| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Shan, Y Ren, Y Liu, L Zhu, Y Wan. Breed difference and regulation of the porcine Sirtuin 1 by insulin. Journal of animal science. vol 88. issue 12. 2011-03-28. PMID:20802141. |
these results indicate that insulin may regulate transcription of sirt1, atgl, and hsl in porcine adipocytes and provide information for manipulating these gene expressions in regulating fat metabolism in pigs. |
2011-03-28 |
2023-08-12 |
Not clear |
| Beamon Agarwal, Joseph A Bau. Resveratrol and life extension. Annals of the New York Academy of Sciences. vol 1215. 2011-03-10. PMID:21261652. |
the polyphenol resveratrol activates sirt1 in an in vitro assay, and produces changes that resemble cr in vivo, including improvements in insulin sensitivity, endurance, and overall survival in obese mice. |
2011-03-10 |
2023-08-12 |
mouse |
| Juhong Yang, Nan Wang, Jingyan Li, Jiaojiao Zhang, Ping Fen. Effects of resveratrol on NO secretion stimulated by insulin and its dependence on SIRT1 in high glucose cultured endothelial cells. Endocrine. vol 37. issue 2. 2011-02-03. PMID:20960276. |
effects of resveratrol on no secretion stimulated by insulin and its dependence on sirt1 in high glucose cultured endothelial cells. |
2011-02-03 |
2023-08-12 |
human |
| Juhong Yang, Nan Wang, Jingyan Li, Jiaojiao Zhang, Ping Fen. Effects of resveratrol on NO secretion stimulated by insulin and its dependence on SIRT1 in high glucose cultured endothelial cells. Endocrine. vol 37. issue 2. 2011-02-03. PMID:20960276. |
after interfering the expression of sirt1 using sirt1 sirna, the effects of resveratrol on the no secretion induced by insulin was impaired. |
2011-02-03 |
2023-08-12 |
human |
| Yong-Ru Chen, Shi-Rong Fang, Yu-Cai Fu, Xiao-Hui Zhou, Ming-Yan Xu, Wen-Can X. Calorie restriction on insulin resistance and expression of SIRT1 and SIRT4 in rats. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 88. issue 4. 2010-12-15. PMID:20651844. |
calorie restriction on insulin resistance and expression of sirt1 and sirt4 in rats. |
2010-12-15 |
2023-08-12 |
rat |
| Yong-Ru Chen, Shi-Rong Fang, Yu-Cai Fu, Xiao-Hui Zhou, Ming-Yan Xu, Wen-Can X. Calorie restriction on insulin resistance and expression of SIRT1 and SIRT4 in rats. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 88. issue 4. 2010-12-15. PMID:20651844. |
sirtuin 1 (sirt1) and sirtuin 4 (sirt4) have been reported to regulate insulin secretion, but their association with the development of insulin resistance and nonalcoholic fatty liver disease remain undefined. |
2010-12-15 |
2023-08-12 |
rat |
| Yong-Ru Chen, Shi-Rong Fang, Yu-Cai Fu, Xiao-Hui Zhou, Ming-Yan Xu, Wen-Can X. Calorie restriction on insulin resistance and expression of SIRT1 and SIRT4 in rats. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 88. issue 4. 2010-12-15. PMID:20651844. |
the aim of this study was to determine the expression of sirt1 and sirt4 in the liver and pancreas of rats fed with different diets and analyze the association of these proteins with insulin resistance and nonalcoholic fatty liver disease. |
2010-12-15 |
2023-08-12 |
rat |
| Yong-Ru Chen, Shi-Rong Fang, Yu-Cai Fu, Xiao-Hui Zhou, Ming-Yan Xu, Wen-Can X. Calorie restriction on insulin resistance and expression of SIRT1 and SIRT4 in rats. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 88. issue 4. 2010-12-15. PMID:20651844. |
