| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Clémence D Côté, Brittany A Rasmussen, Frank A Duca, Melika Zadeh-Tahmasebi, Joseph A Baur, Mira Daljeet, Danna M Breen, Beatrice M Filippi, Tony K T La. Resveratrol activates duodenal Sirt1 to reverse insulin resistance in rats through a neuronal network. Nature medicine. vol 21. issue 5. 2015-08-04. PMID:25849131. |
we show here that acute intraduodenal infusion of resveratrol reversed a 3 d high fat diet (hfd)-induced reduction in duodenal-mucosal sirt1 protein levels while also enhancing insulin sensitivity and lowering hgp. |
2015-08-04 |
2023-08-13 |
rat |
| Clémence D Côté, Brittany A Rasmussen, Frank A Duca, Melika Zadeh-Tahmasebi, Joseph A Baur, Mira Daljeet, Danna M Breen, Beatrice M Filippi, Tony K T La. Resveratrol activates duodenal Sirt1 to reverse insulin resistance in rats through a neuronal network. Nature medicine. vol 21. issue 5. 2015-08-04. PMID:25849131. |
further, we found that duodenum-specific knockdown of sirt1 expression for 14 d was sufficient to induce hepatic insulin resistance in rats fed normal chow. |
2015-08-04 |
2023-08-13 |
rat |
| Clémence D Côté, Brittany A Rasmussen, Frank A Duca, Melika Zadeh-Tahmasebi, Joseph A Baur, Mira Daljeet, Danna M Breen, Beatrice M Filippi, Tony K T La. Resveratrol activates duodenal Sirt1 to reverse insulin resistance in rats through a neuronal network. Nature medicine. vol 21. issue 5. 2015-08-04. PMID:25849131. |
we also found that the glucoregulatory role of duodenally acting resveratrol required activation of sirt1 and amp-activated protein kinase (ampk) in this tissue to initiate a gut-brain-liver neuronal axis that improved hypothalamic insulin sensitivity and in turn, reduced hgp. |
2015-08-04 |
2023-08-13 |
rat |
| Clémence D Côté, Brittany A Rasmussen, Frank A Duca, Melika Zadeh-Tahmasebi, Joseph A Baur, Mira Daljeet, Danna M Breen, Beatrice M Filippi, Tony K T La. Resveratrol activates duodenal Sirt1 to reverse insulin resistance in rats through a neuronal network. Nature medicine. vol 21. issue 5. 2015-08-04. PMID:25849131. |
together, these studies highlight the therapeutic relevance of targeting duodenal sirt1 to reverse insulin resistance and improve glucose homeostasis in obesity and diabetes. |
2015-08-04 |
2023-08-13 |
rat |
| Tsutomu Sasak. Age-Associated Weight Gain, Leptin, and SIRT1: A Possible Role for Hypothalamic SIRT1 in the Prevention of Weight Gain and Aging through Modulation of Leptin Sensitivity. Frontiers in endocrinology. vol 6. 2015-08-03. PMID:26236282. |
sirt1 improves both leptin sensitivity and insulin sensitivity by decreasing the levels of several molecules that impair leptin and insulin signal transduction. |
2015-08-03 |
2023-08-13 |
mouse |
| Magdalena Stefanowicz, Marek Strączkowski, Monika Karczewska-Kupczewsk. [The role of SIRT1 in the pathogenesis of insulin resistance in skeletal muscle]. Postepy higieny i medycyny doswiadczalnej (Online). vol 69. 2015-06-23. PMID:25614674. |
[the role of sirt1 in the pathogenesis of insulin resistance in skeletal muscle]. |
2015-06-23 |
2023-08-13 |
Not clear |
| Magdalena Stefanowicz, Marek Strączkowski, Monika Karczewska-Kupczewsk. [The role of SIRT1 in the pathogenesis of insulin resistance in skeletal muscle]. Postepy higieny i medycyny doswiadczalnej (Online). vol 69. 2015-06-23. PMID:25614674. |
experimental studies indicate that sirt1 may play a role in the pathogenesis of skeletal muscle insulin resistance. |
2015-06-23 |
2023-08-13 |
Not clear |
| Magdalena Stefanowicz, Marek Strączkowski, Monika Karczewska-Kupczewsk. [The role of SIRT1 in the pathogenesis of insulin resistance in skeletal muscle]. Postepy higieny i medycyny doswiadczalnej (Online). vol 69. 2015-06-23. PMID:25614674. |
