| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tae Woo Jung, Kyoung-Tae Lee, Myung Won Lee, Kang-Hyeon K. SIRT1 attenuates palmitate-induced endoplasmic reticulum stress and insulin resistance in HepG2 cells via induction of oxygen-regulated protein 150. Biochemical and biophysical research communications. vol 422. issue 2. 2012-08-27. PMID:22564731. |
our results indicate a novel mechanism by which sirt1 regulates er stress by overexpression of orp150, and suggest that sirt1 ameliorates palmitate-induced insulin resistance in hepg2 cells via regulation of er stress. |
2012-08-27 |
2023-08-12 |
Not clear |
| Yoshiyuki Hori. Diabetes: insulin signal meets SIRT1 at AKT. Nature reviews. Endocrinology. vol 8. issue 3. 2012-08-20. PMID:22105021. |
diabetes: insulin signal meets sirt1 at akt. |
2012-08-20 |
2023-08-12 |
Not clear |
| Ana P Gomes, Filipe V Duarte, Patricia Nunes, Basil P Hubbard, João S Teodoro, Ana T Varela, John G Jones, David A Sinclair, Carlos M Palmeira, Anabela P Rol. Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis. Biochimica et biophysica acta. vol 1822. issue 2. 2012-07-10. PMID:22027215. |
taken together, these data reveal an important role for sirt1 and mitochondrial biogenesis in the preventive effects of bbr on diet-induced insulin resistance. |
2012-07-10 |
2023-08-12 |
Not clear |
| Yoshihiro Morita, Osamu Wada-Hiraike, Tetsu Yano, Akira Shirane, Mana Hirano, Haruko Hiraike, Satoshi Koyama, Hajime Oishi, Osamu Yoshino, Yuichiro Miyamoto, Kenbun Sone, Katsutoshi Oda, Shunsuke Nakagawa, Kazuyoshi Tsutsui, Yuji Taketan. Resveratrol promotes expression of SIRT1 and StAR in rat ovarian granulosa cells: an implicative role of SIRT1 in the ovary. Reproductive biology and endocrinology : RB&E. vol 10. 2012-06-22. PMID:22357324. |
sirtuin 1 (sirt1), originally found as an nad+-dependent histone deacetylase, is a principal modulator of pathways downstream of calorie restriction, and the activation of sirt1 ameliorates glucose homeostasis and insulin sensitivity. |
2012-06-22 |
2023-08-12 |
human |
| Sifan Chen, Jinghua Li, Zili Zhang, Wenxue Li, Yanshuang Sun, Quanxin Zhang, Xiang Feng, Wei Zh. Effects of resveratrol on the amelioration of insulin resistance in KKAy mice. Canadian journal of physiology and pharmacology. vol 90. issue 2. 2012-05-24. PMID:22309033. |
after the treatment, blood glucose, serum insulin, glucose tolerance, and insulin tolerance, as well as other indices such as adiponectin mrna in epididymal adipose tissues, silent information regulator 1 (sirt1), amp-activated protein kinase (ampk), insulin receptor substrate 1 (irs1), and phosphorylated protein kinase b (pkb/akt) proteins in liver and soleus muscles, were investigated. |
2012-05-24 |
2023-08-12 |
mouse |
| Sifan Chen, Jinghua Li, Zili Zhang, Wenxue Li, Yanshuang Sun, Quanxin Zhang, Xiang Feng, Wei Zh. Effects of resveratrol on the amelioration of insulin resistance in KKAy mice. Canadian journal of physiology and pharmacology. vol 90. issue 2. 2012-05-24. PMID:22309033. |
the results indicate that res intervention reduces blood glucose and serum insulin levels, improves insulin and glucose tolerance, increases serum adiponectin and adiponectin mrna levels in epididymal adipose tissues, and more importantly, elevates sirt1, p-ampk, p-irs1, and p-akt levels in liver and soleus muscles. |
2012-05-24 |
2023-08-12 |
mouse |
