| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hong-Ying Li, Xin-Chen Wang, Yu-Min Xu, Na-Chuan Luo, Si Luo, Xu-Yi Hao, Shu-Yi Cheng, Jian-Song Fang, Qi Wang, Shi-Jie Zhang, Yun-Bo Che. Berberine Improves Diabetic Encephalopathy Through the SIRT1/ER Stress Pathway in db/db Mice. Rejuvenation research. vol 21. issue 3. 2018-11-15. PMID:28782427. |
bbr also increased the protein expression of sirt1 and downregulated er stress-associated proteins (perk, ire-1α, eif-2α, pdi, and chop) in the hippocampus of db/db mice. |
2018-11-15 |
2023-08-13 |
mouse |
| Lisa Rancan, Sergio D Paredes, Cruz García, Pablo González, Cruz Rodríguez-Bobada, Mario Calvo-Soto, Bryan Hyacinthe, Elena Vara, Jesús A F Tresguerre. Comparison of the Effect of Melatonin Treatment before and after Brain Ischemic Injury in the Inflammatory and Apoptotic Response in Aged Rats. International journal of molecular sciences. vol 19. issue 7. 2018-10-29. PMID:30029514. |
in general, animals treated with melatonin from 24 h prior to surgery until 7 days after the surgical procedure (prevt) experienced a significant decrease in the levels of tumor necrosis factor-α (tnf-α), interleukin-1β (il-1β), glial fibrillary acidic protein (gfap), bcl-2-associated death promoter (bad), and bcl-2-associated x protein (bax) in both cortex and hippocampus, while hippocampal levels of sirtuin 1 (sirt1) and b-cell lymphoma 2 (bcl-2) increased. |
2018-10-29 |
2023-08-13 |
rat |
| Kyung Eun Kim, Eun Ae Jeong, Jong Youl Lee, Chin-Ok Yi, Kyung-Ah Park, Zhen Jin, Jung Eun Lee, Tamas L Horvath, Gu Seob Ro. Myeloid sirtuin1 deficiency aggravates hippocampal inflammation in mice fed high-fat diets. Biochemical and biophysical research communications. vol 499. issue 4. 2018-10-09. PMID:29634925. |
however, the function of myeloid-specific sirt1 in the hippocampus of obese mice is largely unknown. |
2018-10-09 |
2023-08-13 |
mouse |
| Kyung Eun Kim, Eun Ae Jeong, Jong Youl Lee, Chin-Ok Yi, Kyung-Ah Park, Zhen Jin, Jung Eun Lee, Tamas L Horvath, Gu Seob Ro. Myeloid sirtuin1 deficiency aggravates hippocampal inflammation in mice fed high-fat diets. Biochemical and biophysical research communications. vol 499. issue 4. 2018-10-09. PMID:29634925. |
hfd-induced hippocampal lcn2 expression was lower in hfd-fed sirt1 ko mice than in wt. |
2018-10-09 |
2023-08-13 |
mouse |
| Kyung Eun Kim, Eun Ae Jeong, Jong Youl Lee, Chin-Ok Yi, Kyung-Ah Park, Zhen Jin, Jung Eun Lee, Tamas L Horvath, Gu Seob Ro. Myeloid sirtuin1 deficiency aggravates hippocampal inflammation in mice fed high-fat diets. Biochemical and biophysical research communications. vol 499. issue 4. 2018-10-09. PMID:29634925. |
hippocampal acetylation of nuclear factor-κb (nf-κb) and amyloid precursor protein levels were higher in hfd-fed sirt1 ko mice than in hfd-fed wt mice. |
2018-10-09 |
2023-08-13 |
mouse |
| Qisen Li, Jiacheng Zeng, Meiling Su, Yu He, Banghao Zh. Acetylshikonin from Zicao attenuates cognitive impairment and hippocampus senescence in d-galactose-induced aging mouse model via upregulating the expression of SIRT1. Brain research bulletin. vol 137. 2018-08-31. PMID:29325995. |
acetylshikonin from zicao attenuates cognitive impairment and hippocampus senescence in d-galactose-induced aging mouse model via upregulating the expression of sirt1. |
2018-08-31 |
2023-08-13 |
mouse |
| Qisen Li, Jiacheng Zeng, Meiling Su, Yu He, Banghao Zh. Acetylshikonin from Zicao attenuates cognitive impairment and hippocampus senescence in d-galactose-induced aging mouse model via upregulating the expression of SIRT1. Brain research bulletin. vol 137. 2018-08-31. PMID:29325995. |
