| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Wojcik, K Mac-Marcjanek, L A Woznia. Physiological and pathophysiological functions of SIRT1. Mini reviews in medicinal chemistry. vol 9. issue 3. 2009-05-01. PMID:19275731. |
this review emphasizes catalytic properties of sirt1 and its role in apoptosis, insulin pathway, and neuron survival. |
2009-05-01 |
2023-08-12 |
human |
| Shin-Ichiro Imai, Wieland Kies. Therapeutic potential of SIRT1 and NAMPT-mediated NAD biosynthesis in type 2 diabetes. Frontiers in bioscience (Landmark edition). vol 14. 2009-04-07. PMID:19273250. |
for the past several years, studies on the mammalian nad-dependent protein deacetylase sirt1 and systemic nad biosynthesis mediated by nicotinamide phosphoribosyltransferase (nampt) have demonstrated that these two regulatory components together play a critical role in the regulation of glucose homeostasis, particularly in the regulation of glucose-stimulated insulin secretion in pancreatic beta cells. |
2009-04-07 |
2023-08-12 |
Not clear |
| Takeshi Yoshizaki, Jill C Milne, Takeshi Imamura, Simon Schenk, Noriyuki Sonoda, Jennie L Babendure, Juu-Chin Lu, Jesse J Smith, Michael R Jirousek, Jerrold M Olefsk. SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes. Molecular and cellular biology. vol 29. issue 5. 2009-03-10. PMID:19103747. |
sirt1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes. |
2009-03-10 |
2023-08-12 |
Not clear |
| Takeshi Yoshizaki, Jill C Milne, Takeshi Imamura, Simon Schenk, Noriyuki Sonoda, Jennie L Babendure, Juu-Chin Lu, Jesse J Smith, Michael R Jirousek, Jerrold M Olefsk. SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes. Molecular and cellular biology. vol 29. issue 5. 2009-03-10. PMID:19103747. |
however, the potential effects of sirt1 on insulin signaling pathways are poorly understood. |
2009-03-10 |
2023-08-12 |
Not clear |
| Takeshi Yoshizaki, Jill C Milne, Takeshi Imamura, Simon Schenk, Noriyuki Sonoda, Jennie L Babendure, Juu-Chin Lu, Jesse J Smith, Michael R Jirousek, Jerrold M Olefsk. SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes. Molecular and cellular biology. vol 29. issue 5. 2009-03-10. PMID:19103747. |
in contrast, treatment of cells with specific small molecule sirt1 activators led to an increase in glucose uptake and insulin signaling as well as a decrease in serine phosphorylation of irs-1. |
2009-03-10 |
2023-08-12 |
Not clear |
| Takeshi Yoshizaki, Jill C Milne, Takeshi Imamura, Simon Schenk, Noriyuki Sonoda, Jennie L Babendure, Juu-Chin Lu, Jesse J Smith, Michael R Jirousek, Jerrold M Olefsk. SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes. Molecular and cellular biology. vol 29. issue 5. 2009-03-10. PMID:19103747. |
finally, we show that treatment of 3t3-l1 adipocytes with a sirt1 activator attenuated tumor necrosis factor alpha-induced insulin resistance. |
2009-03-10 |
2023-08-12 |
Not clear |
| Takeshi Yoshizaki, Jill C Milne, Takeshi Imamura, Simon Schenk, Noriyuki Sonoda, Jennie L Babendure, Juu-Chin Lu, Jesse J Smith, Michael R Jirousek, Jerrold M Olefsk. SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes. Molecular and cellular biology. vol 29. issue 5. 2009-03-10. PMID:19103747. |
taken together, these data indicate that sirt1 is a positive regulator of insulin signaling at least partially through the anti-inflammatory actions in 3t3-l1 adipocytes. |
2009-03-10 |
2023-08-12 |
Not clear |
| Alexander S Banks, Ning Kon, Colette Knight, Michihiro Matsumoto, Roger Gutiérrez-Juárez, Luciano Rossetti, Wei Gu, Domenico Accil. SirT1 gain of function increases energy efficiency and prevents diabetes in mice. Cell metabolism. vol 8. issue 4. 2008-12-02. PMID:18840364. |
however, in various models of insulin resistance and diabetes, sirt1 transgenics display improved glucose tolerance due to decreased hepatic glucose production and increased adiponectin levels, without changes in body weight or composition. |
2008-12-02 |
2023-08-12 |
mouse |
| Alexander S Banks, Ning Kon, Colette Knight, Michihiro Matsumoto, Roger Gutiérrez-Juárez, Luciano Rossetti, Wei Gu, Domenico Accil. SirT1 gain of function increases energy efficiency and prevents diabetes in mice. Cell metabolism. vol 8. issue 4. 2008-12-02. PMID:18840364. |
we conclude that sirt1 gain of function primes the organism for metabolic adaptation to insulin resistance, increasing hepatic insulin sensitivity and decreasing whole-body energy requirements. |
2008-12-02 |
2023-08-12 |
mouse |
| Wei-jian Jian. Sirtuins: novel targets for metabolic disease in drug development. Biochemical and biophysical research communications. vol 373. issue 3. 2008-08-06. PMID:18577374. |
sirt1, an nad(+)-dependent deacetylase, is a principal modulator of pathways downstream of calorie restriction that produces beneficial effects on glucose homeostasis and insulin sensitivity. |
2008-08-06 |
2023-08-12 |
mouse |
| Wei-jian Jian. Sirtuins: novel targets for metabolic disease in drug development. Biochemical and biophysical research communications. vol 373. issue 3. 2008-08-06. PMID:18577374. |
