| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Juan He, Zhuo Chen, Xuan Kang, Lin Wu, Jia-Mei Jiang, Su-Mei Liu, Hai-Jun Wei, Yong-Jun Chen, Wei Zou, Chun-Yan Wang, Ping Zhan. SIRT1 Mediates H Neurochemical research. vol 46. issue 3. 2021-09-07. PMID:33534060. |
sirt1 mediates h diabetes-associated cognitive dysfunction (dacd) characterized by hippocampal injury increases the risk of major cerebrovascular events and death. |
2021-09-07 |
2023-08-13 |
Not clear |
| Rundong Liu, Yawei Wang, Lin Bai, Ruike Wang, Yingying Wu, Mengchen Liu, Qiong Li, Yue Ba, Huizhen Zhang, Guoyu Zhou, Xuemin Cheng, Hui Huan. Time-course miRNA alterations and SIRT1 inhibition triggered by adolescent lead exposure in mice. Toxicology research. vol 10. issue 4. 2021-09-07. PMID:34484659. |
in this study, we found that the protein level of sirt1 was inhibited in the hippocampus and cortex of 16-month-old aged mice exposed to pb. |
2021-09-07 |
2023-08-13 |
mouse |
| Jing Yan, Ailin Luo, Rao Sun, Xiaole Tang, Yilin Zhao, Jie Zhang, Biyun Zhou, Hua Zheng, Honghui Yu, Shiyong L. Resveratrol Mitigates Hippocampal Tau Acetylation and Cognitive Deficit by Activation SIRT1 in Aged Rats following Anesthesia and Surgery. Oxidative medicine and cellular longevity. vol 2020. 2021-09-02. PMID:33381265. |
resveratrol mitigates hippocampal tau acetylation and cognitive deficit by activation sirt1 in aged rats following anesthesia and surgery. |
2021-09-02 |
2023-08-13 |
rat |
| Jing Yan, Ailin Luo, Rao Sun, Xiaole Tang, Yilin Zhao, Jie Zhang, Biyun Zhou, Hua Zheng, Honghui Yu, Shiyong L. Resveratrol Mitigates Hippocampal Tau Acetylation and Cognitive Deficit by Activation SIRT1 in Aged Rats following Anesthesia and Surgery. Oxidative medicine and cellular longevity. vol 2020. 2021-09-02. PMID:33381265. |
in the present study, our findings showed that tau acetylation mediated by sirt1 deficiency resulted in tau hyperphosphorylation in the hippocampus of the aged pocd model and consequently contributed to cognitive impairment. |
2021-09-02 |
2023-08-13 |
rat |
| Jing Yan, Ailin Luo, Rao Sun, Xiaole Tang, Yilin Zhao, Jie Zhang, Biyun Zhou, Hua Zheng, Honghui Yu, Shiyong L. Resveratrol Mitigates Hippocampal Tau Acetylation and Cognitive Deficit by Activation SIRT1 in Aged Rats following Anesthesia and Surgery. Oxidative medicine and cellular longevity. vol 2020. 2021-09-02. PMID:33381265. |
interestingly, pretreatment with resveratrol almost restored the expression of sirt1, reduced the levels of acetylated tau and hyperphosphorylated tau in the hippocampus, and improved the cognitive performance in the behavioral tests. |
2021-09-02 |
2023-08-13 |
rat |
| Margarita R Ramis, Fiorella Sarubbo, David Moranta, Silvia Tejada, Jerònia Lladó, Antoni Miralles, Susana Esteba. Cognitive and Neurochemical Changes Following Polyphenol-Enriched Diet in Rats. Nutrients. vol 13. issue 1. 2021-09-01. PMID:33375450. |
in addition, hippocampal sirt1 protein which has an important role in regulating normal brain function was evaluated. |
2021-09-01 |
2023-08-13 |
rat |
| Margarita R Ramis, Fiorella Sarubbo, David Moranta, Silvia Tejada, Jerònia Lladó, Antoni Miralles, Susana Esteba. Cognitive and Neurochemical Changes Following Polyphenol-Enriched Diet in Rats. Nutrients. vol 13. issue 1. 2021-09-01. PMID:33375450. |
the results show that long-term intake of polyphenol-enriched diet improves memory and learning, correlating with restoration of brain monoaminergic neurotransmitters and hippocampal sirt1 levels in aged rats. |
