| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hyunwoo Park, Mia Kim, Im-Joon Shin, Jonghee Park, Soo Yong Bang, Chunsik Yi, Myoung-Ae Kim, Jae-Hwan Lew, Joo Won Suh, Sungho Maen. Woohwangcheongsimwon Prevents High-Fat Diet-Induced Memory Deficits and Induces SIRT1 in Mice. Journal of medicinal food. vol 21. issue 2. 2018-08-15. PMID:29319388. |
the hippocampal expressions of sirt1 and pgc-1α were also measured. |
2018-08-15 |
2023-08-13 |
mouse |
| Hyunwoo Park, Mia Kim, Im-Joon Shin, Jonghee Park, Soo Yong Bang, Chunsik Yi, Myoung-Ae Kim, Jae-Hwan Lew, Joo Won Suh, Sungho Maen. Woohwangcheongsimwon Prevents High-Fat Diet-Induced Memory Deficits and Induces SIRT1 in Mice. Journal of medicinal food. vol 21. issue 2. 2018-08-15. PMID:29319388. |
the herbal treatment also increased the expression of sirt1 and pgc-1α in the hippocampus. |
2018-08-15 |
2023-08-13 |
mouse |
| Hyunwoo Park, Mia Kim, Im-Joon Shin, Jonghee Park, Soo Yong Bang, Chunsik Yi, Myoung-Ae Kim, Jae-Hwan Lew, Joo Won Suh, Sungho Maen. Woohwangcheongsimwon Prevents High-Fat Diet-Induced Memory Deficits and Induces SIRT1 in Mice. Journal of medicinal food. vol 21. issue 2. 2018-08-15. PMID:29319388. |
despite the induction of hippocampal sirt1 expression by whc, resveratrol was not present among the natural compounds identified. |
2018-08-15 |
2023-08-13 |
mouse |
| Qi-Shun Zhang, Wei Liu, Guang-Xiu L. miR-200a-3p promotes b-Amyloid-induced neuronal apoptosis through down-regulation of SIRT1 in Alzheimer's disease. Journal of biosciences. vol 42. issue 3. 2018-08-10. PMID:29358553. |
an increased level of mir-200a-3p and a decreased level of sirt1 in the hippocampus of appswe/ps delta e9 mice (a model for ad) were observed. |
2018-08-10 |
2023-08-13 |
mouse |
| Xinxin Wang, Shanshan Ma, Bo Yang, Tuanjie Huang, Nan Meng, Ling Xu, Qu Xing, Yanting Zhang, Kun Zhang, Qinghua Li, Tao Zhang, Junwei Wu, Greta Luyuan Yang, Fangxia Guan, Jian Wan. Resveratrol promotes hUC-MSCs engraftment and neural repair in a mouse model of Alzheimer's disease. Behavioural brain research. vol 339. 2018-08-07. PMID:29102593. |
moreover, huc-mscs and resveratrol jointly regulate expression of hippocampal sirt1, pcna, p53, ac-p53, p21, and p16. |
2018-08-07 |
2023-08-13 |
mouse |
| P Ding, D Ren, S He, M He, G Zhang, Y Chen, H Sang, Z Peng, W Ya. Sirt1 mediates improvement in cognitive defects induced by focal cerebral ischemia following hyperbaric oxygen preconditioning in rats. Physiological research. vol 66. issue 6. 2018-08-06. PMID:28937253. |
cognitive function and expression of phosphorylated neurofilament heavy polypeptide (pnf-h) and doublecortin (dcx) in the hippocampus were evaluated 14 days after reperfusion and after short interfering rna-mediated knockdown of sirtuin1 (sirt1). |
2018-08-06 |
2023-08-13 |
rat |
| Xiao-Yan Zhang, Xian-Jun Zhang, Jin Xv, Wei Jia, Xiao-Yan Pu, Hai-Yan Wang, Hong Liang, Zhuoma-Lamao, Dian-Xiang L. Crocin attenuates acute hypobaric hypoxia-induced cognitive deficits of rats. European journal of pharmacology. vol 818. 2018-08-06. PMID:29106903. |
crocin attenuates acute hypobaric hypoxia-induced cognitive deficits in rats, accompanied by repairing the structures of hippocampal neurons and improving pgc-1α and sirt1 levels. |
2018-08-06 |
2023-08-13 |
rat |
| Zhiping Hou, Peiyuan He, Mustapha Umar Imam, Jiemen Qi, Shiying Tang, Chengjun Song, Maznah Ismai. Edible Bird's Nest Prevents Menopause-Related Memory and Cognitive Decline in Rats via Increased Hippocampal Sirtuin-1 Expression. Oxidative medicine and cellular longevity. vol 2017. 2018-07-19. PMID:29104731. |