these data suggest that sirt1 and sirt4 were both involved in the development of insulin resistance and nonalcoholic fatty liver disease. |
2010-12-15 |
2023-08-12 |
rat |
| Kian-Peng Goh, Chee-Fang Su. Connecting the dots: molecular and epigenetic mechanisms in type 2 diabetes. Current diabetes reviews. vol 6. issue 4. 2010-10-29. PMID:20528767. |
at the molecular forefront, energy-sensing signaling pathways in t2dm, such as pgc1alpha, ampk, o-glcnac and most recently sirt1 have been shown to play key roles in oxidative stress, mitochondrial dysfunction, inflammation and glucolipotoxicity, which are the hallmarks of insulin resistance and t2dm, furthermore, sirt1, pgc1alpha and o-glcnac also regulate gene expression and may play a role in the epigenetic machinery, thus providing an explanation to how metabolism switches to either a 'thrift' or 'spend' mode depending on food availability. |
2010-10-29 |
2023-08-12 |
Not clear |
| Mizuho Okazaki, Yasumasa Iwasaki, Mitsuru Nishiyama, Takafumi Taguchi, Makoto Tsugita, Shuichi Nakayama, Machiko Kambayashi, Kozo Hashimoto, Yoshio Terad. PPARbeta/delta regulates the human SIRT1 gene transcription via Sp1. Endocrine journal. vol 57. issue 5. 2010-09-07. PMID:20160399. |
we first found that representative metabolic hormones and related factors (glucocorticoid, glucagon/camp, and insulin) did not show significant effect on sirt1 gene transcription. |
2010-09-07 |
2023-08-12 |
human |
| Kimberly R Holloway, Tara N Calhoun, Madhurima Saxena, Cheynita F Metoyer, Ethan F Kandler, Chantal A Rivera, Kevin Pruit. SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 20. 2010-07-22. PMID:20439735. |
because sirt1 regulates very diverse responses such as apoptosis, insulin sensitivity, autophagy, differentiation, and stem cell pluripotency, it has been a challenge to reconcile how it orchestrates such pleiotropic effects. |
2010-07-22 |
2023-08-12 |
Not clear |
| Zhenggang Yang, Barbara B Kahn, Hang Shi, Bing-Zhong Xu. Macrophage alpha1 AMP-activated protein kinase (alpha1AMPK) antagonizes fatty acid-induced inflammation through SIRT1. The Journal of biological chemistry. vol 285. issue 25. 2010-07-21. PMID:20421294. |
in conclusion, ampk negatively regulates lipid-induced inflammation, which acts through sirt1, thereby contributing to the protection against obesity, inflammation, and insulin resistance. |
2010-07-21 |
2023-08-12 |
Not clear |
| Tsutomu Sasaki, Hye-Jin Kim, Masaki Kobayashi, Yukari-Ido Kitamura, Hiromi Yokota-Hashimoto, Tetsuya Shiuchi, Yasuhiko Minokoshi, Tadahiro Kitamur. Induction of hypothalamic Sirt1 leads to cessation of feeding via agouti-related peptide. Endocrinology. vol 151. issue 6. 2010-06-30. PMID:20375183. |
sirt1 has been reported to improve insulin sensitivity in vitro, but the role of hypothalamic sirt1 in regulating feeding has not been addressed. |
2010-06-30 |
2023-08-12 |
mouse |
| Tsutomu Sasaki, Hye-Jin Kim, Masaki Kobayashi, Yukari-Ido Kitamura, Hiromi Yokota-Hashimoto, Tetsuya Shiuchi, Yasuhiko Minokoshi, Tadahiro Kitamur. Induction of hypothalamic Sirt1 leads to cessation of feeding via agouti-related peptide. Endocrinology. vol 151. issue 6. 2010-06-30. PMID:20375183. |
