| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hongliang Li, Mingjiang Xu, Jiyeon Lee, Chaoyong He, Zhonglin Xi. Leucine supplementation increases SIRT1 expression and prevents mitochondrial dysfunction and metabolic disorders in high-fat diet-induced obese mice. American journal of physiology. Endocrinology and metabolism. vol 303. issue 10. 2013-04-09. PMID:22967499. |
these data suggest that increased expression of sirt1 after leucine supplementation may lead to reduced acetylation of pgc1α and foxo1, which is associated with attenuation of hfd-induced mitochondrial dysfunction, insulin resistance, and obesity. |
2013-04-09 |
2023-08-12 |
mouse |
| Xiaohua Su, Young Jin Gi, Deepavali Chakravarti, Io Long Chan, Aijun Zhang, Xuefeng Xia, Kenneth Y Tsai, Elsa R Flore. TAp63 is a master transcriptional regulator of lipid and glucose metabolism. Cell metabolism. vol 16. issue 4. 2013-03-07. PMID:23040072. |
further characterization of tap63-/- mice revealed that these mice develop obesity, insulin resistance, and glucose intolerance similar to those seen in mice lacking two key metabolic regulators, silent information regulator t1 (sirt1) and ampk. |
2013-03-07 |
2023-08-12 |
mouse |
| Giulia Bolasco, Raffaele Calogero, Matteo Carrara, Mumna Al Banchaabouchi, Daniel Bilbao, Gianluigi Mazzoccoli, Manlio Vinciguerr. Cardioprotective mIGF-1/SIRT1 signaling induces hypertension, leukocytosis and fear response in mice. Aging. vol 4. issue 6. 2013-02-12. PMID:22691943. |
locally acting insulin growth factor isoform (migf-1) and the nad+-dependent protein deacetylase sirt1 are implicated in life and health span. |
2013-02-12 |
2023-08-12 |
mouse |
| Dae Hyun Kim, Ji Min Kim, Eun Kyeong Lee, Yeon Ja Choi, Chul Hong Kim, Jae Sue Choi, Nam Deuk Kim, Byung Pal Yu, Hae Young Chun. Modulation of FoxO1 phosphorylation/acetylation by baicalin during aging. The Journal of nutritional biochemistry. vol 23. issue 10. 2013-02-07. PMID:22209681. |
our results further reveal that baicalin regulated foxo1 phosphorylation via pi3k/akt by insulin and foxo1 acetylation by the interaction of cbp and sirt1, leading to changes in catalase gene expression during aging. |
2013-02-07 |
2023-08-12 |
rat |
| Swati Srivastava, Upasana Bedi, Partha Ro. Synergistic actions of insulin-sensitive and Sirt1-mediated pathways in the differentiation of mouse embryonic stem cells to osteoblast. Molecular and cellular endocrinology. vol 361. issue 1-2. 2012-11-28. PMID:22542761. |
this study analyzed the combined effects of insulin and sirt1 on the differentiation of osteoblasts. |
2012-11-28 |
2023-08-12 |
mouse |
| Swati Srivastava, Upasana Bedi, Partha Ro. Synergistic actions of insulin-sensitive and Sirt1-mediated pathways in the differentiation of mouse embryonic stem cells to osteoblast. Molecular and cellular endocrinology. vol 361. issue 1-2. 2012-11-28. PMID:22542761. |
interestingly, blocking the effects of both sirt1 and insulin resulted in decreased osteoblastogenesis (60%) and subsequent increased adipocyte differentiation (195%) (p<0.05). |
2012-11-28 |
2023-08-12 |
mouse |
| Akira Shirane, Osamu Wada-Hiraike, Michihiro Tanikawa, Takayuki Seiki, Haruko Hiraike, Yuichiro Miyamoto, Kenbun Sone, Mana Hirano, Hajime Oishi, Katsutoshi Oda, Kei Kawana, Shunsuke Nakagawa, Yutaka Osuga, Tomoyuki Fujii, Tetsu Yano, Shiro Kozuma, Yuji Taketan. Regulation of SIRT1 determines initial step of endometrial receptivity by controlling E-cadherin expression. Biochemical and biophysical research communications. vol 424. issue 3. 2012-11-19. PMID:22780949. |
