| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yun Shan, Shuchen Zhang, Bin Gao, Shu Liang, Hao Zhang, Xizhong Yu, Juan Zhao, Lifang Ye, Qin Yang, Wenbin Shan. Adipose Tissue SIRT1 Regulates Insulin Sensitizing and Anti-Inflammatory Effects of Berberine. Frontiers in pharmacology. vol 11. 2021-01-05. PMID:33390968. |
adipose tissue sirt1 regulates insulin sensitizing and anti-inflammatory effects of berberine. |
2021-01-05 |
2023-08-13 |
human |
| F Xu, R Chen, C Ma, L Tang, W Wan, F You, L Chen, J Li, Z Chen, F Lian. ELECTROACUPUNCTURE IMPROVES INSULIN SENSITIVITY IN HIGH-FAT DIET-INDUCED INSULIN RESISTANT RATS BY ACTIVATING SIRT1 AND GLUT4 IN QUADRICEPS FEMORIS. Acta endocrinologica (Bucharest, Romania : 2005). vol 16. issue 3. 2021-01-01. PMID:33363647. |
electroacupuncture improves insulin sensitivity in high-fat diet-induced insulin resistant rats by activating sirt1 and glut4 in quadriceps femoris. |
2021-01-01 |
2023-08-13 |
rat |
| Manisha J Oza, Yogesh A Kulkarn. Trifolium pratense (Red Clover) Improve SIRT1 Expression and Glycogen Content in High Fat Diet-Streptozotocin Induced Type 2 Diabetes in Rats. Chemistry & biodiversity. vol 17. issue 4. 2020-12-30. PMID:32187456. |
in present study, our aim was to investigate effect of standardized aqueous extract of flowering tops of trifolium pratense l. on insulin resistance and sirt1 expression in type 2 diabetic rats. |
2020-12-30 |
2023-08-13 |
rat |
| Manisha J Oza, Yogesh A Kulkarn. Trifolium pratense (Red Clover) Improve SIRT1 Expression and Glycogen Content in High Fat Diet-Streptozotocin Induced Type 2 Diabetes in Rats. Chemistry & biodiversity. vol 17. issue 4. 2020-12-30. PMID:32187456. |
results indicate that the aqueous extract of trifolium pratense had beneficial role in improving insulin sensitivity and sirt1 expression. |
2020-12-30 |
2023-08-13 |
rat |
| Gang Luo, Lin Xiao, Dongxia Wang, Ning Wang, Can Luo, Xuefeng Yang, Liping Ha. Resveratrol protects against ethanol-induced impairment of insulin secretion in INS-1 cells through SIRT1-UCP2 axis. Toxicology in vitro : an international journal published in association with BIBRA. vol 65. 2020-12-22. PMID:32087266. |
sirt1 has been proposed to enhance insulin secretion in β-cell through repressing the expression of uncoupling protein2 (ucp2), but whether ethanol-induced β-cell dysfunction is mediated by the disrupted sirt1-ucp2 axis remains unknown. |
2020-12-22 |
2023-08-13 |
rat |
| Gang Luo, Lin Xiao, Dongxia Wang, Ning Wang, Can Luo, Xuefeng Yang, Liping Ha. Resveratrol protects against ethanol-induced impairment of insulin secretion in INS-1 cells through SIRT1-UCP2 axis. Toxicology in vitro : an international journal published in association with BIBRA. vol 65. 2020-12-22. PMID:32087266. |
the results showed that ethanol exposure reduced glucose-stimulated insulin secretion, atp production and sirt1 expression but increased ucp2 expression, while supplementation with resveratrol restored the function of ins-1 cell by upregulating sirt1 and inhibiting ucp2. |
2020-12-22 |
2023-08-13 |
rat |
| Gang Luo, Lin Xiao, Dongxia Wang, Ning Wang, Can Luo, Xuefeng Yang, Liping Ha. Resveratrol protects against ethanol-induced impairment of insulin secretion in INS-1 cells through SIRT1-UCP2 axis. Toxicology in vitro : an international journal published in association with BIBRA. vol 65. 2020-12-22. PMID:32087266. |
moreover, the critical role of sirt1-ucp2 axis was further supported by the results that sirt1 activator srt1720 reversed ethanol-induced impairment of glucose-stimulated insulin secretion by decreasing ucp2, while sirt1 inhibitor ex527 abolished the beneficial effects of resveratrol. |
