| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guo-Liang Dai, Xin-Yi Yang, Shan-Shan Chen, Yi-Qing Wang, Mei-Chen Liu, Yang Cao, Fei-Ran Li, Cheng-Yao Ma, Wen-Zheng J. [Effects of Jiaotai Pills on CUMS-induced depression model in mice based on changes of SIRT1 expression in hippocampus]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 24. 2022-01-07. PMID:34994144. |
western blot was used to detect the protein expression levels of sirt1, p-nf-κb p65, nf-κb p65, and foxo1 in the hippocampus of mice. |
2022-01-07 |
2023-08-13 |
mouse |
| Guo-Liang Dai, Xin-Yi Yang, Shan-Shan Chen, Yi-Qing Wang, Mei-Chen Liu, Yang Cao, Fei-Ran Li, Cheng-Yao Ma, Wen-Zheng J. [Effects of Jiaotai Pills on CUMS-induced depression model in mice based on changes of SIRT1 expression in hippocampus]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 24. 2022-01-07. PMID:34994144. |
in the hippocampus, the expression level of sirt1 was reduced(p<0.01), and the levels of p-nf-κb p65/nf-κb p65 and foxo1 were increased(p<0.01). |
2022-01-07 |
2023-08-13 |
mouse |
| Guo-Liang Dai, Xin-Yi Yang, Shan-Shan Chen, Yi-Qing Wang, Mei-Chen Liu, Yang Cao, Fei-Ran Li, Cheng-Yao Ma, Wen-Zheng J. [Effects of Jiaotai Pills on CUMS-induced depression model in mice based on changes of SIRT1 expression in hippocampus]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 24. 2022-01-07. PMID:34994144. |
the treatment with high-dose jiaotai pills increased the sucrose preference rate, movement distance, and the number of crossing centers(p<0.05), reduced tail suspension time and swimming immobility time(p<0.01), elevated hippocampal sirt1 expression level(p<0.01), decreased hippocampal and serum il-1β, il-6, tnf-α, and mda levels(p<0.01), potentiated sod activity, and up-regulated gsh, da, 5-ht, ne, and bdnf levels in the hippocampus and serum(p<0.05, p<0.01) in model mice. |
2022-01-07 |
2023-08-13 |
mouse |
| Guo-Liang Dai, Xin-Yi Yang, Shan-Shan Chen, Yi-Qing Wang, Mei-Chen Liu, Yang Cao, Fei-Ran Li, Cheng-Yao Ma, Wen-Zheng J. [Effects of Jiaotai Pills on CUMS-induced depression model in mice based on changes of SIRT1 expression in hippocampus]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 24. 2022-01-07. PMID:34994144. |
in conclusion, the results showed that jiaotai pills could improve the depression behaviors of model mice with cums-induced depression, and the underlying mechanism was related to the up-regulation of sirt1 in the hippocampus of mice to exert anti-inflammatory and anti-oxidative stress effects. |
2022-01-07 |
2023-08-13 |
mouse |
| Naihao Shi, Yuwen Lin, Binbin Yan, Xiaowei Jiao, Xiaobao Ding, Yuqing Wu, Chenghua Zho. Hippocampal SIRT1 improves cognitive impairment by deacetylating tau protein in diabetic models. European journal of pharmacology. vol 914. 2021-12-11. PMID:34861210. |
hippocampal sirt1 improves cognitive impairment by deacetylating tau protein in diabetic models. |
2021-12-11 |
2023-08-13 |
rat |
| Naihao Shi, Yuwen Lin, Binbin Yan, Xiaowei Jiao, Xiaobao Ding, Yuqing Wu, Chenghua Zho. Hippocampal SIRT1 improves cognitive impairment by deacetylating tau protein in diabetic models. European journal of pharmacology. vol 914. 2021-12-11. PMID:34861210. |
in this study, we found that the expression of sirtuin 1 (sirt1), a nicotinamide adenine dinucleotide (nad+)-dependent histone deacetylase, was downregulated significantly in the hippocampus of streptozotocin (stz)-induced diabetic cognitive impairment rats. |
2021-12-11 |
2023-08-13 |
rat |
