| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yan-Juan Song, Qi Huang, Li Chen, Ya-Yuan Wang, Yu-Dian Zhou, Feng-Xia Lian. Electroacupuncture improving obesity-induced insulin resistance via regulating intestinal SIRT1/TLR4 signaling pathway. Zhen ci yan jiu = Acupuncture research. vol 48. issue 11. 2023-11-24. PMID:37984910. |
to observe the effect of electroacupuncture (ea) in obese rats with insulin resistance (ir) through regulating intestinal silent information regulator 1 (sirt1)/toll-like receptor 4 (tlr4) signaling pathway, so as to explore the underlying mechanism of ea in improving obesity-induced ir. |
2023-11-24 |
2023-11-28 |
rat |
| Qiuxia Li, Quanjiang Zhang, Young-Rae Kim, Ravinder Reddy Gaddam, Julia S Jacobs, Markus M Bachschmid, Tsneem Younis, Zhiyong Zhu, Leonid Zingman, Barry London, Adam J Rauckhorst, Eric B Taylor, Andrew W Norris, Ajit Vikram, Kaikobad Iran. Deficiency of endothelial sirtuin1 in mice stimulates skeletal muscle insulin sensitivity by modifying the secretome. Nature communications. vol 14. issue 1. 2023-09-11. PMID:37696839. |
downregulation of endothelial sirtuin1 (sirt1) in insulin resistant states contributes to vascular dysfunction. |
2023-09-11 |
2023-10-07 |
mouse |
| Qiuxia Li, Quanjiang Zhang, Young-Rae Kim, Ravinder Reddy Gaddam, Julia S Jacobs, Markus M Bachschmid, Tsneem Younis, Zhiyong Zhu, Leonid Zingman, Barry London, Adam J Rauckhorst, Eric B Taylor, Andrew W Norris, Ajit Vikram, Kaikobad Iran. Deficiency of endothelial sirtuin1 in mice stimulates skeletal muscle insulin sensitivity by modifying the secretome. Nature communications. vol 14. issue 1. 2023-09-11. PMID:37696839. |
furthermore, sirt1 deficiency in skeletal myocytes promotes insulin resistance. |
2023-09-11 |
2023-10-07 |
mouse |
| Qiuxia Li, Quanjiang Zhang, Young-Rae Kim, Ravinder Reddy Gaddam, Julia S Jacobs, Markus M Bachschmid, Tsneem Younis, Zhiyong Zhu, Leonid Zingman, Barry London, Adam J Rauckhorst, Eric B Taylor, Andrew W Norris, Ajit Vikram, Kaikobad Iran. Deficiency of endothelial sirtuin1 in mice stimulates skeletal muscle insulin sensitivity by modifying the secretome. Nature communications. vol 14. issue 1. 2023-09-11. PMID:37696839. |
here, we show that deletion of endothelial sirt1, while impairing endothelial function, paradoxically improves skeletal muscle insulin sensitivity. |
2023-09-11 |
2023-10-07 |
mouse |
| Qiuxia Li, Quanjiang Zhang, Young-Rae Kim, Ravinder Reddy Gaddam, Julia S Jacobs, Markus M Bachschmid, Tsneem Younis, Zhiyong Zhu, Leonid Zingman, Barry London, Adam J Rauckhorst, Eric B Taylor, Andrew W Norris, Ajit Vikram, Kaikobad Iran. Deficiency of endothelial sirtuin1 in mice stimulates skeletal muscle insulin sensitivity by modifying the secretome. Nature communications. vol 14. issue 1. 2023-09-11. PMID:37696839. |
compared to wild-type mice, male mice lacking endothelial sirt1 (e-sirt1-ko) preferentially utilize glucose over fat, and have higher insulin sensitivity, glucose uptake, and akt signaling in fast-twitch skeletal muscle. |
2023-09-11 |
2023-10-07 |
mouse |
| Qiuxia Li, Quanjiang Zhang, Young-Rae Kim, Ravinder Reddy Gaddam, Julia S Jacobs, Markus M Bachschmid, Tsneem Younis, Zhiyong Zhu, Leonid Zingman, Barry London, Adam J Rauckhorst, Eric B Taylor, Andrew W Norris, Ajit Vikram, Kaikobad Iran. Deficiency of endothelial sirtuin1 in mice stimulates skeletal muscle insulin sensitivity by modifying the secretome. Nature communications. vol 14. issue 1. 2023-09-11. PMID:37696839. |
endothelial sirt1 deficiency, by inhibiting autophagy and activating nuclear factor-kappa b signaling, augments expression and secretion of thymosin beta-4 (tβ4) that promotes insulin signaling in skeletal myotubes. |