sirtuin-1 (sirt1) downregulation in the hippocampus is implicated in the underlying molecular mechanism. |
2018-07-19 |
2023-08-13 |
rat |
| Zhiping Hou, Peiyuan He, Mustapha Umar Imam, Jiemen Qi, Shiying Tang, Chengjun Song, Maznah Ismai. Edible Bird's Nest Prevents Menopause-Related Memory and Cognitive Decline in Rats via Increased Hippocampal Sirtuin-1 Expression. Oxidative medicine and cellular longevity. vol 2017. 2018-07-19. PMID:29104731. |
edible bird's nest (ebn) is traditionally used to improve general wellbeing, and in this study, we evaluated its effects on sirt1 expression in the hippocampus and implications on ovariectomy-induced memory and cognitive decline in rats. |
2018-07-19 |
2023-08-13 |
rat |
| Zhiping Hou, Peiyuan He, Mustapha Umar Imam, Jiemen Qi, Shiying Tang, Chengjun Song, Maznah Ismai. Edible Bird's Nest Prevents Menopause-Related Memory and Cognitive Decline in Rats via Increased Hippocampal Sirtuin-1 Expression. Oxidative medicine and cellular longevity. vol 2017. 2018-07-19. PMID:29104731. |
after 12 weeks of intervention, morris water maze (four-day trial and one probe trial) was conducted, and serum estrogen levels, toxicity markers (alanine transaminase, alkaline phosphatase, urea, and creatinine), and hippocampal sirt1 immunohistochemistry were estimated after sacrifice. |
2018-07-19 |
2023-08-13 |
rat |
| Zhiping Hou, Peiyuan He, Mustapha Umar Imam, Jiemen Qi, Shiying Tang, Chengjun Song, Maznah Ismai. Edible Bird's Nest Prevents Menopause-Related Memory and Cognitive Decline in Rats via Increased Hippocampal Sirtuin-1 Expression. Oxidative medicine and cellular longevity. vol 2017. 2018-07-19. PMID:29104731. |
the results indicated that ebn and estrogen enhanced spatial learning and memory and increased serum estrogen and hippocampal sirt1 expression. |
2018-07-19 |
2023-08-13 |
rat |
| YuanBo Cui, ShanShan Ma, ChunYan Zhang, DongPeng Li, Bo Yang, PengJu Lv, Qu Xing, Tuanjie Huang, Greta Luyuan Yang, Wei Cao, FangXia Gua. Pharmacological activation of the Nrf2 pathway by 3H-1, 2-dithiole-3-thione is neuroprotective in a mouse model of Alzheimer disease. Behavioural brain research. vol 336. 2018-06-01. PMID:28887195. |
further mechanistic studies revealed that d3t significantly promoted hippocampal neurogenesis, and up-regulated levels of silent information regulator 1 (sirt1), nrf2 and heme oxygenase-1 (ho-1). |
2018-06-01 |
2023-08-13 |
mouse |
| Sohi Kang, Yeonghoon Son, Sueun Lee, Juhwan Kim, Jong-Choon Kim, Joong-Sun Kim, Uhee Jung, Sung-Ho Kim, Miyoung Yang, Changjong Moo. Changes in epigenetic markers, DNMT1 and HDAC1/2, in the adult mouse hippocampus after cranial irradiation. Neuroscience letters. vol 657. 2018-05-28. PMID:28780164. |
we assessed changes in the levels of enzymes associated with the epigenetic modification of gene expression, including dnmt1, hdac1, hdac2, sirtuin 1 (sirt1), and acetylated histone h3 (ace-h3) in the mouse hippocampus 1 and 30days after a single exposure to cranial irradiation (0 or 10gy). |
2018-05-28 |
2023-08-13 |
mouse |
| Sohi Kang, Yeonghoon Son, Sueun Lee, Juhwan Kim, Jong-Choon Kim, Joong-Sun Kim, Uhee Jung, Sung-Ho Kim, Miyoung Yang, Changjong Moo. Changes in epigenetic markers, DNMT1 and HDAC1/2, in the adult mouse hippocampus after cranial irradiation. Neuroscience letters. vol 657. 2018-05-28. PMID:28780164. |
furthermore, protein levels of sirt1 and ace-h3 were significantly downregulated in the mouse hippocampus 1 and 30days after cranial irradiation. |
