| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F Sarubbo, M R Ramis, C Kienzer, S Aparicio, S Esteban, A Miralles, D Morant. Chronic Silymarin, Quercetin and Naringenin Treatments Increase Monoamines Synthesis and Hippocampal Sirt1 Levels Improving Cognition in Aged Rats. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 13. issue 1. 2019-10-02. PMID:28808887. |
in addition, polyphenolic treatments increased sirt1 levels and decreased nf-κb levels in hippocampus. |
2019-10-02 |
2023-08-13 |
rat |
| Haiyang Yu, Fangfang Zhang, Xidong Gua. Baicalin reverse depressive-like behaviors through regulation SIRT1-NF-kB signaling pathway in olfactory bulbectomized rats. Phytotherapy research : PTR. vol 33. issue 5. 2019-08-12. PMID:30848526. |
furthermore, baicalin regulated sirtuin 1 (sirt1) and decreased the levels of p65 acetylation (ac-p65) in the hippocampus and hypothalamus. |
2019-08-12 |
2023-08-13 |
rat |
| Bo Wang, Yong-Jie Lian, Wen-Jun Su, Wei Peng, Xin Dong, Lin-Lin Liu, Hong Gong, Ting Zhang, Chun-Lei Jiang, Yun-Xia Wan. HMGB1 mediates depressive behavior induced by chronic stress through activating the kynurenine pathway. Brain, behavior, and immunity. vol 72. 2019-07-15. PMID:29195782. |
concurrent with the upregulated hmgb1 protein, the regulator of translocation of hmgb1, sirtuin 1 (sirt1) concentration in the hippocampus remarkably increased. |
2019-07-15 |
2023-08-13 |
mouse |
| Bo Wang, Yong-Jie Lian, Wen-Jun Su, Wei Peng, Xin Dong, Lin-Lin Liu, Hong Gong, Ting Zhang, Chun-Lei Jiang, Yun-Xia Wan. HMGB1 mediates depressive behavior induced by chronic stress through activating the kynurenine pathway. Brain, behavior, and immunity. vol 72. 2019-07-15. PMID:29195782. |
in addition to hmgb1 and sirt1, ido, the rate limiting enzyme of kp, was upregulated at the level of mrna expression and enzyme activity in stressed hippocampi and lps/hmgb1-treated hippocampal slices. |
2019-07-15 |
2023-08-13 |
mouse |
| Hu Hong-Qiang, Shu Mang-Qiao, Xue Fen, Liu Shan-Shan, Cao Hui-Juan, Hou Wu-Gang, Yan Wen-Jun, Peng Zheng-W. Sirt1 mediates improvement of isoflurane-induced memory impairment following hyperbaric oxygen preconditioning in middle-aged mice. Physiology & behavior. vol 195. 2019-06-11. PMID:30040951. |
after hbo preconditioning, cognitive function and expression of hippocampal sirtuin 1 (sirt1), nuclear factor erythroid 2-related factor 2 (nrf2) and heme oxygenase 1 (ho-1) were evaluated 24 h following isoflurane treatment, in the presence or absence of sirt1 knockdown by short hairpin rna (shrna). |
2019-06-11 |
2023-08-13 |
mouse |
| V Rubovitch, A Pharayra, M Har-Even, O Dvir, M P Mattson, C G Pic. Dietary Energy Restriction Ameliorates Cognitive Impairment in a Mouse Model of Traumatic Brain Injury. Journal of molecular neuroscience : MN. vol 67. issue 4. 2019-05-29. PMID:30734244. |
in the present study, we found a significant reduction of sirt1 levels in the cortex and hippocampus in a mouse model of mild weight-drop closed head tbi. |
2019-05-29 |
2023-08-13 |
mouse |
| Junming Fan, Hui Guang, Haizeng Zhang, Danyang Chen, Lu Ding, Xiaofang Fan, Feng Xue, Zhuohui Gan, Yongyu Wang, Sunzhong Mao, Lianggang Hu, Yongsheng Gon. SIRT1 Mediates Apelin-13 in Ameliorating Chronic Normobaric Hypoxia-induced Anxiety-like Behavior by Suppressing NF-κB Pathway in Mice Hippocampus. Neuroscience. vol 381. 2019-04-05. PMID:29680708. |
sirt1 mediates apelin-13 in ameliorating chronic normobaric hypoxia-induced anxiety-like behavior by suppressing nf-κb pathway in mice hippocampus. |
