| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yong-Ru Chen, Yu-Lin Lai, Shao-da Lin, Xi-Tao Li, Yu-Cai Fu, Wen-Can X. SIRT1 interacts with metabolic transcriptional factors in the pancreas of insulin-resistant and calorie-restricted rats. Molecular biology reports. vol 40. issue 4. 2013-09-04. PMID:23292098. |
however, it is still not clear how sirt1 is involved in the development of insulin resistance. |
2013-09-04 |
2023-08-12 |
rat |
| Yong-Ru Chen, Yu-Lin Lai, Shao-da Lin, Xi-Tao Li, Yu-Cai Fu, Wen-Can X. SIRT1 interacts with metabolic transcriptional factors in the pancreas of insulin-resistant and calorie-restricted rats. Molecular biology reports. vol 40. issue 4. 2013-09-04. PMID:23292098. |
to determine the location and expression of sirt1 and its target proteins in rats and analyze the interactions and functions of these proteins in insulin resistance. |
2013-09-04 |
2023-08-12 |
rat |
| Yong-Ru Chen, Yu-Lin Lai, Shao-da Lin, Xi-Tao Li, Yu-Cai Fu, Wen-Can X. SIRT1 interacts with metabolic transcriptional factors in the pancreas of insulin-resistant and calorie-restricted rats. Molecular biology reports. vol 40. issue 4. 2013-09-04. PMID:23292098. |
these data suggest that sirt1 and its regulators are involved in the development of insulin resistance. |
2013-09-04 |
2023-08-12 |
rat |
| Tadahiro Kitamur. [Obesity and the central regulation of energy metabolism]. Nihon rinsho. Japanese journal of clinical medicine. vol 71. issue 2. 2013-07-30. PMID:23631196. |
foxo1 is a downstream effector of insulin signaling and sirt1 is an nad(+)-dependent deacetylase, both of which work as energy sensors at the cellular level. |
2013-07-30 |
2023-08-12 |
Not clear |
| Osamu Yamaguchi, Kinya Ots. Role of autophagy in aging. Journal of cardiovascular pharmacology. vol 60. issue 3. 2013-07-09. PMID:22343371. |
autophagic activity is regulated by many factors, such as the insulin receptor-signaling pathway, the tor pathway, sirt1, and caloric restriction. |
2013-07-09 |
2023-08-12 |
mouse |
| Min Lu, David A Sarruf, Pingping Li, Olivia Osborn, Manuel Sanchez-Alavez, Saswata Talukdar, Ai Chen, Gautam Bandyopadhyay, Jianfeng Xu, Hidetaka Morinaga, Kevin Dines, Steven Watkins, Karl Kaiyala, Michael W Schwartz, Jerrold M Olefsk. Neuronal Sirt1 deficiency increases insulin sensitivity in both brain and peripheral tissues. The Journal of biological chemistry. vol 288. issue 15. 2013-06-07. PMID:23457303. |
neuronal sirt1 deficiency increases insulin sensitivity in both brain and peripheral tissues. |
2013-06-07 |
2023-08-12 |
mouse |
| Min Lu, David A Sarruf, Pingping Li, Olivia Osborn, Manuel Sanchez-Alavez, Saswata Talukdar, Ai Chen, Gautam Bandyopadhyay, Jianfeng Xu, Hidetaka Morinaga, Kevin Dines, Steven Watkins, Karl Kaiyala, Michael W Schwartz, Jerrold M Olefsk. Neuronal Sirt1 deficiency increases insulin sensitivity in both brain and peripheral tissues. The Journal of biological chemistry. vol 288. issue 15. 2013-06-07. PMID:23457303. |
on both standard chow and hfd, sinko mice were more insulin sensitive than sirt1(f/f) mice. |
2013-06-07 |
2023-08-12 |
mouse |
| Min Lu, David A Sarruf, Pingping Li, Olivia Osborn, Manuel Sanchez-Alavez, Saswata Talukdar, Ai Chen, Gautam Bandyopadhyay, Jianfeng Xu, Hidetaka Morinaga, Kevin Dines, Steven Watkins, Karl Kaiyala, Michael W Schwartz, Jerrold M Olefsk. Neuronal Sirt1 deficiency increases insulin sensitivity in both brain and peripheral tissues. The Journal of biological chemistry. vol 288. issue 15. 2013-06-07. PMID:23457303. |