| Naihao Shi, Yuwen Lin, Binbin Yan, Xiaowei Jiao, Xiaobao Ding, Yuqing Wu, Chenghua Zho. Hippocampal SIRT1 improves cognitive impairment by deacetylating tau protein in diabetic models. European journal of pharmacology. vol 914. 2021-12-11. PMID:34861210. |
viral overexpression of hippocampal sirt1 ameliorated cognitive impairment in diabetic rats, but viral knockdown of hippocampal sirt1 mimicked the diabetic effect, eliciting the cognitive decline in normal animals. |
2021-12-11 |
2023-08-13 |
rat |
| Naihao Shi, Yuwen Lin, Binbin Yan, Xiaowei Jiao, Xiaobao Ding, Yuqing Wu, Chenghua Zho. Hippocampal SIRT1 improves cognitive impairment by deacetylating tau protein in diabetic models. European journal of pharmacology. vol 914. 2021-12-11. PMID:34861210. |
further study showed that the decreased level of sirt1 may result in the increase of acetylated tau protein in the hippocampus, which may mediate the development of diabetic cognitive impairment. |
2021-12-11 |
2023-08-13 |
rat |
| Ruike Wang, Zuntao Wu, Mengchen Liu, Yingying Wu, Qiong Li, Yue Ba, Huizhen Zhang, Xuemin Cheng, Guoyu Zhou, Hui Huan. Resveratrol reverses hippocampal synaptic markers injury and SIRT1 inhibition against developmental Pb exposure. Brain research. vol 1767. 2021-12-09. PMID:34175265. |
resveratrol reverses hippocampal synaptic markers injury and sirt1 inhibition against developmental pb exposure. |
2021-12-09 |
2023-08-13 |
rat |
| Gen-Lin He, Ze-Ze Wang, Xue-Ting Yu, Ting-Ting Shen, Zhen Luo, Ping Li, Xue Luo, Yu-Long Tan, Peng Gao, Xue-Sen Yan. The involvement of microglial CX3CR1 in heat acclimation-induced amelioration of adult hippocampal neurogenesis impairment in EMF-exposed mice. Brain research bulletin. vol 177. 2021-11-18. PMID:34555433. |
moreover, pharmacological inhibition of cx3cr1 and sirt1 failed to restore cx3cr1 expression and ameliorate hippocampal neurogenesis impairment following ha plus emf stimulation. |
2021-11-18 |
2023-08-13 |
mouse |
| Ying Zhou, Qiuyun Tian, Chenfei Zheng, Jinge Yang, Junming Fan, Yangping Shent. Myocardial infarction-induced anxiety-like behavior is associated with epigenetic alterations in the hippocampus of rat. Brain research bulletin. vol 164. 2021-10-29. PMID:32871241. |
we also found that mi decreased kdm6b while increased sirt1 expression in the hippocampus of mi rats relative to those in controls. |
2021-10-29 |
2023-08-13 |
rat |
| Ying Zhou, Qiuyun Tian, Chenfei Zheng, Jinge Yang, Junming Fan, Yangping Shent. Myocardial infarction-induced anxiety-like behavior is associated with epigenetic alterations in the hippocampus of rat. Brain research bulletin. vol 164. 2021-10-29. PMID:32871241. |
together, these results suggest a potential role of hippocampal epigenetic signaling in mi-induced anxiety-like behavior in rats, and pharmacological targeting kdm6b or sirt1 could be a strategy to ameliorate anxiety-like behavior induced by mi. |
2021-10-29 |
2023-08-13 |
rat |
| Wei Guo, Xi Xiao, Yu-Tao Tian, Jia-Jia Yan. [The role and mechanism of SIRT1 gene in depression]. Sheng li xue bao : [Acta physiologica Sinica]. vol 73. issue 5. 2021-10-29. PMID:34708240. |
therefore, this review mainly summarizes the relevant research progress on the role and mechanism of sirt1 gene in the hippocampus, prefrontal cortex, amygdala, hypothalamic suprachiasmatic nucleus, and nucleus accumbens in depression, in order to provide new ideas for exploring the mechanism and prevention of depression. |
2021-10-29 |
2023-08-13 |
Not clear |
| Yunhai Tao, Kerun Gao, Bianhong Shen, Kaiyuan Zhang, Zhiwen Zhang, Chengpeng Wan. MicroRNA-135b-5p Downregulation Causes Antidepressant Effects by Regulating SIRT1 Expression. Biochemical genetics. vol 59. issue 6. 2021-10-28. PMID:33999341. |
