| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jun Liu, Ben Zhou, Menghong Yan, Rui Huang, Yuangao Wang, Zhishui He, Yonggang Yang, Changgui Dai, Yiqian Wang, Fang Zhang, Qiwei Zha. CLOCK and BMAL1 Regulate Muscle Insulin Sensitivity via SIRT1 in Male Mice. Endocrinology. vol 157. issue 6. 2017-06-05. PMID:27035655. |
moreover, clock and bmal1 regulate the expression of sirtuin 1 (sirt1), an important regulator of insulin sensitivity, in c2c12 myotubes and mouse skeletal muscle, and two e-box elements in sirt1 promoter are responsible for its clock- and bmal1-dependent transcription in muscle cells. |
2017-06-05 |
2023-08-13 |
mouse |
| Jun Liu, Ben Zhou, Menghong Yan, Rui Huang, Yuangao Wang, Zhishui He, Yonggang Yang, Changgui Dai, Yiqian Wang, Fang Zhang, Qiwei Zha. CLOCK and BMAL1 Regulate Muscle Insulin Sensitivity via SIRT1 in Male Mice. Endocrinology. vol 157. issue 6. 2017-06-05. PMID:27035655. |
further studies show that clock and bmal1 regulate muscle insulin sensitivity through sirt1. |
2017-06-05 |
2023-08-13 |
mouse |
| Jun Liu, Ben Zhou, Menghong Yan, Rui Huang, Yuangao Wang, Zhishui He, Yonggang Yang, Changgui Dai, Yiqian Wang, Fang Zhang, Qiwei Zha. CLOCK and BMAL1 Regulate Muscle Insulin Sensitivity via SIRT1 in Male Mice. Endocrinology. vol 157. issue 6. 2017-06-05. PMID:27035655. |
in addition, we find that bmal1 and sirt1 are decreased in the muscle of mice maintained in constant darkness, and resveratrol supplementation activates sirt1 and improves insulin sensitivity. |
2017-06-05 |
2023-08-13 |
mouse |
| Jun Liu, Ben Zhou, Menghong Yan, Rui Huang, Yuangao Wang, Zhishui He, Yonggang Yang, Changgui Dai, Yiqian Wang, Fang Zhang, Qiwei Zha. CLOCK and BMAL1 Regulate Muscle Insulin Sensitivity via SIRT1 in Male Mice. Endocrinology. vol 157. issue 6. 2017-06-05. PMID:27035655. |
all these data demonstrate that clock and bmal1 regulate muscle insulin sensitivity via sirt1, and activation of sirt1 might be a potential valuable strategy to attenuate muscle insulin resistance related to circadian misalignment. |
2017-06-05 |
2023-08-13 |
mouse |
| Shifeng Wang, Qiao Zhang, Yuxin Zhang, Cheng Shen, Zhen Wang, Qinghua Wu, Yanling Zhang, Shiyou Li, Yanjiang Qia. Agrimol B suppresses adipogenesis through modulation of SIRT1-PPAR gamma signal pathway. Biochemical and biophysical research communications. vol 477. issue 3. 2017-05-31. PMID:27320865. |
studies of human genetics have implicated the role of sirt1 in regulating obesity, insulin resistance, and longevity. |
2017-05-31 |
2023-08-13 |
human |
| Dorota Rogacka, Agnieszka Piwkowska, Irena Audzeyenka, Stefan Angielski, Maciej Jankowsk. SIRT1-AMPK crosstalk is involved in high glucose-dependent impairment of insulin responsiveness in primary rat podocytes. Experimental cell research. vol 349. issue 2. 2017-05-16. PMID:27836811. |
here, we report the involvement of the reciprocal interplay between deacetylase sirt1 and protein kinase ampk in podocyte high glucose-induced abolition of insulin-dependent glucose uptake, manifesting insulin resistance. |
2017-05-16 |
2023-08-13 |
rat |
| Dorota Rogacka, Agnieszka Piwkowska, Irena Audzeyenka, Stefan Angielski, Maciej Jankowsk. SIRT1-AMPK crosstalk is involved in high glucose-dependent impairment of insulin responsiveness in primary rat podocytes. Experimental cell research. vol 349. issue 2. 2017-05-16. PMID:27836811. |
