| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Patricia S Pardo, Aladin M Borie. SIRT1 Regulation in Ageing and Obesity. Mechanisms of ageing and development. vol 188. 2021-09-27. PMID:32320732. |
sirt1 activation has been shown to regulate pathways with beneficiary effects on 1) ageing and obesity-associated metabolic disorders such as metabolic syndrome, insulin resistance and type-ii diabetes with, 2) chronic inflammatory processes such as arthritis, atherosclerosis and emphysema, 3) dna damage and oxidative stress with impact on neurodegenerative diseases, cardiovascular health and some cancers. |
2021-09-27 |
2023-08-13 |
Not clear |
| Carmen Escalona-Garrido, Patricia Vázquez, Paula Mera, Sebastián Zagmutt, Ester García-Casarrubios, Ana Montero-Pedrazuela, Fernanda Rey-Stolle, Ana Guadaño-Ferraz, Francisco J Rupérez, Dolors Serra, Laura Herrero, Maria Jesus Obregon, Ángela M Valverd. Moderate SIRT1 overexpression protects against brown adipose tissue inflammation. Molecular metabolism. vol 42. 2021-09-07. PMID:33049408. |
in this study, we explored the impact of moderate sirtuin 1 (sirt1) overexpression on insulin sensitivity and β-adrenergic responses in bat and brown adipocytes (ba) under pro-inflammatory conditions. |
2021-09-07 |
2023-08-13 |
Not clear |
| Matthew J Myers, Fathima Shaik, Fahema Shaik, Stephen E Alway, Junaith S Mohame. Skeletal Muscle Gene Expression Profile in Response to Caloric Restriction and Aging: A Role for SirT1. Genes. vol 12. issue 5. 2021-08-30. PMID:34063079. |
sirt1 oe did not affect whole-body energy expenditure or augment skeletal muscle insulin sensitivity associated pathways, regardless of aging or diet. |
2021-08-30 |
2023-08-13 |
mouse |
| Anna Bizoń, Anna Słowiak, Grzegorz Franik, Aleksandra Biernacka-Bartnik, Paweł Made. Zinc, copper, sirtuin 1 concentration, and glucose metabolism parameters in the blood of women with polycystic ovary syndrome. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. vol 36. issue 11. 2021-08-27. PMID:32281435. |
however, increased value of body mass index, waist-hip ratio and homeostatic model assessment of insulin resistance (homa-ir) was not associated with changes in zn and sirt1 concentration. |
2021-08-27 |
2023-08-13 |
Not clear |
| Ainaz Mihanfar, Maryam Akbarzadeh, Saber Ghazizadeh Darband, Shirin Sadighparvar, Maryam Majidini. SIRT1: a promising therapeutic target in type 2 diabetes mellitus. Archives of physiology and biochemistry. 2021-08-11. PMID:34379994. |
sirtuin 1 (sirt1) is an nad + dependent protein deacetylase with a critical function in the regulation of glucose/lipid metabolism, insulin resistance, inflammation, oxidative stress, and mitochondrial function. |
2021-08-11 |
2023-08-13 |
Not clear |
| Ainaz Mihanfar, Maryam Akbarzadeh, Saber Ghazizadeh Darband, Shirin Sadighparvar, Maryam Majidini. SIRT1: a promising therapeutic target in type 2 diabetes mellitus. Archives of physiology and biochemistry. 2021-08-11. PMID:34379994. |
sirt1 is also involved in the regulation of insulin secretion from pancreatic β-cells and protecting these cells from inflammation and oxidative stress-mediated tissue damages. |
2021-08-11 |
2023-08-13 |
Not clear |
| Ivana Sirangelo, Margherita Borriello, Maria Liccardo, Marika Scafuro, Paola Russo, Clara Iannuzz. Hydroxytyrosol Selectively Affects Non-Enzymatic Glycation in Human Insulin and Protects by AGEs Cytotoxicity. Antioxidants (Basel, Switzerland). vol 10. issue 7. 2021-08-09. PMID:34356360. |
our data show that ht selectively inhibits protein glycation reaction in human insulin, and it is able to counteract the age-induced cytotoxicity in human neurotypical cells by acting on sirt1 level and oxidative stress, as well as on inflammatory response. |
