| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ja Young Jeon, Sung-E Choi, Eun Suk Ha, Han Byeol Lee, Tae Ho Kim, Seung Jin Han, Hae Jin Kim, Dae Jung Kim, Yup Kang, Kwan-Woo Le. GLP‑1 improves palmitate‑induced insulin resistance in human skeletal muscle via SIRT1 activity. International journal of molecular medicine. vol 44. issue 3. 2020-02-04. PMID:31524229. |
the influence of sirt1 on the glp‑1‑induced activation of insulin signaling pathway was determined using a sirt1 inhibitor. |
2020-02-04 |
2023-08-13 |
human |
| Ja Young Jeon, Sung-E Choi, Eun Suk Ha, Han Byeol Lee, Tae Ho Kim, Seung Jin Han, Hae Jin Kim, Dae Jung Kim, Yup Kang, Kwan-Woo Le. GLP‑1 improves palmitate‑induced insulin resistance in human skeletal muscle via SIRT1 activity. International journal of molecular medicine. vol 44. issue 3. 2020-02-04. PMID:31524229. |
the present findings suggest that in palmitate‑induced insulin‑resistant hsmm, glp‑1 activates sirt1 through the pka/camp pathway, which in turn enhances glucose uptake through glut4 and the insulin signaling pathway. |
2020-02-04 |
2023-08-13 |
human |
| Woo-Cheol Sim, Dong Gwang Kim, Wonseok Lee, Hyungtai Sim, You-Jin Choi, Byung-Hoon Le. Correction to: Activation of SIRT1 by L-serine increases fatty acid oxidation and reverses insulin resistance in C2C12 myotubes. Cell biology and toxicology. vol 35. issue 6. 2020-01-08. PMID:31111276. |
correction to: activation of sirt1 by l-serine increases fatty acid oxidation and reverses insulin resistance in c2c12 myotubes. |
2020-01-08 |
2023-08-13 |
Not clear |
| Irene Choi, Emily Rickert, Marina Fernandez, Nicholas J G Webste. SIRT1 in Astrocytes Regulates Glucose Metabolism and Reproductive Function. Endocrinology. vol 160. issue 6. 2019-12-06. PMID:31127273. |
paradoxically, the effect of these sirt1 mutants on insulin tolerance was reversed, with overexpression showing greater insulin sensitivity. |
2019-12-06 |
2023-08-13 |
mouse |
| J-K Cho, S-U Kim, H-R Hong, J-H Yoon, H-S Kan. Exercise Training Improves Whole Body Insulin Resistance via Adiponectin Receptor 1. International journal of sports medicine. vol 36. issue 13. 2019-11-20. PMID:26528942. |
hfd resulted in whole body insulin resistance, hypoadiponectinemia, suppressed expression of adiponectin receptor 1(adipor1) and 2 (adipor2), suppressed expression of phosphorylated amp-activated protein kinase (p-ampk) and nad-dependent deacetylase sirtuin-1 (sirt1), and decreased mrnas of peroxisome proliferator-activated receptor-α (pparα), carnitine palmitoyltransferase i (cpt1), and acyl coa oxidase (aco) in skeletal muscle. |
2019-11-20 |
2023-08-13 |
mouse |
| Jie Peng, Yinghui Wu, Zhao Deng, Yuanfei Zhou, Tongxing Song, Yang Yang, Xiaming Zhang, Tao Xu, Mao Xia, Anle Cai, Zuhong Liu, Jian Pen. MiR-377 promotes white adipose tissue inflammation and decreases insulin sensitivity in obesity via suppression of sirtuin-1 (SIRT1). Oncotarget. vol 8. issue 41. 2019-11-20. PMID:29050301. |
mir-377 promotes white adipose tissue inflammation and decreases insulin sensitivity in obesity via suppression of sirtuin-1 (sirt1). |
2019-11-20 |
2023-08-13 |
mouse |
| Jie Peng, Yinghui Wu, Zhao Deng, Yuanfei Zhou, Tongxing Song, Yang Yang, Xiaming Zhang, Tao Xu, Mao Xia, Anle Cai, Zuhong Liu, Jian Pen. MiR-377 promotes white adipose tissue inflammation and decreases insulin sensitivity in obesity via suppression of sirtuin-1 (SIRT1). Oncotarget. vol 8. issue 41. 2019-11-20. PMID:29050301. |
