| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fang Li, Huixia Li, Xinxin Jin, Ying Zhang, Xiaomin Kang, Zhuanmin Zhang, Mao Xu, Zhuang Qian, Zhengmin Ma, Xin Gao, Liting Zhao, Shufang Wu, Hongzhi Su. Adipose-specific knockdown of Cell cycle (Georgetown, Tex.). vol 18. issue 17. 2020-08-24. PMID:31296102. |
in this study, we investigated the role of sirt1 in the development of obesity and insulin resistance by generating mice with adipose-specific ablation of |
2020-08-24 |
2023-08-13 |
mouse |
| Jaw Long Sun, Jinwoo Park, Taeseung Lee, Ji Hoon Jeong, Tae Woo Jun. DEL-1 ameliorates high-fat diet-induced insulin resistance in mouse skeletal muscle through SIRT1/SERCA2-mediated ER stress suppression. Biochemical pharmacology. vol 171. 2020-07-27. PMID:31778646. |
here, del-1 treatment augmented sirt1 expression in c2c12 myocytes, thereby increasing serca2 expression in a dose-dependent fashion, and attenuated er stress and insulin resistance under palmitate treatment condition. |
2020-07-27 |
2023-08-13 |
mouse |
| Jaw Long Sun, Jinwoo Park, Taeseung Lee, Ji Hoon Jeong, Tae Woo Jun. DEL-1 ameliorates high-fat diet-induced insulin resistance in mouse skeletal muscle through SIRT1/SERCA2-mediated ER stress suppression. Biochemical pharmacology. vol 171. 2020-07-27. PMID:31778646. |
additionally, sirna transfection-mediated in vivo downregulation of sirt1 suppressed the effects of del-1 on expression of serca2, er stress, and insulin resistance in skeletal muscle of hfd-fed mice. |
2020-07-27 |
2023-08-13 |
mouse |
| Ayse Basak Engin, Atilla Engin, Ipek Isik Gonu. The effect of adipocyte-macrophage crosstalk in obesity-related breast cancer. Journal of molecular endocrinology. vol 62. issue 3. 2020-07-24. PMID:30620711. |
interlinked molecular mechanisms between adipocyte-macrophage-breast cancer cells in obesity involve seven consecutive processes: excessive release of adipocyte- and macrophage-derived inflammatory cytokines, tsc1-tsc2 complex-mtor crosstalk, insulin resistance, endoplasmic reticulum (er) stress and excessive oxidative stress generation, uncoupled respiration and hypoxia, sirt1 controversy, the increased levels of aromatase activity and estrogen production. |
2020-07-24 |
2023-08-13 |
Not clear |
| Ebru Aras, Giorgio Ramadori, Kenichiro Kinouchi, Yu Liu, Rafael M Ioris, Xavier Brenachot, Sanda Ljubicic, Christelle Veyrat-Durebex, Silvia Mannucci, Mirco Galié, Pierre Baldi, Paolo Sassone-Corsi, Roberto Coppar. Light Entrains Diurnal Changes in Insulin Sensitivity of Skeletal Muscle via Ventromedial Hypothalamic Neurons. Cell reports. vol 27. issue 8. 2020-07-16. PMID:31116983. |
mechanistically, by performing loss- and gain-of-light-action and food-restriction experiments, we demonstrate that sirt1 in steroidogenic factor 1 (sf1) neurons of the ventromedial hypothalamic nucleus (vmh) convey photic inputs to entrain the biochemical and metabolic action of insulin in skeletal muscle. |
2020-07-16 |
2023-08-13 |
mouse |
| Xingxing Ren, Ningxin Chen, Yawen Chen, Wei Liu, Yaomin H. TRB3 stimulates SIRT1 degradation and induces insulin resistance by lipotoxicity via COP1. Experimental cell research. vol 382. issue 1. 2020-06-22. PMID:31125554. |
trb3 stimulates sirt1 degradation and induces insulin resistance by lipotoxicity via cop1. |
2020-06-22 |
2023-08-13 |
mouse |
| Long T Nguyen, Hui Chen, Amgad Zaky, Carol Pollock, Sonia Saa. SIRT1 overexpression attenuates offspring metabolic and liver disorders as a result of maternal high-fat feeding. The Journal of physiology. vol 597. issue 2. 2020-05-26. PMID:30381838. |