2021-08-09 |
2023-08-13 |
human |
| Yanyan Zhu, Haixia Yang, Jianjun Deng, Daidi Fa. Ginsenoside Rg5 Improves Insulin Resistance and Mitochondrial Biogenesis of Liver via Regulation of the Sirt1/PGC-1α Signaling Pathway in db/db Mice. Journal of agricultural and food chemistry. vol 69. issue 30. 2021-08-05. PMID:34309383. |
rg5 treatment also increased the level of glycogen synthesis and activated sirtuin1 (sirt1) to increase glucose uptake and insulin sensitivity in insulin-resistant hepg2 (ir-hepg2) cells. |
2021-08-05 |
2023-08-13 |
mouse |
| Samuel S Aguiar, Thiago S Rosa, Rodrigo V P Neves, Patrício L A Leite, Larissa A Maciel, Sara D Gutierrez, Erica C Rosa, Rosângela V Andrade, Hans Degens, Marko T Korhonen, John E Lewis, Herbert G Simõe. Telomere Length, SIRT1, and Insulin in Male Master Athletes: The Path to Healthy Longevity? International journal of sports medicine. 2021-07-15. PMID:34256387. |
telomere length, sirt1, and insulin in male master athletes: the path to healthy longevity? |
2021-07-15 |
2023-08-13 |
Not clear |
| Samuel S Aguiar, Thiago S Rosa, Rodrigo V P Neves, Patrício L A Leite, Larissa A Maciel, Sara D Gutierrez, Erica C Rosa, Rosângela V Andrade, Hans Degens, Marko T Korhonen, John E Lewis, Herbert G Simõe. Telomere Length, SIRT1, and Insulin in Male Master Athletes: The Path to Healthy Longevity? International journal of sports medicine. 2021-07-15. PMID:34256387. |
lower sirt1 and insulin resistance are associated with accelerated telomere shortening. |
2021-07-15 |
2023-08-13 |
Not clear |
| Samuel S Aguiar, Thiago S Rosa, Rodrigo V P Neves, Patrício L A Leite, Larissa A Maciel, Sara D Gutierrez, Erica C Rosa, Rosângela V Andrade, Hans Degens, Marko T Korhonen, John E Lewis, Herbert G Simõe. Telomere Length, SIRT1, and Insulin in Male Master Athletes: The Path to Healthy Longevity? International journal of sports medicine. 2021-07-15. PMID:34256387. |
we compared insulin, sirt1, and telomere length in highly trained male master athletes (n=52; aged 49.9±7.2 yrs) and age-matched non-athletes (n=19; aged 47.3±8.9 yrs). |
2021-07-15 |
2023-08-13 |
Not clear |
| Samuel S Aguiar, Thiago S Rosa, Rodrigo V P Neves, Patrício L A Leite, Larissa A Maciel, Sara D Gutierrez, Erica C Rosa, Rosângela V Andrade, Hans Degens, Marko T Korhonen, John E Lewis, Herbert G Simõe. Telomere Length, SIRT1, and Insulin in Male Master Athletes: The Path to Healthy Longevity? International journal of sports medicine. 2021-07-15. PMID:34256387. |
overnight fasted sirt1 and insulin levels in whole blood were assessed using commercial kits. |
2021-07-15 |
2023-08-13 |
Not clear |
| Samuel S Aguiar, Thiago S Rosa, Rodrigo V P Neves, Patrício L A Leite, Larissa A Maciel, Sara D Gutierrez, Erica C Rosa, Rosângela V Andrade, Hans Degens, Marko T Korhonen, John E Lewis, Herbert G Simõe. Telomere Length, SIRT1, and Insulin in Male Master Athletes: The Path to Healthy Longevity? International journal of sports medicine. 2021-07-15. PMID:34256387. |
master athletes had higher sirt1, lower insulin, and longer telomere length than age-matched non-athletes ( |
2021-07-15 |
2023-08-13 |
Not clear |
| Ying Zhang, Yuhang Ma, Mingyu Gu, Yongde Pen. lncRNA TUG1 promotes the brown remodeling of white adipose tissue by regulating miR‑204‑targeted SIRT1 in diabetic mice. International journal of molecular medicine. vol 46. issue 6. 2021-07-08. PMID:33125086. |
body weight, serum glucose levels, insulin levels and testicular fat, as well as the expression levels of tug1, mir‑204, sirtuin 1 (sirt1) and the amp‑activated protein kinase (ampk)/acetyl‑coa carboxylase (acc) signaling pathway were detected. |
