| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gérald J Prud'homme, Yelena Glinka, Oleksandr Udovyk, Craig Hasilo, Steven Paraskevas, Qinghua Wan. GABA protects pancreatic beta cells against apoptosis by increasing SIRT1 expression and activity. Biochemical and biophysical research communications. vol 452. issue 3. 2015-02-25. PMID:25193706. |
sirt1 is an nad(+)-dependent deacetylase that enhances insulin secretion, and counteracts inflammatory signals in beta cells. |
2015-02-25 |
2023-08-13 |
human |
| Gérald J Prud'homme, Yelena Glinka, Oleksandr Udovyk, Craig Hasilo, Steven Paraskevas, Qinghua Wan. GABA protects pancreatic beta cells against apoptosis by increasing SIRT1 expression and activity. Biochemical and biophysical research communications. vol 452. issue 3. 2015-02-25. PMID:25193706. |
gaba increased insulin production and reduced drug-induced apoptosis, and these actions were reversed by sirt1 inhibitors. |
2015-02-25 |
2023-08-13 |
human |
| Lai-Ling Du, Jia-Zhao Xie, Xiang-Shu Cheng, Xiao-Hong Li, Fan-Li Kong, Xia Jiang, Zhi-Wei Ma, Jian-Zhi Wang, Chen Chen, Xin-Wen Zho. Activation of sirtuin 1 attenuates cerebral ventricular streptozotocin-induced tau hyperphosphorylation and cognitive injuries in rat hippocampi. Age (Dordrecht, Netherlands). vol 36. issue 2. 2014-11-18. PMID:24142524. |
in conclusion, sirt1 protects hippocampus neurons from tau hyperphosphorylation and prevents cognitive impairment induced by icv-stz brain insulin resistance with decreased hippocampus erk1/2 activity. |
2014-11-18 |
2023-08-12 |
rat |
| Jin Hong, Bong-Woo Kim, Hyo-Jung Choo, Jung-Jin Park, Jae-Sung Yi, Dong-Min Yu, Hyun Lee, Gye-Soon Yoon, Jae-Seon Lee, Young-Gyu K. Mitochondrial complex I deficiency enhances skeletal myogenesis but impairs insulin signaling through SIRT1 inactivation. The Journal of biological chemistry. vol 289. issue 29. 2014-10-06. PMID:24895128. |
mitochondrial complex i deficiency enhances skeletal myogenesis but impairs insulin signaling through sirt1 inactivation. |
2014-10-06 |
2023-08-13 |
Not clear |
| Jin Hong, Bong-Woo Kim, Hyo-Jung Choo, Jung-Jin Park, Jae-Sung Yi, Dong-Min Yu, Hyun Lee, Gye-Soon Yoon, Jae-Seon Lee, Young-Gyu K. Mitochondrial complex I deficiency enhances skeletal myogenesis but impairs insulin signaling through SIRT1 inactivation. The Journal of biological chemistry. vol 289. issue 29. 2014-10-06. PMID:24895128. |
the ndufv1 knockdown-induced blockage of insulin signaling was released by protein-tyrosine phosphatase 1b knockdown in c2c12 myotubes, and we found that ndufv1 or sirt1 knockdown did not affect mitochondria biogenesis during c2c12 myogenesis. |
2014-10-06 |
2023-08-13 |
Not clear |
| Jin Hong, Bong-Woo Kim, Hyo-Jung Choo, Jung-Jin Park, Jae-Sung Yi, Dong-Min Yu, Hyun Lee, Gye-Soon Yoon, Jae-Seon Lee, Young-Gyu K. Mitochondrial complex I deficiency enhances skeletal myogenesis but impairs insulin signaling through SIRT1 inactivation. The Journal of biological chemistry. vol 289. issue 29. 2014-10-06. PMID:24895128. |
based on these data, we can conclude that complex i dysfunction-induced sirt1 inactivation leads to myogenesis enhancement but blocks insulin signaling without affecting mitochondria biogenesis. |
2014-10-06 |
2023-08-13 |
Not clear |
| Amita Arora, Chinmoy Sankar De. SIRT2 negatively regulates insulin resistance in C2C12 skeletal muscle cells. Biochimica et biophysica acta. vol 1842. issue 9. 2014-09-25. PMID:24793418. |
