| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Laura Bordone, Maria Carla Motta, Frederic Picard, Ashley Robinson, Ulupi S Jhala, Javier Apfeld, Thomas McDonagh, Madeleine Lemieux, Michael McBurney, Akos Szilvasi, Erin J Easlon, Su-Ju Lin, Leonard Guarent. Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells. PLoS biology. vol 4. issue 2. 2007-01-11. PMID:16366736. |
we show that sirt1 positively regulates insulin secretion in pancreatic beta cells. |
2007-01-11 |
2023-08-12 |
mouse |
| Laura Bordone, Maria Carla Motta, Frederic Picard, Ashley Robinson, Ulupi S Jhala, Javier Apfeld, Thomas McDonagh, Madeleine Lemieux, Michael McBurney, Akos Szilvasi, Erin J Easlon, Su-Ju Lin, Leonard Guarent. Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells. PLoS biology. vol 4. issue 2. 2007-01-11. PMID:16366736. |
in beta cell lines in which sirt1 is reduced by sirna, ucp2 levels are elevated and insulin secretion is blunted. |
2007-01-11 |
2023-08-12 |
mouse |
| Laura Bordone, Maria Carla Motta, Frederic Picard, Ashley Robinson, Ulupi S Jhala, Javier Apfeld, Thomas McDonagh, Madeleine Lemieux, Michael McBurney, Akos Szilvasi, Erin J Easlon, Su-Ju Lin, Leonard Guarent. Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells. PLoS biology. vol 4. issue 2. 2007-01-11. PMID:16366736. |
knockdown of ucp2 restores the ability to secrete insulin in cells with reduced sirt1, showing that ucp2 causes the defect in glucose-stimulated insulin secretion. |
2007-01-11 |
2023-08-12 |
mouse |
| Laura Bordone, Maria Carla Motta, Frederic Picard, Ashley Robinson, Ulupi S Jhala, Javier Apfeld, Thomas McDonagh, Madeleine Lemieux, Michael McBurney, Akos Szilvasi, Erin J Easlon, Su-Ju Lin, Leonard Guarent. Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells. PLoS biology. vol 4. issue 2. 2007-01-11. PMID:16366736. |
our findings show that sirt1 regulates ucp2 in beta cells to affect insulin secretion. |
2007-01-11 |
2023-08-12 |
mouse |
| Jiandi Zhan. Resveratrol inhibits insulin responses in a SirT1-independent pathway. The Biochemical journal. vol 397. issue 3. 2006-08-25. PMID:16626303. |
in addition, rna interference experiment shows that the inhibitory effect of resveratrol on insulin signalling pathway is not weakened in cells with reduced expression of sirt1, the mammalian counterpart of sir2. |
2006-08-25 |
2023-08-12 |
rat |
| Jiandi Zhan. Resveratrol inhibits insulin responses in a SirT1-independent pathway. The Biochemical journal. vol 397. issue 3. 2006-08-25. PMID:16626303. |
these observations raise the possibility that resveratrol may additionally modulate lifespan through inhibition of insulin signalling pathway, independently of its activation of sirt1 histone deacetylase. |
2006-08-25 |
2023-08-12 |
rat |
| Ingo B Leibiger, Per-Olof Berggre. A SIRTain role in pancreatic beta cell function. Cell metabolism. vol 2. issue 2. 2005-09-30. PMID:16098824. |
(2005[this issue of cell metabolism]) now demonstrate that increasing levels of sirt1 in the pancreatic beta cells of mice result in a more efficient glucose handling due to enhanced glucose-stimulated insulin secretion. |
2005-09-30 |
2023-08-12 |
mouse |
| Kathryn A Moynihan, Andrew A Grimm, Marie M Plueger, Ernesto Bernal-Mizrachi, Eric Ford, Corentin Cras-Méneur, M Alan Permutt, Shin-Ichiro Ima. Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice. Cell metabolism. vol 2. issue 2. 2005-09-30. PMID:16098828. |
here we show that increased dosage of sirt1, the mammalian sir2 ortholog, in pancreatic beta cells improves glucose tolerance and enhances insulin secretion in response to glucose in beta cell-specific sirt1-overexpressing (besto) transgenic mice. |
2005-09-30 |
2023-08-12 |
mouse |
| Kathryn A Moynihan, Andrew A Grimm, Marie M Plueger, Ernesto Bernal-Mizrachi, Eric Ford, Corentin Cras-Méneur, M Alan Permutt, Shin-Ichiro Ima. Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice. Cell metabolism. vol 2. issue 2. 2005-09-30. PMID:16098828. |
pancreatic perfusion experiments further demonstrate that sirt1 enhances insulin secretion in response to glucose and kcl. |
2005-09-30 |
2023-08-12 |
mouse |
| Kathryn A Moynihan, Andrew A Grimm, Marie M Plueger, Ernesto Bernal-Mizrachi, Eric Ford, Corentin Cras-Méneur, M Alan Permutt, Shin-Ichiro Ima. Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice. Cell metabolism. vol 2. issue 2. 2005-09-30. PMID:16098828. |
microarray analyses of beta cell lines reveal that sirt1 regulates genes involved in insulin secretion, including uncoupling protein 2 (ucp2). |
2005-09-30 |
2023-08-12 |
mouse |
| Undurti N Da. A defect in the activity of Delta6 and Delta5 desaturases may be a factor predisposing to the development of insulin resistance syndrome. Prostaglandins, leukotrienes, and essential fatty acids. vol 72. issue 5. 2005-09-27. PMID:15850715. |
in addition, sirt1 repressed ppar-gamma, and overexpression of sirt1 attenuated adipogenesis, and upregulation of sirt in differentiated fat cells triggered lipolysis and loss of fat, events that are known to attenuate insulin resistance and prolong life span. |
2005-09-27 |
2023-08-12 |
human |
| Anne Brunet, Lora B Sweeney, J Fitzhugh Sturgill, Katrin F Chua, Paul L Greer, Yingxi Lin, Hien Tran, Sarah E Ross, Raul Mostoslavsky, Haim Y Cohen, Linda S Hu, Hwei-Ling Cheng, Mark P Jedrychowski, Steven P Gygi, David A Sinclair, Frederick W Alt, Michael E Greenber. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science (New York, N.Y.). vol 303. issue 5666. 2004-04-22. PMID:14976264. |
we show that in mammalian cells, the sir2 homolog sirt1 appears to control the cellular response to stress by regulating the foxo family of forkhead transcription factors, a family of proteins that function as sensors of the insulin signaling pathway and as regulators of organismal longevity. |
2004-04-22 |
2023-08-12 |
Not clear |