we have demonstrated that the absence of the stimulating effect of insulin on glucose uptake into primary rat podocytes after long-time exposition to high glucose concentrations, is a result of decreased sirt1 protein levels and activity, associated with decreased ampk phosphorylation degree, presumably underlying the induction of insulin resistance. |
2017-05-16 |
2023-08-13 |
rat |
| Dorota Rogacka, Agnieszka Piwkowska, Irena Audzeyenka, Stefan Angielski, Maciej Jankowsk. SIRT1-AMPK crosstalk is involved in high glucose-dependent impairment of insulin responsiveness in primary rat podocytes. Experimental cell research. vol 349. issue 2. 2017-05-16. PMID:27836811. |
our findings suggest that the interplay between sirt1 and ampk is involved in the regulation of insulin action in podocytes. |
2017-05-16 |
2023-08-13 |
rat |
| b' Marie Boutant, Sameer S Kulkarni, Magali Joffraud, Fr\\xc3\\xa9d\\xc3\\xa9ric Raymond, Sylviane M\\xc3\\xa9tairon, Patrick Descombes, Carles Cant\\xc3\\xb. SIRT1 Gain of Function Does Not Mimic or Enhance the Adaptations to Intermittent Fasting. Cell reports. vol 14. issue 9. 2017-01-10. PMID:26923584.' |
our results indicate that sirt1 transgenesis does not affect the ability of eodf to decrease adiposity and improve insulin sensitivity. |
2017-01-10 |
2023-08-13 |
mouse |
| b' Marie Boutant, Sameer S Kulkarni, Magali Joffraud, Fr\\xc3\\xa9d\\xc3\\xa9ric Raymond, Sylviane M\\xc3\\xa9tairon, Patrick Descombes, Carles Cant\\xc3\\xb. SIRT1 Gain of Function Does Not Mimic or Enhance the Adaptations to Intermittent Fasting. Cell reports. vol 14. issue 9. 2017-01-10. PMID:26923584.' |
therefore, whereas sirt1 overexpression and cr both improve glucose metabolism and insulin sensitivity, the etiologies of these benefits are largely different. |
2017-01-10 |
2023-08-13 |
mouse |
| Thomas K Sin, Angus P Yu, Benjamin Y Yung, Shea P Yip, Lawrence W Chan, Cesar S Wong, John A Rudd, Parco M Si. Effects of long-term resveratrol-induced SIRT1 activation on insulin and apoptotic signalling in aged skeletal muscle. Acta diabetologica. vol 52. issue 6. 2016-12-13. PMID:25959421. |
effects of long-term resveratrol-induced sirt1 activation on insulin and apoptotic signalling in aged skeletal muscle. |
2016-12-13 |
2023-08-13 |
mouse |
| Fen Xu, Xiaobin Zheng, Beisi Lin, Hua Liang, Mengyin Cai, Huanyi Cao, Jianping Ye, Jianping Wen. Diet-induced obesity and insulin resistance are associated with brown fat degeneration in SIRT1-deficient mice. Obesity (Silver Spring, Md.). vol 24. issue 3. 2016-10-31. PMID:26916242. |
this study investigated the role of sirt1 loss-of-function in diet-induced obesity and insulin resistance and the mechanism involved in adipose tissue thermogenesis. |
2016-10-31 |
2023-08-13 |
mouse |
| Yue Cao, Xinli Jiang, Huijie Ma, Yuling Wang, Peng Xue, Yan Li. SIRT1 and insulin resistance. Journal of diabetes and its complications. vol 30. issue 1. 2016-10-12. PMID:26422395. |
sirt1 and insulin resistance. |
2016-10-12 |
2023-08-13 |
Not clear |
| Yue Cao, Xinli Jiang, Huijie Ma, Yuling Wang, Peng Xue, Yan Li. SIRT1 and insulin resistance. Journal of diabetes and its complications. vol 30. issue 1. 2016-10-12. PMID:26422395. |
