| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wen-Jun Yan, Da-Bin Wang, Dong-Qing Ren, Ling-Kai Wang, Zhong-Yuan Hu, Ya-Bing Ma, Jin-Wen Huang, Shao-Li Din. AMPKα1 overexpression improves postoperative cognitive dysfunction in aged rats through AMPK-Sirt1 and autophagy signaling. Journal of cellular biochemistry. 2019-11-20. PMID:30775803. |
furthermore, overexpression of ampkα1 could upregulate the expression of p-ampk and sirt1 in the hippocampus of rats with pocd. |
2019-11-20 |
2023-08-13 |
rat |
| Jesus Campagna, Patricia Spilman, Barbara Jagodzinska, Dongsheng Bai, Asa Hatami, Chunni Zhu, Tina Bilousova, Michael Jun, Chris Jean Elias, Johnny Pham, Gregory Cole, Mary Jo LaDu, Michael E Jung, Dale E Bredesen, Varghese Joh. A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer's disease mouse model. Scientific reports. vol 8. issue 1. 2019-10-25. PMID:30514854. |
in vivo, a03 treatment increased sirt1 levels in the hippocampus of 5xfad-apoe4 (e4fad) alzheimer's disease (ad) model mice and elicited cognitive improvement while inducing no observed toxicity. |
2019-10-25 |
2023-08-13 |
mouse |
| Peng Yao, Yong Chen, Guo-Hai X. [Effect of triptolide on cognitive dysfunction in vascular dementia rats through SIRT1/NF-κB signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 44. issue 16. 2019-10-21. PMID:31602904. |
western blot was used to detect the expression of sirt1,nf-κb,iκbα and caspase 3 in hippocampus. |
2019-10-21 |
2023-08-13 |
rat |
| Peng Yao, Yong Chen, Guo-Hai X. [Effect of triptolide on cognitive dysfunction in vascular dementia rats through SIRT1/NF-κB signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 44. issue 16. 2019-10-21. PMID:31602904. |
the results showed that compared with the sham group,the learning and memory ability of the vascular dementia model rats was reduced,the sod activity in the hippocampus was decreased,the mda activity and il-6 level were increased,the neuronal degeneration changed significantly,the expression of sirt1 and iκbα was decreased and the expression of caspase 3 and nf-κb was significantly increased. |
2019-10-21 |
2023-08-13 |
rat |
| Peng Yao, Yong Chen, Guo-Hai X. [Effect of triptolide on cognitive dysfunction in vascular dementia rats through SIRT1/NF-κB signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 44. issue 16. 2019-10-21. PMID:31602904. |
while,after intervention by triptolide and ex527,the expression of sirt1 was decreased,the levels of oxidative stress and neuronal degeneration in the hippocampus were aggravated,and the learning and memory ability was reduced. |
2019-10-21 |
2023-08-13 |
rat |
| A Hadar, E Milanesi, M Walczak, M Puzianowska-Kuźnicka, J Kuźnicki, A Squassina, P Niola, C Chillotti, J Attems, I Gozes, D Gurwit. SIRT1, miR-132 and miR-212 link human longevity to Alzheimer's Disease. Scientific reports. vol 8. issue 1. 2019-10-08. PMID:29855513. |
here, we studied the expression of sirt1 along with mir-132 and mir-212, two micrornas known to regulate sirt1, in lymphoblastoid cell lines (lcls) from 45 healthy donors aged 21 to 105 years and 24 ad patients, and in postmortem olfactory bulb and hippocampus tissues from 14 ad patients and 20 age-matched non-demented individuals. |
2019-10-08 |
2023-08-13 |
human |
| A Hadar, E Milanesi, M Walczak, M Puzianowska-Kuźnicka, J Kuźnicki, A Squassina, P Niola, C Chillotti, J Attems, I Gozes, D Gurwit. SIRT1, miR-132 and miR-212 link human longevity to Alzheimer's Disease. Scientific reports. vol 8. issue 1. 2019-10-08. PMID:29855513. |