in summary, we conclude that neuronal sirt1 negatively regulates hypothalamic insulin signaling, leading to systemic insulin resistance. |
2013-06-07 |
2023-08-12 |
mouse |
| Min Lu, David A Sarruf, Pingping Li, Olivia Osborn, Manuel Sanchez-Alavez, Saswata Talukdar, Ai Chen, Gautam Bandyopadhyay, Jianfeng Xu, Hidetaka Morinaga, Kevin Dines, Steven Watkins, Karl Kaiyala, Michael W Schwartz, Jerrold M Olefsk. Neuronal Sirt1 deficiency increases insulin sensitivity in both brain and peripheral tissues. The Journal of biological chemistry. vol 288. issue 15. 2013-06-07. PMID:23457303. |
interventions that reduce neuronal sirt1 activity have the potential to improve systemic insulin action and limit weight gain on an obesigenic diet. |
2013-06-07 |
2023-08-12 |
mouse |
| Xiaoling L. SIRT1 and energy metabolism. Acta biochimica et biophysica Sinica. vol 45. issue 1. 2013-06-04. PMID:23257294. |
recent studies have shown that sirt1 controls both glucose and lipid metabolism in the liver, promotes fat mobilization and stimulates brown remodeling of the white fat in white adipose tissue, controls insulin secretion in the pancreas, senses nutrient availability in the hypothalamus, influences obesity-induced inflammation in macrophages, and modulates the activity of circadian clock in metabolic tissues. |
2013-06-04 |
2023-08-12 |
Not clear |
| Cheng Xu, Bo Bai, Pengcheng Fan, Yu Cai, Bosheng Huang, Ivy Km Law, Ling Liu, Aimin Xu, Chunling Tung, Xuechen Li, Fung-Ming Siu, Chi-Ming Che, Paul M Vanhoutte, Yu Wan. Selective overexpression of human SIRT1 in adipose tissue enhances energy homeostasis and prevents the deterioration of insulin sensitivity with ageing in mice. American journal of translational research. vol 5. issue 4. 2013-06-03. PMID:23724165. |
selective overexpression of human sirt1 in adipose tissue enhances energy homeostasis and prevents the deterioration of insulin sensitivity with ageing in mice. |
2013-06-03 |
2023-08-12 |
mouse |
| Cheng Xu, Bo Bai, Pengcheng Fan, Yu Cai, Bosheng Huang, Ivy Km Law, Ling Liu, Aimin Xu, Chunling Tung, Xuechen Li, Fung-Ming Siu, Chi-Ming Che, Paul M Vanhoutte, Yu Wan. Selective overexpression of human SIRT1 in adipose tissue enhances energy homeostasis and prevents the deterioration of insulin sensitivity with ageing in mice. American journal of translational research. vol 5. issue 4. 2013-06-03. PMID:23724165. |
using a tissue-specific transgenic approach, the present study demonstrates that over-expression of human sirt1 selectively in adipose tissue of mice prevents ageing-induced deterioration of insulin sensitivity and ectopic lipid distribution, reduces whole body fat mass and enhances locomotor activity. |
2013-06-03 |
2023-08-12 |
mouse |
| Cheng Xu, Bo Bai, Pengcheng Fan, Yu Cai, Bosheng Huang, Ivy Km Law, Ling Liu, Aimin Xu, Chunling Tung, Xuechen Li, Fung-Ming Siu, Chi-Ming Che, Paul M Vanhoutte, Yu Wan. Selective overexpression of human SIRT1 in adipose tissue enhances energy homeostasis and prevents the deterioration of insulin sensitivity with ageing in mice. American journal of translational research. vol 5. issue 4. 2013-06-03. PMID:23724165. |
in summary, these results demonstrate that adipose sirt1 is a key player in maintaining systemic energy homeostasis and insulin sensitivity; enhancing its activity solely in adipose tissue can prevent ageing-associated metabolic disorders. |
2013-06-03 |