2018-05-28 |
2023-08-13 |
mouse |
| Rubén Corpas, Susana Revilla, Suzanna Ursulet, Marco Castro-Freire, Perla Kaliman, Valérie Petegnief, Lydia Giménez-Llort, Chamsy Sarkis, Mercè Pallàs, Coral Sanfeli. SIRT1 Overexpression in Mouse Hippocampus Induces Cognitive Enhancement Through Proteostatic and Neurotrophic Mechanisms. Molecular neurobiology. vol 54. issue 7. 2018-05-18. PMID:27614878. |
sirt1 overexpression in mouse hippocampus induces cognitive enhancement through proteostatic and neurotrophic mechanisms. |
2018-05-18 |
2023-08-13 |
mouse |
| Rubén Corpas, Susana Revilla, Suzanna Ursulet, Marco Castro-Freire, Perla Kaliman, Valérie Petegnief, Lydia Giménez-Llort, Chamsy Sarkis, Mercè Pallàs, Coral Sanfeli. SIRT1 Overexpression in Mouse Hippocampus Induces Cognitive Enhancement Through Proteostatic and Neurotrophic Mechanisms. Molecular neurobiology. vol 54. issue 7. 2018-05-18. PMID:27614878. |
we aimed to investigate the benefits induced by sirt1 overexpression in the hippocampus of the ad mouse model 3xtg-ad and in control non-transgenic mice. |
2018-05-18 |
2023-08-13 |
mouse |
| Rubén Corpas, Susana Revilla, Suzanna Ursulet, Marco Castro-Freire, Perla Kaliman, Valérie Petegnief, Lydia Giménez-Llort, Chamsy Sarkis, Mercè Pallàs, Coral Sanfeli. SIRT1 Overexpression in Mouse Hippocampus Induces Cognitive Enhancement Through Proteostatic and Neurotrophic Mechanisms. Molecular neurobiology. vol 54. issue 7. 2018-05-18. PMID:27614878. |
a lentiviral vector encoding mouse sirt1 or gfp, selectively transducing neurons, was injected into the dorsal ca1 hippocampal area of 4-month-old mice. |
2018-05-18 |
2023-08-13 |
mouse |
| Vivek Kumar, Ankita Pandey, Sadaf Jahan, Rajendra Kumar Shukla, Dipak Kumar, Akriti Srivastava, Shripriya Singh, Chetan Singh Rajpurohit, Sanjay Yadav, Vinay Kumar Khanna, Aditya Bhushan Pan. Differential responses of Trans-Resveratrol on proliferation of neural progenitor cells and aged rat hippocampal neurogenesis. Scientific reports. vol 6. 2018-04-24. PMID:27334554. |
administration of resveratrol (20 mg/kg body weight) to adult rats significantly increased the number of newly generated cells in the hippocampus, with upregulation of p-creb and sirt1 proteins implicated in neuronal survival and lifespan extension respectively. |
2018-04-24 |
2023-08-13 |
rat |
| Francesco Bellanti, Giuseppina Iannelli, Maria Blonda, Rosanna Tamborra, Rosanna Villani, Adele Romano, Silvio Calcagnini, Gianluigi Mazzoccoli, Manlio Vinciguerra, Silvana Gaetani, Anna Maria Giudetti, Gianluigi Vendemiale, Tommaso Cassano, Gaetano Serviddi. Alterations of Clock Gene RNA Expression in Brain Regions of a Triple Transgenic Model of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 59. issue 2. 2018-04-09. PMID:28671110. |
in other brain areas, age rather than genotype affected gene expression; the effect of genotype was observed on hippocampal sirt1 expression, while it modified the expression of genes regulating the negative feedback loop as well as rorα, csnk1ɛ and sirt1 in the brainstem. |
2018-04-09 |
2023-08-13 |
mouse |
| Dongying Yan, Cuihong Jin, Yang Cao, Lulu Wang, Xiaobo Lu, Jinghua Yang, Shengwen Wu, Yuan Ca. Effects of Aluminium on Long-Term Memory in Rats and on SIRT1 Mediating the Transcription of CREB-Dependent Gene in Hippocampus. Basic & clinical pharmacology & toxicology. vol 121. issue 4. 2018-01-30. PMID:28429887. |
effects of aluminium on long-term memory in rats and on sirt1 mediating the transcription of creb-dependent gene in hippocampus. |
2018-01-30 |
2023-08-13 |
rat |