maternal high-fat diet (mhf) consumption led to metabolic and liver disorders in male offspring, which are associated with reduced sirtuin (sirt)1 expression and activity in the offspring liver sirt1 overexpression in mhf offspring reduced their body weight and adiposity and normalized lipid metabolic markers in epididymal and retroperitoneal adipose tissues sirt1 overexpression in mhf offspring improved glucose tolerance, as well as systemic and hepatic insulin sensitivity sirt1 overexpression ameliorated mhf-induced lipogenesis, oxidative stress and fibrogenesis in the liver of offspring. |
2020-05-26 |
2023-08-13 |
Not clear |
| Andreas Mæchel Fritzen, Anne-Marie Lundsgaard, Jacob Fuglsbjerg Jeppesen, Kim Anker Sjøberg, Louise Dalgas Høeg, Henrik Hall Deleuran, Jørgen F P Wojtaszewski, Erik A Richter, Bente Kien. Fatty acid type-specific regulation of SIRT1 does not affect insulin sensitivity in human skeletal muscle. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 33. issue 4. 2020-05-11. PMID:30707625. |
fatty acid type-specific regulation of sirt1 does not affect insulin sensitivity in human skeletal muscle. |
2020-05-11 |
2023-08-13 |
human |
| Andreas Mæchel Fritzen, Anne-Marie Lundsgaard, Jacob Fuglsbjerg Jeppesen, Kim Anker Sjøberg, Louise Dalgas Høeg, Henrik Hall Deleuran, Jørgen F P Wojtaszewski, Erik A Richter, Bente Kien. Fatty acid type-specific regulation of SIRT1 does not affect insulin sensitivity in human skeletal muscle. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 33. issue 4. 2020-05-11. PMID:30707625. |
moreover, regulation of sirt1 does not seem to be an initiating factor responsible for mediating insulin resistance in human skeletal muscle.-fritzen, a. m., lundsgaard, a.-m., jeppesen, j. f., sjøberg, k. a., høeg, l. d., deleuran, h. h., wojtaszewski, j. f. p., richter, e. a., kiens, b. fatty acid type-specific regulation of sirt1 does not affect insulin sensitivity in human skeletal muscle. |
2020-05-11 |
2023-08-13 |
human |
| Huaibo Yuan, Lina Meng, Wenjuan Wang, Xiping Zh. The effects of Sea buckthorn seed protein on glucose metabolism in streptozotocin-induced diabetic ICR mice. Pakistan journal of pharmaceutical sciences. vol 32. issue 5. 2020-04-27. PMID:31813865. |
the investigated factors included oral glucose tolerance test, insulin resistance, insulin sensitivity index, ampk and sirt1 activity and the expression of liver glucose metabolism genes. |
2020-04-27 |
2023-08-13 |
mouse |
| Hazel Huang, Ali Aminian, Monique Hassan, Olivia Dan, Christopher L Axelrod, Philip R Schauer, Stacy A Brethauer, John P Kirwa. Gastric Bypass Surgery Improves the Skeletal Muscle Ceramide/S1P Ratio and Upregulates the AMPK/ SIRT1/ PGC-1α Pathway in Zucker Diabetic Fatty Rats. Obesity surgery. vol 29. issue 7. 2020-04-23. PMID:30809769. |
we hypothesized that rygb would increase peroxisome proliferator-activated receptor gamma coactivator 1-alpha (pgc-1α), sirtuin-1 (sirt1), ampk/pampk, and citrate synthase (cs) protein expression and decrease insulin resistance and these changes would be mediated by sphingolipids, including ceramides and the sphingolipid metabolite sphingosine-1 phosphate (s1p). |
2020-04-23 |
2023-08-13 |
rat |
| Rafighe Ghiasi, Roya Naderi, Roghayeh Sheervalilou, Mohammad Reza Alipou. Swimming training by affecting the pancreatic Sirtuin1 (SIRT1) and oxidative stress, improves insulin sensitivity in diabetic male rats. Hormone molecular biology and clinical investigation. vol 40. issue 3. 2020-04-16. PMID:31652118. |
swimming training by affecting the pancreatic sirtuin1 (sirt1) and oxidative stress, improves insulin sensitivity in diabetic male rats. |
2020-04-16 |
2023-08-13 |
rat |
| Miao Sui, Guofang Chen, Xiaodong Mao, Xiao Wei, Yu Chen, Chao Liu, Yaofu Fa. Gegen Qinlian Decoction Ameliorates Hepatic Insulin Resistance by Silent Information Regulator1 (SIRT1)-Dependent Deacetylation of Forkhead Box O1 (FOXO1). Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-03-27. PMID:31719515. |