2023-08-12 |
mouse |
| Zhenggang Yang, Xianfeng Wang, Yin He, Ling Qi, Liqing Yu, Bingzhong Xue, Hang Sh. The full capacity of AICAR to reduce obesity-induced inflammation and insulin resistance requires myeloid SIRT1. PloS one. vol 7. issue 11. 2013-05-30. PMID:23183898. |
the full capacity of aicar to reduce obesity-induced inflammation and insulin resistance requires myeloid sirt1. |
2013-05-30 |
2023-08-12 |
mouse |
| Zhenggang Yang, Xianfeng Wang, Yin He, Ling Qi, Liqing Yu, Bingzhong Xue, Hang Sh. The full capacity of AICAR to reduce obesity-induced inflammation and insulin resistance requires myeloid SIRT1. PloS one. vol 7. issue 11. 2013-05-30. PMID:23183898. |
here we aim to determine whether the therapeutic effects of aicar against insulin resistance involve its anti-inflammatory function, which requires macrophage sirt1. |
2013-05-30 |
2023-08-12 |
mouse |
| Zhenggang Yang, Xianfeng Wang, Yin He, Ling Qi, Liqing Yu, Bingzhong Xue, Hang Sh. The full capacity of AICAR to reduce obesity-induced inflammation and insulin resistance requires myeloid SIRT1. PloS one. vol 7. issue 11. 2013-05-30. PMID:23183898. |
interestingly, the beneficial effects of aicar on adipose inflammation and insulin sensitivity were absent in msko mice fed hf diets, suggesting that the full capacity of aicar to antagonize obesity-induced inflammation and insulin resistance requires myeloid sirt1. |
2013-05-30 |
2023-08-12 |
mouse |
| Zhenggang Yang, Xianfeng Wang, Yin He, Ling Qi, Liqing Yu, Bingzhong Xue, Hang Sh. The full capacity of AICAR to reduce obesity-induced inflammation and insulin resistance requires myeloid SIRT1. PloS one. vol 7. issue 11. 2013-05-30. PMID:23183898. |
in summary, aicar negatively regulates hf diet-induced inflammation, which requires myeloid sirt1, thereby contributing to the protection against insulin resistance. |
2013-05-30 |
2023-08-12 |
mouse |
| Ekta Rai, Swarkar Sharma, Surabhi Kaul, Kamal Jain, Kawaljit Matharoo, Amarjit S Bhanwer, Rameshwar N K Bameza. The interactive effect of SIRT1 promoter region polymorphism on type 2 diabetes susceptibility in the North Indian population. PloS one. vol 7. issue 11. 2013-05-07. PMID:23133645. |
recent literature on the role of sirt1 as a potential master switch modulating insulin secretion and regulating gene expression in pancreatic β cells has warranted an evaluation of sirt1 promoter region polymorphisms in the north indian population, which is the main focus of the present study. |
2013-05-07 |
2023-08-12 |
Not clear |
| Hongliang Li, Mingjiang Xu, Jiyeon Lee, Chaoyong He, Zhonglin Xi. Leucine supplementation increases SIRT1 expression and prevents mitochondrial dysfunction and metabolic disorders in high-fat diet-induced obese mice. American journal of physiology. Endocrinology and metabolism. vol 303. issue 10. 2013-04-09. PMID:22967499. |
we therefore examined the involvement of sirt1 in leucine supplementation-prevented obesity and insulin resistance. |
2013-04-09 |
2023-08-12 |
mouse |
| Hongliang Li, Mingjiang Xu, Jiyeon Lee, Chaoyong He, Zhonglin Xi. Leucine supplementation increases SIRT1 expression and prevents mitochondrial dysfunction and metabolic disorders in high-fat diet-induced obese mice. American journal of physiology. Endocrinology and metabolism. vol 303. issue 10. 2013-04-09. PMID:22967499. |
after 2 mo of treatment, alterations in sirt1 expression, insulin signaling, and energy metabolism were analyzed. |
2013-04-09 |
2023-08-12 |
mouse |