| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Colette M Knight, Roger Gutierrez-Juarez, Tony K T Lam, Isabel Arrieta-Cruz, Loli Huang, Gary Schwartz, Nir Barzilai, Luciano Rossett. Mediobasal hypothalamic SIRT1 is essential for resveratrol's effects on insulin action in rats. Diabetes. vol 60. issue 11. 2011-12-14. PMID:21896928. |
mediobasal hypothalamic sirt1 is essential for resveratrol's effects on insulin action in rats. |
2011-12-14 |
2023-08-12 |
rat |
| Gaby Andersen, Alexander Burkon, Florian J Sulzmaier, Joel M Walker, Gunhild Leckband, Rainer Fuhst, Helmut F Erbersdobler, Veronika Somoz. High dose of dietary resveratrol enhances insulin sensitivity in healthy rats but does not lead to metabolite concentrations effective for SIRT1 expression. Molecular nutrition & food research. vol 55. issue 8. 2011-11-28. PMID:21732533. |
high dose of dietary resveratrol enhances insulin sensitivity in healthy rats but does not lead to metabolite concentrations effective for sirt1 expression. |
2011-11-28 |
2023-08-12 |
rat |
| Maria Esméria Corezola do Amaral, Mirian Ueno, Camila A M Oliveira, Natália C Borsonello, Emerielle C Vanzela, Rosane A Ribeiro, Patricia L Alves, Helena C Barbosa, Everardo M Carneiro, Antonio C Boscher. Reduced expression of SIRT1 is associated with diminished glucose-induced insulin secretion in islets from calorie-restricted rats. The Journal of nutritional biochemistry. vol 22. issue 6. 2011-10-21. PMID:20801633. |
reduced expression of sirt1 is associated with diminished glucose-induced insulin secretion in islets from calorie-restricted rats. |
2011-10-21 |
2023-08-12 |
rat |
| Maria Esméria Corezola do Amaral, Mirian Ueno, Camila A M Oliveira, Natália C Borsonello, Emerielle C Vanzela, Rosane A Ribeiro, Patricia L Alves, Helena C Barbosa, Everardo M Carneiro, Antonio C Boscher. Reduced expression of SIRT1 is associated with diminished glucose-induced insulin secretion in islets from calorie-restricted rats. The Journal of nutritional biochemistry. vol 22. issue 6. 2011-10-21. PMID:20801633. |
here, we search for a possible relationship between insulin secretion and the expression of sirt1, sirt4, pkc and pka in islets from adult rats submitted to cr for 21 days. |
2011-10-21 |
2023-08-12 |
rat |
| Maria Esméria Corezola do Amaral, Mirian Ueno, Camila A M Oliveira, Natália C Borsonello, Emerielle C Vanzela, Rosane A Ribeiro, Patricia L Alves, Helena C Barbosa, Everardo M Carneiro, Antonio C Boscher. Reduced expression of SIRT1 is associated with diminished glucose-induced insulin secretion in islets from calorie-restricted rats. The Journal of nutritional biochemistry. vol 22. issue 6. 2011-10-21. PMID:20801633. |
in conclusion, the lower insulin secretion in islets from cr rats was, at least in part, due to an imbalance between the expression of sirt1 and sirt4. |
2011-10-21 |
2023-08-12 |
rat |
| Jaime Uribarri, Weijing Cai, Maya Ramdas, Susan Goodman, Renata Pyzik, Xue Chen, Li Zhu, Gary E Striker, Helen Vlassar. Restriction of advanced glycation end products improves insulin resistance in human type 2 diabetes: potential role of AGER1 and SIRT1. Diabetes care. vol 34. issue 7. 2011-10-19. PMID:21709297. |
restriction of advanced glycation end products improves insulin resistance in human type 2 diabetes: potential role of ager1 and sirt1. |
2011-10-19 |
2023-08-12 |
human |
| Kinyui Alice Lo, Mary K Bauchmann, Amy P Baumann, Christopher J Donahue, Mark A Thiede, Lisa S Hayes, Shelley Ann G des Etages, Ernest Fraenke. Genome-wide profiling of H3K56 acetylation and transcription factor binding sites in human adipocytes. PloS one. vol 6. issue 6. 2011-10-04. PMID:21655096. |