previously it has been reported that down-regulation of sirt1 and sirt3 in c2c12 cells results in impairment of insulin signaling and induces insulin resistance. |
2014-09-25 |
2023-08-13 |
Not clear |
| Alba Rebollo, Núria Roglans, Miguel Baena, Anna Padrosa, Rosa M Sánchez, Manuel Merlos, Marta Alegret, Juan C Lagun. Liquid fructose down-regulates liver insulin receptor substrate 2 and gluconeogenic enzymes by modifying nutrient sensing factors in rats. The Journal of nutritional biochemistry. vol 25. issue 2. 2014-09-15. PMID:24445051. |
liquid fructose affects both insulin signaling (irs-2 and foxo1) and nutrient sensing pathways (p38-mapk, mtor and sirt1), thus disrupting hepatic insulin signaling without increasing the expression of key gluconeogenic enzymes. |
2014-09-15 |
2023-08-12 |
rat |
| Rui-Hong Wang, Xiaoling Xu, Hyun-Seok Kim, Zhen Xiao, Chu-Xia Den. SIRT1 deacetylates FOXA2 and is critical for Pdx1 transcription and β-cell formation. International journal of biological sciences. vol 9. issue 9. 2014-08-19. PMID:24163589. |
consequently, sirt1 mutant mice develop progressive hyperglycemia, glucose intolerance, and insulin insufficiency, which directly correlate with the extent of sirt1 deletion. |
2014-08-19 |
2023-08-12 |
mouse |
| Rui-Hong Wang, Xiaoling Xu, Hyun-Seok Kim, Zhen Xiao, Chu-Xia Den. SIRT1 deacetylates FOXA2 and is critical for Pdx1 transcription and β-cell formation. International journal of biological sciences. vol 9. issue 9. 2014-08-19. PMID:24163589. |
these results uncover an essential role of sirt1 in β-cell formation by maintaining expression of pdx1 and its downstream genes, and identify pancreas-specific sirt1 mutant mice as a relevant model for studying insulin insufficiency. |
2014-08-19 |
2023-08-12 |
mouse |
| O Al Massadi, M Quiñones, P Lear, C Dieguez, R Nogueira. The brain: a new organ for the metabolic actions of SIRT1. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 45. issue 13. 2014-08-18. PMID:23950036. |
recent studies have shown that sirt1 controls glucose and lipid metabolism in both liver and muscle, promotes fat mobilization, stimulates remodeling of white to brown fat, controls insulin secretion in the pancreas, and senses nutrient availability in the hypothalamus. |
2014-08-18 |
2023-08-12 |
Not clear |
| O Al Massadi, M Quiñones, P Lear, C Dieguez, R Nogueira. The brain: a new organ for the metabolic actions of SIRT1. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 45. issue 13. 2014-08-18. PMID:23950036. |
in this short review, we summarize the main actions and molecular pathways triggered by sirt1 that control feeding behavior, energy expenditure, glucose metabolism, and insulin sensitivity, with an emphasis on the emerging role of sirt1 in the brain. |
2014-08-18 |
2023-08-12 |
Not clear |
| Ben Zhou, Yi Zhang, Fang Zhang, Yulei Xia, Jun Liu, Rui Huang, Yuangao Wang, Yanan Hu, Jingxia Wu, Changgui Dai, Hui Wang, Yanyang Tu, Xiaozhong Peng, Yiqian Wang, Qiwei Zha. CLOCK/BMAL1 regulates circadian change of mouse hepatic insulin sensitivity by SIRT1. Hepatology (Baltimore, Md.). vol 59. issue 6. 2014-08-08. PMID:24442997. |
clock/bmal1 regulates circadian change of mouse hepatic insulin sensitivity by sirt1. |
2014-08-08 |
2023-08-12 |
mouse |
