| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Munehiro Kitada, Daisuke Koy. SIRT1 in Type 2 Diabetes: Mechanisms and Therapeutic Potential. Diabetes & metabolism journal. vol 37. issue 5. 2014-06-24. PMID:24199159. |
several sirt1 activators, including resveratrol have been demonstrated to have beneficial effects on glucose homeostasis and insulin sensitivity in animal models of insulin resistance. |
2014-06-24 |
2023-08-12 |
Not clear |
| Weijing Cai, Jaime Uribarri, Li Zhu, Xue Chen, Shobha Swamy, Zhengshan Zhao, Fabrizio Grosjean, Calogera Simonaro, George A Kuchel, Michal Schnaider-Beeri, Mark Woodward, Gary E Striker, Helen Vlassar. Oral glycotoxins are a modifiable cause of dementia and the metabolic syndrome in mice and humans. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 13. 2014-06-02. PMID:24567379. |
the mouse data were enhanced by significant temporal correlations between high circulating ages and impaired cognition, as well as insulin sensitivity in older humans, in whom dietary and serum mg levels strongly and inversely associated with sirt1 gene expression. |
2014-06-02 |
2023-08-12 |
mouse |
| L Luu, F F Dai, K J Prentice, X Huang, A B Hardy, J B Hansen, Y Liu, J W Joseph, M B Wheele. The loss of Sirt1 in mouse pancreatic beta cells impairs insulin secretion by disrupting glucose sensing. Diabetologia. vol 56. issue 9. 2014-05-30. PMID:23783352. |
the loss of sirt1 in mouse pancreatic beta cells impairs insulin secretion by disrupting glucose sensing. |
2014-05-30 |
2023-08-12 |
mouse |
| L Luu, F F Dai, K J Prentice, X Huang, A B Hardy, J B Hansen, Y Liu, J W Joseph, M B Wheele. The loss of Sirt1 in mouse pancreatic beta cells impairs insulin secretion by disrupting glucose sensing. Diabetologia. vol 56. issue 9. 2014-05-30. PMID:23783352. |
sirtuin 1 (sirt1) has emerged as a key metabolic regulator of glucose homeostasis and insulin secretion. |
2014-05-30 |
2023-08-12 |
mouse |
| L Luu, F F Dai, K J Prentice, X Huang, A B Hardy, J B Hansen, Y Liu, J W Joseph, M B Wheele. The loss of Sirt1 in mouse pancreatic beta cells impairs insulin secretion by disrupting glucose sensing. Diabetologia. vol 56. issue 9. 2014-05-30. PMID:23783352. |
the aim of this study was to determine how sirt1 regulates insulin secretion in the pancreatic beta cell. |
2014-05-30 |
2023-08-12 |
mouse |
| S Imai, J Yoshin. The importance of NAMPT/NAD/SIRT1 in the systemic regulation of metabolism and ageing. Diabetes, obesity & metabolism. vol 15 Suppl 3. 2014-04-14. PMID:24003918. |
in the past decade, an accumulating body of evidence has demonstrated that sirt1 and nampt, two essential components in the nad world, play a critical role in regulating insulin sensitivity and insulin secretion throughout the body. |
2014-04-14 |
2023-08-12 |
Not clear |
| Munehiro Kitada, Shinji Kume, Keizo Kanasaki, Ai Takeda-Watanabe, Daisuke Koy. Sirtuins as possible drug targets in type 2 diabetes. Current drug targets. vol 14. issue 6. 2014-03-19. PMID:23445543. |
growing evidence suggests that sirt1 regulates glucose-lipid metabolism through its deacetylase activity for many known substrates and has many roles in the metabolic pathway through its direct or indirect involvement in insulin signaling in insulin-sensitive organs, including adipose tissue, liver and skeletal muscle. |
2014-03-19 |
2023-08-12 |
Not clear |
| Munehiro Kitada, Shinji Kume, Keizo Kanasaki, Ai Takeda-Watanabe, Daisuke Koy. Sirtuins as possible drug targets in type 2 diabetes. Current drug targets. vol 14. issue 6. 2014-03-19. PMID:23445543. |
in addition, sirt1 regulates insulin secretion, and adiponectin production, inflammation, gluconeogenesis, circadian rhythms and oxidative stress, which together contribute to the development of insulin resistance. |
2014-03-19 |
2023-08-12 |
Not clear |
| Munehiro Kitada, Shinji Kume, Keizo Kanasaki, Ai Takeda-Watanabe, Daisuke Koy. Sirtuins as possible drug targets in type 2 diabetes. Current drug targets. vol 14. issue 6. 2014-03-19. PMID:23445543. |
moreover, the overexpression of sirt1 and several sirt1 activators have beneficial effects on glucose homeostasis and insulin sensitivity in diabetic animal models and humans. |
2014-03-19 |
2023-08-12 |
Not clear |
| Munehiro Kitada, Shinji Kume, Keizo Kanasaki, Ai Takeda-Watanabe, Daisuke Koy. Sirtuins as possible drug targets in type 2 diabetes. Current drug targets. vol 14. issue 6. 2014-03-19. PMID:23445543. |