| Sifan Chen, Jinghua Li, Zili Zhang, Wenxue Li, Yanshuang Sun, Quanxin Zhang, Xiang Feng, Wei Zh. Effects of resveratrol on the amelioration of insulin resistance in KKAy mice. Canadian journal of physiology and pharmacology. vol 90. issue 2. 2012-05-24. PMID:22309033. |
in conclusion, res could improve insulin sensitivity and ameliorate insulin resistance in kka(y) mice, which may be associated with the upregulation of sirt1 protein in liver and soleus muscles and consequent ampk activation, as well as insulin-signaling related proteins. |
2012-05-24 |
2023-08-12 |
mouse |
| Li Qiang, Hua V Lin, Ja Young Kim-Muller, Carrie L Welch, Wei Gu, Domenico Accil. Proatherogenic abnormalities of lipid metabolism in SirT1 transgenic mice are mediated through Creb deacetylation. Cell metabolism. vol 14. issue 6. 2012-04-16. PMID:22078933. |
gain of function of the gene encoding deacetylase sirt1 improves insulin sensitivity and could be expected to protect against lipid abnormalities. |
2012-04-16 |
2023-08-12 |
mouse |
| Yan Dong, Tingwei Guo, Michael Traurig, Clint C Mason, Sayuko Kobes, Jessica Perez, William C Knowler, Clifton Bogardus, Robert L Hanson, Leslie J Baie. SIRT1 is associated with a decrease in acute insulin secretion and a sex specific increase in risk for type 2 diabetes in Pima Indians. Molecular genetics and metabolism. vol 104. issue 4. 2012-03-15. PMID:21871827. |
sirt1 is associated with a decrease in acute insulin secretion and a sex specific increase in risk for type 2 diabetes in pima indians. |
2012-03-15 |
2023-08-12 |
human |
| Yu Yamazaki, Isao Usui, Yukiko Kanatani, Yuji Matsuya, Koichi Tsuneyama, Shiho Fujisaka, Agussalim Bukhari, Hikari Suzuki, Satoko Senda, Shingo Imanishi, Kazuya Hirata, Manabu Ishiki, Ryuji Hayashi, Masaharu Urakaze, Hideo Nemoto, Masashi Kobayashi, Kazuyuki Tob. Treatment with SRT1720, a SIRT1 activator, ameliorates fatty liver with reduced expression of lipogenic enzymes in MSG mice. American journal of physiology. Endocrinology and metabolism. vol 297. issue 5. 2012-03-13. PMID:19724016. |
monosodium glutamate (msg) mice, which exhibited obesity and insulin resistance, were treated with srt1720, a specific sirt1 activator from the age of 6-16 wk. |
2012-03-13 |
2023-08-12 |
mouse |
| Jun Yoshino, Kathryn F Mills, Myeong Jin Yoon, Shin-ichiro Ima. Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell metabolism. vol 14. issue 4. 2012-02-03. PMID:21982712. |
nmn also enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through sirt1 activation. |
2012-02-03 |
2023-08-12 |
mouse |
| Giorgio Ramadori, Teppei Fujikawa, Jason Anderson, Eric D Berglund, Renata Frazao, Shaday Michán, Claudia R Vianna, David A Sinclair, Carol F Elias, Roberto Coppar. SIRT1 deacetylase in SF1 neurons protects against metabolic imbalance. Cell metabolism. vol 14. issue 3. 2012-01-20. PMID:21907137. |
conversely, mice overexpressing sirt1 in sf1 neurons are more resistant to diet-induced obesity and insulin resistance due to increased energy expenditure and enhanced skeletal muscle insulin sensitivity. |
2012-01-20 |
2023-08-12 |
mouse |
| Rui-Hong Wang, Hyun-Seok Kim, Cuiying Xiao, Xiaoling Xu, Oksana Gavrilova, Chu-Xia Den. Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance. The Journal of clinical investigation. vol 121. issue 11. 2012-01-03. PMID:21965330. |
hepatic sirt1 deficiency in mice impairs mtorc2/akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance. |
2012-01-03 |
2023-08-12 |
mouse |