2021-09-01 |
2023-08-13 |
rat |
| A E Pukhalskaia, A S Dyatlova, N S Linkova, K L Kozlov, T V Kvetnaia, M V Koroleva, I M Kvetno. Sirtuins as Possible Predictors of Aging and Alzheimer's Disease Development: Verification in the Hippocampus and Saliva. Bulletin of experimental biology and medicine. vol 169. issue 6. 2021-08-23. PMID:33098511. |
we studied the expression of sirt1, sirt3, sirt5, and sirt6 in the hippocampus and saliva of humans without neurological pathologies and in patients with alzheimer's disease of elderly and senile age. |
2021-08-23 |
2023-08-13 |
Not clear |
| A E Pukhalskaia, A S Dyatlova, N S Linkova, K L Kozlov, T V Kvetnaia, M V Koroleva, I M Kvetno. Sirtuins as Possible Predictors of Aging and Alzheimer's Disease Development: Verification in the Hippocampus and Saliva. Bulletin of experimental biology and medicine. vol 169. issue 6. 2021-08-23. PMID:33098511. |
in elderly and senile patients, the expression of sirt1, sirt3, and sirt6 in the hippocampus and saliva was 1.5-4.9-fold reduced in comparison with healthy individuals of the corresponding age. |
2021-08-23 |
2023-08-13 |
Not clear |
| Asmaa A Gomaa, Hanan S El-Abhar, Dalaal M Abdallah, Azza S Awad, Ayman A Soub. Prasugrel anti-ischemic effect in rats: Modulation of hippocampal SUMO2/3-IкBα/Ubc9 and SIRT-1/miR-22 trajectories. Toxicology and applied pharmacology. vol 426. 2021-08-06. PMID:34174262. |
additionally, camp/pka axis increased the hippocampal content of deacetylator silent information regulator 1 (sirt1) and the micro rna (mir)-22 gene expression. |
2021-08-06 |
2023-08-13 |
rat |
| Ruike Wang, Zuntao Wu, Lin Bai, Rundong Liu, Yue Ba, Huizhen Zhang, Xuemin Cheng, Guoyu Zhou, Hui Huan. Resveratrol improved hippocampal neurogenesis following lead exposure in rats through activation of SIRT1 signaling. Environmental toxicology. vol 36. issue 8. 2021-07-05. PMID:33978298. |
resveratrol improved hippocampal neurogenesis following lead exposure in rats through activation of sirt1 signaling. |
2021-07-05 |
2023-08-13 |
rat |
| Min Kyung Song, Joo Hee Lee, Youn-Jung Ki. Effect of chronic handling and social isolation on emotion and cognition in adolescent rats. Physiology & behavior. vol 237. 2021-06-25. PMID:33940083. |
the social isolation group, in contrast, showed a significant increase in immobility times in the forced swim test and in glucocorticoid and sirt1 expression in the hippocampus, as well as a significant reduction in mobility in the open field test and in escape latency times in the passive avoidance test, compared to the control group (p < 0.05). |
2021-06-25 |
2023-08-13 |
rat |
| Yue Tong, Huiling Fu, Changbo Xia, Wen Song, Yuanjie Li, Jianjun Zhao, Xia Zhang, Xiaojuan Gao, Jingjiao Yong, Quanxia Liu, Caiyan Yang, Hanqing Wan. Astragalin Exerted Antidepressant-like Action through SIRT1 Signaling Modulated NLRP3 Inflammasome Deactivation. ACS chemical neuroscience. vol 11. issue 10. 2021-06-18. PMID:32364698. |
our results showed that ast significantly improved the behavioral defects in chronic unpredictable mild stress (cums) model, promoted sirt1 expression, and decreased the protein levels of nf-κb p65, nlrp3, cleaved capase-1, cleaved il-1β and cleaved gasdermin d in the hippocampus. |
2021-06-18 |
2023-08-13 |
Not clear |
| Keyu Huang, Chunqing Yang, Jian Zheng, Xiaobai Liu, Jie Liu, Dongfang Che, Yixue Xue, Ping An, Di Wang, Xuelei Ruan, Bo Y. Effect of circular RNA, mmu_circ_0000296, on neuronal apoptosis in chronic cerebral ischaemia via the miR-194-5p/Runx3/Sirt1 axis. Cell death discovery. vol 7. issue 1. 2021-06-16. PMID:34052838. |
