| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hao-Hao Zhang, Gui-Jun Qin, Xia-Lian Li, Ying-Hui Zhang, Pei-Jie Du, Peng-Yu Zhang, Yan-Yan Zhao, Jing W. SIRT1 overexpression in skeletal muscle in vivo induces increased insulin sensitivity and enhanced complex I but not complex II-V functions in individual subsarcolemmal and intermyofibrillar mitochondria. Journal of physiology and biochemistry. vol 71. issue 2. 2016-02-17. PMID:25782776. |
therefore, we sought to test if acute overexpression of sirt1 in skeletal muscle of high-fat diet (hfd) rats in vivo would affect subsarcolemmal (ss) and intermyofibrillar (imf) mitochondrial complexes i-v activities and antioxidant enzymes thereby improving insulin action. |
2016-02-17 |
2023-08-13 |
rat |
| Hao-Hao Zhang, Gui-Jun Qin, Xia-Lian Li, Ying-Hui Zhang, Pei-Jie Du, Peng-Yu Zhang, Yan-Yan Zhao, Jing W. SIRT1 overexpression in skeletal muscle in vivo induces increased insulin sensitivity and enhanced complex I but not complex II-V functions in individual subsarcolemmal and intermyofibrillar mitochondria. Journal of physiology and biochemistry. vol 71. issue 2. 2016-02-17. PMID:25782776. |
skeletal muscle insulin sensitivity and downstream effects of sirt1 on ampk, sirt3, and mitochondrial biogenesis were studied. |
2016-02-17 |
2023-08-13 |
rat |
| Junfeng Han, Meilin Wei, Qianqian Wang, Xu Li, Chaoyu Zhu, Yueqin Mao, Li Wei, Yongning Sun, Weiping Ji. Association of Genetic Variants of SIRT1 With Type 2 Diabetes Mellitus. Gene expression. vol 16. issue 4. 2016-02-09. PMID:26637398. |
together, our data show that genetic variation of the sirt1 gene is related to insulin resistance and increase risk of t2dm in chinese han population. |
2016-02-09 |
2023-08-13 |
human |
| Sandeep Kumar, Kulbhushan Tiko. Independent role of PP2A and mTORc1 in palmitate induced podocyte death. Biochimie. vol 112. 2016-01-08. PMID:25724269. |
interestingly, selective inhibition of pp2a, by okadaic acid at 5 nm, restored insulin induced phosphorylation of akt, foxo1, sirt1 activity and p53 degradation. |
2016-01-08 |
2023-08-13 |
human |
| Sandeep Kumar, Kulbhushan Tiko. Independent role of PP2A and mTORc1 in palmitate induced podocyte death. Biochimie. vol 112. 2016-01-08. PMID:25724269. |
on the other hand, partial inhibition of mtorc1, by low dose of rapamycin (1 nm) also restored phosphorylation of akt and sirt1 activity, whereas no significant changes were observed in insulin induced phosphorylation of pp2a after mtorc1 inhibition. |
2016-01-08 |
2023-08-13 |
human |
| Kenneth Maies. Programming apoptosis and autophagy with novel approaches for diabetes mellitus. Current neurovascular research. vol 12. issue 2. 2015-12-29. PMID:25742566. |
multiple treatment approaches are being entertained for dm with wnt1 inducible signaling pathway protein 1 (wisp1), mechanistic target of rapamycin (mtor), and silent mating type information regulation 2 homolog) 1 (s. cerevisiae) (sirt1) generating significant interest as target pathways that can address maintenance of glucose homeostasis as well as prevention of cellular pathology by controlling insulin resistance, stem cell proliferation, and the programmed cell death pathways of apoptosis and autophagy. |
2015-12-29 |
2023-08-13 |
Not clear |
| Zhang Haohao, Qin Guijun, Zheng Juan, Kong Wen, Chen Lul. Resveratrol improves high-fat diet induced insulin resistance by rebalancing subsarcolemmal mitochondrial oxidation and antioxidantion. Journal of physiology and biochemistry. vol 71. issue 1. 2015-12-08. PMID:25686565. |
