| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hiroki Okauchi, Sayaka Higo-Yamamoto, Takumi Sowa, Hideaki Oike, Saori Yamamoto, Naoyuki Wada, Katsuhiko Sakamoto, Katsutaka Oish. Chronically skipping breakfast impairs hippocampal memory-related gene expression and memory function accompanied by reduced wakefulness and body temperature in mice. Biochemical and biophysical research communications. vol 524. issue 1. 2020-10-07. PMID:31980181. |
skipping breakfast significantly suppressed mrna expression of the memory-related genes, camk2a, fkbp5, gadd45b, gria1, sirt1 and tet1 in the hippocampus. |
2020-10-07 |
2023-08-13 |
mouse |
| Anorut Jenwitheesuk, Parichart Boontem, Prapimpun Wongchitrat, Jiraporn Tocharus, Sujira Mukda, Piyarat Govitrapon. Melatonin regulates the aging mouse hippocampal homeostasis via the sirtuin1-FOXO1 pathway. EXCLI journal. vol 16. 2020-09-30. PMID:28507478. |
sirtuin1 (sirt1) and forkhead box transcription factor o subfamily 1 (foxo1) play vital roles in the maintenance of hippocampal neuronal homeostasis during aging. |
2020-09-30 |
2023-08-13 |
mouse |
| Anorut Jenwitheesuk, Parichart Boontem, Prapimpun Wongchitrat, Jiraporn Tocharus, Sujira Mukda, Piyarat Govitrapon. Melatonin regulates the aging mouse hippocampal homeostasis via the sirtuin1-FOXO1 pathway. EXCLI journal. vol 16. 2020-09-30. PMID:28507478. |
the present results showed that aged mice (22 months old) exhibited significantly downregulated sirt1, foxo1, and melatonin receptors mt1 and mt2 protein expression but upregulated tumor suppressor protein 53 (p53), acetyl-p53 protein (ac-p53), mouse double minute 2 homolog (mdm2), dickkopf-1 (dkk1) protein expression in mouse hippocampus compared with the young group. |
2020-09-30 |
2023-08-13 |
mouse |
| Anorut Jenwitheesuk, Parichart Boontem, Prapimpun Wongchitrat, Jiraporn Tocharus, Sujira Mukda, Piyarat Govitrapon. Melatonin regulates the aging mouse hippocampal homeostasis via the sirtuin1-FOXO1 pathway. EXCLI journal. vol 16. 2020-09-30. PMID:28507478. |
these present results suggest that melatonin may help the hippocampal neuronal homeostasis by increasing sirt1, foxo1 and melatonin receptors expression while decreasing dkk1 expression in the aging hippocampus. |
2020-09-30 |
2023-08-13 |
mouse |
| Xi Fang, Qiang Han, Shiyong Li, Yilin Zhao, Ailin Lu. Chikusetsu saponin IVa attenuates isoflurane-induced neurotoxicity and cognitive deficits via SIRT1/ERK1/2 in developmental rats. American journal of translational research. vol 9. issue 9. 2020-09-30. PMID:28979702. |
we found that, anesthesia with 1.8% isoflurane for 6 h significantly decreased the expression of sirt1 in hippocampus. |
2020-09-30 |
2023-08-13 |
rat |
| Xi Fang, Qiang Han, Shiyong Li, Yilin Zhao, Ailin Lu. Chikusetsu saponin IVa attenuates isoflurane-induced neurotoxicity and cognitive deficits via SIRT1/ERK1/2 in developmental rats. American journal of translational research. vol 9. issue 9. 2020-09-30. PMID:28979702. |
chiv increased sirt1, p-erk1/2, psd95 level in hippocampus, decreased hippocampal neuron apoptosis and lactate dehydrogenase (ldh) release after isoflurane exposure. |
2020-09-30 |
2023-08-13 |
rat |
| Jing Yan, Ailin Luo, Jie Gao, Xiaole Tang, Yilin Zhao, Biyun Zhou, Zhiqiang Zhou, Shiyong L. The role of SIRT1 in neuroinflammation and cognitive dysfunction in aged rats after anesthesia and surgery. American journal of translational research. vol 11. issue 3. 2020-09-30. PMID:30972182. |
our findings demonstrated that the hippocampal expression of sirt1 decreased with age. |
2020-09-30 |