in this review, we have summarized the recent progress in sirt1 research with a particular focus on the role of sirt1 in insulin resistance at different metabolic tissues. |
2016-10-12 |
2023-08-13 |
Not clear |
| Yue Cao, Xinli Jiang, Huijie Ma, Yuling Wang, Peng Xue, Yan Li. SIRT1 and insulin resistance. Journal of diabetes and its complications. vol 30. issue 1. 2016-10-12. PMID:26422395. |
recent data indicate that activated sirt1 improves the insulin sensitivity of liver, skeletal muscle and adipose tissues and protects the function and cell mass of pancreatic β-cells. |
2016-10-12 |
2023-08-13 |
Not clear |
| Yue Cao, Xinli Jiang, Huijie Ma, Yuling Wang, Peng Xue, Yan Li. SIRT1 and insulin resistance. Journal of diabetes and its complications. vol 30. issue 1. 2016-10-12. PMID:26422395. |
these findings suggest that sirt1 might be a new therapeutic target for the prevention of disease related to insulin resistance, such as metabolic syndrome and type 2 diabetes mellitus. |
2016-10-12 |
2023-08-13 |
Not clear |
| Rebecca A S Palu, Carl S Thumme. Sir2 Acts through Hepatocyte Nuclear Factor 4 to maintain insulin Signaling and Metabolic Homeostasis in Drosophila. PLoS genetics. vol 12. issue 4. 2016-08-16. PMID:27058248. |
here we show that loss of the drosophila sirt1 homolog sir2 leads to the age-progressive onset of hyperglycemia, obesity, glucose intolerance, and insulin resistance. |
2016-08-16 |
2023-08-13 |
mouse |
| Chengying Gu, Yipeng Zeng, Zhaosheng Tang, Chaoxun Wang, Yanju He, Xinge Feng, Ligang Zho. Astragalus polysaccharides affect insulin resistance by regulating the hepatic SIRT1-PGC-1α/PPARα-FGF21 signaling pathway in male Sprague Dawley rats undergoing catch-up growth. Molecular medicine reports. vol 12. issue 5. 2016-08-11. PMID:26323321. |
the present study investigated the effects of astragalus polysaccharides (aps) on insulin resistance by modulation of hepatic sirtuin 1 (sirt1)‑peroxisome proliferator‑activated receptor (ppar)‑γ coactivator (pgc)‑1α/pparα‑fibroblast growth factor (fgf)21, and glucose and lipid metabolism. |
2016-08-11 |
2023-08-13 |
rat |
| Li Cao, Guangyu Yao, Xiaolei Hu, Lujia Chen, Changsheng Y. [Advances in studies on metabolic syndrome and breast cancer]. Zhonghua wai ke za zhi [Chinese journal of surgery]. vol 53. issue 12. 2016-07-22. PMID:26850671. |
the mechanisms underlying the association is not clear yet, but several factors are speculated to be the possible causes, including the elevated level of insulin, insulin like growth factor-1, leptin and pro-inflammatory cytokines, the decreased level of adiponectin as well as the interaction between dbc1 and sirt1. |
2016-07-22 |
2023-08-13 |
Not clear |
| Romy Kursawe, Vishwa D Dixit, Philipp E Scherer, Nicola Santoro, Deepak Narayan, Ruth Gordillo, Cosimo Giannini, Ximena Lopez, Bridget Pierpont, Jessica Nouws, Gerald I Shulman, Sonia Capri. A Role of the Inflammasome in the Low Storage Capacity of the Abdominal Subcutaneous Adipose Tissue in Obese Adolescents. Diabetes. vol 65. issue 3. 2016-07-06. PMID:26718495. |
the increase in inflammation markers was paralleled by a decrease in genes related to insulin sensitivity (adipoq, glut4, pparg2, and sirt1) and lipogenesis (srebp1c, acc, lpl, and fasn). |
2016-07-06 |
2023-08-13 |
Not clear |