| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Asmaa A Gomaa, Hanan S El-Abhar, Dalaal M Abdallah, Azza S Awad, Ayman A Soub. Prasugrel anti-ischemic effect in rats: Modulation of hippocampal SUMO2/3-IкBα/Ubc9 and SIRT-1/miR-22 trajectories. Toxicology and applied pharmacology. vol 426. 2021-08-06. PMID:34174262. |
additionally, camp/pka axis increased the hippocampal content of deacetylator silent information regulator 1 (sirt1) and the micro rna (mir)-22 gene expression. |
2021-08-06 |
2023-08-13 |
rat |
| Ruike Wang, Zuntao Wu, Lin Bai, Rundong Liu, Yue Ba, Huizhen Zhang, Xuemin Cheng, Guoyu Zhou, Hui Huan. Resveratrol improved hippocampal neurogenesis following lead exposure in rats through activation of SIRT1 signaling. Environmental toxicology. vol 36. issue 8. 2021-07-05. PMID:33978298. |
resveratrol improved hippocampal neurogenesis following lead exposure in rats through activation of sirt1 signaling. |
2021-07-05 |
2023-08-13 |
rat |
| Min Kyung Song, Joo Hee Lee, Youn-Jung Ki. Effect of chronic handling and social isolation on emotion and cognition in adolescent rats. Physiology & behavior. vol 237. 2021-06-25. PMID:33940083. |
the social isolation group, in contrast, showed a significant increase in immobility times in the forced swim test and in glucocorticoid and sirt1 expression in the hippocampus, as well as a significant reduction in mobility in the open field test and in escape latency times in the passive avoidance test, compared to the control group (p < 0.05). |
2021-06-25 |
2023-08-13 |
rat |
| Yue Tong, Huiling Fu, Changbo Xia, Wen Song, Yuanjie Li, Jianjun Zhao, Xia Zhang, Xiaojuan Gao, Jingjiao Yong, Quanxia Liu, Caiyan Yang, Hanqing Wan. Astragalin Exerted Antidepressant-like Action through SIRT1 Signaling Modulated NLRP3 Inflammasome Deactivation. ACS chemical neuroscience. vol 11. issue 10. 2021-06-18. PMID:32364698. |
our results showed that ast significantly improved the behavioral defects in chronic unpredictable mild stress (cums) model, promoted sirt1 expression, and decreased the protein levels of nf-κb p65, nlrp3, cleaved capase-1, cleaved il-1β and cleaved gasdermin d in the hippocampus. |
2021-06-18 |
2023-08-13 |
Not clear |
| Keyu Huang, Chunqing Yang, Jian Zheng, Xiaobai Liu, Jie Liu, Dongfang Che, Yixue Xue, Ping An, Di Wang, Xuelei Ruan, Bo Y. Effect of circular RNA, mmu_circ_0000296, on neuronal apoptosis in chronic cerebral ischaemia via the miR-194-5p/Runx3/Sirt1 axis. Cell death discovery. vol 7. issue 1. 2021-06-16. PMID:34052838. |
here, we found that ht22 cells and hippocampus treated with cci had low expression of circ_0000296, runx3, sirt1, but high expression of mir-194-5p. |
2021-06-16 |
2023-08-13 |
Not clear |
| Margarita R Ramis, Fiorella Sarubbo, David Moranta, Silvia Tejada, Jerònia Lladó, Antoni Miralles, Susana Esteba. Neurochemical and Cognitive Beneficial Effects of Moderate Physical Activity and Catechin in Aged Rats. Antioxidants (Basel, Switzerland). vol 10. issue 4. 2021-05-18. PMID:33921628. |
the results show that physical activity by itself improved age-related memory and learning deficits, correlating with the restoration of brain monoaminergic neurotransmitters and sirt1 protein levels in the hippocampus. |
2021-05-18 |
2023-08-13 |
rat |
| Chun-Mei Duan, Jian-Rong Zhang, Teng-Fei Wan, Yue Wang, Hui-Sheng Chen, Liang Li. SRT2104 attenuates chronic unpredictable mild stress-induced depressive-like behaviors and imbalance between microglial M1 and M2 phenotypes in the mice. Behavioural brain research. vol 378. 2021-04-29. PMID:31618623. |