h3k56 is acetylated by cbp and p300, and deacetylated by sirt1, all are proteins with important roles in diabetes and insulin signaling. |
2011-10-04 |
2023-08-12 |
mouse |
| Rocco Barazzoni, Michela Zanetti, Mauro Sturnega, Marco Stebel, Annamaria Semolic, Alessia Pirulli, Pierandrea Vinci, Lorena Zentilin, Mauro Giacca, Luigi Cattin, Gianfranco Guarnier. Insulin downregulates SIRT1 and AMPK activation and is associated with changes in liver fat, but not in inflammation and mitochondrial oxidative capacity, in streptozotocin-diabetic rat. Clinical nutrition (Edinburgh, Scotland). vol 30. issue 3. 2011-10-03. PMID:21106280. |
insulin downregulates sirt1 and ampk activation and is associated with changes in liver fat, but not in inflammation and mitochondrial oxidative capacity, in streptozotocin-diabetic rat. |
2011-10-03 |
2023-08-12 |
rat |
| Rocco Barazzoni, Michela Zanetti, Mauro Sturnega, Marco Stebel, Annamaria Semolic, Alessia Pirulli, Pierandrea Vinci, Lorena Zentilin, Mauro Giacca, Luigi Cattin, Gianfranco Guarnier. Insulin downregulates SIRT1 and AMPK activation and is associated with changes in liver fat, but not in inflammation and mitochondrial oxidative capacity, in streptozotocin-diabetic rat. Clinical nutrition (Edinburgh, Scotland). vol 30. issue 3. 2011-10-03. PMID:21106280. |
in streptozotocin-diabetic rats, we hypothesized that insulin negatively modulates liver sirt1 and activates ampk-inhibited lipogenic mediators leading to triglyceride accumulation. |
2011-10-03 |
2023-08-12 |
rat |
| Tetsuo Ogawa, Chizu Wakai, Tomomi Saito, Aya Murayama, Yuuichi Mimura, Sachiko Youfu, Tomoya Nakamachi, Makiko Kuwagata, Kazue Satoh, Seiji Shiod. Distribution of the longevity gene product, SIRT1, in developing mouse organs. Congenital anomalies. vol 51. issue 2. 2011-09-13. PMID:21054562. |
the mammalian homolog of sir2, sirt1(sirtuin 1), has been shown to play important roles related to anti-aging effects (regulating apoptosis, stress tolerance, insulin resistance, and fat metabolism). |
2011-09-13 |
2023-08-12 |
mouse |
| Laurène Vetterli, Pierre Maechle. Resveratrol-activated SIRT1 in liver and pancreatic β-cells: a Janus head looking to the same direction of metabolic homeostasis. Aging. vol 3. issue 4. 2011-08-29. PMID:21483037. |
sirt1 is one of the targets of resveratrol, a polyphenol that has been shown to increase lifespan and to protect animal models against high-calorie diet induced obesity and insulin resistance. |
2011-08-29 |
2023-08-12 |
Not clear |
| Yasar Colak, Oguzhan Ozturk, Ebubekir Senates, Ilyas Tuncer, Elif Yorulmaz, Gupse Adali, Levent Doganay, Feruze Yilmaz En. SIRT1 as a potential therapeutic target for treatment of nonalcoholic fatty liver disease. Medical science monitor : international medical journal of experimental and clinical research. vol 17. issue 5. 2011-08-17. PMID:21525818. |
recently, it has been shown that sirt1 plays key roles in the regulation of lipid and glucose homeostasis, control of insulin secretion and sensitivity, antiinflammatory effects, control of oxidative stress and the improvements in endothelial function that result due to increased mitochondrial biogenesis and β-oxidation capacity. |
2011-08-17 |
2023-08-12 |
mouse |
| Thaddeus T Schug, Xiaoling L. Sirtuin 1 in lipid metabolism and obesity. Annals of medicine. vol 43. issue 3. 2011-07-29. PMID:21345154. |