sirt1 directly influences insulin signal transduction pathway. |
2015-06-23 |
2023-08-13 |
Not clear |
| Magdalena Stefanowicz, Marek Strączkowski, Monika Karczewska-Kupczewsk. [The role of SIRT1 in the pathogenesis of insulin resistance in skeletal muscle]. Postepy higieny i medycyny doswiadczalnej (Online). vol 69. 2015-06-23. PMID:25614674. |
moreover, sirt1 interacts with pgc1α and ampk to stimulate muscle glucose uptake and fatty acid oxidation and thus it can prevent insulin resistance. |
2015-06-23 |
2023-08-13 |
Not clear |
| Magdalena Stefanowicz, Marek Strączkowski, Monika Karczewska-Kupczewsk. [The role of SIRT1 in the pathogenesis of insulin resistance in skeletal muscle]. Postepy higieny i medycyny doswiadczalnej (Online). vol 69. 2015-06-23. PMID:25614674. |
sirt1 activators might be useful in the treatment of insulin resistance-related diseases. |
2015-06-23 |
2023-08-13 |
Not clear |
| Wei Chen, Shiyong Fan, Xinni Xie, Nina Xue, Xueyuan Jin, Lili Wan. Novel PPAR pan agonist, ZBH ameliorates hyperlipidemia and insulin resistance in high fat diet induced hyperlipidemic hamster. PloS one. vol 9. issue 4. 2015-06-19. PMID:24759758. |
these results suggested that zbh significantly lowered hyperlipidemia and ameliorated insulin resistance more efficiently than bezafibrate in the hyperlipidemic hamsters primarily by activating of pparα, and sirt1 promotion and activation. |
2015-06-19 |
2023-08-13 |
Not clear |
| Yasar Colak, Atakan Yesil, Hasan Huseyin Mutlu, Ozge Telci Caklili, Celal Ulasoglu, Ebubekir Senates, Mumtaz Takir, Osman Kostek, Yusuf Yilmaz, Feruze Yilmaz Enc, Guralp Tasan, Ilyas Tunce. A potential treatment of non-alcoholic fatty liver disease with SIRT1 activators. Journal of gastrointestinal and liver diseases : JGLD. vol 23. issue 3. 2015-05-29. PMID:25267960. |
among the effects of sirt1 are: its healing activity on insulin sensitivity, thereby ameliorating glycemic regulation; its mimetic activity on calorie restriction; its antihyperlipidemic activity on lipid homeostasis via the liver, adipose tissues and skeletal muscles; its anti-inflammatory activities; its protective effects against cardiovascular events and endothelial dysfunction; its positive influence on autophagy, apoptosis and cancer; and finally, its anti-aging activity. |
2015-05-29 |
2023-08-13 |
Not clear |
| Rafael Mayoral, Olivia Osborn, Joanne McNelis, Andrew M Johnson, Da Young Oh, Cristina Llorente Izquierdo, Heekyung Chung, Pingping Li, Paqui G Traves, Gautam Bandyopadhyay, Ariane R Pessentheiner, Jachelle M Ofrecio, Joshua R Cook, Li Qiang, Domenico Accili, Jerrold M Olefsk. Adipocyte SIRT1 knockout promotes PPARγ activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity. Molecular metabolism. vol 4. issue 5. 2015-05-14. PMID:25973386. |
adipocyte sirt1 knockout promotes pparγ activity, adipogenesis and insulin sensitivity in chronic-hfd and obesity. |
2015-05-14 |
2023-08-13 |
Not clear |
| Sun-O Ka, Mi-Young Song, Eun Ju Bae, Byung-Hyun Par. Myeloid SIRT1 regulates macrophage infiltration and insulin sensitivity in mice fed a high-fat diet. The Journal of endocrinology. vol 224. issue 2. 2015-04-13. PMID:25349250. |
myeloid sirt1 regulates macrophage infiltration and insulin sensitivity in mice fed a high-fat diet. |
2015-04-13 |
2023-08-13 |
mouse |
| Sun-O Ka, Mi-Young Song, Eun Ju Bae, Byung-Hyun Par. Myeloid SIRT1 regulates macrophage infiltration and insulin sensitivity in mice fed a high-fat diet. The Journal of endocrinology. vol 224. issue 2. 2015-04-13. PMID:25349250. |