here, we intended to investigate whether activation of sirt1 in hippocampus has antidepressant potential in relation to microglial phenotypic switch. |
2021-04-29 |
2023-08-13 |
mouse |
| Chun-Mei Duan, Jian-Rong Zhang, Teng-Fei Wan, Yue Wang, Hui-Sheng Chen, Liang Li. SRT2104 attenuates chronic unpredictable mild stress-induced depressive-like behaviors and imbalance between microglial M1 and M2 phenotypes in the mice. Behavioural brain research. vol 378. 2021-04-29. PMID:31618623. |
we found that activation of sirt1 in hippocampus ameliorate cums-induced depressive-like behaviors, as indicated by sucrose preference test, tail suspension test and forced swim test. |
2021-04-29 |
2023-08-13 |
mouse |
| Chun-Mei Duan, Jian-Rong Zhang, Teng-Fei Wan, Yue Wang, Hui-Sheng Chen, Liang Li. SRT2104 attenuates chronic unpredictable mild stress-induced depressive-like behaviors and imbalance between microglial M1 and M2 phenotypes in the mice. Behavioural brain research. vol 378. 2021-04-29. PMID:31618623. |
in addition, srt2104 treatment ameliorated cums-induced sirt1 decreased expression in the hippocampus coincides with the up-regulation phosphorylation levels of gsk3β and pten. |
2021-04-29 |
2023-08-13 |
mouse |
| Ayşegul Kapucu, Gülay Üzüm, Zülal Kaptan, Kadriye Akgün-Da. Effects of erythropoietin pretreatment on single dose pentylentetrazole-induced seizures in rats. Biotechnic & histochemistry : official publication of the Biological Stain Commission. vol 95. issue 6. 2021-04-07. PMID:32003592. |
bdnf, trkb and sirt1 levels were measured in serum, hippocampus and cortex. |
2021-04-07 |
2023-08-13 |
rat |
| Archita Khanna, Anamika, Suwarna Chakraborty, Sunil Jamuna Tripathi, Arup Acharjee, Shankaranarayana Rao Bs, Surendra K Trigu. SIRT1 activation by resveratrol reverses atrophy of apical dendrites of hippocampal CA1 pyramidal neurons and neurobehavioral impairments in moderate grade hepatic encephalopathy rats. Journal of chemical neuroanatomy. vol 106. 2021-04-06. PMID:32334029. |
the present study compared the profile of relevant neurobehavioral pattern vs neuromorphometry of hippocampal ca1 neurons and sirt1 activity in the hippocampus of the chronic liver failure (clf) model of moderate grade he (mohe) rats induced by administration of 100 mg/kg body weight of thioacetamide i.p. |
2021-04-06 |
2023-08-13 |
rat |
| Archita Khanna, Anamika, Suwarna Chakraborty, Sunil Jamuna Tripathi, Arup Acharjee, Shankaranarayana Rao Bs, Surendra K Trigu. SIRT1 activation by resveratrol reverses atrophy of apical dendrites of hippocampal CA1 pyramidal neurons and neurobehavioral impairments in moderate grade hepatic encephalopathy rats. Journal of chemical neuroanatomy. vol 106. 2021-04-06. PMID:32334029. |
concordantly, mohe associated declined sirt1 activity in the hippocampus could be normalized back due to rsv treatment to those mohe rats. |
2021-04-06 |
2023-08-13 |
rat |
| Irene Puig-Parnau, Soleil Garcia-Brito, Nastaran Faghihi, Carme Gubern, Laura Aldavert-Vera, Pilar Segura-Torres, Gemma Huguet, Elisabet Kádá. Intracranial Self-Stimulation Modulates Levels of SIRT1 Protein and Neural Plasticity-Related microRNAs. Molecular neurobiology. vol 57. issue 6. 2021-03-19. PMID:32219698. |
thus, we aimed to analyze the effects of mfb-icss on mirnas expression and sirt1 protein levels in hippocampal subfields and serum. |
2021-03-19 |
2023-08-13 |
rat |