2021-07-08 |
2023-08-13 |
mouse |
| Chiara Lanzillotta, Antonella Tramutola, Graziella Di Giacomo, Federico Marini, D Allan Butterfield, Fabio Di Domenico, Marzia Perluigi, Eugenio Baron. Insulin resistance, oxidative stress and mitochondrial defects in Ts65dn mice brain: A harmful synergistic path in down syndrome. Free radical biology & medicine. vol 165. 2021-06-28. PMID:33516914. |
furthermore, we analyzed whether changes of brain insulin signaling were associated with alterations of: (i) proteins regulating brain energy metabolism (mitochondrial complexes, hexokinase-ii, sirt1); (ii) oxidative stress (os) markers (iii) app cleavage; and (iv) proteins mediating synaptic plasticity mechanisms (psd95, syntaxin-1 and bdnf). |
2021-06-28 |
2023-08-13 |
mouse |
| Ying Zhang, Mingyu Gu, Yuhang Ma, Yongde Pen. LncRNA TUG1 reduces inflammation and enhances insulin sensitivity in white adipose tissue by regulating miR-204/SIRT1 axis in obesity mice. Molecular and cellular biochemistry. vol 475. issue 1-2. 2021-06-23. PMID:32888158. |
then, body weight, serum glucose, insulin tolerance, testicular fat weight were detected, as well as the expression of tug1, microrna-204 (mir-204), sirtuin1 (sirt1), and inflammation and fatty accumulation associated proteins and cytokines. |
2021-06-23 |
2023-08-13 |
mouse |
| Ying Zhang, Mingyu Gu, Yuhang Ma, Yongde Pen. LncRNA TUG1 reduces inflammation and enhances insulin sensitivity in white adipose tissue by regulating miR-204/SIRT1 axis in obesity mice. Molecular and cellular biochemistry. vol 475. issue 1-2. 2021-06-23. PMID:32888158. |
overexpression of tug1 could significantly attenuate the weight, serum glucose, glucose, insulin tolerance, fatty accumulation, and inflammation in obesity mice, as well as the elevation of mir-204, but increase the expression of sirt1, phosphorylated akt (p-akt), glucose transporter4 (glut4), and peroxisome proliferator activated receptorγ (pparγ). |
2021-06-23 |
2023-08-13 |
mouse |
| Hossein Nikroo, Seyyed Reza Attarzadeh Hosseini, Mehrdad Fathi, Mohammad Ali Sardar, Majid Khazae. The effect of aerobic, resistance, and combined training on PPAR-α, SIRT1 gene expression, and insulin resistance in high-fat diet-induced NAFLD male rats. Physiology & behavior. vol 227. 2021-06-21. PMID:32888948. |
the effect of aerobic, resistance, and combined training on ppar-α, sirt1 gene expression, and insulin resistance in high-fat diet-induced nafld male rats. |
2021-06-21 |
2023-08-13 |
rat |
| Hossein Nikroo, Seyyed Reza Attarzadeh Hosseini, Mehrdad Fathi, Mohammad Ali Sardar, Majid Khazae. The effect of aerobic, resistance, and combined training on PPAR-α, SIRT1 gene expression, and insulin resistance in high-fat diet-induced NAFLD male rats. Physiology & behavior. vol 227. 2021-06-21. PMID:32888948. |
insulin resistance (ir) is known as the most important cause of non-alcoholic fatty liver disease (nafld), which is accompanied by a decline in gene expression of hepatic's peroxisomes proliferator-activated receptors-alpha (ppar-α) and sirtuin-1 (sirt1). |
2021-06-21 |
2023-08-13 |
rat |
| Bin Feng, Bin Huang, Yali Jing, Shanmei Shen, Wenhuan Feng, Weimin Wang, Ran Meng, Dalong Zh. Silymarin ameliorates the disordered glucose metabolism of mice with diet-induced obesity by activating the hepatic SIRT1 pathway. Cellular signalling. vol 84. 2021-05-31. PMID:33901577. |
these findings suggest that hepatic sirt1 may be an important pharmacological target of slm and mediate effects on insulin resistance and gluconeogenesis, which may underlie its anti-diabetic activity. |
2021-05-31 |
2023-08-13 |
mouse |