| Ben Zhou, Yi Zhang, Fang Zhang, Yulei Xia, Jun Liu, Rui Huang, Yuangao Wang, Yanan Hu, Jingxia Wu, Changgui Dai, Hui Wang, Yanyang Tu, Xiaozhong Peng, Yiqian Wang, Qiwei Zha. CLOCK/BMAL1 regulates circadian change of mouse hepatic insulin sensitivity by SIRT1. Hepatology (Baltimore, Md.). vol 59. issue 6. 2014-08-08. PMID:24442997. |
the protein deacetylase, sirtuin 1 (sirt1), involved in regulating hepatic insulin sensitivity, shows circadian oscillation and regulates the circadian clock. |
2014-08-08 |
2023-08-12 |
mouse |
| Ben Zhou, Yi Zhang, Fang Zhang, Yulei Xia, Jun Liu, Rui Huang, Yuangao Wang, Yanan Hu, Jingxia Wu, Changgui Dai, Hui Wang, Yanyang Tu, Xiaozhong Peng, Yiqian Wang, Qiwei Zha. CLOCK/BMAL1 regulates circadian change of mouse hepatic insulin sensitivity by SIRT1. Hepatology (Baltimore, Md.). vol 59. issue 6. 2014-08-08. PMID:24442997. |
moreover, circadian change of insulin sensitivity is impaired in clock mutant, liver-specific bmal1 knockout (ko) or sirt1 ko mice, and clock and bmal1 are required for hepatic circadian expression of sirt1. |
2014-08-08 |
2023-08-12 |
mouse |
| Ben Zhou, Yi Zhang, Fang Zhang, Yulei Xia, Jun Liu, Rui Huang, Yuangao Wang, Yanan Hu, Jingxia Wu, Changgui Dai, Hui Wang, Yanyang Tu, Xiaozhong Peng, Yiqian Wang, Qiwei Zha. CLOCK/BMAL1 regulates circadian change of mouse hepatic insulin sensitivity by SIRT1. Hepatology (Baltimore, Md.). vol 59. issue 6. 2014-08-08. PMID:24442997. |
further studies show that clock/bmal1 binds to the sirt1 promoter to enhance its expression and regulates hepatic insulin sensitivity by sirt1. |
2014-08-08 |
2023-08-12 |
mouse |
| Erwan Gouranton, Béatrice Romier, Julie Marcotorchino, Franck Tourniaire, Julien Astier, Franck Peiretti, Jean-François Landrie. Visfatin is involved in TNFα-mediated insulin resistance via an NAD(+)/Sirt1/PTP1B pathway in 3T3-L1 adipocytes. Adipocyte. vol 3. issue 3. 2014-07-28. PMID:25068084. |
here, we demonstrated a complete pathway involving visfatin, nad(+), sirt1, and ptp1b that led to the perturbation of insulin signaling by tnfα in 3t3-l1 adipocytes. |
2014-07-28 |
2023-08-13 |
Not clear |
| Hyangkyu Lee, Sang Hui Chu, Jae Yeo Park, Hyun Ki Park, Jee Aee Im, Ji Won Le. Visceral adiposity is associated with SIRT1 expression in peripheral blood mononuclear cells: a pilot study. Endocrine journal. vol 60. issue 11. 2014-06-27. PMID:23933590. |
sirtuin1 (sirt1) is activated during calorie restriction and appears to be related to energy balance through glucose or lipid metabolism and insulin signaling. |
2014-06-27 |
2023-08-12 |
Not clear |
| Hyangkyu Lee, Sang Hui Chu, Jae Yeo Park, Hyun Ki Park, Jee Aee Im, Ji Won Le. Visceral adiposity is associated with SIRT1 expression in peripheral blood mononuclear cells: a pilot study. Endocrine journal. vol 60. issue 11. 2014-06-27. PMID:23933590. |
sirt1 expression levels negatively correlated with body mass index, waist circumference, abdominal visceral fat area, and homeostasis model of assessment of insulin resistance (homa-ir) and positively correlated with adiponectin levels. |
2014-06-27 |
2023-08-12 |
Not clear |
| Munehiro Kitada, Daisuke Koy. SIRT1 in Type 2 Diabetes: Mechanisms and Therapeutic Potential. Diabetes & metabolism journal. vol 37. issue 5. 2014-06-24. PMID:24199159. |
sirt1 in pancreatic β-cells positively regulates insulin secretion and protects cells from oxidative stress and inflammation, and has positive roles in the metabolic pathway via the modulation in insulin signaling. |
2014-06-24 |
2023-08-12 |
Not clear |