| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Takeshi Yoshizaki, Simon Schenk, Takeshi Imamura, Jennie L Babendure, Noriyuki Sonoda, Eun Ju Bae, Da Young Oh, Min Lu, Jill C Milne, Christoph Westphal, Gautam Bandyopadhyay, Jerrold M Olefsk. SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity. American journal of physiology. Endocrinology and metabolism. vol 298. issue 3. 2010-03-30. PMID:19996381. |
treatment of zucker fatty rats with a sirt1 activator leads to greatly improved glucose tolerance, reduced hyperinsulinemia, and enhanced systemic insulin sensitivity during glucose clamp studies. |
2010-03-30 |
2023-08-12 |
mouse |
| Takeshi Yoshizaki, Simon Schenk, Takeshi Imamura, Jennie L Babendure, Noriyuki Sonoda, Eun Ju Bae, Da Young Oh, Min Lu, Jill C Milne, Christoph Westphal, Gautam Bandyopadhyay, Jerrold M Olefsk. SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity. American journal of physiology. Endocrinology and metabolism. vol 298. issue 3. 2010-03-30. PMID:19996381. |
in conclusion, these results define a novel role for sirt1 as an important regulator of macrophage inflammatory responses in the context of insulin resistance and raise the possibility that targeting of sirt1 might be a useful strategy for treating the inflammatory component of metabolic diseases. |
2010-03-30 |
2023-08-12 |
mouse |
| Morgan D Fullerton, Gregory R Steinber. SIRT1 takes a backseat to AMPK in the regulation of insulin sensitivity by resveratrol. Diabetes. vol 59. issue 3. 2010-03-30. PMID:20190133. |
sirt1 takes a backseat to ampk in the regulation of insulin sensitivity by resveratrol. |
2010-03-30 |
2023-08-12 |
Not clear |
| Françoise Chanu. The sirt1 gene promotes insulin secretion in accord with diet. PLoS biology. vol 4. issue 2. 2010-01-20. PMID:20076530. |
the sirt1 gene promotes insulin secretion in accord with diet. |
2010-01-20 |
2023-08-12 |
Not clear |
| Giorgio Ramadori, Laurent Gautron, Teppei Fujikawa, Claudia R Vianna, Joel K Elmquist, Roberto Coppar. Central administration of resveratrol improves diet-induced diabetes. Endocrinology. vol 150. issue 12. 2010-01-19. PMID:19819963. |
because sirt1 is expressed in central nervous system (cns) neurons known to control glucose and insulin homeostasis, we hypothesized that resveratrol antidiabetic effects are mediated by the brain. |
2010-01-19 |
2023-08-12 |
mouse |
| Federico Cacciapuot. Opposite effects of metabolic syndrome and calorie restriction on thrombotic disease: heads and tails of the same coin--resveratrol's role. Metabolic syndrome and related disorders. vol 7. issue 5. 2009-12-17. PMID:18928399. |
the antithrombotic effect is due to the activation of sirt1 acting through an increase of insulin sensitivity, which reduces endothelial dysfunction. |
2009-12-17 |
2023-08-12 |
Not clear |
| Fengxia Liang, Shinji Kume, Daisuke Koy. SIRT1 and insulin resistance. Nature reviews. Endocrinology. vol 5. issue 7. 2009-09-01. PMID:19455179. |
sirt1 and insulin resistance. |
2009-09-01 |
2023-08-12 |
mouse |
| Fengxia Liang, Shinji Kume, Daisuke Koy. SIRT1 and insulin resistance. Nature reviews. Endocrinology. vol 5. issue 7. 2009-09-01. PMID:19455179. |
growing evidence suggests that sirt1 regulates glucose or lipid metabolism through its deacetylase activity for over two dozen known substrates, and has a positive role in the metabolic pathway through its direct or indirect involvement in insulin signaling. |
2009-09-01 |
2023-08-12 |
mouse |
| Fengxia Liang, Shinji Kume, Daisuke Koy. SIRT1 and insulin resistance. Nature reviews. Endocrinology. vol 5. issue 7. 2009-09-01. PMID:19455179. |
sirt1 stimulates a glucose-dependent insulin secretion from pancreatic beta cells, and directly stimulates insulin signaling pathways in insulin-sensitive organs. |
2009-09-01 |
2023-08-12 |
mouse |
| Fengxia Liang, Shinji Kume, Daisuke Koy. SIRT1 and insulin resistance. Nature reviews. Endocrinology. vol 5. issue 7. 2009-09-01. PMID:19455179. |
furthermore, sirt1 regulates adiponectin secretion, inflammatory responses, gluconeogenesis, and levels of reactive oxygen species, which together contribute to the development of insulin resistance. |
2009-09-01 |
2023-08-12 |
mouse |
| Fengxia Liang, Shinji Kume, Daisuke Koy. SIRT1 and insulin resistance. Nature reviews. Endocrinology. vol 5. issue 7. 2009-09-01. PMID:19455179. |
moreover, overexpression of sirt1 and several sirt1 activators has beneficial effects on glucose homeostasis and insulin sensitivity in obese mice models. |
2009-09-01 |
2023-08-12 |
mouse |
| Fengxia Liang, Shinji Kume, Daisuke Koy. SIRT1 and insulin resistance. Nature reviews. Endocrinology. vol 5. issue 7. 2009-09-01. PMID:19455179. |
