| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ishitha Reddy, Yamini Yadav, Chinmoy Sankar De. Cellular and Molecular Regulation of Exercise-A Neuronal Perspective. Cellular and molecular neurobiology. 2022-08-20. PMID:35986789. |
exerkines such as fndc5/irisin, cathepsin b, adiponectin, and il-6 circulate through the bloodstream, cross the blood-brain barrier, and modulate the expression of important signaling molecules such as ampk, sirt1, pgc1α, bdnf, igf-1, and vegf which further contribute to improved energy metabolism, glucose homeostasis, insulin sensitivity, neurogenesis, synaptic plasticity, and overall well-being of the body and brain. |
2022-08-20 |
2023-08-14 |
Not clear |
| Pei-Pei Su, Dong-Wei Liu, Si-Jie Zhou, Hang Chen, Xian-Ming Wu, Zhang-Suo Li. Down-regulation of Risa improves podocyte injury by enhancing autophagy in diabetic nephropathy. Military Medical Research. vol 9. issue 1. 2022-05-25. PMID:35614465. |
lncrna ak044604 (regulator of insulin sensitivity and autophagy, risa) and autophagy-related factors sirt1 and gsk3β play important roles in diabetic nephropathy (dn). |
2022-05-25 |
2023-08-13 |
Not clear |
| Emily Leong, Reena Dosanjh, Johnson Huynh, Yujin Hur, Christiane Cabreros, Yue Tong Lee, Ningkun Wan. Dissecting the Mechanism of Allosteric Regulation of SIRT1. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35555597. |
the enzyme sirt1 is a lysine deacetylase that plays a part in various pathways in the body, including insulin secretion and neurodegeneration, rendering it as a potential drug target for common diseases such as type ii diabetes and alzheimer's disease. |
2022-05-13 |
2023-08-13 |
Not clear |
| Rebecca A S Palu, Katie G Owings, John G Garces, Audrey Nico. A natural genetic variation screen identifies insulin signaling, neuronal communication, and innate immunity as modifiers of hyperglycemia in the absence of Sirt1. G3 (Bethesda, Md.). 2022-04-18. PMID:35435227. |
a natural genetic variation screen identifies insulin signaling, neuronal communication, and innate immunity as modifiers of hyperglycemia in the absence of sirt1. |
2022-04-18 |
2023-08-13 |
drosophila_melanogaster |
| Samanta Taurone, Chiara De Ponte, Dante Rotili, Elena De Santis, Antonello Mai, Francesco Fiorentino, Susanna Scarpa, Marco Artico, Alessandra Micer. Biochemical Functions and Clinical Characterizations of the Sirtuins in Diabetes-Induced Retinal Pathologies. International journal of molecular sciences. vol 23. issue 7. 2022-04-12. PMID:35409409. |
sirt1, 3, 5, and 6 are key enzymes in dr since they modulate glucose metabolism, insulin sensitivity, and inflammation. |
2022-04-12 |
2023-08-13 |
Not clear |
| Kunpeng Liu, Xiaogao Jin, Xiaoying Zhang, Hongkai Lian, Jianping Y. The mechanisms of nucleotide actions in insulin resistance. Journal of genetics and genomics = Yi chuan xue bao. 2022-02-08. PMID:35134563. |
atp and nadh, derivatives of adenosine, inhibit insulin signaling inside cells by downregulation of activities of ampk and sirt1, respectively. |
2022-02-08 |
2023-08-13 |
Not clear |
| Chao Geng, Yuan Xue, Jia Hui Yang, Ming Yue Gao, Wei Zhao, Chun Mei Li, Xiang Hong Xie, Wei Hong Zhang, Hua Bing Zhang, Fu De Fang, Hong Yao, Xiao Jun Li. SIRT1 Mediates Sestrin1-Induced Improvement in Hepatic Insulin Resistance. Biomedical and environmental sciences : BES. vol 35. issue 1. 2022-01-26. PMID:35078566. |
sirt1 mediates sestrin1-induced improvement in hepatic insulin resistance. |
2022-01-26 |
2023-08-13 |
Not clear |
| Mehdi Mahmudpour, Katayoun Vahdat, Mohsen Keshavarz, Iraj Nabipou. The COVID-19-diabetes mellitus molecular tetrahedron. Molecular biology reports. 2022-01-24. PMID:35067816. |
the entrance of sars-cov-2 using ace2 receptor triggers an array of multiple molecular signaling beyond that of the angiotensin ii/ace2-ang-(1-7) axis, such as down-regulation of pgc-1 α/irisin, increased srebp-1c activity, upregulation of cd36 and sirt1 inhibition leading to insulin resistance. |
2022-01-24 |
2023-08-13 |
Not clear |
| Mehdi Mahmudpour, Katayoun Vahdat, Mohsen Keshavarz, Iraj Nabipou. The COVID-19-diabetes mellitus molecular tetrahedron. Molecular biology reports. 2022-01-24. PMID:35067816. |
in another arm of the molecular cascade, the sars-cov-2 hijacking and replication induces a series of molecular events in the host cell metabolic machinery, including upregulation of srebp-2, decrement in sirt1 expression, dysregulation in ppar-ɣ, and lpi resulting in insulin resistance. |
2022-01-24 |
2023-08-13 |
Not clear |
| Jing Li, Yingjiang Zhang, Xin Zeng, Yahong Cheng, Liu Tang, Ding Hong, Xiaolong Yan. Lycopene ameliorates insulin resistance and increases muscle capillary density in aging via activation of SIRT1. The Journal of nutritional biochemistry. vol 99. 2021-11-26. PMID:34530111. |
lycopene ameliorates insulin resistance and increases muscle capillary density in aging via activation of sirt1. |
2021-11-26 |
2023-08-13 |
human |
