| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chunjie Su, Qian Cheng, Liyun Wan. Roux-en-Y Gastric Bypass Improves Hepatic Glucose Metabolism Involving Upregulation of Sirt1 in Type 2 Diabetes Mellitus. Diabetes, metabolic syndrome and obesity : targets and therapy. vol 14. 2021-05-30. PMID:34045876. |
previous studies have reported that silent information regulator 1 (sirt1) closely relates to many pathological processes of glucose metabolism and insulin resistance (ir). |
2021-05-30 |
2023-08-13 |
Not clear |
| Yan-Mei Wang, Ting-Lei Huang, Chao Meng, Jia Zhang, Ning-Yuan Fan. SIRT1 deacetylates mitochondrial trifunctional enzyme α subunit to inhibit ubiquitylation and decrease insulin resistance. Cell death & disease. vol 11. issue 10. 2021-05-13. PMID:33009367. |
sirt1 deacetylates mitochondrial trifunctional enzyme α subunit to inhibit ubiquitylation and decrease insulin resistance. |
2021-05-13 |
2023-08-13 |
mouse |
| Yu Chen, Jingfan Zhang, Ping Li, Cong Liu, Ling L. N1‑methylnicotinamide ameliorates insulin resistance in skeletal muscle of type 2 diabetic mice by activating the SIRT1/PGC‑1α signaling pathway. Molecular medicine reports. vol 23. issue 4. 2021-05-10. PMID:33576435. |
the present study aimed to determine the effects of n1‑methylnicotinamide (mnam) on insulin resistance (ir) in skeletal muscle from a mouse model of type 2 diabetes mellitus (t2dm), and to investigate the regulatory mechanisms of the sirtuin 1 (sirt1)/peroxisome proliferator‑activated receptor γ coactivator‑1α (pgc‑1α) signaling pathway. |
2021-05-10 |
2023-08-13 |
mouse |
| Hasan Gencogl. Maca modulates fat and liver energy metabolism markers insulin, IRS1, leptin, and SIRT1 in rats fed normal and high-fat diets. Archives of physiology and biochemistry. 2021-05-06. PMID:32951476. |
maca modulates fat and liver energy metabolism markers insulin, irs1, leptin, and sirt1 in rats fed normal and high-fat diets. |
2021-05-06 |
2023-08-13 |
rat |
| Hasan Gencogl. Maca modulates fat and liver energy metabolism markers insulin, IRS1, leptin, and SIRT1 in rats fed normal and high-fat diets. Archives of physiology and biochemistry. 2021-05-06. PMID:32951476. |
maca root extract on insulin, insulin receptor substrate-1 (irs1), leptin, and nad-dependent deacetylase sirtuin-1 (sirt1), as well as body weight changes evaluated in this study for a 60 days model of normal and high-fat diet (hfd) fed rats. |
2021-05-06 |
2023-08-13 |
rat |
| Viola J Kosgei, David Coelho, Rosa-Maria Guéant-Rodriguez, Jean-Louis Guéan. Sirt1-PPARS Cross-Talk in Complex Metabolic Diseases and Inherited Disorders of the One Carbon Metabolism. Cells. vol 9. issue 8. 2021-04-12. PMID:32796716. |
sirt1 plays an important role in the differentiation of adipocytes and in insulin signaling regulated by foxo1 and phosphatidylinositol 3'-kinase (pi3k) signaling. |
2021-04-12 |
2023-08-13 |
rat |
| Munehiro Kitada, Yoshio Ogura, Itaru Monno, Daisuke Koy. Supplementation with Red Wine Extract Increases Insulin Sensitivity and Peripheral Blood Mononuclear Sirt1 Expression in Nondiabetic Humans. Nutrients. vol 12. issue 10. 2021-04-12. PMID:33053742. |
supplementation with red wine extract increases insulin sensitivity and peripheral blood mononuclear sirt1 expression in nondiabetic humans. |
2021-04-12 |
2023-08-13 |
human |
| Munehiro Kitada, Yoshio Ogura, Itaru Monno, Daisuke Koy. Supplementation with Red Wine Extract Increases Insulin Sensitivity and Peripheral Blood Mononuclear Sirt1 Expression in Nondiabetic Humans. Nutrients. vol 12. issue 10. 2021-04-12. PMID:33053742. |