2020-12-22 |
2023-08-13 |
rat |
| Peivasteh Safarpour, Milad Daneshi-Maskooni, Mohammadreza Vafa, Mitra Nourbakhsh, Leila Janani, Mohsen Maddah, Fatemeh-Sadat Amiri, Fereshteh Mohammadi, Homa Sadegh. Vitamin D supplementation improves SIRT1, Irisin, and glucose indices in overweight or obese type 2 diabetic patients: a double-blind randomized placebo-controlled clinical trial. BMC family practice. vol 21. issue 1. 2020-11-30. PMID:32033527. |
vitamin d (vd) may increase sirtuin 1 (sirt1) and subsequently ppar-γ coactivator 1α (pgc-1α) and irisin levels and these improvements may reduce insulin resistance (ir). |
2020-11-30 |
2023-08-13 |
Not clear |
| Makoto Kurano, Kazuhisa Tsukamoto, Tomo Shimizu, Hidetoshi Kassai, Kazuki Nakao, Atsu Aiba, Masumi Hara, Yutaka Yatom. Protection Against Insulin Resistance by Apolipoprotein M/Sphingosine-1-Phosphate. Diabetes. vol 69. issue 5. 2020-10-27. PMID:31915150. |
presumably, apom/s1p exerts its protective effect against insulin resistance by activating insulin signaling pathways, such as the akt and ampk pathways, and also by improving the mitochondrial functions through upregulation of sirt1 protein levels. |
2020-10-27 |
2023-08-13 |
mouse |
| Akiko Takikawa, Isao Usui, Shiho Fujisaka, Masashi Ikutani, Satoko Senda, Shinpei Hattori, Koichi Tsuneyama, Yukiko Koshimizu, Ran Inoue, Ayumi Tanaka-Hayashi, Takashi Nakagawa, Yoshinori Nagai, Kiyoshi Takatsu, Toshiyasu Sasaoka, Hisashi Mori, Kazuyuki Tob. Deletion of SIRT1 in myeloid cells impairs glucose metabolism with enhancing inflammatory response to adipose tissue hypoxia. Diabetology international. vol 7. issue 1. 2020-10-01. PMID:30603244. |
myeloid cell-specific sirt1 deletion impaired insulin sensitivity and glucose tolerance assessed by the glucose- or insulin-tolerance test, which was associated with the enhanced expression of inflammation-related genes in epididymal adipose tissue of high-fat-fed mice. |
2020-10-01 |
2023-08-13 |
mouse |
| Michalina Alicka, Piotr Major, Michał Wysocki, Krzysztof Maryc. Adipose-Derived Mesenchymal Stem Cells Isolated from Patients with Type 2 Diabetes Show Reduced "Stemness" through an Altered Secretome Profile, Impaired Anti-Oxidative Protection, and Mitochondrial Dynamics Deterioration. Journal of clinical medicine. vol 8. issue 6. 2020-10-01. PMID:31151180. |
significant differences were observed in the expressions of mirna involved in cell proliferations (mir-16-5p, mir-146a-5p, and mir-145-5p), as well as mirna and genes responsible for glucose homeostasis and insulin sensitivity (mir-24-3p, 140-3p, mir-17-5p, sirt1, hif-1α, lin28, foxo1, and tgfβ). |
2020-10-01 |
2023-08-13 |
Not clear |
| Laia Vilà, Carles Roca, Ivet Elias, Alba Casellas, Ricardo Lage, Sylvie Franckhauser, Fatima Bosc. AAV-mediated Molecular therapy. Methods & clinical development. vol 5. 2020-09-30. PMID:27909699. |
sirt1 is a key protein in the regulation of lipid oxidation and its expression is reduced in the skeletal muscle of insulin resistant mice. |
2020-09-30 |
2023-08-13 |
mouse |
| Elham Karimi-Sales, Sajad Jeddi, Abbas Ebrahimi-Kalan, Mohammad Reza Alipou. Trans-chalcone enhances insulin sensitivity through the miR-34a/SIRT1 pathway. Iranian journal of basic medical sciences. vol 21. issue 4. 2020-09-30. PMID:29796217. |
sirtuin 1 (sirt1) as a direct target of mir-34a controls homeostasis of glucose, and also improves insulin sensitivity. |
2020-09-30 |
2023-08-13 |
Not clear |