systemic and skeletal muscle insulin sensitivity together with expressions of several genes related to mitochondrial biogenesis and skeletal muscle sirt1, sirt3 protein levels were studied in rats fed a normal diet, a hfd, and a hfd with intervention of res for 8 weeks. |
2015-12-08 |
2023-08-13 |
rat |
| Thomas K Sin, Benjamin Y Yung, Parco M Si. Modulation of SIRT1-Foxo1 signaling axis by resveratrol: implications in skeletal muscle aging and insulin resistance. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 35. issue 2. 2015-10-13. PMID:25612477. |
accumulating body of evidence have shown that resveratrol, a natural polyphenol in grapes and red wine, activates the longevity-related protein sirtuin 1 (sirt1) and augments insulin sensitivity in addition to its well-documented effects on mitochondrial energetics. |
2015-10-13 |
2023-08-13 |
Not clear |
| Thomas K Sin, Benjamin Y Yung, Parco M Si. Modulation of SIRT1-Foxo1 signaling axis by resveratrol: implications in skeletal muscle aging and insulin resistance. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 35. issue 2. 2015-10-13. PMID:25612477. |
the present review summarizes the role of foxo1/sirt1 in insulin signaling in skeletal muscle and proposes the insight that activation of sirt1 deacetylase activity to deacetylate and suppress the foxo1-induced transactivation of pdk4 may represent an anti-hyperglycemic mechanism of resveratrol in aging skeletal muscle. |
2015-10-13 |
2023-08-13 |
Not clear |
| Vina Yanti Susanti, Tsutomu Sasaki, Hiromi Yokota-Hashimoto, Sho Matsui, Yong-Soo Lee, Osamu Kikuchi, Mayumi Shimpuku, Hye-Jin Kim, Masaki Kobayashi, Tadahiro Kitamur. Sirt1 rescues the obesity induced by insulin-resistant constitutively-nuclear FoxO1 in POMC neurons of male mice. Obesity (Silver Spring, Md.). vol 22. issue 10. 2015-09-21. PMID:25044690. |
foxo1 is a transcription factor regulated by insulin signaling that is deacetylated by sirt1, a nicotinamide adenine dinucleotide- (nad(+) -) dependent deacetylase. |
2015-09-21 |
2023-08-13 |
mouse |
| Kyung Eun Kim, Hwajin Kim, Rok Won Heo, Hyun Joo Shin, Chin-Ok Yi, Dong Hoon Lee, Hyun Joon Kim, Sang Soo Kang, Gyeong Jae Cho, Wan Sung Choi, Gu Seob Ro. Myeloid-specific SIRT1 Deletion Aggravates Hepatic Inflammation and Steatosis in High-fat Diet-fed Mice. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 19. issue 5. 2015-09-02. PMID:26330758. |
the organ-specific deletion of sirt1 induces local inflammation and insulin resistance in dietary and genetic obesity. |
2015-09-02 |
2023-08-13 |
mouse |
| Kyung Eun Kim, Hwajin Kim, Rok Won Heo, Hyun Joo Shin, Chin-Ok Yi, Dong Hoon Lee, Hyun Joon Kim, Sang Soo Kang, Gyeong Jae Cho, Wan Sung Choi, Gu Seob Ro. Myeloid-specific SIRT1 Deletion Aggravates Hepatic Inflammation and Steatosis in High-fat Diet-fed Mice. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 19. issue 5. 2015-09-02. PMID:26330758. |
macrophage-mediated inflammation contributes to insulin resistance and metabolic syndrome, however, the macrophage-specific sirt1 function in the context of obesity is largely unknown. |
2015-09-02 |
2023-08-13 |
mouse |
| Kyung Eun Kim, Hwajin Kim, Rok Won Heo, Hyun Joo Shin, Chin-Ok Yi, Dong Hoon Lee, Hyun Joon Kim, Sang Soo Kang, Gyeong Jae Cho, Wan Sung Choi, Gu Seob Ro. Myeloid-specific SIRT1 Deletion Aggravates Hepatic Inflammation and Steatosis in High-fat Diet-fed Mice. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 19. issue 5. 2015-09-02. PMID:26330758. |
sirt1 deletion enhanced hfd-induced changes on body and liver weight gain, and increased glucose and insulin resistance. |
2015-09-02 |
2023-08-13 |
mouse |
