| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kathryn Moynihan Ramsey, Kathryn F Mills, Akiko Satoh, Shin-Ichiro Ima. Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice. Aging cell. vol 7. issue 1. 2008-02-25. PMID:18005249. |
we previously reported that an increased dosage of sirt1 in pancreatic beta cells enhances glucose-stimulated insulin secretion (gsis) and improves glucose tolerance in beta cell-specific sirt1-overexpressing (besto) transgenic mice at 3 and 8 months of age. |
2008-02-25 |
2023-08-12 |
mouse |
| Jiandi Zhan. The direct involvement of SirT1 in insulin-induced insulin receptor substrate-2 tyrosine phosphorylation. The Journal of biological chemistry. vol 282. issue 47. 2008-01-23. PMID:17901049. |
protein deacetylase activity of sirt1, the mammalian homologue of sir2, was suppressed through either nicotinamide treatment or rna interference in several cell lines, and these cells displayed impaired insulin responses. |
2008-01-23 |
2023-08-12 |
Not clear |
| Jiandi Zhan. The direct involvement of SirT1 in insulin-induced insulin receptor substrate-2 tyrosine phosphorylation. The Journal of biological chemistry. vol 282. issue 47. 2008-01-23. PMID:17901049. |
further analyses showed that both irs-1 and irs-2 interacted with sirt1, and the acetylation level of irs-2 was down-regulated by insulin treatment. |
2008-01-23 |
2023-08-12 |
Not clear |
| Jiandi Zhan. The direct involvement of SirT1 in insulin-induced insulin receptor substrate-2 tyrosine phosphorylation. The Journal of biological chemistry. vol 282. issue 47. 2008-01-23. PMID:17901049. |
these results suggest a possible regulatory effect of sirt1 on insulin-induced tyrosine phosphorylation of irs-2, a vital step in insulin signaling pathway, through deacetylation of irs-2 protein. |
2008-01-23 |
2023-08-12 |
Not clear |
| Jill C Milne, Philip D Lambert, Simon Schenk, David P Carney, Jesse J Smith, David J Gagne, Lei Jin, Olivier Boss, Robert B Perni, Chi B Vu, Jean E Bemis, Roger Xie, Jeremy S Disch, Pui Yee Ng, Joseph J Nunes, Amy V Lynch, Hongying Yang, Heidi Galonek, Kristine Israelian, Wendy Choy, Andre Iffland, Siva Lavu, Oliver Medvedik, David A Sinclair, Jerrold M Olefsky, Michael R Jirousek, Peter J Elliott, Christoph H Westpha. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. vol 450. issue 7170. 2008-01-07. PMID:18046409. |
sirt1, an nad+-dependent deacetylase, is a principal modulator of pathways downstream of calorie restriction that produce beneficial effects on glucose homeostasis and insulin sensitivity. |
2008-01-07 |
2023-08-12 |
mouse |
| Jill C Milne, Philip D Lambert, Simon Schenk, David P Carney, Jesse J Smith, David J Gagne, Lei Jin, Olivier Boss, Robert B Perni, Chi B Vu, Jean E Bemis, Roger Xie, Jeremy S Disch, Pui Yee Ng, Joseph J Nunes, Amy V Lynch, Hongying Yang, Heidi Galonek, Kristine Israelian, Wendy Choy, Andre Iffland, Siva Lavu, Oliver Medvedik, David A Sinclair, Jerrold M Olefsky, Michael R Jirousek, Peter J Elliott, Christoph H Westpha. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. vol 450. issue 7170. 2008-01-07. PMID:18046409. |
resveratrol, a polyphenolic sirt1 activator, mimics the anti-ageing effects of calorie restriction in lower organisms and in mice fed a high-fat diet ameliorates insulin resistance, increases mitochondrial content, and prolongs survival. |
2008-01-07 |
2023-08-12 |
mouse |
| Jill C Milne, Philip D Lambert, Simon Schenk, David P Carney, Jesse J Smith, David J Gagne, Lei Jin, Olivier Boss, Robert B Perni, Chi B Vu, Jean E Bemis, Roger Xie, Jeremy S Disch, Pui Yee Ng, Joseph J Nunes, Amy V Lynch, Hongying Yang, Heidi Galonek, Kristine Israelian, Wendy Choy, Andre Iffland, Siva Lavu, Oliver Medvedik, David A Sinclair, Jerrold M Olefsky, Michael R Jirousek, Peter J Elliott, Christoph H Westpha. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. vol 450. issue 7170. 2008-01-07. PMID:18046409. |
in zucker fa/fa rats, hyperinsulinaemic-euglycaemic clamp studies demonstrate that sirt1 activators improve whole-body glucose homeostasis and insulin sensitivity in adipose tissue, skeletal muscle and liver. |
2008-01-07 |
2023-08-12 |
mouse |
| Janice M Zabolotny, Young-Bum Ki. Silencing insulin resistance through SIRT1. Cell metabolism. vol 6. issue 4. 2007-12-06. PMID:17908551. |
silencing insulin resistance through sirt1. |
2007-12-06 |
2023-08-12 |
Not clear |
| Janice M Zabolotny, Young-Bum Ki. Silencing insulin resistance through SIRT1. Cell metabolism. vol 6. issue 4. 2007-12-06. PMID:17908551. |