the aim of this study was to investigate the effects of dietary supplementation with a nonalcoholic red wine extract (rwe), including resveratrol and polyphenols, on insulin sensitivity and sirt1 expression in nondiabetic humans. |
2021-04-12 |
2023-08-13 |
human |
| Munehiro Kitada, Yoshio Ogura, Itaru Monno, Daisuke Koy. Supplementation with Red Wine Extract Increases Insulin Sensitivity and Peripheral Blood Mononuclear Sirt1 Expression in Nondiabetic Humans. Nutrients. vol 12. issue 10. 2021-04-12. PMID:33053742. |
additionally, rwe supplementation induced an increase in sirt1 expression in pbmncs, which may be associated with an improvement in insulin sensitivity. |
2021-04-12 |
2023-08-13 |
human |
| Huixia Li, Zhuanmin Zhang, Dongxu Feng, Lin Xu, Fang Li, Jiali Liu, Xinxin Jin, Zhuang Qian, Xiaomin Kang, Hongzhi Su. PGRN exerts inflammatory effects via SIRT1-NF-κB in adipose insulin resistance. Journal of molecular endocrinology. vol 64. issue 3. 2021-04-08. PMID:31990656. |
finally, we showed that sirtuin 1 (sirt1) expression was downregulated by pgrn treatment, whereas sirt1 overexpression improved pgrn-induced insulin resistance, nf-κb activation, and inflammatory gene expression. |
2021-04-08 |
2023-08-13 |
Not clear |
| Bugga Paramesha, Mohammed Soheb Anwar, Himanshu Meghwani, Subir Kumar Maulik, Sudheer Kumar Arava, Sanjay K Banerje. Sirt1 and Sirt3 Activation Improved Cardiac Function of Diabetic Rats via Modulation of Mitochondrial Function. Antioxidants (Basel, Switzerland). vol 10. issue 3. 2021-03-27. PMID:33668369. |
in the present study, we aimed to evaluate the effect of sirt1, sirt3 and combined activation in high fructose diet-induced insulin resistance rat heart and assessed the cardiac function focusing on mitochondrial health and function. |
2021-03-27 |
2023-08-13 |
rat |
| Isabella Supardi Parida, Soo Takasu, Junya Ito, Ryoichi Ikeda, Kenji Yamagishi, Toshiyuki Kimura, Takahiro Eitsuka, Kiyotaka Nakagaw. Supplementation of Bacillus amyloliquefaciens AS385 culture broth powder containing 1-deoxynojirimycin in a high-fat diet altered the gene expressions related to lipid metabolism and insulin signaling in mice epididymal white adipose tissue. Food & function. vol 11. issue 5. 2021-03-23. PMID:32374310. |
to investigate how these physiological events could take place, we analyzed the expression of genes involved in lipid metabolism and insulin signaling in epididymal white adipose tissue and found that cbp had a regulatory effect on the expression of genes related to lipid metabolism (pparγ, srebf1c, acc, scd, hsl, lpl), adiponectin secretion (foxo1 and sirt1), and insulin signaling (irs1 and akt2). |
2021-03-23 |
2023-08-13 |
mouse |
| Michael B Zeme. Modulation of Energy Sensing by Leucine Synergy with Natural Sirtuin Activators: Effects on Health Span. Journal of medicinal food. vol 23. issue 11. 2021-03-05. PMID:32758058. |
however, we found that combining low resveratrol doses with leucine increased skeletal muscle and adipocyte sirt1 activity, mitochondrial biogenesis and fatty acid oxidation; these effects result in increased lifespan and marked reductions in insulin resistance, inflammatory markers, body weight, and visceral adiposity in preclinical models. |
2021-03-05 |
2023-08-13 |
human |
| Adam Włodarski, Justyna Strycharz, Adam Wróblewski, Jacek Kasznicki, Józef Drzewoski, Agnieszka Śliwińsk. The Role of microRNAs in Metabolic Syndrome-Related Oxidative Stress. International journal of molecular sciences. vol 21. issue 18. 2021-02-26. PMID:32962281. |