conversely, mir-377 inhibition increased sirt1 mrna and protein levels, ameliorated inflammation and improved insulin sensitivity. |
2019-11-20 |
2023-08-13 |
mouse |
| Jie Peng, Yinghui Wu, Zhao Deng, Yuanfei Zhou, Tongxing Song, Yang Yang, Xiaming Zhang, Tao Xu, Mao Xia, Anle Cai, Zuhong Liu, Jian Pen. MiR-377 promotes white adipose tissue inflammation and decreases insulin sensitivity in obesity via suppression of sirtuin-1 (SIRT1). Oncotarget. vol 8. issue 41. 2019-11-20. PMID:29050301. |
in conclusion, our findings suggest that mir-377 promotes white adipose tissue inflammation and decreases insulin sensitivity in obesity, at least in part, through suppressing sirt1. |
2019-11-20 |
2023-08-13 |
mouse |
| Colette M Knight, Roger Gutierrez-Juarez, Tony K T Lam, Isabel Arrieta-Cruz, Loli Huang, Gary Schwartz, Nir Barzilai, Luciano Rossett. Erratum. Mediobasal Hypothalamic SIRT1 Is Essential for Resveratrol's Effects on Insulin Action in Rats. Diabetes 2011;60:2691-2700. Diabetes. vol 66. issue 12. 2019-11-20. PMID:29162736. |
mediobasal hypothalamic sirt1 is essential for resveratrol's effects on insulin action in rats. |
2019-11-20 |
2023-08-13 |
rat |
| Oak-Kee Hong, Yoon-Hee Choi, Hyuk-Sang Kwon, Hee-Kyoung Jeong, Jang-Won Son, Seong-Su Lee, Sung-Rae Kim, Kun-Ho Yoon, Soon Jib Yo. Long-term insulin treatment leads to a change in myosin heavy chain fiber distribution in OLETF rat skeletal muscle. Journal of cellular biochemistry. 2019-11-20. PMID:30230025. |
insulin glargine treatment significantly increased the phosphorylation levels of ampk, sirt1, and pgc-1α. |
2019-11-20 |
2023-08-13 |
rat |
| Allah Nawaz, Arshad Mehmood, Yukiko Kanatani, Tomonobu Kado, Yoshiko Igarashi, Akiko Takikawa, Seiji Yamamoto, Keisuke Okabe, Takashi Nakagawa, Kunimasa Yagi, Shiho Fujisaka, Kazuyuki Tob. Publisher Correction: Sirt1 activator induces proangiogenic genes in preadipocytes to rescue insulin resistance in diet-induced obese mice. Scientific reports. vol 8. issue 1. 2019-11-20. PMID:30254249. |
publisher correction: sirt1 activator induces proangiogenic genes in preadipocytes to rescue insulin resistance in diet-induced obese mice. |
2019-11-20 |
2023-08-13 |
mouse |
| M Li, Y Guo, X-J Wang, B-H Duan, L L. HOTAIR participates in hepatic insulin resistance via regulating SIRT1. European review for medical and pharmacological sciences. vol 22. issue 22. 2019-11-14. PMID:30536334. |
hotair participates in hepatic insulin resistance via regulating sirt1. |
2019-11-14 |
2023-08-13 |
Not clear |
| Allah Nawaz, Arshad Mehmood, Yukiko Kanatani, Tomonobu Kado, Yoshiko Igarashi, Akiko Takikawa, Seiji Yamamoto, Keisuke Okabe, Takashi Nakagawa, Kunimasa Yagi, Shiho Fujisaka, Kazuyuki Tob. Sirt1 activator induces proangiogenic genes in preadipocytes to rescue insulin resistance in diet-induced obese mice. Scientific reports. vol 8. issue 1. 2019-10-16. PMID:30054532. |
sirt1 activator induces proangiogenic genes in preadipocytes to rescue insulin resistance in diet-induced obese mice. |
2019-10-16 |
2023-08-13 |
mouse |
| Allah Nawaz, Arshad Mehmood, Yukiko Kanatani, Tomonobu Kado, Yoshiko Igarashi, Akiko Takikawa, Seiji Yamamoto, Keisuke Okabe, Takashi Nakagawa, Kunimasa Yagi, Shiho Fujisaka, Kazuyuki Tob. Sirt1 activator induces proangiogenic genes in preadipocytes to rescue insulin resistance in diet-induced obese mice. Scientific reports. vol 8. issue 1. 2019-10-16. PMID:30054532. |
