| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sareh Kazmi, Fereshteh Farajdokht, Reza Meynaghizadeh-Zargar, Saeed Sadigh-Eteghad, Amir Pasokh, Mohammad Farzipour, Narmin Farazi, Michael R Hamblin, Javad Mahmoud. Transcranial photobiomodulation mitigates learning and memory impairments induced by hindlimb unloading in a mouse model of microgravity exposure by suppression of oxidative stress and neuroinflammation signaling pathways. Brain research. 2023-09-17. PMID:37717889. |
spatial learning and memory were assessed in the lashley iii maze and hippocampus tissue samples were collected to assess oxidative stress markers and protein expression of brain-derived neurotrophic factor (bdnf), nuclear factor erythroid 2-related factor 2 (nrf2), sirtuin 1 (sirt1), and nuclear factor kappa-light-chain-enhancer of activated b cells (nf-κb). |
2023-09-17 |
2023-10-07 |
mouse |
| Sahar Salemi, Mohammad Yasin Zamanian, Lydia Giménez-Llort, Zahra Jalali, Mehdi Mahmoodi, Maryam Golmohammadi, Ayat Kaeidi, Zahra Taghipour, Morteza Khademalhosseini, Mona Modanloo, Mohammad Reza Hajizadeh. Distinct signatures on d-galactose-induced aging and preventive/protective potency of two low-dose vitamin D supplementation regimens on working memory, muscular damage, cardiac and cerebral oxidative stress, and SIRT1 and calstabin2 downregulation. Food science & nutrition. vol 11. issue 9. 2023-09-13. PMID:37701236. |
d-gal-induced notorious alterations in working memory, a strong increase in brain malondialdehyde (mda) oxidative levels, and strong downregulation of sirtuin 1 (sirt1) in the heart and hippocampus and of calstabin2 in the heart. |
2023-09-13 |
2023-10-07 |
Not clear |
| Hyejin Kwon, Eun-Hwa Lee, So-Young Park, Jin-Young Park, Jin-Hwan Hong, Eun-Kyung Kim, Tae-Seop Shin, Yoon-Keun Kim, Pyung-Lim Ha. Lactobacillus-derived extracellular vesicles counteract Aβ42-induced abnormal transcriptional changes through the upregulation of MeCP2 and Sirt1 and improve Aβ pathology in Tg-APP/PS1 mice. Experimental & molecular medicine. 2023-09-13. PMID:37704750. |
lpc-ev treatment restores the downregulated expression of bdnf, nt4/5, trkb, mmp-2, mmp-9, and nep; induces the upregulation of mecp2 and sirt1 in the hippocampus; alleviates aβ accumulation and neuroinflammatory responses in the brain; and mitigates cognitive decline in tg-app/ps1 mice. |
2023-09-13 |
2023-10-07 |
mouse |
| Yanan Wu, Kaiyi Zhou, Baiyang Liu, Jindong Xu, Liming Lei, Jiaqi Hu, Xiao Cheng, Feng Zhong, Sheng Wan. Glial Activation, Mitochondrial Imbalance, and Akt/mTOR Signaling May Be Potential Mechanisms of Cognitive Impairment in Heart Failure Mice. Neurotoxicity research. 2023-09-05. PMID:37668877. |
in addition, the mitochondrial biogenesis genes tfam and sirt1 decreased, and the fission gene drp1 increased in the hippocampus. |
2023-09-05 |
2023-09-07 |
mouse |
| Yanping Liu, Qiang Liu, Haibi Wang, Yongkang Qiu, Jiatao Lin, Weifeng Wu, Ning Wang, Wei Dong, Jie Wan, Chen Chen, Shuai Li, Hui Zheng, Yuqing W. Hippocampal synaptic plasticity injury mediated by SIRT1 downregulation is involved in chronic pain-related cognitive dysfunction. CNS neuroscience & therapeutics. 2023-08-18. PMID:37592394. |
hippocampal synaptic plasticity injury mediated by sirt1 downregulation is involved in chronic pain-related cognitive dysfunction. |
2023-08-18 |
2023-09-07 |
Not clear |
| Bentolhoda Shafiei, Ali Afgar, Mohammad Hadi Nematollahi, Mohammad Shabani, Mahdieh Nazari-Robat. Effect of trehalose on miR-132 and SIRT1 in the hippocampus of aged rats. Neuroscience letters. 2023-08-07. PMID:37549864. |