2023-09-11 |
2023-10-07 |
mouse |
| Qiuxia Li, Quanjiang Zhang, Young-Rae Kim, Ravinder Reddy Gaddam, Julia S Jacobs, Markus M Bachschmid, Tsneem Younis, Zhiyong Zhu, Leonid Zingman, Barry London, Adam J Rauckhorst, Eric B Taylor, Andrew W Norris, Ajit Vikram, Kaikobad Iran. Deficiency of endothelial sirtuin1 in mice stimulates skeletal muscle insulin sensitivity by modifying the secretome. Nature communications. vol 14. issue 1. 2023-09-11. PMID:37696839. |
thus, unlike in skeletal myocytes, sirt1 deficiency in the endothelium promotes glucose homeostasis by stimulating skeletal muscle insulin sensitivity through a blood-borne mechanism, and augmented secretion of tβ4 by sirt1-deficient endothelial cells boosts insulin signaling in skeletal muscle cells. |
2023-09-11 |
2023-10-07 |
mouse |
| Julia Matuszewska, Joanna Nowacka-Woszuk, Anna Radziejewska, Emilia Grzęda, Ewa Pruszynska-Oszmałek, Łukasz Dylewski, Agata Chmurzynska, Joanna H Sliwowsk. Maternal cafeteria diet and reproductive functions in offspring. Biology of reproduction. 2023-09-04. PMID:37665248. |
we found that caf offspring had: lower weight and altered body composition; increased cholesterol and triglycerides levels, sex-specific changes in glucose and insulin levels; sex-dependent changes in sirt1/kiss1 mrna ratio in the hypothalamus, sex-specific alterations in kiss1 and sirt1 mrna in the liver with more diversity in males; a delayed puberty onset in females. |
2023-09-04 |
2023-09-07 |
rat |
| Jiang Li, Shaofeng Xu, Ling Wang, Xiaoliang Wan. PHPB Attenuated Cognitive Impairment in Type 2 Diabetic KK-Ay Mice by Modulating SIRT1/Insulin Signaling Pathway and Inhibiting Generation of AGEs. Pharmaceuticals (Basel, Switzerland). vol 16. issue 2. 2023-06-01. PMID:37259448. |
also, phpb treatment improved the insulin signaling pathway by increasing sirtuin1 (sirt1) deacetylase activity and attenuated oxidative stress evidenced by elevating glucose-6-phosphate dehydrogenase (g-6-pd) protein expression, promoting the production of reduced glutathione (gsh) and reduced nicotinamide adenine dinucleotide phosphate (nadph), restoring mitochondrial membrane potential, increasing adenosine triphosphate (atp) generation, and reducing malondialdehyde (mda) levels in the brain. |
2023-06-01 |
2023-08-14 |
mouse |
| Zhipeng Tao, Zhiyong Chen. Hormonal regulation of metabolism-recent lessons learned from insulin and estrogen. Clinical science (London, England : 1979). vol 137. issue 6. 2023-03-21. PMID:36942499. |
insulin and estrogen signaling converge on sirt1, mtor, and pi3k in the joint regulation of autophagy and mitochondrial metabolism. |
2023-03-21 |
2023-08-14 |
Not clear |
| Zhipeng Tao, Zhiyong Chen. Hormonal regulation of metabolism-recent lessons learned from insulin and estrogen. Clinical science (London, England : 1979). vol 137. issue 6. 2023-03-21. PMID:36942499. |
in addition, we discuss the cross-talk between estrogen signaling and insulin signaling via sirt1, mtor, and pi3k, as well as new therapeutic options such as agonists of glp1 receptor, gip receptor, and β3-ar. |
2023-03-21 |
2023-08-14 |
Not clear |
| Masroor Anwar, Rashmita Pradhan, Sharmistha Dey, Rahul Kuma. The Role of Sirtuins in Sarcopenia and Frailty. Aging and disease. vol 14. issue 1. 2023-02-23. PMID:36818553. |
in addition, sirt1 improves insulin sensitivity and induces autophagy in the aged mice. |
2023-02-23 |
2023-08-14 |
mouse |
| Dorota Rogacka, Patrycja Rachubik, Irena Audzeyenka, Tomasz Kulesza, Maria Szrejder, Dorota Myślińska, Stefan Angielski, Agnieszka Piwkowsk. Inhibition of phosphodiesterase 5A by tadalafil improves SIRT1 expression and activity in insulin-resistant podocytes. Cellular signalling. 2023-02-08. PMID:36754339. |
