| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jie Peng, Yuanfei Zhou, Zhao Deng, Hong Zhang, Yinghui Wu, Tongxing Song, Yang Yang, Hongkui Wei, Jian Pen. miR-221 negatively regulates inflammation and insulin sensitivity in white adipose tissue by repression of sirtuin-1 (SIRT1). Journal of cellular biochemistry. vol 119. issue 8. 2019-05-16. PMID:29236311. |
in conclusion, our data suggest that mir-221 promotes white adipose tissue inflammation and decreases insulin sensitivity in obesity, at least in part, through suppressing sirt1. |
2019-05-16 |
2023-08-13 |
human |
| Yu S Stafeev, S S Michurina, E S Zubkova, I B Beloglazova, E I Ratner, E V Parfenova, M Yu Men'shiko. Modulation of the Inflammatory Status of Macrophages and Their Paracrine Effect on the Sensitivity of Adipocytes to Insulin with Sirtuin and PPARγ Receptor Activators. Bulletin of experimental biology and medicine. vol 165. issue 4. 2018-11-19. PMID:30121911. |
we studied the effect of sirt1 deacetylase and pparγ receptor activators on proinflammatory (m1), anti-inflammatory (m2) polarization of raw264.7 macrophages and their modulating effects on insulin sensitivity of adipocytes. |
2018-11-19 |
2023-08-13 |
Not clear |
| Kyung Eun Kim, Eun Ae Jeong, Jong Youl Lee, Chin-Ok Yi, Kyung-Ah Park, Zhen Jin, Jung Eun Lee, Tamas L Horvath, Gu Seob Ro. Myeloid sirtuin1 deficiency aggravates hippocampal inflammation in mice fed high-fat diets. Biochemical and biophysical research communications. vol 499. issue 4. 2018-10-09. PMID:29634925. |
myeloid sirtuin1 (sirt1) deficiency aggravates high-fat diet (hfd)-induced insulin resistance. |
2018-10-09 |
2023-08-13 |
mouse |
| Kyung Eun Kim, Eun Ae Jeong, Jong Youl Lee, Chin-Ok Yi, Kyung-Ah Park, Zhen Jin, Jung Eun Lee, Tamas L Horvath, Gu Seob Ro. Myeloid sirtuin1 deficiency aggravates hippocampal inflammation in mice fed high-fat diets. Biochemical and biophysical research communications. vol 499. issue 4. 2018-10-09. PMID:29634925. |
we found that hfd-fed sirt1 ko mice had increased insulin resistance and macrophage infiltration in adipose tissue than wild type (wt) mice. |
2018-10-09 |
2023-08-13 |
mouse |
| Kyung Eun Kim, Eun Ae Jeong, Jong Youl Lee, Chin-Ok Yi, Kyung-Ah Park, Zhen Jin, Jung Eun Lee, Tamas L Horvath, Gu Seob Ro. Myeloid sirtuin1 deficiency aggravates hippocampal inflammation in mice fed high-fat diets. Biochemical and biophysical research communications. vol 499. issue 4. 2018-10-09. PMID:29634925. |
taken together, our results suggest that targeted induction of the anti-inflammatory effects of sirt1 and lcn2 may help prevent obesity-associated insulin resistance and neuroinflammation. |
2018-10-09 |
2023-08-13 |
mouse |
| Yue Cao, Zi Yan, Tong Zhou, Guixia Wan. SIRT1 Regulates Cognitive Performance and Ability of Learning and Memory in Diabetic and Nondiabetic Models. Journal of diabetes research. vol 2017. 2018-07-23. PMID:29164153. |
sirt1, as one of the modulators in insulin resistance, is indispensable for learning and memory. |
2018-07-23 |
2023-08-13 |
Not clear |
| K Svensson, S A LaBarge, V F Martins, S Schen. Temporal overexpression of SIRT1 in skeletal muscle of adult mice does not improve insulin sensitivity or markers of mitochondrial biogenesis. Acta physiologica (Oxford, England). vol 221. issue 3. 2018-06-13. PMID:28544355. |
temporal overexpression of sirt1 in skeletal muscle of adult mice does not improve insulin sensitivity or markers of mitochondrial biogenesis. |
2018-06-13 |
2023-08-13 |
mouse |