effect of trehalose on mir-132 and sirt1 in the hippocampus of aged rats. |
2023-08-07 |
2023-08-14 |
rat |
| Bentolhoda Shafiei, Ali Afgar, Mohammad Hadi Nematollahi, Mohammad Shabani, Mahdieh Nazari-Robat. Effect of trehalose on miR-132 and SIRT1 in the hippocampus of aged rats. Neuroscience letters. 2023-08-07. PMID:37549864. |
however, little is known about the interactive effects of aging and trehalose on the expression pattern of mir-132 and sirt1 in the hippocampus. |
2023-08-07 |
2023-08-14 |
rat |
| Bentolhoda Shafiei, Ali Afgar, Mohammad Hadi Nematollahi, Mohammad Shabani, Mahdieh Nazari-Robat. Effect of trehalose on miR-132 and SIRT1 in the hippocampus of aged rats. Neuroscience letters. 2023-08-07. PMID:37549864. |
at the end of treatment, the levels of sirt1 mrna and its protein, malondialdehyde, protein carbonyl content, total antioxidant capacity, tumor necrosis factor α (tnf-α), as well as the expression of mir-132 were measured in the hippocampus. |
2023-08-07 |
2023-08-14 |
rat |
| Bentolhoda Shafiei, Ali Afgar, Mohammad Hadi Nematollahi, Mohammad Shabani, Mahdieh Nazari-Robat. Effect of trehalose on miR-132 and SIRT1 in the hippocampus of aged rats. Neuroscience letters. 2023-08-07. PMID:37549864. |
in conclusion, our data indicated that trehalose restored antioxidant status and alleviated inflammation in the hippocampus which was probably associated with the upregulation of sirt1 and mir-132. |
2023-08-07 |
2023-08-14 |
rat |
| Xiao Qiu, Pengcheng Lu, Xinyu Zeng, Shengjie Jin, Xianghe Che. Study on the Mechanism for SIRT1 during the Process of Exercise Improving Depression. Brain sciences. vol 13. issue 5. 2023-05-27. PMID:37239191. |
silent information regulator 1 (sirt1) is a key player in regulating energy metabolism, and it can regulate depression by mediating the inflammatory response (e.g., nuclear factor-kappa b (nf-κb), tumor necrosis factor-α (tnf-α), interleukin-1β (il-1β)), gene expression in the nucleus accumben (nac) and ca1 region of the hippocampus (e.g., nescient helix-loop-helix2 (nhlh2), monoamine oxidase (mao-a), and 5-hydroxyindole-3-acetic acid (5-hiaa)), and neuronal regeneration in the ca3 region of the hippocampus. |
2023-05-27 |
2023-08-14 |
Not clear |
| Hui-Ru Li, Qiang Liu, Cheng-Long Zhu, Xiao-Yang Sun, Chen-Yan Sun, Chang-Meng Yu, Peng Li, Xiao-Ming Deng, Jia-Feng Wan. β-Nicotinamide mononucleotide activates NAD+/SIRT1 pathway and attenuates inflammatory and oxidative responses in the hippocampus regions of septic mice. Redox biology. vol 63. 2023-05-18. PMID:37201414. |
sirtuin 1 (sirt1) has been reported to be downregulated in the hippocampus and sirt1 agonists can attenuated the cognitive dysfunction in septic mice. |
2023-05-18 |
2023-08-14 |
mouse |
| Hui-Ru Li, Qiang Liu, Cheng-Long Zhu, Xiao-Yang Sun, Chen-Yan Sun, Chang-Meng Yu, Peng Li, Xiao-Ming Deng, Jia-Feng Wan. β-Nicotinamide mononucleotide activates NAD+/SIRT1 pathway and attenuates inflammatory and oxidative responses in the hippocampus regions of septic mice. Redox biology. vol 63. 2023-05-18. PMID:37201414. |
as a result, the levels of nad+, sirt1 and pgc-1α were significantly reduced in the hippocampus of septic mice, while the acetylation of total lysine, phosphorylation of p38 and p65 were enhanced. |
2023-05-18 |
2023-08-14 |
mouse |
| Eun Hye Jang, Soon Ae Ki. Acute valproate exposure affects proneural factor expression by increasing FOXO3 in the hippocampus of juvenile mice with a sex-based difference. Neuroscience letters. 2023-04-05. PMID:37019270. |
furthermore, vpa exposure induced significant expression changes of mitochondria-related genes, including cox4 and sirt1, in hippocampal tissues, associated with sex-based differences. |