forced expression of wild-type sirt1 in the mediobasal hypothalamus by adenovirus microinjection suppressed foxo1-induced hyperphagia, a model for central insulin resistance. |
2010-06-30 |
2023-08-12 |
mouse |
| Jarno Rutanen, Nagendra Yaluri, Shalem Modi, Jussi Pihlajamäki, Markku Vänttinen, Paula Itkonen, Sakari Kainulainen, Hiroyasu Yamamoto, Marie Lagouge, David A Sinclair, Peter Elliott, Christoph Westphal, Johan Auwerx, Markku Laaks. SIRT1 mRNA expression may be associated with energy expenditure and insulin sensitivity. Diabetes. vol 59. issue 4. 2010-04-23. PMID:20107110. |
sirt1 mrna expression may be associated with energy expenditure and insulin sensitivity. |
2010-04-23 |
2023-08-12 |
Not clear |
| Jarno Rutanen, Nagendra Yaluri, Shalem Modi, Jussi Pihlajamäki, Markku Vänttinen, Paula Itkonen, Sakari Kainulainen, Hiroyasu Yamamoto, Marie Lagouge, David A Sinclair, Peter Elliott, Christoph Westphal, Johan Auwerx, Markku Laaks. SIRT1 mRNA expression may be associated with energy expenditure and insulin sensitivity. Diabetes. vol 59. issue 4. 2010-04-23. PMID:20107110. |
sirtuin 1 (sirt1) is implicated in the regulation of mitochondrial function, energy metabolism, and insulin sensitivity in rodents. |
2010-04-23 |
2023-08-12 |
Not clear |
| Jarno Rutanen, Nagendra Yaluri, Shalem Modi, Jussi Pihlajamäki, Markku Vänttinen, Paula Itkonen, Sakari Kainulainen, Hiroyasu Yamamoto, Marie Lagouge, David A Sinclair, Peter Elliott, Christoph Westphal, Johan Auwerx, Markku Laaks. SIRT1 mRNA expression may be associated with energy expenditure and insulin sensitivity. Diabetes. vol 59. issue 4. 2010-04-23. PMID:20107110. |
no studies are available in humans to demonstrate that sirt1 expression in insulin-sensitive tissues is associated with energy expenditure and insulin sensitivity. |
2010-04-23 |
2023-08-12 |
Not clear |
| Jee-Hyun Um, Sung-Jun Park, Hyeog Kang, Shutong Yang, Marc Foretz, Michael W McBurney, Myung K Kim, Benoit Viollet, Jay H Chun. AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol. Diabetes. vol 59. issue 3. 2010-03-30. PMID:19934007. |
although it is thought that resveratrol targets sirt1, this is controversial because resveratrol also activates 5' amp-activated protein kinase (ampk), which also regulates insulin sensitivity and mitochondrial biogenesis. |
2010-03-30 |
2023-08-12 |
mouse |
| Takeshi Yoshizaki, Simon Schenk, Takeshi Imamura, Jennie L Babendure, Noriyuki Sonoda, Eun Ju Bae, Da Young Oh, Min Lu, Jill C Milne, Christoph Westphal, Gautam Bandyopadhyay, Jerrold M Olefsk. SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity. American journal of physiology. Endocrinology and metabolism. vol 298. issue 3. 2010-03-30. PMID:19996381. |
sirt1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity. |
2010-03-30 |
2023-08-12 |
mouse |
| Takeshi Yoshizaki, Simon Schenk, Takeshi Imamura, Jennie L Babendure, Noriyuki Sonoda, Eun Ju Bae, Da Young Oh, Min Lu, Jill C Milne, Christoph Westphal, Gautam Bandyopadhyay, Jerrold M Olefsk. SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity. American journal of physiology. Endocrinology and metabolism. vol 298. issue 3. 2010-03-30. PMID:19996381. |
the mammalian silent information regulator 2 homolog sirt1 modulates several physiological processes important for life span, and a potential role of sirt1 in the regulation of insulin sensitivity has been shown. |
2010-03-30 |
2023-08-12 |
mouse |