| Irene Puig-Parnau, Soleil Garcia-Brito, Nastaran Faghihi, Carme Gubern, Laura Aldavert-Vera, Pilar Segura-Torres, Gemma Huguet, Elisabet Kádá. Intracranial Self-Stimulation Modulates Levels of SIRT1 Protein and Neural Plasticity-Related microRNAs. Molecular neurobiology. vol 57. issue 6. 2021-03-19. PMID:32219698. |
this work shows for the first time that a dbs procedure, specifically mfb-icss, modulates the levels of plasticity-related mirnas and sirt1 in specific hippocampal subfields. |
2021-03-19 |
2023-08-13 |
rat |
| Mei-Hsin Hsu, Jiunn-Ming Sheen, I-Chun Lin, Hong-Ren Yu, Mao-Meng Tiao, You-Lin Tain, Li-Tung Huan. Effects of Maternal Resveratrol on Maternal High-Fat Diet/Obesity with or without Postnatal High-Fat Diet. International journal of molecular sciences. vol 21. issue 10. 2021-02-22. PMID:32408716. |
maternal hfd/obesity decreased adiponectin, phosphorylation alpha serine/threonine-protein kinase (pakt), sirtuin 1 (sirt1), and brain-derived neurotrophic factor (bdnf) in rat placenta, male fetal brain, and adult male offspring dorsal hippocampus. |
2021-02-22 |
2023-08-13 |
rat |
| Ayong Tian, Wan Li, Qing Zai, Hui Li, Rong-Wei Zhan. 3‑N‑Butyphthalide improves learning and memory in rats with vascular cognitive impairment by activating the SIRT1/BDNF pathway. Molecular medicine reports. vol 22. issue 1. 2021-02-16. PMID:32377741. |
molecular examination indicated that sirt1 and bdnf expression levels in the hippocampus were increased by nbp treatment. |
2021-02-16 |
2023-08-13 |
rat |
| Teresa Diaz-Perdigon, Francisco B Belloch, Ana Ricobaraza, Elghareeb E Elboray, Takayoshi Suzuki, Rosa M Tordera, Elena Puert. Early sirtuin 2 inhibition prevents age-related cognitive decline in a senescence-accelerated mouse model. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 2. 2020-12-28. PMID:31471557. |
samp8 showed hyperphosphorylation of tau protein and decrease levels of sirt1 in the hippocampus, which were not altered by 33i treatment. |
2020-12-28 |
2023-08-13 |
mouse |
| Margarita R Ramis, Fiorella Sarubbo, Silvia Tejada, Manuel Jiménez, Susana Esteban, Antoni Miralles, David Morant. Chronic Polyphenon-60 or Catechin Treatments Increase Brain Monoamines Syntheses and Hippocampal SIRT1 Levels Improving Cognition in Aged Rats. Nutrients. vol 12. issue 2. 2020-11-27. PMID:31991916. |
chronic polyphenon-60 or catechin treatments increase brain monoamines syntheses and hippocampal sirt1 levels improving cognition in aged rats. |
2020-11-27 |
2023-08-13 |
rat |
| Margarita R Ramis, Fiorella Sarubbo, Silvia Tejada, Manuel Jiménez, Susana Esteban, Antoni Miralles, David Morant. Chronic Polyphenon-60 or Catechin Treatments Increase Brain Monoamines Syntheses and Hippocampal SIRT1 Levels Improving Cognition in Aged Rats. Nutrients. vol 12. issue 2. 2020-11-27. PMID:31991916. |
both polyphenolic treatments also reverted the age-associated reduction of the neuroinflammation by modulating protein sirtuin 1 (sirt1) expression in hippocampus, but no effects were observed in the usual reduction of the histone-binding protein rbap46/48 protein linked to aging. |
2020-11-27 |
2023-08-13 |
rat |
| Xiaole Tang, Yilin Zhao, Zhiqiang Zhou, Jing Yan, Biyun Zhou, Xiaohui Chi, Ailin Luo, Shiyong L. Resveratrol Mitigates Sevoflurane-Induced Neurotoxicity by the SIRT1-Dependent Regulation of BDNF Expression in Developing Mice. Oxidative medicine and cellular longevity. vol 2020. 2020-10-19. PMID:32148659. |
pretreatment of neonatal mice with resveratrol nearly reversed the reduction in hippocampal sirt1 expression, which increased the expression of bdnf in developing mice exposed to sevoflurane. |
2020-10-19 |
2023-08-13 |
mouse |