2019-04-05 |
2023-08-13 |
mouse |
| Junming Fan, Hui Guang, Haizeng Zhang, Danyang Chen, Lu Ding, Xiaofang Fan, Feng Xue, Zhuohui Gan, Yongyu Wang, Sunzhong Mao, Lianggang Hu, Yongsheng Gon. SIRT1 Mediates Apelin-13 in Ameliorating Chronic Normobaric Hypoxia-induced Anxiety-like Behavior by Suppressing NF-κB Pathway in Mice Hippocampus. Neuroscience. vol 381. 2019-04-05. PMID:29680708. |
we showed that apelin-13 treatment reversed a decrease in sirt1 and an increase in acetylated p65 (lysine 310) proteins' expression in hippocampus of cnh-treated mice, indicating that apelin-13 inhibited nf-κb signaling pathway by activating sirt1. |
2019-04-05 |
2023-08-13 |
mouse |
| Sydney Aten, Chloe E Page, Anisha Kalidindi, Kelin Wheaton, Anzela Niraula, Jon P Godbout, Kari R Hoyt, Karl Obrieta. miR-132/212 is induced by stress and its dysregulation triggers anxiety-related behavior. Neuropharmacology. vol 144. 2019-03-04. PMID:30342060. |
further, expression of sirt1 and pten-two mir-132 target genes that have been implicated in the regulation of anxiety-were differentially regulated in the hippocampus and amygdala of mir-132/212 conditional knockout and mir-132 transgenic mice. |
2019-03-04 |
2023-08-13 |
mouse |
| Ravikanth Velagapudi, Abdelmeneim El-Bakoush, Olumayokun A Olajid. Activation of Nrf2 Pathway Contributes to Neuroprotection by the Dietary Flavonoid Tiliroside. Molecular neurobiology. vol 55. issue 10. 2018-12-18. PMID:29508282. |
the effects of tiliroside on nrf2 and sirt1 activities in bv2 microglia and ht22 hippocampal neurons were investigated using immunoblotting and dna binding assays. |
2018-12-18 |
2023-08-13 |
mouse |
| Ravikanth Velagapudi, Abdelmeneim El-Bakoush, Olumayokun A Olajid. Activation of Nrf2 Pathway Contributes to Neuroprotection by the Dietary Flavonoid Tiliroside. Molecular neurobiology. vol 55. issue 10. 2018-12-18. PMID:29508282. |
the compound also produced inhibition of nf-κb acetylation through activation of sirt1, as well as increasing sirt1 activity in mouse hippocampal neurons. |
2018-12-18 |
2023-08-13 |
mouse |
| Hong-Ying Li, Xin-Chen Wang, Yu-Min Xu, Na-Chuan Luo, Si Luo, Xu-Yi Hao, Shu-Yi Cheng, Jian-Song Fang, Qi Wang, Shi-Jie Zhang, Yun-Bo Che. Berberine Improves Diabetic Encephalopathy Through the SIRT1/ER Stress Pathway in db/db Mice. Rejuvenation research. vol 21. issue 3. 2018-11-15. PMID:28782427. |
bbr also increased the protein expression of sirt1 and downregulated er stress-associated proteins (perk, ire-1α, eif-2α, pdi, and chop) in the hippocampus of db/db mice. |
2018-11-15 |
2023-08-13 |
mouse |
| Lisa Rancan, Sergio D Paredes, Cruz García, Pablo González, Cruz Rodríguez-Bobada, Mario Calvo-Soto, Bryan Hyacinthe, Elena Vara, Jesús A F Tresguerre. Comparison of the Effect of Melatonin Treatment before and after Brain Ischemic Injury in the Inflammatory and Apoptotic Response in Aged Rats. International journal of molecular sciences. vol 19. issue 7. 2018-10-29. PMID:30029514. |
in general, animals treated with melatonin from 24 h prior to surgery until 7 days after the surgical procedure (prevt) experienced a significant decrease in the levels of tumor necrosis factor-α (tnf-α), interleukin-1β (il-1β), glial fibrillary acidic protein (gfap), bcl-2-associated death promoter (bad), and bcl-2-associated x protein (bax) in both cortex and hippocampus, while hippocampal levels of sirtuin 1 (sirt1) and b-cell lymphoma 2 (bcl-2) increased. |
2018-10-29 |
2023-08-13 |
rat |
