| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L M Karabatas, M Arata, L Anaya, J C Cresto, O H Pivetta, J C Basab. First phase of insulin secretion stimulated by glucose plus theophylline and inhibitory effect of somatostatin in genetically diabetic mice (C57BL/KsJ-mdb). Diabetologia. vol 31. issue 6. 1988-10-27. PMID:2901377. |
first phase of insulin secretion stimulated by glucose plus theophylline and inhibitory effect of somatostatin in genetically diabetic mice (c57bl/ksj-mdb). |
1988-10-27 |
2023-08-11 |
mouse |
| L M Karabatas, M Arata, L Anaya, J C Cresto, O H Pivetta, J C Basab. First phase of insulin secretion stimulated by glucose plus theophylline and inhibitory effect of somatostatin in genetically diabetic mice (C57BL/KsJ-mdb). Diabetologia. vol 31. issue 6. 1988-10-27. PMID:2901377. |
in a previous study in c57bl/ksj mdb/mdb mice aged 4 to 12 days we observed a diminished first phase of glucose-induced insulin secretion in vitro, and alterations in the inhibitory effect of somatostatin on insulin secretion. |
1988-10-27 |
2023-08-11 |
mouse |
| L M Karabatas, M Arata, L Anaya, J C Cresto, O H Pivetta, J C Basab. First phase of insulin secretion stimulated by glucose plus theophylline and inhibitory effect of somatostatin in genetically diabetic mice (C57BL/KsJ-mdb). Diabetologia. vol 31. issue 6. 1988-10-27. PMID:2901377. |
this study explores, using perifused pancreatic slices, whether the reduced b-cell responsiveness to somatostatin in mdb/mdb mice can be overcome upon induction of a biphasic insulin release by using theophylline. |
1988-10-27 |
2023-08-11 |
mouse |
| L M Karabatas, M Arata, L Anaya, J C Cresto, O H Pivetta, J C Basab. First phase of insulin secretion stimulated by glucose plus theophylline and inhibitory effect of somatostatin in genetically diabetic mice (C57BL/KsJ-mdb). Diabetologia. vol 31. issue 6. 1988-10-27. PMID:2901377. |
under these conditions our results show: (1) in mdb/mdb mice aged 4 to 6 days, the restoration of the first peak of insulin secretion overcomes the reduced b-cell sensitivity to somatostatin; and (2) in mdb/mdb mice aged 7 to 12 days, the addition of theophylline only causes a partial restoration of b-cell responsiveness to somatostatin, suggesting that other mechanisms could be involved in the progressive impairement of b-cell sensitivity to somatostatin inhibitory effect. |
1988-10-27 |
2023-08-11 |
mouse |
| H H von Dorsche, K Fält, H J Hahn, H Reihe. [Immunocytochemical studies of the development of basal cell types of human islet organs]. Acta histochemica. Supplementband. vol 35. 1988-10-27. PMID:2901775. |
the detection of the 4 islet hormones insulin, glucagon, somatostatin and pp ist carried out in pap-technique. |
1988-10-27 |
2023-08-11 |
human |
| R Yui, Y Nagata, T Fujit. Immunocytochemical studies on the islet and the gut of the arctic lamprey, Lampetra japonica. Archives of histology and cytology. vol 51. issue 1. 1988-10-25. PMID:3137945. |
the islet consisted exclusively of insulin immunoreactive cells in the larvae (ammocoetes), whereas in the adult somatostatin immunoreactive cells were added to the insulin immunoreactive cells; the gut epithelium in the adult was now devoid of somatostatin cells. |
1988-10-25 |
2023-08-11 |
Not clear |
| T Karashima, A V Schall. Superactive somatostatin analog decreases plasma glucose and glucagon levels in diabetic rats. Peptides. vol 9. issue 3. 1988-10-21. PMID:2901737. |
this analog may be useful as an adjunct to insulin in the treatment of diabetic patients, although caution should be exercised, to prevent hypoglycemia when using somatostatin analogs together with insulin. |
1988-10-21 |
2023-08-11 |
rat |
| S Harvey, C Foltzer-Jourdainne, H Karmann, P Mialh. Thyrotrophin-releasing hormone-induced growth hormone secretion in ducks: independence of peripheral plasma somatostatin, insulin, and glucagon. General and comparative endocrinology. vol 70. issue 3. 1988-10-18. PMID:2901384. |
thyrotrophin-releasing hormone-induced growth hormone secretion in ducks: independence of peripheral plasma somatostatin, insulin, and glucagon. |
1988-10-18 |
2023-08-11 |
Not clear |
| K Hermanse. Effects of galanin on the release of insulin, glucagon and somatostatin from the isolated, perfused dog pancreas. Acta endocrinologica. vol 119. issue 1. 1988-10-13. PMID:2458006. |
effects of galanin on the release of insulin, glucagon and somatostatin from the isolated, perfused dog pancreas. |
1988-10-13 |
2023-08-11 |
dog |