here, we found that ht22 cells and hippocampus treated with cci had low expression of circ_0000296, runx3, sirt1, but high expression of mir-194-5p. |
2021-06-16 |
2023-08-13 |
Not clear |
| Margarita R Ramis, Fiorella Sarubbo, David Moranta, Silvia Tejada, Jerònia Lladó, Antoni Miralles, Susana Esteba. Neurochemical and Cognitive Beneficial Effects of Moderate Physical Activity and Catechin in Aged Rats. Antioxidants (Basel, Switzerland). vol 10. issue 4. 2021-05-18. PMID:33921628. |
the results show that physical activity by itself improved age-related memory and learning deficits, correlating with the restoration of brain monoaminergic neurotransmitters and sirt1 protein levels in the hippocampus. |
2021-05-18 |
2023-08-13 |
rat |
| Chun-Mei Duan, Jian-Rong Zhang, Teng-Fei Wan, Yue Wang, Hui-Sheng Chen, Liang Li. SRT2104 attenuates chronic unpredictable mild stress-induced depressive-like behaviors and imbalance between microglial M1 and M2 phenotypes in the mice. Behavioural brain research. vol 378. 2021-04-29. PMID:31618623. |
here, we intended to investigate whether activation of sirt1 in hippocampus has antidepressant potential in relation to microglial phenotypic switch. |
2021-04-29 |
2023-08-13 |
mouse |
| Chun-Mei Duan, Jian-Rong Zhang, Teng-Fei Wan, Yue Wang, Hui-Sheng Chen, Liang Li. SRT2104 attenuates chronic unpredictable mild stress-induced depressive-like behaviors and imbalance between microglial M1 and M2 phenotypes in the mice. Behavioural brain research. vol 378. 2021-04-29. PMID:31618623. |
we found that activation of sirt1 in hippocampus ameliorate cums-induced depressive-like behaviors, as indicated by sucrose preference test, tail suspension test and forced swim test. |
2021-04-29 |
2023-08-13 |
mouse |
| Chun-Mei Duan, Jian-Rong Zhang, Teng-Fei Wan, Yue Wang, Hui-Sheng Chen, Liang Li. SRT2104 attenuates chronic unpredictable mild stress-induced depressive-like behaviors and imbalance between microglial M1 and M2 phenotypes in the mice. Behavioural brain research. vol 378. 2021-04-29. PMID:31618623. |
in addition, srt2104 treatment ameliorated cums-induced sirt1 decreased expression in the hippocampus coincides with the up-regulation phosphorylation levels of gsk3β and pten. |
2021-04-29 |
2023-08-13 |
mouse |
| Ayşegul Kapucu, Gülay Üzüm, Zülal Kaptan, Kadriye Akgün-Da. Effects of erythropoietin pretreatment on single dose pentylentetrazole-induced seizures in rats. Biotechnic & histochemistry : official publication of the Biological Stain Commission. vol 95. issue 6. 2021-04-07. PMID:32003592. |
bdnf, trkb and sirt1 levels were measured in serum, hippocampus and cortex. |
2021-04-07 |
2023-08-13 |
rat |
| Archita Khanna, Anamika, Suwarna Chakraborty, Sunil Jamuna Tripathi, Arup Acharjee, Shankaranarayana Rao Bs, Surendra K Trigu. SIRT1 activation by resveratrol reverses atrophy of apical dendrites of hippocampal CA1 pyramidal neurons and neurobehavioral impairments in moderate grade hepatic encephalopathy rats. Journal of chemical neuroanatomy. vol 106. 2021-04-06. PMID:32334029. |
the present study compared the profile of relevant neurobehavioral pattern vs neuromorphometry of hippocampal ca1 neurons and sirt1 activity in the hippocampus of the chronic liver failure (clf) model of moderate grade he (mohe) rats induced by administration of 100 mg/kg body weight of thioacetamide i.p. |
2021-04-06 |
2023-08-13 |
rat |