moreover, western blot results showed that as can up-regulate the expression of sirtuin 1 (sirt1) and inhibit d-gal-induced activation of p53/p21 signaling pathway in the hippocampus of mice. |
2018-08-31 |
2023-08-13 |
mouse |
| Anorut Jenwitheesuk, Seongjoon Park, Prapimpun Wongchitrat, Jiraporn Tocharus, Sujira Mukda, Isao Shimokawa, Piyarat Govitrapon. Comparing the Effects of Melatonin with Caloric Restriction in the Hippocampus of Aging Mice: Involvement of Sirtuin1 and the FOXOs Pathway. Neurochemical research. vol 43. issue 1. 2018-08-16. PMID:28770437. |
this study aimed to compare the effects of melatonin (mel) and caloric restriction (cr) on the expression of sirt1, foxo1, foxo3a and foxos target genes in the aging mouse hippocampus. |
2018-08-16 |
2023-08-13 |
mouse |
| Anorut Jenwitheesuk, Seongjoon Park, Prapimpun Wongchitrat, Jiraporn Tocharus, Sujira Mukda, Isao Shimokawa, Piyarat Govitrapon. Comparing the Effects of Melatonin with Caloric Restriction in the Hippocampus of Aging Mice: Involvement of Sirtuin1 and the FOXOs Pathway. Neurochemical research. vol 43. issue 1. 2018-08-16. PMID:28770437. |
mel treatment upregulated the mrna expression of sirt1, foxos (foxo1 and foxo3a) target genes that regulated the cell cycle [e.g., cyclin-dependent kinase inhibitor 1b (p27)], wingless and int-1 (wnt1) and inducible signaling pathway protein 1 (wisp1) in the aged mouse hippocampus. |
2018-08-16 |
2023-08-13 |
mouse |
| Hyunwoo Park, Mia Kim, Im-Joon Shin, Jonghee Park, Soo Yong Bang, Chunsik Yi, Myoung-Ae Kim, Jae-Hwan Lew, Joo Won Suh, Sungho Maen. Woohwangcheongsimwon Prevents High-Fat Diet-Induced Memory Deficits and Induces SIRT1 in Mice. Journal of medicinal food. vol 21. issue 2. 2018-08-15. PMID:29319388. |
the hippocampal expressions of sirt1 and pgc-1α were also measured. |
2018-08-15 |
2023-08-13 |
mouse |
| Hyunwoo Park, Mia Kim, Im-Joon Shin, Jonghee Park, Soo Yong Bang, Chunsik Yi, Myoung-Ae Kim, Jae-Hwan Lew, Joo Won Suh, Sungho Maen. Woohwangcheongsimwon Prevents High-Fat Diet-Induced Memory Deficits and Induces SIRT1 in Mice. Journal of medicinal food. vol 21. issue 2. 2018-08-15. PMID:29319388. |
the herbal treatment also increased the expression of sirt1 and pgc-1α in the hippocampus. |
2018-08-15 |
2023-08-13 |
mouse |
| Hyunwoo Park, Mia Kim, Im-Joon Shin, Jonghee Park, Soo Yong Bang, Chunsik Yi, Myoung-Ae Kim, Jae-Hwan Lew, Joo Won Suh, Sungho Maen. Woohwangcheongsimwon Prevents High-Fat Diet-Induced Memory Deficits and Induces SIRT1 in Mice. Journal of medicinal food. vol 21. issue 2. 2018-08-15. PMID:29319388. |
despite the induction of hippocampal sirt1 expression by whc, resveratrol was not present among the natural compounds identified. |
2018-08-15 |
2023-08-13 |
mouse |
| Qi-Shun Zhang, Wei Liu, Guang-Xiu L. miR-200a-3p promotes b-Amyloid-induced neuronal apoptosis through down-regulation of SIRT1 in Alzheimer's disease. Journal of biosciences. vol 42. issue 3. 2018-08-10. PMID:29358553. |
an increased level of mir-200a-3p and a decreased level of sirt1 in the hippocampus of appswe/ps delta e9 mice (a model for ad) were observed. |
2018-08-10 |
2023-08-13 |
mouse |
| Xinxin Wang, Shanshan Ma, Bo Yang, Tuanjie Huang, Nan Meng, Ling Xu, Qu Xing, Yanting Zhang, Kun Zhang, Qinghua Li, Tao Zhang, Junwei Wu, Greta Luyuan Yang, Fangxia Guan, Jian Wan. Resveratrol promotes hUC-MSCs engraftment and neural repair in a mouse model of Alzheimer's disease. Behavioural brain research. vol 339. 2018-08-07. PMID:29102593. |