| Qing Shu, Li Chen, Song Wu, Jia Li, Jianmin Liu, Ling Xiao, Rui Chen, Fengxia Lian. Acupuncture Targeting SIRT1 in the Hypothalamic Arcuate Nucleus Can Improve Obesity in High-Fat-Diet-Induced Rats with Insulin Resistance via an Anorectic Effect. Obesity facts. vol 13. issue 1. 2020-09-23. PMID:31935731. |
acupuncture targeting sirt1 in the hypothalamic arcuate nucleus can improve obesity in high-fat-diet-induced rats with insulin resistance via an anorectic effect. |
2020-09-23 |
2023-08-13 |
rat |
| Qing Shu, Li Chen, Song Wu, Jia Li, Jianmin Liu, Ling Xiao, Rui Chen, Fengxia Lian. Acupuncture Targeting SIRT1 in the Hypothalamic Arcuate Nucleus Can Improve Obesity in High-Fat-Diet-Induced Rats with Insulin Resistance via an Anorectic Effect. Obesity facts. vol 13. issue 1. 2020-09-23. PMID:31935731. |
to investigate the anorexigenic and anti-obesity effectiveness of electroacupuncture (ea) on high-fat-diet-induced (hfdi) obese rats with insulin resistance (ir) and to reveal the possible mechanisms of ea affecting sirt1 (silent mating type information regulation 2 homolog 1) in the central nervous system (cns). |
2020-09-23 |
2023-08-13 |
rat |
| Tae Woo Jung, Sung Ho Ahn, Jong Wook Shin, Hyoung-Chun Kim, Eon Sub Park, A M Abd El-Aty, Ahmet Hacımüftüoğlu, Ki Hak Song, Ji Hoon Jeon. Protectin DX ameliorates palmitate-induced hepatic insulin resistance through AMPK/SIRT1-mediated modulation of fetuin-A and SeP expression. Clinical and experimental pharmacology & physiology. vol 46. issue 10. 2020-09-08. PMID:31246318. |
in in vitro experiments, pdx treatment increased amp-activated protein kinase (ampk) phosphorylation and sirt1 expression and attenuated palmitate-induced fetuin-a and sep expression and insulin resistance in hepatocytes. |
2020-09-08 |
2023-08-13 |
human |
| Tae Woo Jung, Sung Ho Ahn, Jong Wook Shin, Hyoung-Chun Kim, Eon Sub Park, A M Abd El-Aty, Ahmet Hacımüftüoğlu, Ki Hak Song, Ji Hoon Jeon. Protectin DX ameliorates palmitate-induced hepatic insulin resistance through AMPK/SIRT1-mediated modulation of fetuin-A and SeP expression. Clinical and experimental pharmacology & physiology. vol 46. issue 10. 2020-09-08. PMID:31246318. |
ampk or sirt1 sirna mitigated the suppressive effects of pdx on palmitate-induced fetuin-a through nf-κb and sep expression linked to foxo1 and insulin resistance. |
2020-09-08 |
2023-08-13 |
human |
| Tian Su, Yuzhong Xiao, Ye Xiao, Qi Guo, Changjun Li, Yan Huang, Qiufang Deng, Jingxiang Wen, Fangliang Zhou, Xiang-Hang Lu. Bone Marrow Mesenchymal Stem Cells-Derived Exosomal MiR-29b-3p Regulates Aging-Associated Insulin Resistance. ACS nano. vol 13. issue 2. 2020-08-31. PMID:30715852. |
mechanistically, sirt1 (sirtuin 1) was identified to function as the downstream target of exosomal mir-29b-3p in regulating insulin resistance. |
2020-08-31 |
2023-08-13 |
mouse |
| Woo-Cheol Sim, Dong Gwang Kim, Wonseok Lee, Hyungtai Sim, You-Jin Choi, Byung-Hoon Le. Activation of SIRT1 by L-serine increases fatty acid oxidation and reverses insulin resistance in C2C12 myotubes. Cell biology and toxicology. vol 35. issue 5. 2020-08-28. PMID:30721374. |
activation of sirt1 by l-serine increases fatty acid oxidation and reverses insulin resistance in c2c12 myotubes. |
2020-08-28 |
2023-08-13 |
Not clear |
| Fang Li, Huixia Li, Xinxin Jin, Ying Zhang, Xiaomin Kang, Zhuanmin Zhang, Mao Xu, Zhuang Qian, Zhengmin Ma, Xin Gao, Liting Zhao, Shufang Wu, Hongzhi Su. Adipose-specific knockdown of Cell cycle (Georgetown, Tex.). vol 18. issue 17. 2020-08-24. PMID:31296102. |
adipose-specific knockdown of sirtuin1 (sirt1) has recently emerged as a pivotal regulator of glucose metabolism and insulin sensitivity. |
2020-08-24 |
2023-08-13 |
mouse |