| Lizhi Fu, Antje Bruckbauer, Fenfen Li, Qiang Cao, Xin Cui, Rui Wu, Hang Shi, Michael B Zemel, Bingzhong Xu. Leucine amplifies the effects of metformin on insulin sensitivity and glycemic control in diet-induced obese mice. Metabolism: clinical and experimental. vol 64. issue 7. 2015-08-06. PMID:25858853. |
leucine (leu) activates sirt1 by lowering its km for nad(+) and potentiates other sirtuin/ampk-activators, resulting in improvement of insulin sensitivity. |
2015-08-06 |
2023-08-13 |
mouse |
| Hao-Hao Zhang, Xiao-Jun Ma, Li-Na Wu, Yan-Yan Zhao, Peng-Yu Zhang, Ying-Hui Zhang, Ming-Wei Shao, Fei Liu, Fei Li, Gui-Jun Qi. SIRT1 attenuates high glucose-induced insulin resistance via reducing mitochondrial dysfunction in skeletal muscle cells. Experimental biology and medicine (Maywood, N.J.). vol 240. issue 5. 2015-08-04. PMID:25710929. |
sirt1 attenuates high glucose-induced insulin resistance via reducing mitochondrial dysfunction in skeletal muscle cells. |
2015-08-04 |
2023-08-13 |
Not clear |
| Hao-Hao Zhang, Xiao-Jun Ma, Li-Na Wu, Yan-Yan Zhao, Peng-Yu Zhang, Ying-Hui Zhang, Ming-Wei Shao, Fei Liu, Fei Li, Gui-Jun Qi. SIRT1 attenuates high glucose-induced insulin resistance via reducing mitochondrial dysfunction in skeletal muscle cells. Experimental biology and medicine (Maywood, N.J.). vol 240. issue 5. 2015-08-04. PMID:25710929. |
silent information regulator 1 (sirt1) is one member of the sirt2 (sir2)-like family of proteins involved in glucose homeostasis and insulin secretion in mammals. |
2015-08-04 |
2023-08-13 |
Not clear |
| Hao-Hao Zhang, Xiao-Jun Ma, Li-Na Wu, Yan-Yan Zhao, Peng-Yu Zhang, Ying-Hui Zhang, Ming-Wei Shao, Fei Liu, Fei Li, Gui-Jun Qi. SIRT1 attenuates high glucose-induced insulin resistance via reducing mitochondrial dysfunction in skeletal muscle cells. Experimental biology and medicine (Maywood, N.J.). vol 240. issue 5. 2015-08-04. PMID:25710929. |
although sirt1 has a therapeutic effect on metabolic deterioration in insulin resistance, it is still not clear how sirt1 is involved in the development of insulin resistance. |
2015-08-04 |
2023-08-13 |
Not clear |
| Hao-Hao Zhang, Xiao-Jun Ma, Li-Na Wu, Yan-Yan Zhao, Peng-Yu Zhang, Ying-Hui Zhang, Ming-Wei Shao, Fei Liu, Fei Li, Gui-Jun Qi. SIRT1 attenuates high glucose-induced insulin resistance via reducing mitochondrial dysfunction in skeletal muscle cells. Experimental biology and medicine (Maywood, N.J.). vol 240. issue 5. 2015-08-04. PMID:25710929. |
here, we demonstrate that pcdna3.1 vector-mediated overexpression of sirt1 attenuates insulin resistance in the high glucose-induced insulin-resistant skeleton muscle cells. |
2015-08-04 |
2023-08-13 |
Not clear |
| Hao-Hao Zhang, Xiao-Jun Ma, Li-Na Wu, Yan-Yan Zhao, Peng-Yu Zhang, Ying-Hui Zhang, Ming-Wei Shao, Fei Liu, Fei Li, Gui-Jun Qi. SIRT1 attenuates high glucose-induced insulin resistance via reducing mitochondrial dysfunction in skeletal muscle cells. Experimental biology and medicine (Maywood, N.J.). vol 240. issue 5. 2015-08-04. PMID:25710929. |
taken together, these results showed that sirt1 improves insulin sensitivity via the amelioration of mitochondrial dysfunction, and this is achieved through the sirt1-sirt3-mitochondrial complex i pathway. |
2015-08-04 |
2023-08-13 |
Not clear |
| Clémence D Côté, Brittany A Rasmussen, Frank A Duca, Melika Zadeh-Tahmasebi, Joseph A Baur, Mira Daljeet, Danna M Breen, Beatrice M Filippi, Tony K T La. Resveratrol activates duodenal Sirt1 to reverse insulin resistance in rats through a neuronal network. Nature medicine. vol 21. issue 5. 2015-08-04. PMID:25849131. |
resveratrol activates duodenal sirt1 to reverse insulin resistance in rats through a neuronal network. |
2015-08-04 |
2023-08-13 |
rat |