-16 |
2023-08-11 |
human |
| P Miralles, E Peiró, R A Silvestre, M L Villanueva, J Marc. Effects of galanin on islet cell secretory responses to VIP, GIP, 8-CCK, and glucagon by the perfused rat pancreas. Metabolism: clinical and experimental. vol 37. issue 8. 1988-09-12. PMID:2457142. |
to achieve further insight into the influence of galanin on the endocrine pancreas, we have investigated the effect of synthetic porcine galanin (a 200 ng bolus followed by constant infusion at a concentration of 16.8 ng/ml for 16 to 24 minutes) on unstimulated insulin, glucagon, and somatostatin release, as well as on the responses of these hormones to 1 nmol/l vasoactive intestinal peptide (vip), 1 nmol/l gastric inhibitory peptide (gip), 1 nmol/l 26 to 33 octapeptide form of cholecystokinin (8-cck) or 10 nmol/l glucagon in the perfused rat pancreas. |
1988-09-12 |
2023-08-11 |
rat |
| P Miralles, E Peiró, R A Silvestre, M L Villanueva, J Marc. Effects of galanin on islet cell secretory responses to VIP, GIP, 8-CCK, and glucagon by the perfused rat pancreas. Metabolism: clinical and experimental. vol 37. issue 8. 1988-09-12. PMID:2457142. |
galanin infusion reduced unstimulated insulin secretion by 60% without modifying glucagon and somatostatin output. |
1988-09-12 |
2023-08-11 |
rat |
| P Miralles, E Peiró, R A Silvestre, M L Villanueva, J Marc. Effects of galanin on islet cell secretory responses to VIP, GIP, 8-CCK, and glucagon by the perfused rat pancreas. Metabolism: clinical and experimental. vol 37. issue 8. 1988-09-12. PMID:2457142. |
galanin also blocked insulin release elicited by vip, gip, and 8-cck, it did not affect the glucagon responses to vip and gip, or the somatostatin responses to vip, gip, and 8-cck. |
1988-09-12 |
2023-08-11 |
rat |
| P Miralles, E Peiró, R A Silvestre, M L Villanueva, J Marc. Effects of galanin on islet cell secretory responses to VIP, GIP, 8-CCK, and glucagon by the perfused rat pancreas. Metabolism: clinical and experimental. vol 37. issue 8. 1988-09-12. PMID:2457142. |
finally, galanin inhibited the insulin output, but not the somatostatin release induced by glucagon. |
1988-09-12 |
2023-08-11 |
rat |
| D R Lynch, J C Venable, S M Strittmatter, S H Snyde. Enkephalin convertase: characterization and localization using [3H]guanidinoethylmercaptosuccinic acid. Biochimie. vol 70. issue 1. 1988-09-12. PMID:3135843. |
in the pancreas, [3h]gemsa binding sites are localized to the islets suggesting an involvement in insulin, glucagon, or somatostatin formation. |
1988-09-12 |
2023-08-11 |
Not clear |
| H Wiedec. [Animal experiments on swine with regard to jejunal nutrition therapy. Bile and pancreatic secretion and changes in gastrointestinal hormones]. Infusionstherapie (Basel, Switzerland). vol 15. issue 2. 1988-09-02. PMID:2456273. |
the insulin and somatostatin levels remained within normal ranges during the whole period of investigations. |
1988-09-02 |
2023-08-11 |
Not clear |
| C E Lewis, A Clark, S J Ashcroft, G J Cooper, J F Morri. Calcitonin gene-related peptide and somatostatin inhibit insulin release from individual rat B cells. Molecular and cellular endocrinology. vol 57. issue 1-2. 1988-08-26. PMID:2899526. |
calcitonin gene-related peptide and somatostatin inhibit insulin release from individual rat b cells. |
1988-08-26 |
2023-08-11 |
rat |
| C E Lewis, A Clark, S J Ashcroft, G J Cooper, J F Morri. Calcitonin gene-related peptide and somatostatin inhibit insulin release from individual rat B cells. Molecular and cellular endocrinology. vol 57. issue 1-2. 1988-08-26. PMID:2899526. |
somatostatin and calcitonin gene-related peptide, fragment 28-37 (cgrp28-37) were shown to inhibit glucose-stimulated insulin release as assessed by the size of individual plaques and the number of recruited b cells, and hence to reduce the total area of plaques formed. |
1988-08-26 |
2023-08-11 |
rat |
| C E Lewis, A Clark, S J Ashcroft, G J Cooper, J F Morri. Calcitonin gene-related peptide and somatostatin inhibit insulin release from individual rat B cells. Molecular and cellular endocrinology. vol 57. issue 1-2. 1988-08-26. PMID:2899526. |
in the presence of 15 mm glucose, a dose-dependent effect of cgrp28-37 on the secretion of insulin was observed, with the size of plaques formed by individual b cells reduced at concentrations of cgrp28-37 between 10(-5) and 10(-11) m. thus, both somatostatin and cgrp28-37 can act directly on individual b cells to inhibit their secretory response to increasing levels of glucose. |
1988-08-26 |
2023-08-11 |
rat |
| J W Grant, P J Gallagher, C Hedinge. Haemangioblastoma. An immunohistochemical study of ten cases. Acta neuropathologica. vol 76. issue 1. 1988-08-25. PMID:3394496. |
ten cases of cerebellar haemangioblastoma were studied using the immunoperoxidase technique for glial fibrillary acidic protein (gfap), factor viii-related antigen (f8ra), ulex europeus agglutinin 1 (uea-1), s-100 protein, neurone-specific enolase (nse), leucocyte common antigen, synaptophysin, chromogranin and eight polypeptide hormones (bombesin, pancreatic polypeptide, somatostatin, thyroglobulin, calcitonin, glucagon, insulin and gastrin). |
1988-08-25 |
2023-08-11 |
Not clear |