| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marianne Basta, Samar R Saleh, Rania G Aly, Abeer E Die. Resveratrol ameliorates the behavioural and molecular changes in rats exposed to uninephrectomy: role of hippocampal SIRT1, BDNF and AChE. Journal of physiology and biochemistry. 2022-12-05. PMID:36469209. |
decreased sirt1 in immune-stained sections, oxidative stress, inflammatory changes, and increased ache activity in hippocampal homogenates were found in unix rats, and resveratrol once more was capable to reverse such pathological changes. |
2022-12-05 |
2023-08-14 |
rat |
| Kumar Surya, Nivethitha Manickam, Kesavan Swaminathan Jayachandran, Mahesh Kandasamy, Muthuswamy Anusuyadev. Resveratrol Mediated Regulation of Hippocampal Neuroregenerative Plasticity via SIRT1 Pathway in Synergy with Wnt Signaling: Neurotherapeutic Implications to Mitigate Memory Loss in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2022-12-04. PMID:36463442. |
resveratrol mediated regulation of hippocampal neuroregenerative plasticity via sirt1 pathway in synergy with wnt signaling: neurotherapeutic implications to mitigate memory loss in alzheimer's disease. |
2022-12-04 |
2023-08-14 |
Not clear |
| Kumar Surya, Nivethitha Manickam, Kesavan Swaminathan Jayachandran, Mahesh Kandasamy, Muthuswamy Anusuyadev. Resveratrol Mediated Regulation of Hippocampal Neuroregenerative Plasticity via SIRT1 Pathway in Synergy with Wnt Signaling: Neurotherapeutic Implications to Mitigate Memory Loss in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2022-12-04. PMID:36463442. |
resveratrol (rsv) is a potent sirtuin1 (sirt1) enhancer that facilitates neuroprotection and promotes neurogenesis in the hippocampus of the adult brain. |
2022-12-04 |
2023-08-14 |
Not clear |
| Kumar Surya, Nivethitha Manickam, Kesavan Swaminathan Jayachandran, Mahesh Kandasamy, Muthuswamy Anusuyadev. Resveratrol Mediated Regulation of Hippocampal Neuroregenerative Plasticity via SIRT1 Pathway in Synergy with Wnt Signaling: Neurotherapeutic Implications to Mitigate Memory Loss in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2022-12-04. PMID:36463442. |
however, the possible therapeutic roles of rsv-mediated sirt1 enhancement on the regulation of hippocampal neurogenesis and reversal of memory loss through the wnt signaling pathway have not been addressed yet. |
2022-12-04 |
2023-08-14 |
Not clear |
| Kumar Surya, Nivethitha Manickam, Kesavan Swaminathan Jayachandran, Mahesh Kandasamy, Muthuswamy Anusuyadev. Resveratrol Mediated Regulation of Hippocampal Neuroregenerative Plasticity via SIRT1 Pathway in Synergy with Wnt Signaling: Neurotherapeutic Implications to Mitigate Memory Loss in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2022-12-04. PMID:36463442. |
taken together, this review describes rsv-mediated effects on the regulation of hippocampal neurogenesis via the activation of sirt1 in synergy with the wnt signaling. |
2022-12-04 |
2023-08-14 |
Not clear |
| Yang Deng, Junqing Zou, Ye Hong, Qiang Peng, Xinxin Fu, Rui Duan, Jie Chen, Xiangliang Che. Higher Circulating Trimethylamine N-Oxide Aggravates Cognitive Impairment Probably via Downregulating Hippocampal SIRT1 in Vascular Dementia Rats. Cells. vol 11. issue 22. 2022-11-26. PMID:36429082. |
higher circulating trimethylamine n-oxide aggravates cognitive impairment probably via downregulating hippocampal sirt1 in vascular dementia rats. |
2022-11-26 |
2023-08-14 |
rat |