| Rui-Hong Wang, Hyun-Seok Kim, Cuiying Xiao, Xiaoling Xu, Oksana Gavrilova, Chu-Xia Den. Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance. The Journal of clinical investigation. vol 121. issue 11. 2012-01-03. PMID:21965330. |
the protein encoded by the sirtuin 1 (sirt1) gene, which is a mouse homolog of yeast sir2, is implicated in the regulation of glucose metabolism and insulin sensitivity; however, the underlying mechanism remains elusive. |
2012-01-03 |
2023-08-12 |
mouse |
| Rui-Hong Wang, Hyun-Seok Kim, Cuiying Xiao, Xiaoling Xu, Oksana Gavrilova, Chu-Xia Den. Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance. The Journal of clinical investigation. vol 121. issue 11. 2012-01-03. PMID:21965330. |
these data delineate a pathway through which sirt1 maintains insulin sensitivity and suggest that treatment with antioxidants might provide protection against progressive insulin resistance in older human populations. |
2012-01-03 |
2023-08-12 |
mouse |
| Simon Schenk, Carrie E McCurdy, Andrew Philp, Mark Z Chen, Michael J Holliday, Gautum K Bandyopadhyay, Olivia Osborn, Keith Baar, Jerrold M Olefsk. Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction. The Journal of clinical investigation. vol 121. issue 11. 2012-01-03. PMID:21985785. |
sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction. |
2012-01-03 |
2023-08-12 |
mouse |
| Simon Schenk, Carrie E McCurdy, Andrew Philp, Mark Z Chen, Michael J Holliday, Gautum K Bandyopadhyay, Olivia Osborn, Keith Baar, Jerrold M Olefsk. Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction. The Journal of clinical investigation. vol 121. issue 11. 2012-01-03. PMID:21985785. |
recently, the mammalian ortholog of sir2, sirtuin 1 (sirt1), has been identified as a potential transducer of perturbations in cellular energy flux into subsequent metabolic adaptations, including modulation of skeletal muscle insulin action. |
2012-01-03 |
2023-08-12 |
mouse |
| Simon Schenk, Carrie E McCurdy, Andrew Philp, Mark Z Chen, Michael J Holliday, Gautum K Bandyopadhyay, Olivia Osborn, Keith Baar, Jerrold M Olefsk. Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction. The Journal of clinical investigation. vol 121. issue 11. 2012-01-03. PMID:21985785. |
these adaptations in skeletal muscle insulin action were completely abrogated in mice lacking sirt1 deacetylase activity. |
2012-01-03 |
2023-08-12 |
mouse |
| Simon Schenk, Carrie E McCurdy, Andrew Philp, Mark Z Chen, Michael J Holliday, Gautum K Bandyopadhyay, Olivia Osborn, Keith Baar, Jerrold M Olefsk. Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction. The Journal of clinical investigation. vol 121. issue 11. 2012-01-03. PMID:21985785. |
mechanistically, sirt1 was found to be required for the deacetylation and inactivation of the transcription factor stat3 during cr, which resulted in decreased gene and protein expression of the p55α/p50α subunits of pi3k, thereby promoting more efficient pi3k signaling during insulin stimulation. |
2012-01-03 |
2023-08-12 |
mouse |
| Simon Schenk, Carrie E McCurdy, Andrew Philp, Mark Z Chen, Michael J Holliday, Gautum K Bandyopadhyay, Olivia Osborn, Keith Baar, Jerrold M Olefsk. Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction. The Journal of clinical investigation. vol 121. issue 11. 2012-01-03. PMID:21985785. |
thus, these data demonstrate that sirt1 is an integral signaling node in skeletal muscle linking cr to improved insulin action, primarily via modulation of pi3k signaling. |
2012-01-03 |
2023-08-12 |
mouse |