| Jing Li, Yingjiang Zhang, Xin Zeng, Yahong Cheng, Liu Tang, Ding Hong, Xiaolong Yan. Lycopene ameliorates insulin resistance and increases muscle capillary density in aging via activation of SIRT1. The Journal of nutritional biochemistry. vol 99. 2021-11-26. PMID:34530111. |
finally, in the insulin resistance cell model, we knocked down the sirt1 and administrated with ly, and found that it couldn't restore insulin transdution. |
2021-11-26 |
2023-08-13 |
human |
| Jing Li, Yingjiang Zhang, Xin Zeng, Yahong Cheng, Liu Tang, Ding Hong, Xiaolong Yan. Lycopene ameliorates insulin resistance and increases muscle capillary density in aging via activation of SIRT1. The Journal of nutritional biochemistry. vol 99. 2021-11-26. PMID:34530111. |
in conclusion, all the data in this study demonstrate that ly could reactivate sirt1 and improve insulin resistance, which was a reversible cause of vascular aging. |
2021-11-26 |
2023-08-13 |
human |
| Faiza Alam, Hareem Syed, Sofia Amjad, Mukhtiar Baig, Taseer Ahmed Khan, Rehana Rehma. Interplay between oxidative stress, SIRT1, reproductive and metabolic functions. Current research in physiology. vol 4. 2021-11-10. PMID:34746831. |
sirt1 improves insulin resistance by reducing os and regulating mitochondrial biogenesis and function. |
2021-11-10 |
2023-08-13 |
Not clear |
| Do Hyeon Pyun, Tae Jin Kim, Seung Yeon Park, Hyun Jung Lee, A M Abd El-Aty, Ji Hoon Jeong, Tae Woo Jun. Patchouli alcohol ameliorates skeletal muscle insulin resistance and NAFLD via AMPK/SIRT1-mediated suppression of inflammation. Molecular and cellular endocrinology. vol 538. 2021-10-27. PMID:34601002. |
sirna-mediated suppression of ampk or sirt1 mitigated the effects of pa on palmitate-induced inflammation and insulin resistance in c2c12 myocytes and lipid accumulation in hepg2 cells. |
2021-10-27 |
2023-08-13 |
mouse |
| Do Hyeon Pyun, Tae Jin Kim, Seung Yeon Park, Hyun Jung Lee, A M Abd El-Aty, Ji Hoon Jeong, Tae Woo Jun. Patchouli alcohol ameliorates skeletal muscle insulin resistance and NAFLD via AMPK/SIRT1-mediated suppression of inflammation. Molecular and cellular endocrinology. vol 538. 2021-10-27. PMID:34601002. |
animal experiments demonstrated that pa administration increased ampk phosphorylation and sirt1 expression, and ameliorated inflammation, thereby attenuating skeletal muscle insulin resistance and hepatic steatosis in high-fat diet-fed mice. |
2021-10-27 |
2023-08-13 |
mouse |
| X Charlie Don. Sirtuin biology and relevance to diabetes treatment. Diabetes management (London, England). vol 2. issue 3. 2021-10-21. PMID:23024708. |
sirt1 regulates glucose and lipid homeostasis in the liver, modulates insulin secretion in pancreatic islets, controls insulin sensitivity and glucose uptake in skeletal muscle, increases adiponectin expression in white adipose tissue and controls food intake and energy expenditure in the brain. |
2021-10-21 |
2023-08-12 |
mouse |
| X Charlie Don. Sirtuin biology and relevance to diabetes treatment. Diabetes management (London, England). vol 2. issue 3. 2021-10-21. PMID:23024708. |
although it is controversial, the sirt1 activator srt1720 has been reported to be effective in improving glucose metabolism and insulin sensitivity in animal models. |
2021-10-21 |
2023-08-12 |
mouse |
| Dorota Rogacka, Irena Audzeyenka, Patrycja Rachubik, Maria Szrejder, Marlena Typiak, Stefan Angielski, Agnieszka Piwkowsk. Involvement of nitric oxide synthase/nitric oxide pathway in the regulation of SIRT1-AMPK crosstalk in podocytes: Impact on glucose uptake. Archives of biochemistry and biophysics. vol 709. 2021-09-30. PMID:34252390. |
the protein deacetylase sirtuin 1 (sirt1) and adenosine monophosphate-dependent protein kinase (ampk) play important roles in the development of insulin resistance. |
2021-09-30 |
2023-08-13 |
Not clear |
| Dorota Rogacka, Irena Audzeyenka, Patrycja Rachubik, Maria Szrejder, Marlena Typiak, Stefan Angielski, Agnieszka Piwkowsk. Involvement of nitric oxide synthase/nitric oxide pathway in the regulation of SIRT1-AMPK crosstalk in podocytes: Impact on glucose uptake. Archives of biochemistry and biophysics. vol 709. 2021-09-30. PMID:34252390. |
sirt1 protein levels and activity and ampk phosphorylation decrease under hyperglycemic conditions, with concomitant inhibition of the effect of insulin on glucose uptake into these cells. |
2021-09-30 |
2023-08-13 |
Not clear |
| Dorota Rogacka, Irena Audzeyenka, Patrycja Rachubik, Maria Szrejder, Marlena Typiak, Stefan Angielski, Agnieszka Piwkowsk. Involvement of nitric oxide synthase/nitric oxide pathway in the regulation of SIRT1-AMPK crosstalk in podocytes: Impact on glucose uptake. Archives of biochemistry and biophysics. vol 709. 2021-09-30. PMID:34252390. |
inhibition of the nos/no pathway reduced sirt1 protein levels and activity, leading to a decrease in ampk phosphorylation and blockade of the effect of insulin on glucose uptake. |
2021-09-30 |
2023-08-13 |
Not clear |