gegen qinlian decoction ameliorates hepatic insulin resistance by silent information regulator1 (sirt1)-dependent deacetylation of forkhead box o1 (foxo1). |
2020-03-27 |
2023-08-13 |
mouse |
| Miao Sui, Guofang Chen, Xiaodong Mao, Xiao Wei, Yu Chen, Chao Liu, Yaofu Fa. Gegen Qinlian Decoction Ameliorates Hepatic Insulin Resistance by Silent Information Regulator1 (SIRT1)-Dependent Deacetylation of Forkhead Box O1 (FOXO1). Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-03-27. PMID:31719515. |
we aimed to evaluate the effect of ggqld on hepatic insulin resistance (ir) through silent information regulator1 (sirt1)/forkhead box o1 (foxo1) in an ir mouse model. |
2020-03-27 |
2023-08-13 |
mouse |
| Qi Huang, Rui Chen, Miao Peng, Lun Li, Tong Li, Feng-Xia Liang, Fen X. [Effect of electroacupuncture on SIRT1/NF-κB signaling pathway in adipose tissue of obese rats]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. vol 40. issue 2. 2020-03-17. PMID:32100506. |
to explore the effect of electroacupuncture (ea) on insulin sensitivity, adipose tissue inflammatory reaction and silent information regulation factor 1(sirt1)/nuclear factor kappa b (nf-κb) signaling pathway in obese rats. |
2020-03-17 |
2023-08-13 |
rat |
| Jie Song, Bing Yang, Xiaobin Jia, Mingyu Li, Wei Tan, Shitang Ma, Xinhong Shi, Liang Fen. Distinctive Roles of Sirtuins on Diabetes, Protective or Detrimental? Frontiers in endocrinology. vol 9. 2020-02-25. PMID:30559718. |
it's worth noting that sirt1, sirt2, sirt3, and sirt6 are positive regulators of insulin resistance in most cases. |
2020-02-25 |
2023-08-13 |
Not clear |
| Xin Tao, Lisi Cai, Lei Chen, Shuqi Ge, Xuanying Den. Effects of metformin and Exenatide on insulin resistance and AMPKα-SIRT1 molecular pathway in PCOS rats. Journal of ovarian research. vol 12. issue 1. 2020-02-24. PMID:31526389. |
this study was designed to evaluate the protective effects of ampkα and sirt1 on insulin resistance in pcos rats, and to illuminate the underlying mechanisms. |
2020-02-24 |
2023-08-13 |
rat |
| Ja Young Jeon, Sung-E Choi, Eun Suk Ha, Han Byeol Lee, Tae Ho Kim, Seung Jin Han, Hae Jin Kim, Dae Jung Kim, Yup Kang, Kwan-Woo Le. GLP‑1 improves palmitate‑induced insulin resistance in human skeletal muscle via SIRT1 activity. International journal of molecular medicine. vol 44. issue 3. 2020-02-04. PMID:31524229. |
glp‑1 improves palmitate‑induced insulin resistance in human skeletal muscle via sirt1 activity. |
2020-02-04 |
2023-08-13 |
human |
| Ja Young Jeon, Sung-E Choi, Eun Suk Ha, Han Byeol Lee, Tae Ho Kim, Seung Jin Han, Hae Jin Kim, Dae Jung Kim, Yup Kang, Kwan-Woo Le. GLP‑1 improves palmitate‑induced insulin resistance in human skeletal muscle via SIRT1 activity. International journal of molecular medicine. vol 44. issue 3. 2020-02-04. PMID:31524229. |
to determine whether sirt‑1 contributes to glp‑1 action in hsmms with palmitate‑induced insulin resistance, the levels of peroxisome proliferator‑activated receptor γ coactivator 1α (pgc1α) deacetylation and sirt‑1 activity were assessed using a sirt1 inhibitor and small interfering rna (sirna). |
2020-02-04 |
2023-08-13 |
human |
| Ja Young Jeon, Sung-E Choi, Eun Suk Ha, Han Byeol Lee, Tae Ho Kim, Seung Jin Han, Hae Jin Kim, Dae Jung Kim, Yup Kang, Kwan-Woo Le. GLP‑1 improves palmitate‑induced insulin resistance in human skeletal muscle via SIRT1 activity. International journal of molecular medicine. vol 44. issue 3. 2020-02-04. PMID:31524229. |
the influence of sirt1 on the glp‑1‑induced activation of insulin signaling pathway was determined using a sirt1 inhibitor. |
2020-02-04 |
2023-08-13 |
human |