sirt1 is known to be involved in gluconeogenesis in the liver, fat mobilization in white adipose tissue, and insulin secretion in the pancreas. |
2011-07-29 |
2023-08-12 |
Not clear |
| Jing Pang, Huan Gong, Chao Xi, Wei Fan, Yang Dai, Tie-Mei Zhan. Poly(ADP-ribose) polymerase 1 is involved in glucose toxicity through SIRT1 modulation in HepG2 hepatocytes. Journal of cellular biochemistry. vol 112. issue 1. 2011-07-19. PMID:21031461. |
these data suggest that high-glucose-induced parp1 activation might play a role in glucose toxicity by down-regulating sirt1 and ampk activity through nad depletion and resulting in insulin insensitivity. |
2011-07-19 |
2023-08-12 |
Not clear |
| Timothy R H Regnault, Lin Zhao, Jacky S S Chiu, Stephanie K Gottheil, Allison Foran, Siu-Pok Ye. Peroxisome Proliferator-Activated Receptor -β/δ, -γ Agonists and Resveratrol Modulate Hypoxia Induced Changes in Nuclear Receptor Activators of Muscle Oxidative Metabolism. PPAR research. vol 2010. 2011-07-14. PMID:21113404. |
ppar-α, ppar-β, and ppar-γ, and rxr in conjunction with pgc-1α and sirt1, activate oxidative metabolism genes determining insulin sensitivity. |
2011-07-14 |
2023-08-12 |
Not clear |
| Yu Li, Shanqin Xu, Amber Giles, Kazuto Nakamura, Jong Woo Lee, Xiuyun Hou, Gizem Donmez, Ji Li, Zhijun Luo, Kenneth Walsh, Leonard Guarente, Mengwei Zan. Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 25. issue 5. 2011-06-28. PMID:21321189. |
hepatic overexpression of sirt1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver. |
2011-06-28 |
2023-08-12 |
mouse |
| Yu Li, Shanqin Xu, Amber Giles, Kazuto Nakamura, Jong Woo Lee, Xiuyun Hou, Gizem Donmez, Ji Li, Zhijun Luo, Kenneth Walsh, Leonard Guarente, Mengwei Zan. Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 25. issue 5. 2011-06-28. PMID:21321189. |
although sirt1 has a therapeutic effect on metabolic deterioration in t2dm, the precise mechanisms by which sirt1 improves insulin resistance remain unclear. |
2011-06-28 |
2023-08-12 |
mouse |
| Yu Li, Shanqin Xu, Amber Giles, Kazuto Nakamura, Jong Woo Lee, Xiuyun Hou, Gizem Donmez, Ji Li, Zhijun Luo, Kenneth Walsh, Leonard Guarente, Mengwei Zan. Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 25. issue 5. 2011-06-28. PMID:21321189. |
here, we demonstrate that adenovirus-mediated overexpression of sirt1 in the liver of diet-induced insulin-resistant low-density lipoprotein receptor-deficient mice and of genetically obese ob/ob mice attenuates hepatic steatosis and ameliorates systemic insulin resistance. |
2011-06-28 |
2023-08-12 |
mouse |
| Yu Li, Shanqin Xu, Amber Giles, Kazuto Nakamura, Jong Woo Lee, Xiuyun Hou, Gizem Donmez, Ji Li, Zhijun Luo, Kenneth Walsh, Leonard Guarente, Mengwei Zan. Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 25. issue 5. 2011-06-28. PMID:21321189. |
these studies indicate that sirt1 serves as a negative regulator of upr signaling in t2dm and that sirt1 attenuates hepatic steatosis, ameliorates insulin resistance, and restores glucose homeostasis, largely through the inhibition of mtorc1 and er stress. |
2011-06-28 |
2023-08-12 |
mouse |
| Sara Fröjdö, Christine Durand, Laurent Molin, Andrew L Carey, Assam El-Osta, Bronwyn A Kingwell, Mark A Febbraio, Florence Solari, Hubert Vidal, Luciano Pirol. Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1. Molecular and cellular endocrinology. vol 335. issue 2. 2011-06-20. PMID:21241768. |
phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by sirt1. |
2011-06-20 |
2023-08-12 |
caenorhabditis_elegans |