| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Romy Kursawe, Vishwa D Dixit, Philipp E Scherer, Nicola Santoro, Deepak Narayan, Ruth Gordillo, Cosimo Giannini, Ximena Lopez, Bridget Pierpont, Jessica Nouws, Gerald I Shulman, Sonia Capri. A Role of the Inflammasome in the Low Storage Capacity of the Abdominal Subcutaneous Adipose Tissue in Obese Adolescents. Diabetes. vol 65. issue 3. 2016-07-06. PMID:26718495. |
the increase in inflammation markers was paralleled by a decrease in genes related to insulin sensitivity (adipoq, glut4, pparg2, and sirt1) and lipogenesis (srebp1c, acc, lpl, and fasn). |
2016-07-06 |
2023-08-13 |
Not clear |
| Águeda González-Rodríguez, Beatriz Santamaría, José Antonio Mas-Gutierrez, Patricia Rada, Elisa Fernández-Millán, Virginia Pardo, Carmen Álvarez, Antonio Cuadrado, Manuel Ros, Manuel Serrano, Ángela M Valverd. Resveratrol treatment restores peripheral insulin sensitivity in diabetic mice in a sirt1-independent manner. Molecular nutrition & food research. vol 59. issue 8. 2016-05-17. PMID:25808216. |
in this study, we have investigated whether sirt1 mediates the effects of resveratrol in controlling insulin resistance in diabetic mice. |
2016-05-17 |
2023-08-13 |
mouse |
| Stefania Mariani, Daniela Fiore, Sabrina Basciani, Agnese Persichetti, Savina Contini, Carla Lubrano, Luisa Salvatori, Andrea Lenzi, Lucio Gness. Plasma levels of SIRT1 associate with non-alcoholic fatty liver disease in obese patients. Endocrine. vol 49. issue 3. 2016-04-25. PMID:25358448. |
bmi, transaminases, insulin, homa-index, hba1c, body composition (dxa), plasma sirt1 levels (elisa) and representative measures of metabolic syndrome (waist circumference, fasting plasma glucose, blood pressure, hdl-cholesterol, triglycerides) and inflammation (esr, crp, fibrinogen) were evaluated. |
2016-04-25 |
2023-08-13 |
Not clear |
| Xiaojing Hu, Liyi Chi, Wentao Zhang, Tiao Bai, Wei Zhao, Zhanbin Feng, Hongyan Tia. Down-regulation of the miR-543 alleviates insulin resistance through targeting the SIRT1. Biochemical and biophysical research communications. vol 468. issue 4. 2016-04-19. PMID:26562529. |
down-regulation of the mir-543 alleviates insulin resistance through targeting the sirt1. |
2016-04-19 |
2023-08-13 |
human |
| Xiaojing Hu, Liyi Chi, Wentao Zhang, Tiao Bai, Wei Zhao, Zhanbin Feng, Hongyan Tia. Down-regulation of the miR-543 alleviates insulin resistance through targeting the SIRT1. Biochemical and biophysical research communications. vol 468. issue 4. 2016-04-19. PMID:26562529. |
recently, sirtuin-1 (sirt1) has been found to participate in regulation of insulin resistance. |
2016-04-19 |
2023-08-13 |
human |
| Xiaojing Hu, Liyi Chi, Wentao Zhang, Tiao Bai, Wei Zhao, Zhanbin Feng, Hongyan Tia. Down-regulation of the miR-543 alleviates insulin resistance through targeting the SIRT1. Biochemical and biophysical research communications. vol 468. issue 4. 2016-04-19. PMID:26562529. |
therefore, further studies focused on the sirt1 regulators might provide a potential approach for combating insulin resistance and hypertension. |
2016-04-19 |
2023-08-13 |
human |
| Xiaojing Hu, Liyi Chi, Wentao Zhang, Tiao Bai, Wei Zhao, Zhanbin Feng, Hongyan Tia. Down-regulation of the miR-543 alleviates insulin resistance through targeting the SIRT1. Biochemical and biophysical research communications. vol 468. issue 4. 2016-04-19. PMID:26562529. |