moreover, huc-mscs and resveratrol jointly regulate expression of hippocampal sirt1, pcna, p53, ac-p53, p21, and p16. |
2018-08-07 |
2023-08-13 |
mouse |
| P Ding, D Ren, S He, M He, G Zhang, Y Chen, H Sang, Z Peng, W Ya. Sirt1 mediates improvement in cognitive defects induced by focal cerebral ischemia following hyperbaric oxygen preconditioning in rats. Physiological research. vol 66. issue 6. 2018-08-06. PMID:28937253. |
cognitive function and expression of phosphorylated neurofilament heavy polypeptide (pnf-h) and doublecortin (dcx) in the hippocampus were evaluated 14 days after reperfusion and after short interfering rna-mediated knockdown of sirtuin1 (sirt1). |
2018-08-06 |
2023-08-13 |
rat |
| Xiao-Yan Zhang, Xian-Jun Zhang, Jin Xv, Wei Jia, Xiao-Yan Pu, Hai-Yan Wang, Hong Liang, Zhuoma-Lamao, Dian-Xiang L. Crocin attenuates acute hypobaric hypoxia-induced cognitive deficits of rats. European journal of pharmacology. vol 818. 2018-08-06. PMID:29106903. |
crocin attenuates acute hypobaric hypoxia-induced cognitive deficits in rats, accompanied by repairing the structures of hippocampal neurons and improving pgc-1α and sirt1 levels. |
2018-08-06 |
2023-08-13 |
rat |
| Zhiping Hou, Peiyuan He, Mustapha Umar Imam, Jiemen Qi, Shiying Tang, Chengjun Song, Maznah Ismai. Edible Bird's Nest Prevents Menopause-Related Memory and Cognitive Decline in Rats via Increased Hippocampal Sirtuin-1 Expression. Oxidative medicine and cellular longevity. vol 2017. 2018-07-19. PMID:29104731. |
sirtuin-1 (sirt1) downregulation in the hippocampus is implicated in the underlying molecular mechanism. |
2018-07-19 |
2023-08-13 |
rat |
| Zhiping Hou, Peiyuan He, Mustapha Umar Imam, Jiemen Qi, Shiying Tang, Chengjun Song, Maznah Ismai. Edible Bird's Nest Prevents Menopause-Related Memory and Cognitive Decline in Rats via Increased Hippocampal Sirtuin-1 Expression. Oxidative medicine and cellular longevity. vol 2017. 2018-07-19. PMID:29104731. |
edible bird's nest (ebn) is traditionally used to improve general wellbeing, and in this study, we evaluated its effects on sirt1 expression in the hippocampus and implications on ovariectomy-induced memory and cognitive decline in rats. |
2018-07-19 |
2023-08-13 |
rat |
| Zhiping Hou, Peiyuan He, Mustapha Umar Imam, Jiemen Qi, Shiying Tang, Chengjun Song, Maznah Ismai. Edible Bird's Nest Prevents Menopause-Related Memory and Cognitive Decline in Rats via Increased Hippocampal Sirtuin-1 Expression. Oxidative medicine and cellular longevity. vol 2017. 2018-07-19. PMID:29104731. |
after 12 weeks of intervention, morris water maze (four-day trial and one probe trial) was conducted, and serum estrogen levels, toxicity markers (alanine transaminase, alkaline phosphatase, urea, and creatinine), and hippocampal sirt1 immunohistochemistry were estimated after sacrifice. |
2018-07-19 |
2023-08-13 |
rat |
| Zhiping Hou, Peiyuan He, Mustapha Umar Imam, Jiemen Qi, Shiying Tang, Chengjun Song, Maznah Ismai. Edible Bird's Nest Prevents Menopause-Related Memory and Cognitive Decline in Rats via Increased Hippocampal Sirtuin-1 Expression. Oxidative medicine and cellular longevity. vol 2017. 2018-07-19. PMID:29104731. |
the results indicated that ebn and estrogen enhanced spatial learning and memory and increased serum estrogen and hippocampal sirt1 expression. |
2018-07-19 |
2023-08-13 |
rat |