2023-08-13 |
rat |
| Jing Yan, Ailin Luo, Jie Gao, Xiaole Tang, Yilin Zhao, Biyun Zhou, Zhiqiang Zhou, Shiyong L. The role of SIRT1 in neuroinflammation and cognitive dysfunction in aged rats after anesthesia and surgery. American journal of translational research. vol 11. issue 3. 2020-09-30. PMID:30972182. |
furthermore, we found that decreased sirt1 was associated with downregulated expression of dna methyltransferase 1 (dnmt1) and upregulated acetylated-nuclear factor kappa b (ac-nf-κb) expression, resulting in microglial activation and increased proinflammatory cytokines in the hippocampus of aged rats. |
2020-09-30 |
2023-08-13 |
rat |
| Jing Yan, Ailin Luo, Jie Gao, Xiaole Tang, Yilin Zhao, Biyun Zhou, Zhiqiang Zhou, Shiyong L. The role of SIRT1 in neuroinflammation and cognitive dysfunction in aged rats after anesthesia and surgery. American journal of translational research. vol 11. issue 3. 2020-09-30. PMID:30972182. |
taken together, our findings suggest that anesthesia and surgery-induced inhibition of hippocampal sirt1 expression is involved in the activation of neuroinflammation and cognitive impairment in aged rats and that activating sirt1 might paved a promising path to preventing this postsurgical sequela. |
2020-09-30 |
2023-08-13 |
rat |
| Zhuangzhi Meng, Jianguo Li, Honglin Zhao, Haiying Liu, Guowei Zhang, Lingzhan Wang, H E Hu, D I Li, Mingjing Liu, Fulong Bi, Xiaoping Wang, Geng Tian, Qiang Liu, Batu Bure. Resveratrol relieves ischemia-induced oxidative stress in the hippocampus by activating SIRT1. Experimental and therapeutic medicine. vol 10. issue 2. 2020-09-29. PMID:26622348. |
resveratrol relieves ischemia-induced oxidative stress in the hippocampus by activating sirt1. |
2020-09-29 |
2023-08-13 |
rat |
| Zhuangzhi Meng, Jianguo Li, Honglin Zhao, Haiying Liu, Guowei Zhang, Lingzhan Wang, H E Hu, D I Li, Mingjing Liu, Fulong Bi, Xiaoping Wang, Geng Tian, Qiang Liu, Batu Bure. Resveratrol relieves ischemia-induced oxidative stress in the hippocampus by activating SIRT1. Experimental and therapeutic medicine. vol 10. issue 2. 2020-09-29. PMID:26622348. |
healthy adult male sprague-dawley rats were subjected to cerebral ischemia in order to study the protective effect of resveratrol on the brain following ischemia, and to investigate the effects of sirt1 activation on the hippocampus. |
2020-09-29 |
2023-08-13 |
rat |
| Jin-Xi Zuo, Min Li, Li Jiang, Fang Lan, Yi-Yun Tang, Xuan Kang, Wei Zou, Chun-Yan Wang, Ping Zhang, Xiao-Qing Tan. Hydrogen Sulfide Prevents Sleep Deprivation-Induced Hippocampal Damage by Upregulation of Sirt1 in the Hippocampus. Frontiers in neuroscience. vol 14. 2020-09-28. PMID:32218719. |
hydrogen sulfide prevents sleep deprivation-induced hippocampal damage by upregulation of sirt1 in the hippocampus. |
2020-09-28 |
2023-08-13 |
Not clear |
| Cuixia Li, Feng Wang, Pei Miao, Libo Yan, Silin Liu, Xian Wang, Zuolin Jin, Zexu G. miR-138 Increases Depressive-Like Behaviors by Targeting SIRT1 in Hippocampus. Neuropsychiatric disease and treatment. vol 16. 2020-09-28. PMID:32308399. |
mir-138 increases depressive-like behaviors by targeting sirt1 in hippocampus. |
2020-09-28 |
2023-08-13 |
Not clear |
| Lina Shi, Jing Zhang, Yan Wang, Qingfei Hao, Haoming Chen, Xiuyong Chen. Sirt1 Regulates Oxidative Stress in Oxygen-Glucose Deprived Hippocampal Neurons. Frontiers in pediatrics. vol 8. 2020-09-28. PMID:32923413. |
sirt1 regulates oxidative stress in oxygen-glucose deprived hippocampal neurons. |
2020-09-28 |
2023-08-13 |
Not clear |