therefore, sirt1 may represent a new therapeutic target for the prevention of diseases related to insulin resistance and t2dm. |
2014-03-19 |
2023-08-12 |
Not clear |
| Yan Y Lam, Courtney M Peterson, Eric Ravussi. Resveratrol vs. calorie restriction: data from rodents to humans. Experimental gerontology. vol 48. issue 10. 2014-03-11. PMID:23624181. |
resveratrol activates sirt1 and the associated improvement in energy utilization and insulin sensitivity closely resembles the benefits of calorie restriction. |
2014-03-11 |
2023-08-12 |
Not clear |
| Pieter de Lange, Federica Cioffi, Elena Silvestri, Maria Moreno, Fernando Goglia, Antonia Lann. (Healthy) ageing: focus on iodothyronines. International journal of molecular sciences. vol 14. issue 7. 2014-02-11. PMID:23880847. |
findings suggesting that t3, t2, and their signaling pathways, such as those involving sirt1 and amp-activated protein kinase (ampk), are associated with improvements in diet-induced obesity and insulin resistance emphasize the potential importance of the thyroid during ageing and in ageing-associated metabolic diseases. |
2014-02-11 |
2023-08-12 |
Not clear |
| A T White, C E McCurdy, A Philp, D L Hamilton, C D Johnson, S Schen. Skeletal muscle-specific overexpression of SIRT1 does not enhance whole-body energy expenditure or insulin sensitivity in young mice. Diabetologia. vol 56. issue 7. 2014-01-10. PMID:23604553. |
skeletal muscle-specific overexpression of sirt1 does not enhance whole-body energy expenditure or insulin sensitivity in young mice. |
2014-01-10 |
2023-08-12 |
mouse |
| A T White, C E McCurdy, A Philp, D L Hamilton, C D Johnson, S Schen. Skeletal muscle-specific overexpression of SIRT1 does not enhance whole-body energy expenditure or insulin sensitivity in young mice. Diabetologia. vol 56. issue 7. 2014-01-10. PMID:23604553. |
accordingly, we sought to determine the effect of skeletal muscle-specific overexpression of sirt1 on skeletal muscle insulin sensitivity and whole-body energy metabolism. |
2014-01-10 |
2023-08-12 |
mouse |
| Alice Toniolo, Erica Alessia Warden, Alberto Nassi, Andrea Cignarella, Chiara Boleg. Regulation of SIRT1 in vascular smooth muscle cells from streptozotocin-diabetic rats. PloS one. vol 8. issue 5. 2014-01-06. PMID:23734259. |
sirt1 downregulation by 17β-estradiol could be observed as well in human peripheral blood mononuclear cells, a cell type in which sirt1 downregulation is associated with insulin resistance and subclinical atherosclerosis. |
2014-01-06 |
2023-08-12 |
human |
| Graziamaria Corbi, Valeria Conti, Giusy Russomanno, Giancarlo Longobardi, Giuseppe Furgi, Amelia Filippelli, Nicola Ferrar. Adrenergic signaling and oxidative stress: a role for sirtuins? Frontiers in physiology. vol 4. 2013-11-22. PMID:24265619. |
sirt1 increases cellular stress resistance, by an increased insulin sensitivity, a decreased circulating free fatty acids and insulin-like growth factor (igf-1), an increased activity of ampk, increased activity of pgc-1a, and increased mitochondrial number. |
2013-11-22 |
2023-08-12 |
Not clear |
| Y Liu, Z Yao, L Zhang, H Zhu, W Deng, C Qi. Insulin induces neurite outgrowth via SIRT1 in SH-SY5Y cells. Neuroscience. vol 238. 2013-10-17. PMID:23357110. |
insulin induces neurite outgrowth via sirt1 in sh-sy5y cells. |
2013-10-17 |
2023-08-12 |
Not clear |
| Y Liu, Z Yao, L Zhang, H Zhu, W Deng, C Qi. Insulin induces neurite outgrowth via SIRT1 in SH-SY5Y cells. Neuroscience. vol 238. 2013-10-17. PMID:23357110. |
however, whether insulin is directly involved in regulating sirt1 expression in neurons or whether it affects synapses remains largely unknown. |
2013-10-17 |
2023-08-12 |
Not clear |
| Y Liu, Z Yao, L Zhang, H Zhu, W Deng, C Qi. Insulin induces neurite outgrowth via SIRT1 in SH-SY5Y cells. Neuroscience. vol 238. 2013-10-17. PMID:23357110. |
here, we show that insulin promotes neurite outgrowth and increases sirt1 expression in sh-sy5y cells. |
2013-10-17 |
2023-08-12 |
Not clear |
| Y Liu, Z Yao, L Zhang, H Zhu, W Deng, C Qi. Insulin induces neurite outgrowth via SIRT1 in SH-SY5Y cells. Neuroscience. vol 238. 2013-10-17. PMID:23357110. |
taken together, these results suggest that the regulation of sirt1 by insulin is important for the neurite outgrowth of neuroblastoma cells. |
2013-10-17 |
2023-08-12 |
Not clear |