| Veera Ganesh Yerra, Anil Kumar Kalvala, Ashutosh Kuma. Isoliquiritigenin reduces oxidative damage and alleviates mitochondrial impairment by SIRT1 activation in experimental diabetic neuropathy. The Journal of nutritional biochemistry. vol 47. 2018-05-09. PMID:28528294. |
sirtuin (sirt1) inactivation underlies the pathogenesis of insulin resistance and hyperglycaemia-associated vascular complications, but its role in diabetic neuropathy (dn) has not been yet explored. |
2018-05-09 |
2023-08-13 |
rat |
| Peng Liu, Tingting Feng, Xuan Zuo, Xiao Wang, Jinque Luo, Ni Li, Xiaowan Han, Ningyu Zhu, Suowen Xu, Yanni Xu, Zheng Gen Jin, Shuyi S. A novel SIRT1 activator E6155 improves insulin sensitivity in type 2 diabetic KKA Biochemical and biophysical research communications. vol 498. issue 3. 2018-05-03. PMID:29524414. |
a novel sirt1 activator e6155 improves insulin sensitivity in type 2 diabetic kka sirtuin 1 (sirt1) is an nad |
2018-05-03 |
2023-08-13 |
Not clear |
| Dorota Rogacka, Irena Audzeyenka, Michał Rychłowski, Patrycja Rachubik, Maria Szrejder, Stefan Angielski, Agnieszka Piwkowsk. Metformin overcomes high glucose-induced insulin resistance of podocytes by pleiotropic effects on SIRT1 and AMPK. Biochimica et biophysica acta. Molecular basis of disease. vol 1864. issue 1. 2018-03-26. PMID:29032153. |
metformin overcomes high glucose-induced insulin resistance of podocytes by pleiotropic effects on sirt1 and ampk. |
2018-03-26 |
2023-08-13 |
rat |
| Dorota Rogacka, Irena Audzeyenka, Michał Rychłowski, Patrycja Rachubik, Maria Szrejder, Stefan Angielski, Agnieszka Piwkowsk. Metformin overcomes high glucose-induced insulin resistance of podocytes by pleiotropic effects on SIRT1 and AMPK. Biochimica et biophysica acta. Molecular basis of disease. vol 1864. issue 1. 2018-03-26. PMID:29032153. |
energy-sensing pathways, such as amp-dependent protein kinase (ampk) and protein deacetylase sirt1, have been shown to play an important role in insulin resistance. |
2018-03-26 |
2023-08-13 |
rat |
| Dorota Rogacka, Irena Audzeyenka, Michał Rychłowski, Patrycja Rachubik, Maria Szrejder, Stefan Angielski, Agnieszka Piwkowsk. Metformin overcomes high glucose-induced insulin resistance of podocytes by pleiotropic effects on SIRT1 and AMPK. Biochimica et biophysica acta. Molecular basis of disease. vol 1864. issue 1. 2018-03-26. PMID:29032153. |
the absence of a stimulating effect of insulin on glucose uptake into podocytes after exposure to hyperglycemic conditions has been demonstrated to be related to a decreased level and activity of sirt1 protein, leading to reduced ampk phosphorylation. |
2018-03-26 |
2023-08-13 |
rat |
| Dorota Rogacka, Irena Audzeyenka, Michał Rychłowski, Patrycja Rachubik, Maria Szrejder, Stefan Angielski, Agnieszka Piwkowsk. Metformin overcomes high glucose-induced insulin resistance of podocytes by pleiotropic effects on SIRT1 and AMPK. Biochimica et biophysica acta. Molecular basis of disease. vol 1864. issue 1. 2018-03-26. PMID:29032153. |
the present work was undertaken to investigate metformin's ability to restore the insulin responsiveness of podocytes by regulating sirt1 and ampk activities. |
2018-03-26 |
2023-08-13 |
rat |
| Shafat Ali, Shazia Nafis, Ponnusamy Kalaiarasan, Ekta Rai, Swarkar Sharma, Rameshwar N Bameza. Understanding Genetic Heterogeneity in Type 2 Diabetes by Delineating Physiological Phenotypes: SIRT1 and its Gene Network in Impaired Insulin Secretion. The review of diabetic studies : RDS. vol 13. issue 1. 2017-11-03. PMID:27563694. |