sirtuin 1 (sirt1), originally found as a class iii histone deacetylase, is a principal modulator of pathways downstream of calorie restriction, and the activation of sirt1 ameliorates glucose homeostasis and insulin sensitivity. |
2012-11-19 |
2023-08-12 |
human |
| Ling Wu, Libin Zhou, Yan Lu, Juan Zhang, Fangfang Jian, Yun Liu, Fengying Li, Wenyi Li, Xiao Wang, Guo L. Activation of SIRT1 protects pancreatic β-cells against palmitate-induced dysfunction. Biochimica et biophysica acta. vol 1822. issue 11. 2012-11-13. PMID:22968147. |
in pancreatic β-cells, sirt1 has been shown to up-regulate insulin secretion in response to glucose stimulation. |
2012-11-13 |
2023-08-12 |
rat |
| Ling Wu, Libin Zhou, Yan Lu, Juan Zhang, Fangfang Jian, Yun Liu, Fengying Li, Wenyi Li, Xiao Wang, Guo L. Activation of SIRT1 protects pancreatic β-cells against palmitate-induced dysfunction. Biochimica et biophysica acta. vol 1822. issue 11. 2012-11-13. PMID:22968147. |
in addition, resveratrol improved glucose-stimulated insulin secretion decreased by palmitate, which was abrogated by ex527, a specific sirt1 inhibitor. |
2012-11-13 |
2023-08-12 |
rat |
| Ling Wu, Libin Zhou, Yan Lu, Juan Zhang, Fangfang Jian, Yun Liu, Fengying Li, Wenyi Li, Xiao Wang, Guo L. Activation of SIRT1 protects pancreatic β-cells against palmitate-induced dysfunction. Biochimica et biophysica acta. vol 1822. issue 11. 2012-11-13. PMID:22968147. |
furthermore, inhibition of sirt1 activity by ex527 or a knockdown of sirt1 suppressed insulin promoter activity, along with decreased insulin, v-maf musculoaponeurotic fibrosarcoma oncogene homolog a (mafa), and nk6 homeodomain 1 (nkx6.1) mrna expressions. |
2012-11-13 |
2023-08-12 |
rat |
| Ling Wu, Libin Zhou, Yan Lu, Juan Zhang, Fangfang Jian, Yun Liu, Fengying Li, Wenyi Li, Xiao Wang, Guo L. Activation of SIRT1 protects pancreatic β-cells against palmitate-induced dysfunction. Biochimica et biophysica acta. vol 1822. issue 11. 2012-11-13. PMID:22968147. |
activation of sirt1 by resveratrol or overexpression of sirt1 antagonized palmitate-inhibited insulin transcriptional activity. |
2012-11-13 |
2023-08-12 |
rat |
| Ling Wu, Libin Zhou, Yan Lu, Juan Zhang, Fangfang Jian, Yun Liu, Fengying Li, Wenyi Li, Xiao Wang, Guo L. Activation of SIRT1 protects pancreatic β-cells against palmitate-induced dysfunction. Biochimica et biophysica acta. vol 1822. issue 11. 2012-11-13. PMID:22968147. |
sirt1 overexpression exerted an additive effect on pancreatic and duodenal homeobox 1 (pdx1)-stimulated insulin promoter activity and abolished forkhead box o1 protein (foxo1)-decreased insulin transcriptional activity. |
2012-11-13 |
2023-08-12 |
rat |
| Riccarda Granata, Davide Gallo, Raul M Luque, Alessandra Baragli, Francesca Scarlatti, Cristina Grande, Iacopo Gesmundo, Jose Córdoba-Chacón, Loredana Bergandi, Fabio Settanni, Gabriele Togliatto, Marco Volante, Stefano Garetto, Marta Annunziata, Belén Chanclón, Eleonora Gargantini, Stefano Rocchietto, Lina Matera, Giacomo Datta, Mario Morino, Maria Felice Brizzi, Huy Ong, Giovanni Camussi, Justo P Castaño, Mauro Papotti, Ezio Ghig. Obestatin regulates adipocyte function and protects against diet-induced insulin resistance and inflammation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 26. issue 8. 2012-10-16. PMID:22601779. |