further analysis showed that the overexpression of the mir-543 lowered the sirt1 mrna and protein levels, resulting in the insulin resistance in the hepg2 cells; the inhibition of mir-543, however, enhanced the mrna and protein expression of the sirt1, and alleviated the insulin resistance. |
2016-04-19 |
2023-08-13 |
human |
| Xiaojing Hu, Liyi Chi, Wentao Zhang, Tiao Bai, Wei Zhao, Zhanbin Feng, Hongyan Tia. Down-regulation of the miR-543 alleviates insulin resistance through targeting the SIRT1. Biochemical and biophysical research communications. vol 468. issue 4. 2016-04-19. PMID:26562529. |
furthermore, the sirt1 overexpression abrogated the effect of mir-543 on insulin resistance. |
2016-04-19 |
2023-08-13 |
human |
| Xiaojing Hu, Liyi Chi, Wentao Zhang, Tiao Bai, Wei Zhao, Zhanbin Feng, Hongyan Tia. Down-regulation of the miR-543 alleviates insulin resistance through targeting the SIRT1. Biochemical and biophysical research communications. vol 468. issue 4. 2016-04-19. PMID:26562529. |
in summary, our study suggested that the downregulation of the mir-543 could alleviate the insulin resistance via the modulation of the sirt1 expression, which might be a potential new strategy for treating insulin resistance and a promising therapeutic method for hypertension. |
2016-04-19 |
2023-08-13 |
human |
| Amanda E Brandon, Jennifer Tid-Ang, Lauren E Wright, Ella Stuart, Eurwin Suryana, Nicholas Bentley, Nigel Turner, Gregory J Cooney, Neil B Ruderman, Edward W Kraege. Overexpression of SIRT1 in rat skeletal muscle does not alter glucose induced insulin resistance. PloS one. vol 10. issue 3. 2016-03-25. PMID:25798922. |
overexpression of sirt1 in rat skeletal muscle does not alter glucose induced insulin resistance. |
2016-03-25 |
2023-08-13 |
rat |
| Amanda E Brandon, Jennifer Tid-Ang, Lauren E Wright, Ella Stuart, Eurwin Suryana, Nicholas Bentley, Nigel Turner, Gregory J Cooney, Neil B Ruderman, Edward W Kraege. Overexpression of SIRT1 in rat skeletal muscle does not alter glucose induced insulin resistance. PloS one. vol 10. issue 3. 2016-03-25. PMID:25798922. |
in the current study we investigated whether acute changes in sirt1 expression affect markers of muscle mitochondrial content and also determined whether sirt1 influenced muscle insulin resistance induced by acute glucose oversupply. |
2016-03-25 |
2023-08-13 |
rat |
| Amanda E Brandon, Jennifer Tid-Ang, Lauren E Wright, Ella Stuart, Eurwin Suryana, Nicholas Bentley, Nigel Turner, Gregory J Cooney, Neil B Ruderman, Edward W Kraege. Overexpression of SIRT1 in rat skeletal muscle does not alter glucose induced insulin resistance. PloS one. vol 10. issue 3. 2016-03-25. PMID:25798922. |
therefore we conclude that acute increases in sirt1 protein have little impact on mitochondrial content and that overexpressing sirt1 does not prevent the development of insulin resistance during hyperglycaemia. |
2016-03-25 |
2023-08-13 |
rat |
| P K Bagul, S K Banerje. Application of resveratrol in diabetes: rationale, strategies and challenges. Current molecular medicine. vol 15. issue 4. 2016-03-24. PMID:25941821. |
improving insulin sensitivity, enhancing glut4 translocation, reducing oxidative stress, regulating carbohydrate metabolizing enzymes, activating sirt1 and ampk, and decreasing adipogenic genes are some promising mechanisms established until now for resveratrol. |
2016-03-24 |
2023-08-13 |
Not clear |
| Li Qiang, Ning Kon, Wenhui Zhao, Le Jiang, Colette M Knight, Carrie Welch, Utpal Pajvani, Wei Gu, Domenico Accil. Hepatic SirT1-Dependent Gain of Function of Stearoyl-CoA Desaturase-1 Conveys Dysmetabolic and Tumor Progression Functions. Cell reports. vol 11. issue 11. 2016-03-24. PMID:26074075. |