2023-04-05 |
2023-08-14 |
mouse |
| Lan Wei, Qiang Tao, Minmin Yao, Zhimeng Zhao, Shengjin G. Caloric Restriction Can Ameliorate Postoperative Cognitive Dysfunction by Upregulating the Expression of Sirt1, MeCP2 and BDNF in the Hippocampal CA1 Region of Aged C57BL/6 Mice. Brain sciences. vol 13. issue 3. 2023-03-29. PMID:36979272. |
by using western blot and immunofluorescence, the expression of sirt1, mecp2, and bdnf in the hippocampus and hippocampal ca1 region was quantified. |
2023-03-29 |
2023-08-14 |
mouse |
| Lan Wei, Qiang Tao, Minmin Yao, Zhimeng Zhao, Shengjin G. Caloric Restriction Can Ameliorate Postoperative Cognitive Dysfunction by Upregulating the Expression of Sirt1, MeCP2 and BDNF in the Hippocampal CA1 Region of Aged C57BL/6 Mice. Brain sciences. vol 13. issue 3. 2023-03-29. PMID:36979272. |
sirt1, mecp2, and bdnf expression in the hippocampus and ca1 region in the hippocampus of the alc and crc groups of mice were correlated with cognitive improvement. |
2023-03-29 |
2023-08-14 |
mouse |
| Lan Wei, Qiang Tao, Minmin Yao, Zhimeng Zhao, Shengjin G. Caloric Restriction Can Ameliorate Postoperative Cognitive Dysfunction by Upregulating the Expression of Sirt1, MeCP2 and BDNF in the Hippocampal CA1 Region of Aged C57BL/6 Mice. Brain sciences. vol 13. issue 3. 2023-03-29. PMID:36979272. |
in conclusion, cr could enhance the postoperative cognitive function in aged mice, most likely by increasing the expression of sirt1, mecp2, and bdnf in the ca1 region of the hippocampus. |
2023-03-29 |
2023-08-14 |
mouse |
| Juan Chen, Lijun Xiao, Ying Chen, Wei Li, Yinan Liu, Ying Zhou, Hong Ta. YT521-B homology domain containing 1 ameliorates mitochondrial damage and ferroptosis in sleep deprivation by activating the sirtuin 1/nuclear factor erythroid-derived 2-like 2/heme oxygenase 1 pathway. Brain research bulletin. 2023-03-19. PMID:36935054. |
sd mice had downregulated ythdc1, sirt1, nrf2, and ho1 protein expression in hippocampal tissues and increased ferroptosis. |
2023-03-19 |
2023-08-14 |
mouse |
| Lv Du, Lei Chen, Bang Luo, Yong-Jun Chen, Ping Zhang, Yi-Yun Tang, Jia-Mei Jiang, Wei Zo. Silent information regulator 1 mediates H2S-inhibited chronic restraint stress-induced depressive-like behaviors by regulating hippocampal autophagy. Neuroreport. 2023-02-02. PMID:36728843. |
hence, this study aimed to investigate whether sirt1 mediates the protective effect of h2s on crs-induced depressive-like behaviors by regulating hippocampal autophagy. |
2023-02-02 |
2023-08-14 |
rat |
| Dexiao Zhu, Jian Zhang, Fei Gao, Mei Hu, Jack Hashem, Chu Che. Augmentation of 2-arachidonoylglycerol signaling in astrocytes maintains synaptic functionality by regulation of miRNA-30b. Experimental neurology. 2022-12-08. PMID:36481187. |
here, we provide evidence that pharmacological inactivation of magl suppresses hippocampal expression of mir-30b, a small non-coding microrna, and upregulates expression of its targets, including ephrin type-b receptor 2 (ephb2), sirtuin1 (sirt1), and glutamate ionotropic receptor ampa type subunit 2 (glua2). |
2022-12-08 |
2023-08-14 |
Not clear |
| Marianne Basta, Samar R Saleh, Rania G Aly, Abeer E Die. Resveratrol ameliorates the behavioural and molecular changes in rats exposed to uninephrectomy: role of hippocampal SIRT1, BDNF and AChE. Journal of physiology and biochemistry. 2022-12-05. PMID:36469209. |
resveratrol ameliorates the behavioural and molecular changes in rats exposed to uninephrectomy: role of hippocampal sirt1, bdnf and ache. |
2022-12-05 |
2023-08-14 |
rat |