obestatin also enhanced glucose uptake in either the absence or presence of insulin, promoted glut4 translocation, and increased akt phosphorylation and sirtuin 1 (sirt1) protein expression. |
2012-10-16 |
2023-08-12 |
mouse |
| Cheynita F Metoyer, Kevin Pruit. The role of sirtuin proteins in obesity. Pathophysiology : the official journal of the International Society for Pathophysiology. vol 15. issue 2. 2012-10-02. PMID:18599274. |
sirt1 has been shown to regulate the expression of adipokines, repress the activity of factors required for maturation of fat cells, regulate insulin secretion, modulate plasma glucose levels and insulin sensitivity and alter mitochondrial capacity. |
2012-10-02 |
2023-08-12 |
Not clear |
| B Zhou, C Li, W Qi, Y Zhang, F Zhang, J X Wu, Y N Hu, D M Wu, Y Liu, T T Yan, Q Jing, M F Liu, Q W Zha. Downregulation of miR-181a upregulates sirtuin-1 (SIRT1) and improves hepatic insulin sensitivity. Diabetologia. vol 55. issue 7. 2012-09-25. PMID:22476949. |
downregulation of mir-181a upregulates sirtuin-1 (sirt1) and improves hepatic insulin sensitivity. |
2012-09-25 |
2023-08-12 |
Not clear |
| B Zhou, C Li, W Qi, Y Zhang, F Zhang, J X Wu, Y N Hu, D M Wu, Y Liu, T T Yan, Q Jing, M F Liu, Q W Zha. Downregulation of miR-181a upregulates sirtuin-1 (SIRT1) and improves hepatic insulin sensitivity. Diabetologia. vol 55. issue 7. 2012-09-25. PMID:22476949. |
sirtuin-1 (sirt1) is a potential therapeutic target to combat insulin resistance and type 2 diabetes. |
2012-09-25 |
2023-08-12 |
Not clear |
| B Zhou, C Li, W Qi, Y Zhang, F Zhang, J X Wu, Y N Hu, D M Wu, Y Liu, T T Yan, Q Jing, M F Liu, Q W Zha. Downregulation of miR-181a upregulates sirtuin-1 (SIRT1) and improves hepatic insulin sensitivity. Diabetologia. vol 55. issue 7. 2012-09-25. PMID:22476949. |
this study aims to identify a microrna (mirna) targeting sirt1 to regulate hepatic insulin sensitivity. |
2012-09-25 |
2023-08-12 |
Not clear |
| Tae Woo Jung, Kyoung-Tae Lee, Myung Won Lee, Kang-Hyeon K. SIRT1 attenuates palmitate-induced endoplasmic reticulum stress and insulin resistance in HepG2 cells via induction of oxygen-regulated protein 150. Biochemical and biophysical research communications. vol 422. issue 2. 2012-08-27. PMID:22564731. |
sirt1 attenuates palmitate-induced endoplasmic reticulum stress and insulin resistance in hepg2 cells via induction of oxygen-regulated protein 150. |
2012-08-27 |
2023-08-12 |
Not clear |
| Tae Woo Jung, Kyoung-Tae Lee, Myung Won Lee, Kang-Hyeon K. SIRT1 attenuates palmitate-induced endoplasmic reticulum stress and insulin resistance in HepG2 cells via induction of oxygen-regulated protein 150. Biochemical and biophysical research communications. vol 422. issue 2. 2012-08-27. PMID:22564731. |
although sirt1 has a therapeutic effect on t2dm, the mechanisms by which sirt1 ameliorates insulin resistance (ir) remain unclear. |
2012-08-27 |
2023-08-12 |
Not clear |
| Tae Woo Jung, Kyoung-Tae Lee, Myung Won Lee, Kang-Hyeon K. SIRT1 attenuates palmitate-induced endoplasmic reticulum stress and insulin resistance in HepG2 cells via induction of oxygen-regulated protein 150. Biochemical and biophysical research communications. vol 422. issue 2. 2012-08-27. PMID:22564731. |
treatment with resveratrol, a sirt1 activator significantly inhibited palmitate-induced er stress, leading to the protection against palmitate-induced er stress and insulin resistance. |
2012-08-27 |
2023-08-12 |
Not clear |