in this work, we demonstrate that genetic ablation of the endogenous inhibitor of sirt1, deleted-in-breast-cancer-1 (dbc1), unexpectedly results in obesity and insulin resistance. |
2016-03-24 |
2023-08-13 |
mouse |
| Laura Bordone, Maria Carla Motta, Frederic Picard, Ashley Robinson, Ulupi S Jhala, Javier Apfeld, Thomas McDonagh, Madeleine Lemieux, Michael McBurney, Akos Szilvasi, Erin J Easlon, Su-Ju Lin, Leonard Guarent. Correction: Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells. PLoS biology. vol 13. issue 12. 2016-03-21. PMID:26714029. |
correction: sirt1 regulates insulin secretion by repressing ucp2 in pancreatic β cells. |
2016-03-21 |
2023-08-13 |
Not clear |
| Yuting Wu, Xuejiao Liu, Qun Zhou, Cheng Huang, Xiaoming Meng, Fengyun Xu, Jun L. Silent information regulator 1 (SIRT1) ameliorates liver fibrosis via promoting activated stellate cell apoptosis and reversion. Toxicology and applied pharmacology. vol 289. issue 2. 2016-03-08. PMID:26435214. |
restoration of sirt1 protein was observed in the in vivo spontaneously liver fibrosis reversion model and in vitro mdi (isobutylmethylxanthine, dexamethasone, and insulin)-induced reversed stellate cells, and forced expression of sirt1 also promoted the reversal of activated stellate cells. |
2016-03-08 |
2023-08-13 |
mouse |
| Andreia V Pinho, Mohammed Bensellam, Elke Wauters, Maxine Rees, Marc Giry-Laterriere, Amanda Mawson, Le Quan Ly, Andrew V Biankin, Jianmin Wu, D Ross Laybutt, Ilse Rooma. Pancreas-Specific Sirt1-Deficiency in Mice Compromises Beta-Cell Function without Development of Hyperglycemia. PloS one. vol 10. issue 6. 2016-03-04. PMID:26046931. |
sirtuin 1 (sirt1) has been reported to be a critical positive regulator of glucose-stimulated insulin secretion in pancreatic beta-cells. |
2016-03-04 |
2023-08-13 |
mouse |
| Ulkan Kilic, Ozlem Gok, Birsen Elibol-Can, Ilker Tolga Ozgen, Ufuk Erenberk, Omer Uysal, Mehmet Rusen Dundaro. SIRT1 gene variants are related to risk of childhood obesity. European journal of pediatrics. vol 174. issue 4. 2016-03-01. PMID:25233986. |
sirt1 gene has important effects on the regulation of adiponectin, caloric restriction, insulin sensitivity, coronary atherosclerosis, and cardiovascular diseases. |
2016-03-01 |
2023-08-13 |
Not clear |
| Hao-Hao Zhang, Gui-Jun Qin, Xia-Lian Li, Ying-Hui Zhang, Pei-Jie Du, Peng-Yu Zhang, Yan-Yan Zhao, Jing W. SIRT1 overexpression in skeletal muscle in vivo induces increased insulin sensitivity and enhanced complex I but not complex II-V functions in individual subsarcolemmal and intermyofibrillar mitochondria. Journal of physiology and biochemistry. vol 71. issue 2. 2016-02-17. PMID:25782776. |
sirt1 overexpression in skeletal muscle in vivo induces increased insulin sensitivity and enhanced complex i but not complex ii-v functions in individual subsarcolemmal and intermyofibrillar mitochondria. |
2016-02-17 |
2023-08-13 |
rat |
| Hao-Hao Zhang, Gui-Jun Qin, Xia-Lian Li, Ying-Hui Zhang, Pei-Jie Du, Peng-Yu Zhang, Yan-Yan Zhao, Jing W. SIRT1 overexpression in skeletal muscle in vivo induces increased insulin sensitivity and enhanced complex I but not complex II-V functions in individual subsarcolemmal and intermyofibrillar mitochondria. Journal of physiology and biochemistry. vol 71. issue 2. 2016-02-17. PMID:25782776. |
sirt1 is known to improve insulin resistance (ir), but whether this effect is direct or not is still unclear, and this question has not been addressed in vivo in the skeletal muscle. |
2016-02-17 |
2023-08-13 |
rat |