collectively, these findings suggest a novel role of srt1720-induced sirt1 activation in the induction of angiogenic genes in preadipocytes, thereby reducing inflammation and fibrosis in white adipose tissue (wat) and promoting insulin sensitivity. |
2019-10-16 |
2023-08-13 |
mouse |
| Sifan Chen, Zhongliang Zhao, Liangru Ke, Zilun Li, Wenxue Li, Zili Zhang, Ying Zhou, Xiang Feng, Wei Zh. Resveratrol improves glucose uptake in insulin-resistant adipocytes via Sirt1. The Journal of nutritional biochemistry. vol 55. 2019-09-17. PMID:29554499. |
mechanistically, res up-regulates the protein level of sirt1 that improves insulin signaling pathway and promotes cellular membrane glut4 accumulation. |
2019-09-17 |
2023-08-13 |
mouse |
| Anjum Dihingia, Dibyajyoti Ozah, Shatadal Ghosh, Abhijit Sarkar, Pranab Kumar Baruah, Jatin Kalita, Parames C Sil, Prasenjit Mann. Vitamin K1 inversely correlates with glycemia and insulin resistance in patients with type 2 diabetes (T2D) and positively regulates SIRT1/AMPK pathway of glucose metabolism in liver of T2D mice and hepatocytes cultured in high glucose. The Journal of nutritional biochemistry. vol 52. 2019-09-06. PMID:29175667. |
results showed that vk1 supplementation [1, 3, 5 μg/kg body weight (bw), 8 weeks] dose dependently improved the glucose tolerance; decreased bw gain, fasting glucose and insulin, glycated hemoglobin, homa-ir and cytokine secretion (monocyte chemoattractant protein-1 and interleukin-6); and regulated the signaling pathway of hepatic glucose metabolism [sirtuin 1 (sirt1)/amp-activated protein kinase (ampk)/phosphoinositide 3-kinase/phosphatase and tensin homolog/glucose transporter 2/glucokinase/glucose 6 phosphatase], lipid oxidation (peroxisome proliferator-activated receptor alpha/carnitine palmitoyltransferase 1a) and inflammation (nuclear factor kappa b) in t2d mice. |
2019-09-06 |
2023-08-13 |
mouse |
| Xingxing Mo, Xiao Wang, Qinmin Ge, Fan Bia. The effects of SIRT1/FoxO1 on LPS induced INS-1 cells dysfunction. Stress (Amsterdam, Netherlands). vol 22. issue 1. 2019-09-04. PMID:30345866. |
after being treated with 1 mg/l lps together with or without sirt1 activator resveratrol (rsv) or sirt1 inhibitor ex527, cell viability, ros generation, malondialdehyde (mda), superoxide, insulin secretion, and activity of superoxide dismutase (sod) in ins-1 cells were measured by specific assays. |
2019-09-04 |
2023-08-13 |
Not clear |
| Kyung Eun Kim, Eun Ae Jeong, Hyun Joo Shin, Jong Youl Lee, Eun Bee Choi, Hyeong Seok An, Kyung-Ah Park, Zhen Jin, Dong Kun Lee, Tamas L Horvath, Gu Seob Ro. Effects of myeloid sirtuin 1 deficiency on hypothalamic neurogranin in mice fed a high-fat diet. Biochemical and biophysical research communications. vol 508. issue 1. 2019-06-03. PMID:30471862. |
myeloid-specific sirtuin 1 (sirt1) deletion aggravates insulin resistance and hypothalamic inflammation in hfd-fed mice. |
2019-06-03 |
2023-08-13 |
mouse |
| Bingguo Luan, Caixia Su. MiR-138-5p affects insulin resistance to regulate type 2 diabetes progression through inducing autophagy in HepG2 cells by regulating SIRT1. Nutrition research (New York, N.Y.). vol 59. 2019-05-28. PMID:30442237. |
mir-138-5p affects insulin resistance to regulate type 2 diabetes progression through inducing autophagy in hepg2 cells by regulating sirt1. |
2019-05-28 |
2023-08-13 |
human |
| Su Myung Jung, David A Guerti. Insulin PACS a Punch in SIRT1 Activity. Molecular cell. vol 72. issue 6. 2019-05-20. PMID:30576653. |
insulin pacs a punch in sirt1 activity. |
2019-05-20 |
2023-08-13 |
Not clear |