| Sabrina Salberg, Himanthri Weerwardhena, Reid Collins, Raylene A Reimer, Richelle Mychasiu. The behavioural and pathophysiological effects of the ketogenic diet on mild traumatic brain injury in adolescent rats. Behavioural brain research. vol 376. 2020-09-22. PMID:31518660. |
the timing of kd administration also differentially modified expression of prefrontal cortex, hippocampus, and intestinal mrna for our genes of interest (fgf2, iba1, opa1, sirt1, claudin3, occ, and zo1) this study demonstrates the neuroprotective and therapeutic potential of the kd for mtbi and warrants further investigation. |
2020-09-22 |
2023-08-13 |
rat |
| Minmin Yao, Zhimeng Zhao, Lan Wei, Di Zhou, Zhanggang Xue, Shengjin G. HSF1/HSP pathway in the hippocampus is involved in SIRT1-mediated caloric restriction-induced neuroprotection after surgery in aged mice. Experimental gerontology. vol 119. 2020-07-15. PMID:30772489. |
cr increased hsp70 expression through the hsf1/hsp pathway in a sirt1-mediated manner, and inhibition of sirt1 in the hippocampus by lentivirus injection partially reduced the benefits of cr (increased hsp70, deacetylated hsf1, reduced er-stress, and improved memory). |
2020-07-15 |
2023-08-13 |
mouse |
| Weiming Li, Baolin Guo, Kai Tao, Fei Li, Zhenru Liu, Han Yao, Dayun Feng, Xufeng Li. Inhibition of SIRT1 in hippocampal CA1 ameliorates PTSD-like behaviors in mice by protections of neuronal plasticity and serotonin homeostasis via NHLH2/MAO-A pathway. Biochemical and biophysical research communications. vol 518. issue 2. 2020-06-15. PMID:31421827. |
hippocampal sirt1 dysfunction and gene variation have previously been found potentially involved in depressive and anxiety disorders. |
2020-06-15 |
2023-08-13 |
mouse |
| Weiming Li, Baolin Guo, Kai Tao, Fei Li, Zhenru Liu, Han Yao, Dayun Feng, Xufeng Li. Inhibition of SIRT1 in hippocampal CA1 ameliorates PTSD-like behaviors in mice by protections of neuronal plasticity and serotonin homeostasis via NHLH2/MAO-A pathway. Biochemical and biophysical research communications. vol 518. issue 2. 2020-06-15. PMID:31421827. |
moreover, the expression of sirt1 in the ventral ca1 (vca1) region of hippocampus showed no significant changes following sps induction, but the activity of sirt1 enzyme was significantly increased post-sps. |
2020-06-15 |
2023-08-13 |
mouse |
| Ning Jiang, Jingwei Lv, Haixia Wang, Hong Huang, Qiong Wang, Cong Lu, Guirong Zeng, Xin-Min Li. Ginsenoside Rg1 ameliorates chronic social defeat stress-induced depressive-like behaviors and hippocampal neuroinflammation. Life sciences. vol 252. 2020-06-01. PMID:32298740. |
meanwhile, rg1 regulated sirt1 and decreased the levels of acetylated p65 (ac-p65) in the hippocampus. |
2020-06-01 |
2023-08-13 |
mouse |
| Ning Jiang, Jingwei Lv, Haixia Wang, Hong Huang, Qiong Wang, Cong Lu, Guirong Zeng, Xin-Min Li. Ginsenoside Rg1 ameliorates chronic social defeat stress-induced depressive-like behaviors and hippocampal neuroinflammation. Life sciences. vol 252. 2020-06-01. PMID:32298740. |
in conclusion, our findings suggest that rg1 prevents depressive-like behavior in csds-exposed mice, partially through the downregulation of hippocampal neuroinflammation and the upregulation of adult hippocampal neurogenesis and that these changes presumably occur through increased anti-inflammatory effects and the inhibition of proinflammatory cytokine and neurotoxic mediator expression and microglial activation, which is partly mediated by the regulation of the mapk and sirt1 signaling pathways and results in the inhibition of nf-κb transcriptional activity. |
2020-06-01 |
2023-08-13 |
mouse |