correlations of sirt1, mir-132 and mir-212 expression with cognitive scores were observed for ad patient-derived lcls and postmortem ad olfactory bulb and hippocampus tissues, suggesting that higher sirt1 expression, possibly mediated by lower mir-132 and mir-212, may protect aged individuals from dementia and is reflected in their peripheral tissues. |
2019-10-08 |
2023-08-13 |
human |
| Shuhu Zhou, Baojun Qiao, Xu Chu, Qingxia Kon. Oxymatrine attenuates cognitive deficits through SIRT1-mediated autophagy in ischemic stroke. Journal of neuroimmunology. vol 323. 2019-10-03. PMID:30196826. |
oxymatrine may attenuate hippocampus ischemia/reperfusion injury through upregulation sirt1, further influencing the processes of apoptosis and autophagy. |
2019-10-03 |
2023-08-13 |
rat |
| F Sarubbo, M R Ramis, C Kienzer, S Aparicio, S Esteban, A Miralles, D Morant. Chronic Silymarin, Quercetin and Naringenin Treatments Increase Monoamines Synthesis and Hippocampal Sirt1 Levels Improving Cognition in Aged Rats. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 13. issue 1. 2019-10-02. PMID:28808887. |
chronic silymarin, quercetin and naringenin treatments increase monoamines synthesis and hippocampal sirt1 levels improving cognition in aged rats. |
2019-10-02 |
2023-08-13 |
rat |
| F Sarubbo, M R Ramis, C Kienzer, S Aparicio, S Esteban, A Miralles, D Morant. Chronic Silymarin, Quercetin and Naringenin Treatments Increase Monoamines Synthesis and Hippocampal Sirt1 Levels Improving Cognition in Aged Rats. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 13. issue 1. 2019-10-02. PMID:28808887. |
in addition, polyphenolic treatments increased sirt1 levels and decreased nf-κb levels in hippocampus. |
2019-10-02 |
2023-08-13 |
rat |
| Haiyang Yu, Fangfang Zhang, Xidong Gua. Baicalin reverse depressive-like behaviors through regulation SIRT1-NF-kB signaling pathway in olfactory bulbectomized rats. Phytotherapy research : PTR. vol 33. issue 5. 2019-08-12. PMID:30848526. |
furthermore, baicalin regulated sirtuin 1 (sirt1) and decreased the levels of p65 acetylation (ac-p65) in the hippocampus and hypothalamus. |
2019-08-12 |
2023-08-13 |
rat |
| Bo Wang, Yong-Jie Lian, Wen-Jun Su, Wei Peng, Xin Dong, Lin-Lin Liu, Hong Gong, Ting Zhang, Chun-Lei Jiang, Yun-Xia Wan. HMGB1 mediates depressive behavior induced by chronic stress through activating the kynurenine pathway. Brain, behavior, and immunity. vol 72. 2019-07-15. PMID:29195782. |
concurrent with the upregulated hmgb1 protein, the regulator of translocation of hmgb1, sirtuin 1 (sirt1) concentration in the hippocampus remarkably increased. |
2019-07-15 |
2023-08-13 |
mouse |
| Bo Wang, Yong-Jie Lian, Wen-Jun Su, Wei Peng, Xin Dong, Lin-Lin Liu, Hong Gong, Ting Zhang, Chun-Lei Jiang, Yun-Xia Wan. HMGB1 mediates depressive behavior induced by chronic stress through activating the kynurenine pathway. Brain, behavior, and immunity. vol 72. 2019-07-15. PMID:29195782. |
in addition to hmgb1 and sirt1, ido, the rate limiting enzyme of kp, was upregulated at the level of mrna expression and enzyme activity in stressed hippocampi and lps/hmgb1-treated hippocampal slices. |
2019-07-15 |
2023-08-13 |
mouse |
| Hu Hong-Qiang, Shu Mang-Qiao, Xue Fen, Liu Shan-Shan, Cao Hui-Juan, Hou Wu-Gang, Yan Wen-Jun, Peng Zheng-W. Sirt1 mediates improvement of isoflurane-induced memory impairment following hyperbaric oxygen preconditioning in middle-aged mice. Physiology & behavior. vol 195. 2019-06-11. PMID:30040951. |