| Kyung Eun Kim, Eun Ae Jeong, Jong Youl Lee, Chin-Ok Yi, Kyung-Ah Park, Zhen Jin, Jung Eun Lee, Tamas L Horvath, Gu Seob Ro. Myeloid sirtuin1 deficiency aggravates hippocampal inflammation in mice fed high-fat diets. Biochemical and biophysical research communications. vol 499. issue 4. 2018-10-09. PMID:29634925. |
however, the function of myeloid-specific sirt1 in the hippocampus of obese mice is largely unknown. |
2018-10-09 |
2023-08-13 |
mouse |
| Kyung Eun Kim, Eun Ae Jeong, Jong Youl Lee, Chin-Ok Yi, Kyung-Ah Park, Zhen Jin, Jung Eun Lee, Tamas L Horvath, Gu Seob Ro. Myeloid sirtuin1 deficiency aggravates hippocampal inflammation in mice fed high-fat diets. Biochemical and biophysical research communications. vol 499. issue 4. 2018-10-09. PMID:29634925. |
hfd-induced hippocampal lcn2 expression was lower in hfd-fed sirt1 ko mice than in wt. |
2018-10-09 |
2023-08-13 |
mouse |
| Kyung Eun Kim, Eun Ae Jeong, Jong Youl Lee, Chin-Ok Yi, Kyung-Ah Park, Zhen Jin, Jung Eun Lee, Tamas L Horvath, Gu Seob Ro. Myeloid sirtuin1 deficiency aggravates hippocampal inflammation in mice fed high-fat diets. Biochemical and biophysical research communications. vol 499. issue 4. 2018-10-09. PMID:29634925. |
hippocampal acetylation of nuclear factor-κb (nf-κb) and amyloid precursor protein levels were higher in hfd-fed sirt1 ko mice than in hfd-fed wt mice. |
2018-10-09 |
2023-08-13 |
mouse |
| Qisen Li, Jiacheng Zeng, Meiling Su, Yu He, Banghao Zh. Acetylshikonin from Zicao attenuates cognitive impairment and hippocampus senescence in d-galactose-induced aging mouse model via upregulating the expression of SIRT1. Brain research bulletin. vol 137. 2018-08-31. PMID:29325995. |
acetylshikonin from zicao attenuates cognitive impairment and hippocampus senescence in d-galactose-induced aging mouse model via upregulating the expression of sirt1. |
2018-08-31 |
2023-08-13 |
mouse |
| Qisen Li, Jiacheng Zeng, Meiling Su, Yu He, Banghao Zh. Acetylshikonin from Zicao attenuates cognitive impairment and hippocampus senescence in d-galactose-induced aging mouse model via upregulating the expression of SIRT1. Brain research bulletin. vol 137. 2018-08-31. PMID:29325995. |
moreover, western blot results showed that as can up-regulate the expression of sirtuin 1 (sirt1) and inhibit d-gal-induced activation of p53/p21 signaling pathway in the hippocampus of mice. |
2018-08-31 |
2023-08-13 |
mouse |
| Anorut Jenwitheesuk, Seongjoon Park, Prapimpun Wongchitrat, Jiraporn Tocharus, Sujira Mukda, Isao Shimokawa, Piyarat Govitrapon. Comparing the Effects of Melatonin with Caloric Restriction in the Hippocampus of Aging Mice: Involvement of Sirtuin1 and the FOXOs Pathway. Neurochemical research. vol 43. issue 1. 2018-08-16. PMID:28770437. |
this study aimed to compare the effects of melatonin (mel) and caloric restriction (cr) on the expression of sirt1, foxo1, foxo3a and foxos target genes in the aging mouse hippocampus. |
2018-08-16 |
2023-08-13 |
mouse |
| Anorut Jenwitheesuk, Seongjoon Park, Prapimpun Wongchitrat, Jiraporn Tocharus, Sujira Mukda, Isao Shimokawa, Piyarat Govitrapon. Comparing the Effects of Melatonin with Caloric Restriction in the Hippocampus of Aging Mice: Involvement of Sirtuin1 and the FOXOs Pathway. Neurochemical research. vol 43. issue 1. 2018-08-16. PMID:28770437. |
mel treatment upregulated the mrna expression of sirt1, foxos (foxo1 and foxo3a) target genes that regulated the cell cycle [e.g., cyclin-dependent kinase inhibitor 1b (p27)], wingless and int-1 (wnt1) and inducible signaling pathway protein 1 (wisp1) in the aged mouse hippocampus. |
2018-08-16 |
2023-08-13 |
mouse |