resveratrol, a polyphenolic sirt1 activator, mimics the effects of calorie restriction in lower organisms and in mice fed a high-fat diet ameliorates insulin resistance. |
2008-08-06 |
2023-08-12 |
mouse |
| Peter J Elliott, Michael Jirouse. Sirtuins: novel targets for metabolic disease. Current opinion in investigational drugs (London, England : 2000). vol 9. issue 4. 2008-07-10. PMID:18393104. |
as such, enhanced sirt1 activity decreases glucose levels, improves insulin sensitivity, increases mitochondrial number and function, decreases adiposity, improves exercise tolerance and potentially lowers body weight. |
2008-07-10 |
2023-08-12 |
Not clear |
| Taku Nedachi, Akito Kadotani, Miyako Ariga, Hideki Katagiri, Makoto Kanzak. Ambient glucose levels qualify the potency of insulin myogenic actions by regulating SIRT1 and FoxO3a in C2C12 myocytes. American journal of physiology. Endocrinology and metabolism. vol 294. issue 4. 2008-05-22. PMID:18230695. |
ambient glucose levels qualify the potency of insulin myogenic actions by regulating sirt1 and foxo3a in c2c12 myocytes. |
2008-05-22 |
2023-08-12 |
Not clear |
| Taku Nedachi, Akito Kadotani, Miyako Ariga, Hideki Katagiri, Makoto Kanzak. Ambient glucose levels qualify the potency of insulin myogenic actions by regulating SIRT1 and FoxO3a in C2C12 myocytes. American journal of physiology. Endocrinology and metabolism. vol 294. issue 4. 2008-05-22. PMID:18230695. |
intriguingly, insulin appears to exert opposite actions, depending on glucose availability, with regard to the regulation of sirt1 and foxo3a abundance, which apparently contributes to modulating the potency of insulin's myogenic action. |
2008-05-22 |
2023-08-12 |
Not clear |
| Taku Nedachi, Akito Kadotani, Miyako Ariga, Hideki Katagiri, Makoto Kanzak. Ambient glucose levels qualify the potency of insulin myogenic actions by regulating SIRT1 and FoxO3a in C2C12 myocytes. American journal of physiology. Endocrinology and metabolism. vol 294. issue 4. 2008-05-22. PMID:18230695. |
namely, insulin exerts a potent myogenic effect in the presence of sufficient glucose, whereas insulin is unable to exert its myogenic action under lg conditions, since insulin evokes massive upregulation of both sirt1 and foxo3a in the absence of sufficient ambient glucose. |
2008-05-22 |
2023-08-12 |
Not clear |
| Taku Nedachi, Akito Kadotani, Miyako Ariga, Hideki Katagiri, Makoto Kanzak. Ambient glucose levels qualify the potency of insulin myogenic actions by regulating SIRT1 and FoxO3a in C2C12 myocytes. American journal of physiology. Endocrinology and metabolism. vol 294. issue 4. 2008-05-22. PMID:18230695. |
in addition, the hampered differentiation state under lg is significantly restored by sirtinol, a sirt1 inhibitor, whereas insulin abolished this sirtinol-dependent restoration, indicating that insulin can function as a negative as well as a positive myogenic factor depending on glucose availability. |
2008-05-22 |
2023-08-12 |
Not clear |
| Taku Nedachi, Akito Kadotani, Miyako Ariga, Hideki Katagiri, Makoto Kanzak. Ambient glucose levels qualify the potency of insulin myogenic actions by regulating SIRT1 and FoxO3a in C2C12 myocytes. American journal of physiology. Endocrinology and metabolism. vol 294. issue 4. 2008-05-22. PMID:18230695. |
taken together, our data reveal the importance of ambient glucose levels in the regulation of myogenesis and also in the determination of insulin's myogenic potency, which is achieved, at least in part, through regulation of the cellular contents and localization of sirt1 and foxo3a in differentiating c(2)c(12) myocytes. |
2008-05-22 |
2023-08-12 |
Not clear |
| Nicole Engel, Ulrich Mahlknech. Aging and anti-aging: unexpected side effects of everyday medication through sirtuin1 modulation. International journal of molecular medicine. vol 21. issue 2. 2008-03-07. PMID:18204789. |
in this context, we identified l-thyroxin, insulin and sodium nitroprusside to be potent activators of human sirt1 expression. |
2008-03-07 |
2023-08-12 |
human |
| Nicole Engel, Ulrich Mahlknech. Aging and anti-aging: unexpected side effects of everyday medication through sirtuin1 modulation. International journal of molecular medicine. vol 21. issue 2. 2008-03-07. PMID:18204789. |
in addition, treatment of pbmcs with sodium nitroprusside was associated with a significant cellular lifespan extension, while l-thyroxin and insulin were unable to prolong lifespan, suggesting that isolated upregulation of sirt1 is in fact insufficient to promote longevity. |
2008-03-07 |
2023-08-12 |
human |
| Kathryn Moynihan Ramsey, Kathryn F Mills, Akiko Satoh, Shin-Ichiro Ima. Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice. Aging cell. vol 7. issue 1. 2008-02-25. PMID:18005249. |
in mammals, the sir2 ortholog sirt1 promotes fat mobilization, fatty acid oxidation, glucose production, and insulin secretion in response to nutrient availability. |
2008-02-25 |
2023-08-12 |
mouse |