a new study in this issue of cell metabolism (sun et al., 2007) shows that sirt1, a mammalian sirtuin homolog and histone deacetylase, can ameliorate insulin resistance by silencing expression of protein tyrosine phosphatase 1b, a major negative regulator of insulin action. |
2007-12-06 |
2023-08-12 |
Not clear |
| Cheng Sun, Fang Zhang, Xinjian Ge, Tingting Yan, Xingmiao Chen, Xianglin Shi, Qiwei Zha. SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B. Cell metabolism. vol 6. issue 4. 2007-12-06. PMID:17908559. |
sirt1 improves insulin sensitivity under insulin-resistant conditions by repressing ptp1b. |
2007-12-06 |
2023-08-12 |
Not clear |
| Cheng Sun, Fang Zhang, Xinjian Ge, Tingting Yan, Xingmiao Chen, Xianglin Shi, Qiwei Zha. SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B. Cell metabolism. vol 6. issue 4. 2007-12-06. PMID:17908559. |
sirt1 has been reported to be involved in the processes of glucose metabolism and insulin secretion. |
2007-12-06 |
2023-08-12 |
Not clear |
| Cheng Sun, Fang Zhang, Xinjian Ge, Tingting Yan, Xingmiao Chen, Xianglin Shi, Qiwei Zha. SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B. Cell metabolism. vol 6. issue 4. 2007-12-06. PMID:17908559. |
however, whether sirt1 is directly involved in insulin sensitivity is still largely unknown. |
2007-12-06 |
2023-08-12 |
Not clear |
| Cheng Sun, Fang Zhang, Xinjian Ge, Tingting Yan, Xingmiao Chen, Xianglin Shi, Qiwei Zha. SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B. Cell metabolism. vol 6. issue 4. 2007-12-06. PMID:17908559. |
here we show that sirt1 is downregulated in insulin-resistant cells and tissues and that knockdown or inhibition of sirt1 induces insulin resistance. |
2007-12-06 |
2023-08-12 |
Not clear |
| Cheng Sun, Fang Zhang, Xinjian Ge, Tingting Yan, Xingmiao Chen, Xianglin Shi, Qiwei Zha. SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B. Cell metabolism. vol 6. issue 4. 2007-12-06. PMID:17908559. |
furthermore, increased expression of sirt1 improved insulin sensitivity, especially under insulin-resistant conditions. |
2007-12-06 |
2023-08-12 |
Not clear |
| Cheng Sun, Fang Zhang, Xinjian Ge, Tingting Yan, Xingmiao Chen, Xianglin Shi, Qiwei Zha. SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B. Cell metabolism. vol 6. issue 4. 2007-12-06. PMID:17908559. |
similarly, resveratrol, a sirt1 activator, enhanced insulin sensitivity in vitro in a sirt1-dependent manner and attenuated high-fat-diet-induced insulin resistance in vivo at a dose of 2.5 mg/kg/day. |
2007-12-06 |
2023-08-12 |
Not clear |
| Cheng Sun, Fang Zhang, Xinjian Ge, Tingting Yan, Xingmiao Chen, Xianglin Shi, Qiwei Zha. SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B. Cell metabolism. vol 6. issue 4. 2007-12-06. PMID:17908559. |
further studies demonstrated that the effect of sirt1 on insulin resistance is mediated by repressing ptp1b transcription at the chromatin level. |
2007-12-06 |
2023-08-12 |
Not clear |
| Cheng Sun, Fang Zhang, Xinjian Ge, Tingting Yan, Xingmiao Chen, Xianglin Shi, Qiwei Zha. SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B. Cell metabolism. vol 6. issue 4. 2007-12-06. PMID:17908559. |
taken together, the finding that sirt1 improves insulin sensitivity has implications toward resolving insulin resistance and type 2 diabetes. |
2007-12-06 |
2023-08-12 |
Not clear |
| Joseph T Rodgers, Pere Puigserve. Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 31. 2007-09-21. PMID:17646659. |
knockdown of sirt1 in liver caused mild hypoglycemia, increased systemic glucose and insulin sensitivity, and decreased glucose production. |
2007-09-21 |
2023-08-12 |
Not clear |
| Vasantha M Nayagam, Xukun Wang, Yong Cheng Tan, Anders Poulsen, Kee Chuan Goh, Tony Ng, Haishan Wang, Hong Yan Song, Binhui Ni, Michael Entzeroth, Walter Stünke. SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin-sensitizing agents. Journal of biomolecular screening. vol 11. issue 8. 2007-02-21. PMID:17099246. |
in contrast, a sirt1 inhibitory compound showed a stimulatory activity on the differentiation of adipocytes, a feature often linked to insulin sensitization. |
2007-02-21 |
2023-08-12 |
mouse |
| Laura Bordone, Maria Carla Motta, Frederic Picard, Ashley Robinson, Ulupi S Jhala, Javier Apfeld, Thomas McDonagh, Madeleine Lemieux, Michael McBurney, Akos Szilvasi, Erin J Easlon, Su-Ju Lin, Leonard Guarent. Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells. PLoS biology. vol 4. issue 2. 2007-01-11. PMID:16366736. |
sirt1 regulates insulin secretion by repressing ucp2 in pancreatic beta cells. |
2007-01-11 |
2023-08-12 |
mouse |