understanding genetic heterogeneity in type 2 diabetes by delineating physiological phenotypes: sirt1 and its gene network in impaired insulin secretion. |
2017-11-03 |
2023-08-13 |
Not clear |
| Shafat Ali, Shazia Nafis, Ponnusamy Kalaiarasan, Ekta Rai, Swarkar Sharma, Rameshwar N Bameza. Understanding Genetic Heterogeneity in Type 2 Diabetes by Delineating Physiological Phenotypes: SIRT1 and its Gene Network in Impaired Insulin Secretion. The review of diabetic studies : RDS. vol 13. issue 1. 2017-11-03. PMID:27563694. |
this review is also intended to explain the genetic basis of the pathophysiology of insulin secretion in the context of variations in the sirt1 gene, a major switch that modulates insulin secretion, and a set of other genes such as hhex, pgc-α, tcf7l2, ucp2, and nd3 which were found to be in association with t2d. |
2017-11-03 |
2023-08-13 |
Not clear |
| Harumasa Nakazawa, Kyungho Chang, Shohei Shinozaki, Takashi Yasukawa, Kazuhiro Ishimaru, Shingo Yasuhara, Yong-Ming Yu, J A Jeevendra Martyn, Ronald G Tompkins, Kentaro Shimokado, Masao Kanek. iNOS as a Driver of Inflammation and Apoptosis in Mouse Skeletal Muscle after Burn Injury: Possible Involvement of Sirt1 S-Nitrosylation-Mediated Acetylation of p65 NF-κB and p53. PloS one. vol 12. issue 1. 2017-08-16. PMID:28099528. |
our data suggest that sirt1 s-nitrosylation may play a role in inos-mediated enhanced inflammatory response and apoptotic change, which, in turn, contribute to muscle wasting and supposedly to insulin resistance after burn injury. |
2017-08-16 |
2023-08-13 |
mouse |
| Xiaoyan Hui, Mingliang Zhang, Ping Gu, Kuai Li, Yuan Gao, Donghai Wu, Yu Wang, Aimin X. Adipocyte SIRT1 controls systemic insulin sensitivity by modulating macrophages in adipose tissue. EMBO reports. vol 18. issue 4. 2017-08-15. PMID:28270525. |
adipocyte sirt1 controls systemic insulin sensitivity by modulating macrophages in adipose tissue. |
2017-08-15 |
2023-08-13 |
Not clear |
| Limei Liu, Chungang Liu, Qianzhen Zhang, Junjie Shen, Heng Zhang, Juanjuan Shan, Guangjie Duan, Deyu Guo, Xuejiao Chen, Jiamin Cheng, Yanmin Xu, Zhi Yang, Chao Yao, Maode Lai, Cheng Qia. SIRT1-mediated transcriptional regulation of SOX2 is important for self-renewal of liver cancer stem cells. Hepatology (Baltimore, Md.). vol 64. issue 3. 2017-08-02. PMID:27312708. |
furthermore, we demonstrated that insulin growth factor signaling plays an important role in maintaining sirt1 expression through increased sirt1 protein stability. |
2017-08-02 |
2023-08-13 |
human |
| Dan Yu, Xianlong Ye, Qiang Wu, Shujie Li, Yongbi Yang, Jinjiao He, Yunye Liu, Xiaoyu Zhang, Qingyan Yuan, Mingyao Liu, Deshan Li, Guiping Re. Insulin sensitizes FGF21 in glucose and lipid metabolisms via activating common AKT pathway. Endocrine. vol 52. issue 3. 2017-07-13. PMID:26607153. |
the results demonstrate that insulin sensitizes fgf21 through elevating the phosphorylation of common gene akt and amplifying fgf21 downstream signaling, including increasing expression of glut1 sirt1, pgc-1α, ucp-1, and decreasing fasn expression. |
2017-07-13 |
2023-08-13 |
mouse |
| Jun Liu, Ben Zhou, Menghong Yan, Rui Huang, Yuangao Wang, Zhishui He, Yonggang Yang, Changgui Dai, Yiqian Wang, Fang Zhang, Qiwei Zha. CLOCK and BMAL1 Regulate Muscle Insulin Sensitivity via SIRT1 in Male Mice. Endocrinology. vol 157. issue 6. 2017-06-05. PMID:27035655. |
clock and bmal1 regulate muscle insulin sensitivity via sirt1 in male mice. |
2017-06-05 |
2023-08-13 |
mouse |