dysregulated micrornas either directly or indirectly affect the expression and/or activity of molecules of antioxidative signaling pathways (sirt1, foxos, keap1/nrf2) along with effector enzymes (e.g., gpx-1, sod1/2, ho-1), ros producers (e.g., nox4/5), as well as genes of numerous signaling pathways connected with inflammation, insulin sensitivity, and lipid metabolism, thus promoting the progression of metabolic imbalance. |
2021-02-26 |
2023-08-13 |
Not clear |
| Jay S Mishra, Hanjie Zhao, Sari Hattis, Sathish Kuma. Elevated Glucose and Insulin Levels Decrease DHA Transfer across Human Trophoblasts via SIRT1-Dependent Mechanism. Nutrients. vol 12. issue 5. 2021-02-15. PMID:32365792. |
this study investigated whether the high glucose and insulin condition of gdm regulates dha transfer and expression of fatty acid transporters and if this effect is related to sirt1 expression and function. |
2021-02-15 |
2023-08-13 |
human |
| Mahnaz Ghadimi, Farshad Foroughi, Sima Hashemipour, Mohammadreza Rashidi Nooshabadi, Mohammad Hossein Ahmadi, Mojtaba Ghadimi Yari, Maria Kavianpour, Hossein Khadem Haghighia. Decreased insulin resistance in diabetic patients by influencing Sirtuin1 and Fetuin-A following supplementation with ellagic acid: a randomized controlled trial. Diabetology & metabolic syndrome. vol 13. issue 1. 2021-02-10. PMID:33546744. |
this study aimed to investigate the effect of oral ellagic acid (ea) supplement on insulin resistance (ir) and fetuin-a and serum sirtuin1 (sirt1) in type 2 diabetics. |
2021-02-10 |
2023-08-13 |
Not clear |
| Ángeles Ramírez, Miriam Hernández, Rocío Suárez-Sánchez, Clara Ortega, Jesús Peralta, Jaime Gómez, Adán Valladares, Miguel Cruz, Miguel Alexander Vázquez-Moreno, Fernando Suárez-Sánche. Type 2 diabetes-associated polymorphisms correlate with SIRT1 and TGF-β1 gene expression. Annals of human genetics. vol 84. issue 2. 2021-02-04. PMID:31799723. |
it has been described that sirt1 and tgf-β1 participate in cell growth and regulation of production and secretion of insulin in the pancreas. |
2021-02-04 |
2023-08-13 |
Not clear |
| R Tural, N Altan, C Irkec, D Sahin, H Z Batur Caglaya. The probable role of insulin resistance and SIRT1 proteins in the Alzheimer's disease. Bratislavske lekarske listy. vol 121. issue 11. 2021-01-19. PMID:33164543. |
the probable role of insulin resistance and sirt1 proteins in the alzheimer's disease. |
2021-01-19 |
2023-08-13 |
Not clear |
| June Guo, Troy J Pereira, Yusaku Mori, Marel Gonzalez Medina, Danna M Breen, Prasad S Dalvi, Hangjun Zhang, Declan F McCole, Michael W McBurney, Scott P Heximer, Evangelia L Tsiani, Vernon W Dolinsky, Adria Giacc. Resveratrol Inhibits Neointimal Growth after Arterial Injury in High-Fat-Fed Rodents: The Roles of SIRT1 and AMPK. Journal of vascular research. vol 57. issue 6. 2021-01-18. PMID:32777783. |
since rsv, in addition to increasing insulin sensitivity, can activate enos via pathways that are independent of insulin signaling, such as the activation of sirtuin 1 (sirt1) and amp-activated kinase (ampk), we speculated that unlike insulin, the vasculoprotective effect of rsv would be retained in high-fat-fed rats. |
2021-01-18 |
2023-08-13 |
mouse |
| Yi-Li Rong, Yong-Ming Pan, Jun-Jie Huang, Chen Yu, Ke-Yan Zhu, Min-Li Che. [Expression of Sirtuin 1 in visceral adipose tissue in Tibetan mini-pigs with obesity and insulin resistance induced by high fat/cholesterol diet]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 36. issue 4. 2021-01-18. PMID:33167100. |
to investigate the role of sirt1 in visceral adipose tissue in tibetan mini-pigs with obesity and insulin resistance induced by high fat/cholesterol diet. |
2021-01-18 |
2023-08-13 |
Not clear |