we found that pde5a protein levels increased in hyperglycemia, and pde5a downregulation improved the insulin responsiveness of podocytes with reestablished sirt1 expression and activity. |
2023-02-08 |
2023-08-14 |
Not clear |
| Dorota Rogacka, Patrycja Rachubik, Irena Audzeyenka, Tomasz Kulesza, Maria Szrejder, Dorota Myślińska, Stefan Angielski, Agnieszka Piwkowsk. Inhibition of phosphodiesterase 5A by tadalafil improves SIRT1 expression and activity in insulin-resistant podocytes. Cellular signalling. 2023-02-08. PMID:36754339. |
therefore, we investigated the effects of tadalafil on sirt1 and ampk in the context of improving the insulin sensitivity in podocytes and podocyte function in hyperglycemia. |
2023-02-08 |
2023-08-14 |
Not clear |
| Shuchao Pang, Zhengjun Zhang, Yu Zhou, Jie Zhang, Bo Ya. Genetic Variants of International journal of endocrinology. vol 2023. 2023-02-07. PMID:36747995. |
accumulating evidence indicates that sirt1 is involved in insulin resistance and impaired pancreatic |
2023-02-07 |
2023-08-14 |
human |
| Jing Li, Xin Zeng, Xiaolong Yang, Hong Din. Lycopene ameliorates skin aging by regulating the insulin resistance pathway and activating SIRT1. Food & function. 2022-10-13. PMID:36226790. |
lycopene ameliorates skin aging by regulating the insulin resistance pathway and activating sirt1. |
2022-10-13 |
2023-08-14 |
Not clear |
| Hai-Feng Han, Shao-Zhuang Liu, Xiang Zhang, Meng Wei, Xin Huang, Wen-Bin Y. Duodenal-jejunal bypass increases intraduodenal bile acids and upregulates duodenal SIRT1 expression in high-fat diet and streptozotocin-induced diabetic rats. World journal of gastroenterology. vol 28. issue 31. 2022-09-26. PMID:36159018. |
however, the duodenum has emerged as an important regulator of glucose homeostasis, and elevated duodenal sirt1 leads to improved hepatic insulin sensitivity. |
2022-09-26 |
2023-08-14 |
rat |
| Dorota Rogacka, Patrycja Rachubik, Irena Audzeyenka, Maria Szrejder, Tomasz Kulesza, Dorota Myślińska, Stefan Angielski, Agnieszka Piwkowsk. Enhancement of cGMP-dependent pathway activity ameliorates hyperglycemia-induced decrease in SIRT1-AMPK activity in podocytes: Impact on glucose uptake and podocyte function. Biochimica et biophysica acta. Molecular cell research. 2022-09-24. PMID:36152759. |
in podocytes that are exposed to high glucose concentrations, crosstalk between the protein deacetylase sirtuin 1 (sirt1) and adenosine monophosphate-dependent protein kinase (ampk) decreased, attenuating insulin responsiveness and impairing podocyte function. |
2022-09-24 |
2023-08-14 |
Not clear |
| Jie Yang, Zi-Xuan Wang, Lei Fang, Tu-Shuai Li, Zhi-Hong Liu, Ying Pan, Ling-Dong Kon. Atractylodes lancea and Magnolia officinalis combination protects against high fructose-impaired insulin signaling in glomerular podocytes through upregulating Sirt1 to inhibit p53-driven miR-221. Journal of ethnopharmacology. 2022-09-06. PMID:36067838. |
atractylodes lancea and magnolia officinalis combination protects against high fructose-impaired insulin signaling in glomerular podocytes through upregulating sirt1 to inhibit p53-driven mir-221. |
2022-09-06 |
2023-08-14 |
Not clear |
| Mali Wu, Jie Zhang, Ran Gu, Fangfang Dai, Dongyong Yang, Yajing Zheng, Wei Tan, Yifan Jia, Bingshu Li, Yanxiang Chen. The role of Sirtuin 1 in the pathophysiology of polycystic ovary syndrome. European journal of medical research. vol 27. issue 1. 2022-08-27. PMID:36030228. |
moreover, sirt1 participates in the pathophysiological processes of oxidative stress, autophagy, ovulation disturbance and insulin resistance, which may be a vital link in the occurrence of pcos. |
2022-08-27 |
2023-08-14 |
human |