after hbo preconditioning, cognitive function and expression of hippocampal sirtuin 1 (sirt1), nuclear factor erythroid 2-related factor 2 (nrf2) and heme oxygenase 1 (ho-1) were evaluated 24 h following isoflurane treatment, in the presence or absence of sirt1 knockdown by short hairpin rna (shrna). |
2019-06-11 |
2023-08-13 |
mouse |
| V Rubovitch, A Pharayra, M Har-Even, O Dvir, M P Mattson, C G Pic. Dietary Energy Restriction Ameliorates Cognitive Impairment in a Mouse Model of Traumatic Brain Injury. Journal of molecular neuroscience : MN. vol 67. issue 4. 2019-05-29. PMID:30734244. |
in the present study, we found a significant reduction of sirt1 levels in the cortex and hippocampus in a mouse model of mild weight-drop closed head tbi. |
2019-05-29 |
2023-08-13 |
mouse |
| Junming Fan, Hui Guang, Haizeng Zhang, Danyang Chen, Lu Ding, Xiaofang Fan, Feng Xue, Zhuohui Gan, Yongyu Wang, Sunzhong Mao, Lianggang Hu, Yongsheng Gon. SIRT1 Mediates Apelin-13 in Ameliorating Chronic Normobaric Hypoxia-induced Anxiety-like Behavior by Suppressing NF-κB Pathway in Mice Hippocampus. Neuroscience. vol 381. 2019-04-05. PMID:29680708. |
sirt1 mediates apelin-13 in ameliorating chronic normobaric hypoxia-induced anxiety-like behavior by suppressing nf-κb pathway in mice hippocampus. |
2019-04-05 |
2023-08-13 |
mouse |
| Junming Fan, Hui Guang, Haizeng Zhang, Danyang Chen, Lu Ding, Xiaofang Fan, Feng Xue, Zhuohui Gan, Yongyu Wang, Sunzhong Mao, Lianggang Hu, Yongsheng Gon. SIRT1 Mediates Apelin-13 in Ameliorating Chronic Normobaric Hypoxia-induced Anxiety-like Behavior by Suppressing NF-κB Pathway in Mice Hippocampus. Neuroscience. vol 381. 2019-04-05. PMID:29680708. |
we showed that apelin-13 treatment reversed a decrease in sirt1 and an increase in acetylated p65 (lysine 310) proteins' expression in hippocampus of cnh-treated mice, indicating that apelin-13 inhibited nf-κb signaling pathway by activating sirt1. |
2019-04-05 |
2023-08-13 |
mouse |
| Sydney Aten, Chloe E Page, Anisha Kalidindi, Kelin Wheaton, Anzela Niraula, Jon P Godbout, Kari R Hoyt, Karl Obrieta. miR-132/212 is induced by stress and its dysregulation triggers anxiety-related behavior. Neuropharmacology. vol 144. 2019-03-04. PMID:30342060. |
further, expression of sirt1 and pten-two mir-132 target genes that have been implicated in the regulation of anxiety-were differentially regulated in the hippocampus and amygdala of mir-132/212 conditional knockout and mir-132 transgenic mice. |
2019-03-04 |
2023-08-13 |
mouse |
| Ravikanth Velagapudi, Abdelmeneim El-Bakoush, Olumayokun A Olajid. Activation of Nrf2 Pathway Contributes to Neuroprotection by the Dietary Flavonoid Tiliroside. Molecular neurobiology. vol 55. issue 10. 2018-12-18. PMID:29508282. |
the effects of tiliroside on nrf2 and sirt1 activities in bv2 microglia and ht22 hippocampal neurons were investigated using immunoblotting and dna binding assays. |
2018-12-18 |
2023-08-13 |
mouse |
| Ravikanth Velagapudi, Abdelmeneim El-Bakoush, Olumayokun A Olajid. Activation of Nrf2 Pathway Contributes to Neuroprotection by the Dietary Flavonoid Tiliroside. Molecular neurobiology. vol 55. issue 10. 2018-12-18. PMID:29508282. |
the compound also produced inhibition of nf-κb acetylation through activation of sirt1, as well as increasing sirt1 activity in mouse hippocampal neurons. |
2018-12-18 |
2023-08-13 |
mouse |