| Yang Deng, Junqing Zou, Ye Hong, Qiang Peng, Xinxin Fu, Rui Duan, Jie Chen, Xiangliang Che. Higher Circulating Trimethylamine N-Oxide Aggravates Cognitive Impairment Probably via Downregulating Hippocampal SIRT1 in Vascular Dementia Rats. Cells. vol 11. issue 22. 2022-11-26. PMID:36429082. |
moreover, tmao treatment activated the nlrp3 inflammasome and decreased sirt1 protein expression within the hippocampus. |
2022-11-26 |
2023-08-14 |
rat |
| Jun Zhang, Yang Liu, Hejian Li, Yanhui Hu, Shuchun Yu, Qin Liu, Yong Che. Stellate Ganglion Block Improves Postoperative Cognitive Dysfunction in aged rats by SIRT1-mediated White Matter Lesion Repair. Neurochemical research. 2022-10-31. PMID:36315371. |
moreover, sgb treatment enhanced the expression of sirt1 in the hippocampus and white matter, decreased nf-κb activity in the hippocampus and white matter. |
2022-10-31 |
2023-08-14 |
rat |
| Na Zhao, Xianliang Zhang, Baixia Li, Jing Wang, Chenfei Zhang, Bo X. Treadmill Exercise Improves PINK1/Parkin-Mediated Mitophagy Activity Against Alzheimer's Disease Pathologies by Upregulated SIRT1-FOXO1/3 Axis in APP/PS1 Mice. Molecular neurobiology. 2022-10-19. PMID:36261693. |
moreover, using the sirt1 inhibitor ex527, we found that 12 weeks of treadmill exercise rescued pink1/parkin-mediated mitophagy by activating the sirt1-foxo1/3 axis in the hippocampus of app/ps1 mice. |
2022-10-19 |
2023-08-14 |
mouse |
| Jie Liu, Jingyao Huang, Zhenjiang Zhang, Rui Zhang, Qijuan Sun, Zhihao Zhang, Yongxin Liu, Baoyu M. Mesenchymal Stem Cell-Derived Exosomes Ameliorate Delayed Neurocognitive Recovery in Aged Mice by Inhibiting Hippocampus Ferroptosis via Activating SIRT1/Nrf2/HO-1 Signaling Pathway. Oxidative medicine and cellular longevity. vol 2022. 2022-10-14. PMID:36238648. |
mscs-exo inhibit hippocampus ferroptosis and increase the expression of silent information regulator 1 (sirt1), factor nuclear factor-erythroid 2-related factor 2 (nrf2), and heme oxygenase-1 (ho-1) in dncr aged mice. |
2022-10-14 |
2023-08-14 |
mouse |
| Yuanyuan Ma, Yelong Ji, Li Xu, Zheng Li, Shengjin G. Obesity aggravated hippocampal-dependent cognitive impairment after sleeve gastrectomy in C57/BL6J mice via SIRT1/CREB/BDNF pathway. Experimental brain research. 2022-09-17. PMID:36114835. |
expression of sirtuin1 (sirt1), phosphorylated camp-responsive element binding protein (p-creb), creb and brain-derived neurotrophic factor (bdnf) in the hippocampus were measured. |
2022-09-17 |
2023-08-14 |
mouse |
| Yuanyuan Ma, Yelong Ji, Li Xu, Zheng Li, Shengjin G. Obesity aggravated hippocampal-dependent cognitive impairment after sleeve gastrectomy in C57/BL6J mice via SIRT1/CREB/BDNF pathway. Experimental brain research. 2022-09-17. PMID:36114835. |
hippocampal expression of sirt1, p-creb, and bdnf in the hds group was significantly lower than that of the hdc group. |
2022-09-17 |
2023-08-14 |
mouse |
| Xi Fang, Qiang Han, Shiyong Li, Ailin Lu. Melatonin attenuates spatial learning and memory dysfunction in developing rats by suppressing isoflurane-induced endoplasmic reticulum stress via the SIRT1/Mfn2/PERK signaling pathway. Heliyon. vol 8. issue 9. 2022-09-12. PMID:36091956. |
the hippocampal tissue and serum were collected to determine the levels of sirt1, mfn2, perk, and other proteins or cytokines related to er stress, apoptosis, and neuroinflammation. |
2022-09-12 |
2023-08-14 |
rat |
| Nan Chen, Xin-Chen Wang, Ling-Ling Fan, Yu-Huang Zhu, Qi Wang, Yun-Bo Che. Berberine ameliorates lipopolysaccharide-induced cognitive impairment through Sirt1/Nrf2/NF-κB signaling pathway in C57BL/6J mice. Rejuvenation research. 2022-08-27. PMID:36029207. |