in addition, the expression levels of sirt1 were significantly reduced in mouse peripheral blood and hippocampal tissue samples, while the expression of mir-135b-5p exhibited the opposite effects. |
2021-10-28 |
2023-08-13 |
mouse |
| Yunhai Tao, Kerun Gao, Bianhong Shen, Kaiyuan Zhang, Zhiwen Zhang, Chengpeng Wan. MicroRNA-135b-5p Downregulation Causes Antidepressant Effects by Regulating SIRT1 Expression. Biochemical genetics. vol 59. issue 6. 2021-10-28. PMID:33999341. |
moreover, the mir-135b-5p inhibitor significantly reduced the cums-induced increase of the inflammatory factors il-1β, il-6 and tnf-α in the hippocampal mouse samples, while significantly increasing the expression levels of sirt1. |
2021-10-28 |
2023-08-13 |
mouse |
| Xianshengjie Lang, Na Zhao, Qiang He, Xun Li, Xuejiao Li, Chuanning Sun, Xianliang Zhan. Treadmill exercise mitigates neuroinflammation and increases BDNF via activation of SIRT1 signaling in a mouse model of T2DM. Brain research bulletin. vol 165. 2021-10-26. PMID:32987101. |
our results showed that long-term moderate intensity treadmill exercise can alleviate inflammatory response in the hippocampus and increase bdnf expression in t2dm mice by activating sirt1. |
2021-10-26 |
2023-08-13 |
mouse |
| Li-Ling He, Yun-Cui Wang, Ya-Ting Ai, Ling Wang, Si-Meng Gu, Ping Wang, Qing-Hua Long, Hui H. Qiangji Decoction Alleviates Neurodegenerative Changes and Hippocampal Neuron Apoptosis Induced by D-Galactose Frontiers in pharmacology. vol 12. 2021-10-12. PMID:34630111. |
besides, the protein expression levels of bcl-2, bax, caspase-3, cleaved caspase-3, ampkα, p-ampkα-thr172, sirt1, iκbα, nf-κb p65, p-iκbα-ser32, and p-nf-κb p65-ser536 in the hippocampus of different groups were detected by western blot (wb). |
2021-10-12 |
2023-08-13 |
mouse |
| Ning Jiang, Lv Jingwei, Haixia Wang, Hong Huang, Qiong Wang, Guirong Zeng, Shanshan Li, Xinmin Li. Ginsenoside 20(S)-protopanaxadiol attenuates depressive-like behaviour and neuroinflammation in chronic unpredictable mild stress-induced depressive rats. Behavioural brain research. vol 393. 2021-10-04. PMID:32464121. |
furthermore, our results suggested that rats treated with ppd displayed decreased inos, cox2, cleaved-caspase3, cleaved-caspase9, bax, bcl-2, and ac-p65 levels and increased sirt1 levels in the hippocampus. |
2021-10-04 |
2023-08-13 |
rat |
| Lin Cong, Meng-Yu Lei, Zhi-Qi Liu, Zhuo-Fan Liu, Zhuo Ma, Kuan Liu, Jing Li, Yu Deng, Wei Liu, Bin X. Resveratrol attenuates manganese-induced oxidative stress and neuroinflammation through SIRT1 signaling in mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 153. 2021-10-04. PMID:34029668. |
to evaluate whether rsv treatment relieves the oxidative stress and neuroinflammation in the hippocampus after mn exposure through sirt1 signaling, c57bl/6 adult mice were exposed to mncl |
2021-10-04 |
2023-08-13 |
mouse |
| Xi Jiang, Ziwei Chen, Xuefeng Yu, Jin Chen, Chonglu Sun, Changfeng Jing, Lexing Xu, Fuhe Liu, Wenjuan Ni, Lei Che. Lipopolysaccharide-induced depression is associated with estrogen receptor-α/SIRT1/NF-κB signaling pathway in old female mice. Neurochemistry international. vol 148. 2021-09-08. PMID:34119591. |
in the experiments of mechanism exploration in old female mice, e2 improved lps-induced depressive-like behavior, and simultaneously elevated sirt1 levels and downregulated expressions of nf-κb and inflammatory cytokines in the hippocampus and frontal cortex. |
2021-09-08 |
2023-08-13 |
mouse |