| K Hermanse. Effects of galanin on the release of insulin, glucagon and somatostatin from the isolated, perfused dog pancreas. Acta endocrinologica. vol 119. issue 1. 1988-10-13. PMID:2458006. |
the lowest galanin concentration that caused a significant suppression of insulin and somatostatin secretion was 10(-11) and 10(-10) mol/l, respectively. |
1988-10-13 |
2023-08-11 |
dog |
| K Hermanse. Effects of galanin on the release of insulin, glucagon and somatostatin from the isolated, perfused dog pancreas. Acta endocrinologica. vol 119. issue 1. 1988-10-13. PMID:2458006. |
galanin (10(-9) mol/l) caused a more pronounced inhibition of insulin and somatostatin secretion at high (10 mmol/l) and normal (5 mmol/l) than at low glucose (1.3 mmol/l). |
1988-10-13 |
2023-08-11 |
dog |
| K Hermanse. Effects of galanin on the release of insulin, glucagon and somatostatin from the isolated, perfused dog pancreas. Acta endocrinologica. vol 119. issue 1. 1988-10-13. PMID:2458006. |
perfusion of 10(-6) mol/l of atropine, phentolamine and propranolol had no effect on the galanin-mediated (10(-10) mol/l) inhibition of insulin and somatostatin secretion. |
1988-10-13 |
2023-08-11 |
dog |
| K Hermanse. Effects of galanin on the release of insulin, glucagon and somatostatin from the isolated, perfused dog pancreas. Acta endocrinologica. vol 119. issue 1. 1988-10-13. PMID:2458006. |
galanin (10(-12)-10(-10) mol/l) and somatostatin (10(-12)-10(-10) mol/l) were equipotent in inhibiting insulin secretion whereas only somatostatin exerted a suppression of the glucagon secretion at normal glucose. |
1988-10-13 |
2023-08-11 |
dog |
| K Hermanse. Effects of galanin on the release of insulin, glucagon and somatostatin from the isolated, perfused dog pancreas. Acta endocrinologica. vol 119. issue 1. 1988-10-13. PMID:2458006. |
thus, galanin exerts a differential effect on islet hormone secretion and may participate in the hormonal control of insulin, glucagon and somatostatin secretion. |
1988-10-13 |
2023-08-11 |
dog |
| G Ribes, R Gross, D Chenon, M M Loubatières-Marian. Effect of insulin on basal pancreaticoduodenal output of somatostatin in normal and diabetic dogs. Acta endocrinologica. vol 119. issue 1. 1988-10-13. PMID:2901182. |
effect of insulin on basal pancreaticoduodenal output of somatostatin in normal and diabetic dogs. |
1988-10-13 |
2023-08-11 |
Not clear |
| B E Dunning, G J Taborsk. Galanin--sympathetic neurotransmitter in endocrine pancreas? Diabetes. vol 37. issue 9. 1988-10-07. PMID:2457528. |
1) galanin administration inhibits basal insulin and somatostatin secretion and stimulates basal glucagon secretion from the pancreas, qualitatively reproducing the effects of sympathetic nerve stimulation. |
1988-10-07 |
2023-08-11 |
Not clear |
| B E Dunning, G J Taborsk. Galanin--sympathetic neurotransmitter in endocrine pancreas? Diabetes. vol 37. issue 9. 1988-10-07. PMID:2457528. |
the quantity released is sufficient to reproduce sympathetic nerve stimulation-induced effects on insulin secretion and to contribute to the neural effects on somatostatin and glucagon release. |
1988-10-07 |
2023-08-11 |
Not clear |
| A Verrillo, A de Teresa, C Martino, G di Chiara, L Verrill. Somatostatin response to glucose before and after prolonged fasting in lean and obese non-diabetic subjects. Regulatory peptides. vol 21. issue 3-4. 1988-09-26. PMID:2901133. |
insulin, glucagon, and somatostatin concentrations were measured in 7 lean and 7 obese non-diabetic subjects over 7 days of fasting. |
1988-09-26 |
2023-08-11 |
human |
| A Verrillo, A de Teresa, C Martino, G di Chiara, L Verrill. Somatostatin response to glucose before and after prolonged fasting in lean and obese non-diabetic subjects. Regulatory peptides. vol 21. issue 3-4. 1988-09-26. PMID:2901133. |
in lean subjects complete food deprivation induced a significant decrease in the circulating levels of both insulin and somatostatin, while glucagon nearly doubled by 48 h and then remained constant for the duration of starvation. |
1988-09-26 |
2023-08-11 |
human |
| A Verrillo, A de Teresa, C Martino, G di Chiara, L Verrill. Somatostatin response to glucose before and after prolonged fasting in lean and obese non-diabetic subjects. Regulatory peptides. vol 21. issue 3-4. 1988-09-26. PMID:2901133. |
refeeding with oral glucose suppressed the increased plasma glucagon, but insulin and somatostatin responses were enhanced in comparison with the prefast values, as assessed by the integrated areas of change. |
1988-09-26 |
2023-08-11 |
human |