we found that berberine reduced neuronal damage in the hippocampus by nissl staining, and verified by western blot and immunofluorescence that berberine improved lps-induced cognitive impairment through the sirt1/nrf2/nf-κb signaling pathway.the results showed that berberine plays an anti-inflammatory and antioxidant role by targeting sirt1/nrf2/nfκb signaling pathway so as to reduce the cognitive impairment and neuronal damage caused by lipopolysaccharide in c57bl/6j mice.berberine pre-protection increased the expression of heme oxygenase-1 (ho-1) after activating nuclear factor e2 related factor 2 (nrf2), and inhibited the activation of nf-κb and the release of inos, which may be related to berberine activating sirt1. |
2022-08-27 |
2023-08-14 |
mouse |
| Jian Zhao, Wenqiang Li, Yue Wang, Yuanhe Jiang, Chunyan Ding, Huaibin Li, Jian Ding, Lin Wan. The effect of electroacupuncture on the expression of Sirt1 and STAT3 in hippocampus and amygdala of vascular dementia rats. Neuroreport. 2022-07-26. PMID:35882013. |
the effect of electroacupuncture on the expression of sirt1 and stat3 in hippocampus and amygdala of vascular dementia rats. |
2022-07-26 |
2023-08-14 |
rat |
| Xing-Yuan Zhao, Dong Yu, Xingjie Shi, Shiqiang Hou, Da Ten. Resveratrol reduces p38 mitogen-activated protein kinase phosphorylation by activating Sirtuin 1 to alleviate cognitive dysfunction after traumatic brain injury in mice. Neuroreport. vol 33. issue 11. 2022-07-01. PMID:35775323. |
two days after tbi, the hippocampus of mice was extracted, and western blot analysis was performed for sirtuin 1 (sirt1), synaptophysin (syp), p38 mitogen-activated protein kinase (mapk), and p-p38 mapk. |
2022-07-01 |
2023-08-14 |
mouse |
| Xing-Yuan Zhao, Dong Yu, Xingjie Shi, Shiqiang Hou, Da Ten. Resveratrol reduces p38 mitogen-activated protein kinase phosphorylation by activating Sirtuin 1 to alleviate cognitive dysfunction after traumatic brain injury in mice. Neuroreport. vol 33. issue 11. 2022-07-01. PMID:35776938. |
two days after tbi, the hippocampus of mice was extracted, and western blot analysis was performed for sirtuin 1 (sirt1), synaptophysin (syp), p38 mitogen-activated protein kinase (mapk), and p-p38 mapk. |
2022-07-01 |
2023-08-14 |
mouse |
| Zuhao Sun, Shuang Zhao, Xinjun Suo, Yan Do. Sirt1 protects against hippocampal atrophy and its induced cognitive impairment in middle-aged mice. BMC neuroscience. vol 23. issue 1. 2022-06-06. PMID:35668361. |
sirt1 protects against hippocampal atrophy and its induced cognitive impairment in middle-aged mice. |
2022-06-06 |
2023-08-14 |
mouse |
| Zuhao Sun, Shuang Zhao, Xinjun Suo, Yan Do. Sirt1 protects against hippocampal atrophy and its induced cognitive impairment in middle-aged mice. BMC neuroscience. vol 23. issue 1. 2022-06-06. PMID:35668361. |
hippocampal volume is considered to be the most sensitive brain imaging phenotype for cognition, but the effect of sirt1 on hippocampal morphology during aging has not been reported. |
2022-06-06 |
2023-08-14 |
mouse |
| Ning Jiang, Yiwen Zhang, Caihong Yao, Hong Huang, Qiong Wang, Shuangxue Huang, Qinghu He, Xinmin Li. Ginsenosides Rb1 Attenuates Chronic Social Defeat Stress-Induced Depressive Behavior Frontiers in nutrition. vol 9. 2022-05-31. PMID:35634375. |
moreover, rb1 administration considerably reduced the protein expression of nlrp3 (inflammasome) and promoted the protein expressions of nrf2, ho-1 and sirtuin1(sirt1) activation in the hippocampus. |
2022-05-31 |
2023-08-13 |
mouse |