| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sara Fröjdö, Christine Durand, Laurent Molin, Andrew L Carey, Assam El-Osta, Bronwyn A Kingwell, Mark A Febbraio, Florence Solari, Hubert Vidal, Luciano Pirol. Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1. Molecular and cellular endocrinology. vol 335. issue 2. 2011-06-20. PMID:21241768. |
phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by sirt1. |
2011-06-20 |
2023-08-12 |
caenorhabditis_elegans |
| Sara Fröjdö, Christine Durand, Laurent Molin, Andrew L Carey, Assam El-Osta, Bronwyn A Kingwell, Mark A Febbraio, Florence Solari, Hubert Vidal, Luciano Pirol. Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1. Molecular and cellular endocrinology. vol 335. issue 2. 2011-06-20. PMID:21241768. |
the latter may underscore a tight link between sirt1 and insulin signaling components. |
2011-06-20 |
2023-08-12 |
caenorhabditis_elegans |
| Sara Fröjdö, Christine Durand, Laurent Molin, Andrew L Carey, Assam El-Osta, Bronwyn A Kingwell, Mark A Febbraio, Florence Solari, Hubert Vidal, Luciano Pirol. Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1. Molecular and cellular endocrinology. vol 335. issue 2. 2011-06-20. PMID:21241768. |
however, whether sirt1 has a direct effect on insulin resistance and whether resveratrol acts directly or indirectly in this context is still a matter of controversy and this question has not been addressed in muscle cells. |
2011-06-20 |
2023-08-12 |
caenorhabditis_elegans |
| Sara Fröjdö, Christine Durand, Laurent Molin, Andrew L Carey, Assam El-Osta, Bronwyn A Kingwell, Mark A Febbraio, Florence Solari, Hubert Vidal, Luciano Pirol. Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1. Molecular and cellular endocrinology. vol 335. issue 2. 2011-06-20. PMID:21241768. |
here, we show that sirt1 protein expression is decreased in muscle biopsies and primary myotubes derived from type 2 diabetic patients, suggesting a contribution of diminished sirt1 in the determination of muscle insulin resistance. |
2011-06-20 |
2023-08-12 |
caenorhabditis_elegans |
| Sara Fröjdö, Christine Durand, Laurent Molin, Andrew L Carey, Assam El-Osta, Bronwyn A Kingwell, Mark A Febbraio, Florence Solari, Hubert Vidal, Luciano Pirol. Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1. Molecular and cellular endocrinology. vol 335. issue 2. 2011-06-20. PMID:21241768. |
to investigate the functional impact of sirt1 on the insulin pathway, the activation of insulin downstream effector pkb was evaluated after sirt1 inactivation by rnai, sirt1 overexpression, or resveratrol treatments. |
2011-06-20 |
2023-08-12 |
caenorhabditis_elegans |
| Sara Fröjdö, Christine Durand, Laurent Molin, Andrew L Carey, Assam El-Osta, Bronwyn A Kingwell, Mark A Febbraio, Florence Solari, Hubert Vidal, Luciano Pirol. Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1. Molecular and cellular endocrinology. vol 335. issue 2. 2011-06-20. PMID:21241768. |
we then investigated whether resveratrol may improve insulin signaling in muscle cells via sirt1, or alternative targets. |
2011-06-20 |
2023-08-12 |
caenorhabditis_elegans |
| Sara Fröjdö, Christine Durand, Laurent Molin, Andrew L Carey, Assam El-Osta, Bronwyn A Kingwell, Mark A Febbraio, Florence Solari, Hubert Vidal, Luciano Pirol. Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1. Molecular and cellular endocrinology. vol 335. issue 2. 2011-06-20. PMID:21241768. |
our data identify sirt1 as a positive modulator of insulin signaling in muscle cells through pi3k, and this mechanism appears to be conserved from c. elegans through humans. |
2011-06-20 |
2023-08-12 |
caenorhabditis_elegans |
| Deepti Ramachandran, Upasana Roy, Swati Garg, Sanchari Ghosh, Sulabha Pathak, Ullas Kolthur-Seethara. Sirt1 and mir-9 expression is regulated during glucose-stimulated insulin secretion in pancreatic β-islets. The FEBS journal. vol 278. issue 7. 2011-06-06. PMID:21288303. |
sirt1 and mir-9 expression is regulated during glucose-stimulated insulin secretion in pancreatic β-islets. |
2011-06-06 |
2023-08-12 |
Not clear |
| Deepti Ramachandran, Upasana Roy, Swati Garg, Sanchari Ghosh, Sulabha Pathak, Ullas Kolthur-Seethara. Sirt1 and mir-9 expression is regulated during glucose-stimulated insulin secretion in pancreatic β-islets. The FEBS journal. vol 278. issue 7. 2011-06-06. PMID:21288303. |
however, little is known about the regulation of sirt1 and mir-9 levels in pancreatic β-cells, particularly during glucose-dependent insulin secretion. |
2011-06-06 |
2023-08-12 |
Not clear |
| Deepti Ramachandran, Upasana Roy, Swati Garg, Sanchari Ghosh, Sulabha Pathak, Ullas Kolthur-Seethara. Sirt1 and mir-9 expression is regulated during glucose-stimulated insulin secretion in pancreatic β-islets. The FEBS journal. vol 278. issue 7. 2011-06-06. PMID:21288303. |