our results indicate that myeloid sirt1 plays a crucial role in macrophage polarization and chemotaxis, and thus regulates the development of hfd-induced pancreatic inflammation and insulin secretion, and metabolic derangements in liver and adipose tissue. |
2015-04-13 |
2023-08-13 |
mouse |
| Moisés Pérez-Mendoza, Julieta B Rivera-Zavala, Mauricio Díaz-Muño. Daytime restricted feeding modifies the daily variations of liver gluconeogenesis: adaptations in biochemical and endocrine regulators. Chronobiology international. vol 31. issue 7. 2015-03-05. PMID:24766192. |
we explored the hepatic gluconeogenic response in drf rats by the temporal profiles of the following: (1) the activity of glucose 6-phosphatase (g6pase) and phosphoenolpyruvate carboxykinase (pepck), as well as the periportal and pericentral distribution of pepck; (2) conversion of alanine to glucose; (3) glycemia and liver glycogen content; (4) presence of glycogen synthase (gys) and its phosphorylated form (at ser641, pgys); (5) circulating levels of corticosterone, glucagon and insulin; (6) glucose-tolerance test; and (7) sirtuin 1 (sirt1) and peroxisome proliferator-activated receptor-coactivator 1α (pgc-1α). |
2015-03-05 |
2023-08-13 |
rat |
| Moisés Pérez-Mendoza, Julieta B Rivera-Zavala, Mauricio Díaz-Muño. Daytime restricted feeding modifies the daily variations of liver gluconeogenesis: adaptations in biochemical and endocrine regulators. Chronobiology international. vol 31. issue 7. 2015-03-05. PMID:24766192. |
the results showed that drf promoted: (1) a phase shift in g6pase activity and an increase in pepck activity as well as a change of pepck from periportal to pericentral hepatocytes, (2) a net conversion of alanine to circulating glucose, (3) a decrease in glycemic values and a phase shift in the liver glycogen content, (4) a phase shift in gys and an increase of pgys, (5) an increase in the daily levels of corticosterone and glucagon, but a reduction in the levels of insulin, (6) normal glucose homeostasis in all groups and (7) an enhanced presence of sirt1 and pgc-1α. |
2015-03-05 |
2023-08-13 |
rat |
| Amanda T White, Andrew Philp, Heidi N Fridolfsson, Jan M Schilling, Anne N Murphy, D Lee Hamilton, Carrie E McCurdy, Hemal H Patel, Simon Schen. High-fat diet-induced impairment of skeletal muscle insulin sensitivity is not prevented by SIRT1 overexpression. American journal of physiology. Endocrinology and metabolism. vol 307. issue 9. 2015-02-26. PMID:25159328. |
high-fat diet-induced impairment of skeletal muscle insulin sensitivity is not prevented by sirt1 overexpression. |
2015-02-26 |
2023-08-13 |
mouse |
| Amanda T White, Andrew Philp, Heidi N Fridolfsson, Jan M Schilling, Anne N Murphy, D Lee Hamilton, Carrie E McCurdy, Hemal H Patel, Simon Schen. High-fat diet-induced impairment of skeletal muscle insulin sensitivity is not prevented by SIRT1 overexpression. American journal of physiology. Endocrinology and metabolism. vol 307. issue 9. 2015-02-26. PMID:25159328. |
herein, we investigated whether constitutive activation of sirt1 in skeletal muscle prevents hfd-induced muscle insulin resistance. |
2015-02-26 |
2023-08-13 |
mouse |
| Amanda T White, Andrew Philp, Heidi N Fridolfsson, Jan M Schilling, Anne N Murphy, D Lee Hamilton, Carrie E McCurdy, Hemal H Patel, Simon Schen. High-fat diet-induced impairment of skeletal muscle insulin sensitivity is not prevented by SIRT1 overexpression. American journal of physiology. Endocrinology and metabolism. vol 307. issue 9. 2015-02-26. PMID:25159328. |
together, these results demonstrate that activation of sirt1 in skeletal muscle alone does not prevent hfd-induced glucose intolerance, weight gain, or insulin resistance. |
2015-02-26 |
2023-08-13 |
mouse |