these findings suggest that sirt1 might be a new therapeutic target for the prevention of disease related to insulin resistance, such as metabolic syndrome and diabetes mellitus, although direct evidence from clinical studies in humans is needed to prove this possibility. |
2009-09-01 |
2023-08-12 |
mouse |
| Fengxia Liang, Shinji Kume, Daisuke Koy. SIRT1 and insulin resistance. Nature reviews. Endocrinology. vol 5. issue 7. 2009-09-01. PMID:19455179. |
in this review, we discuss the potential role and therapeutic promise of sirt1 in insulin resistance on the basis of the latest experimental studies. |
2009-09-01 |
2023-08-12 |
mouse |
| Jean E Bemis, Chi B Vu, Roger Xie, Joseph J Nunes, Pui Yee Ng, Jeremy S Disch, Jill C Milne, David P Carney, Amy V Lynch, Lei Jin, Jesse J Smith, Siva Lavu, Andre Iffland, Michael R Jirousek, Robert B Pern. Discovery of oxazolo[4,5-b]pyridines and related heterocyclic analogs as novel SIRT1 activators. Bioorganic & medicinal chemistry letters. vol 19. issue 8. 2009-08-26. PMID:19303289. |
sirt1 is an nad(+)-dependent protein deacetylase that appears to produce beneficial effects on metabolic parameters such as glucose and insulin homeostasis. |
2009-08-26 |
2023-08-12 |
mouse |
| Jean E Bemis, Chi B Vu, Roger Xie, Joseph J Nunes, Pui Yee Ng, Jeremy S Disch, Jill C Milne, David P Carney, Amy V Lynch, Lei Jin, Jesse J Smith, Siva Lavu, Andre Iffland, Michael R Jirousek, Robert B Pern. Discovery of oxazolo[4,5-b]pyridines and related heterocyclic analogs as novel SIRT1 activators. Bioorganic & medicinal chemistry letters. vol 19. issue 8. 2009-08-26. PMID:19303289. |
activation of sirt1 by resveratrol (1) has been shown to modulate insulin resistance, increase mitochondrial content and prolong survival in lower organisms and in mice on a high fat diet. |
2009-08-26 |
2023-08-12 |
mouse |
| Li Zeng, Rui Chen, Fengxia Liang, Hiroshi Tsuchiya, Hiroshi Murai, Takeshi Nakahashi, Kunimitsu Iwai, Takashi Takahashi, Tsugiyasu Kanda, Shigeto Morimot. Silent information regulator, Sirtuin 1, and age-related diseases. Geriatrics & gerontology international. vol 9. issue 1. 2009-07-30. PMID:19260974. |
it is widely reported that sirt1 can promote not only carcinogenesis but also metastasis and insulin resistance, andhave beneficial effects in metabolic diseases, mediate high-density lipoprotein synthesis and regulate endothelial nitric oxide to protect against cardiovascular disease, have a cardioprotective role in heart failure, protect against neurodegenerative pathological changes, promote osteoblast differentiation, and also play a pivotal role as an anti-inflammatory mediator in copd. |
2009-07-30 |
2023-08-12 |
Not clear |
| Francisco J Alcaín, José M Villalb. Sirtuin activators. Expert opinion on therapeutic patents. vol 19. issue 4. 2009-07-27. PMID:19441923. |
sirt1 down-regulates p53 activity, increasing lifespan, cell survival, and neuroprotection; it also deacetylates peroxisome proliferator-activated receptor-gamma and its coactivator 1alpha, promoting fat mobilization, increasing mitochondrial size and number, and positively regulating insulin secretion. |
2009-07-27 |
2023-08-12 |
Not clear |
| Derek M Erion, Shin Yonemitsu, Yongzhan Nie, Yoshio Nagai, Matthew P Gillum, Jennifer J Hsiao, Takanori Iwasaki, Romana Stark, Dirk Weismann, Xing Xian Yu, Susan F Murray, Sanjay Bhanot, Brett P Monia, Tamas L Horvath, Qian Gao, Varman T Samuel, Gerald I Shulma. SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 27. 2009-07-27. PMID:19549853. |
sirt1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats. |
2009-07-27 |
2023-08-12 |
rat |
| Derek M Erion, Shin Yonemitsu, Yongzhan Nie, Yoshio Nagai, Matthew P Gillum, Jennifer J Hsiao, Takanori Iwasaki, Romana Stark, Dirk Weismann, Xing Xian Yu, Susan F Murray, Sanjay Bhanot, Brett P Monia, Tamas L Horvath, Qian Gao, Varman T Samuel, Gerald I Shulma. SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 27. 2009-07-27. PMID:19549853. |
whole body insulin sensitivity was also increased in the sirt1 aso treated rats as reflected by a 25% increase in the glucose infusion rate required to maintain euglycemia during the hyperinsulinemic-euglycemic clamp and could entirely be attributed to increased suppression of hepatic glucose production by insulin. |
2009-07-27 |
2023-08-12 |
rat |
| M Wojcik, K Mac-Marcjanek, L A Woznia. Physiological and pathophysiological functions of SIRT1. Mini reviews in medicinal chemistry. vol 9. issue 3. 2009-05-01. PMID:19275731. |
a variety of sirt1 substrates hints that this protein is involved in the regulation of diverse biological processes, including cell survival, apoptosis, gluconeogenesis, adipogenesis, lipolysis, stress resistance, muscle differentiation, and insulin secretion. |
2009-05-01 |
2023-08-12 |
human |