in this article, we report that mir-9 and sirt1 protein levels are actively regulated in vivo in β-islets during glucose-dependent insulin secretion. |
2011-06-06 |
2023-08-12 |
Not clear |
| Deepti Ramachandran, Upasana Roy, Swati Garg, Sanchari Ghosh, Sulabha Pathak, Ullas Kolthur-Seethara. Sirt1 and mir-9 expression is regulated during glucose-stimulated insulin secretion in pancreatic β-islets. The FEBS journal. vol 278. issue 7. 2011-06-06. PMID:21288303. |
this targeting is relevant in pancreatic β-islets, where we show a reduction in sirt1 protein levels when mir-9 expression is high during glucose-dependent insulin secretion. |
2011-06-06 |
2023-08-12 |
Not clear |
| Deepti Ramachandran, Upasana Roy, Swati Garg, Sanchari Ghosh, Sulabha Pathak, Ullas Kolthur-Seethara. Sirt1 and mir-9 expression is regulated during glucose-stimulated insulin secretion in pancreatic β-islets. The FEBS journal. vol 278. issue 7. 2011-06-06. PMID:21288303. |
this functional interplay between insulin secretion, mir-9 and sirt1 expression could be relevant in diabetes. |
2011-06-06 |
2023-08-12 |
Not clear |
| Xiangqun Deng, Jinluo Cheng, Yunping Zhang, Ningxu Li, Lulu Che. Effects of caloric restriction on SIRT1 expression and apoptosis of islet beta cells in type 2 diabetic rats. Acta diabetologica. vol 47 Suppl 1. 2011-04-15. PMID:19876588. |
these data show that caloric restriction notably improves the sensitivity to insulin and significantly increases mrna and protein expression of sirt1 while decreasing the apoptosis ratio of islet beta cells in diabetic rats. |
2011-04-15 |
2023-08-12 |
rat |
| Laurène Vetterli, Thierry Brun, Laurianne Giovannoni, Domenico Bosco, Pierre Maechle. Resveratrol potentiates glucose-stimulated insulin secretion in INS-1E beta-cells and human islets through a SIRT1-dependent mechanism. The Journal of biological chemistry. vol 286. issue 8. 2011-04-14. PMID:21163946. |
overexpression of sirt1 in ins-1e cells potentiated resveratrol effects on insulin secretion. |
2011-04-14 |
2023-08-12 |
human |
| Laurène Vetterli, Thierry Brun, Laurianne Giovannoni, Domenico Bosco, Pierre Maechle. Resveratrol potentiates glucose-stimulated insulin secretion in INS-1E beta-cells and human islets through a SIRT1-dependent mechanism. The Journal of biological chemistry. vol 286. issue 8. 2011-04-14. PMID:21163946. |
these effects were mediated by and fully dependent on active sirt1, defining a new role for sirt1 in the regulation of insulin secretion. |
2011-04-14 |
2023-08-12 |
human |
| Tsutomu Sasaki, Tadahiro Kitamur. Roles of FoxO1 and Sirt1 in the central regulation of food intake. Endocrine journal. vol 57. issue 11. 2011-04-11. PMID:21048357. |
foxo1 is a downstream effecter of insulin signaling and sirt1 is an nad(+)-dependent deacetylase, both of which have been reported to play important roles in the regulation of metabolism in various organs including liver, pancreas, muscle, adipose tissue and hypothalamus. |
2011-04-11 |
2023-08-12 |
Not clear |
| Shiqin Xiong, Gloria Salazar, Nikolay Patrushev, R Wayne Alexande. FoxO1 mediates an autofeedback loop regulating SIRT1 expression. The Journal of biological chemistry. vol 286. issue 7. 2011-04-11. PMID:21149440. |
forkhead transcription factor foxo1 and the nad(+)-dependent histone deacetylase sirt1 are evolutionarily conserved regulators of the development of aging, oxidative stress resistance, insulin resistance, and metabolism in species ranging from invertebrates to mammals. |
2011-04-11 |
2023-08-12 |
rat |
| T Shan, Y Ren, Y Liu, L Zhu, Y Wan. Breed difference and regulation of the porcine Sirtuin 1 by insulin. Journal of animal science. vol 88. issue 12. 2011-03-28. PMID:20802141. |
in addition, the effect of insulin on the gene expression of sirt1 and the major lipase, adipose triglyceride lipase (atgl), and hormone-sensitive lipase (hsl) in fat metabolism was also studied in vitro. |
2011-03-28 |
2023-08-12 |
Not clear |
| T Shan, Y Ren, Y Liu, L Zhu, Y Wan. Breed difference and regulation of the porcine Sirtuin 1 by insulin. Journal of animal science. vol 88. issue 12. 2011-03-28. PMID:20802141. |
in vitro, treatment with a different dose of insulin (10, 50 and 100 nm) decreased (p < 0.01) glycerol release and the mrna abundance of sirt1, atgl, and hsl in porcine adipocytes. |
2011-03-28 |
2023-08-12 |
Not clear |
| T Shan, Y Ren, Y Liu, L Zhu, Y Wan. Breed difference and regulation of the porcine Sirtuin 1 by insulin. Journal of animal science. vol 88. issue 12. 2011-03-28. PMID:20802141. |
likewise, treatment with 50 nm insulin for 24 and 48 h also decreased (p < 0.05) glycerol release and the expression of sirt1, atgl, and hsl in porcine adipocytes. |
2011-03-28 |
2023-08-12 |
Not clear |