| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gen-Lin He, Ze-Ze Wang, Xue-Ting Yu, Ting-Ting Shen, Zhen Luo, Ping Li, Xue Luo, Yu-Long Tan, Peng Gao, Xue-Sen Yan. The involvement of microglial CX3CR1 in heat acclimation-induced amelioration of adult hippocampal neurogenesis impairment in EMF-exposed mice. Brain research bulletin. vol 177. 2021-11-18. PMID:34555433. |
moreover, pharmacological inhibition of cx3cr1 and sirt1 failed to restore cx3cr1 expression and ameliorate hippocampal neurogenesis impairment following ha plus emf stimulation. |
2021-11-18 |
2023-08-13 |
mouse |
| Ying Zhou, Qiuyun Tian, Chenfei Zheng, Jinge Yang, Junming Fan, Yangping Shent. Myocardial infarction-induced anxiety-like behavior is associated with epigenetic alterations in the hippocampus of rat. Brain research bulletin. vol 164. 2021-10-29. PMID:32871241. |
we also found that mi decreased kdm6b while increased sirt1 expression in the hippocampus of mi rats relative to those in controls. |
2021-10-29 |
2023-08-13 |
rat |
| Ying Zhou, Qiuyun Tian, Chenfei Zheng, Jinge Yang, Junming Fan, Yangping Shent. Myocardial infarction-induced anxiety-like behavior is associated with epigenetic alterations in the hippocampus of rat. Brain research bulletin. vol 164. 2021-10-29. PMID:32871241. |
together, these results suggest a potential role of hippocampal epigenetic signaling in mi-induced anxiety-like behavior in rats, and pharmacological targeting kdm6b or sirt1 could be a strategy to ameliorate anxiety-like behavior induced by mi. |
2021-10-29 |
2023-08-13 |
rat |
| Wei Guo, Xi Xiao, Yu-Tao Tian, Jia-Jia Yan. [The role and mechanism of SIRT1 gene in depression]. Sheng li xue bao : [Acta physiologica Sinica]. vol 73. issue 5. 2021-10-29. PMID:34708240. |
therefore, this review mainly summarizes the relevant research progress on the role and mechanism of sirt1 gene in the hippocampus, prefrontal cortex, amygdala, hypothalamic suprachiasmatic nucleus, and nucleus accumbens in depression, in order to provide new ideas for exploring the mechanism and prevention of depression. |
2021-10-29 |
2023-08-13 |
Not clear |
| Yunhai Tao, Kerun Gao, Bianhong Shen, Kaiyuan Zhang, Zhiwen Zhang, Chengpeng Wan. MicroRNA-135b-5p Downregulation Causes Antidepressant Effects by Regulating SIRT1 Expression. Biochemical genetics. vol 59. issue 6. 2021-10-28. PMID:33999341. |
in addition, the expression levels of sirt1 were significantly reduced in mouse peripheral blood and hippocampal tissue samples, while the expression of mir-135b-5p exhibited the opposite effects. |
2021-10-28 |
2023-08-13 |
mouse |
| Yunhai Tao, Kerun Gao, Bianhong Shen, Kaiyuan Zhang, Zhiwen Zhang, Chengpeng Wan. MicroRNA-135b-5p Downregulation Causes Antidepressant Effects by Regulating SIRT1 Expression. Biochemical genetics. vol 59. issue 6. 2021-10-28. PMID:33999341. |
moreover, the mir-135b-5p inhibitor significantly reduced the cums-induced increase of the inflammatory factors il-1β, il-6 and tnf-α in the hippocampal mouse samples, while significantly increasing the expression levels of sirt1. |
2021-10-28 |
2023-08-13 |
mouse |
| Xianshengjie Lang, Na Zhao, Qiang He, Xun Li, Xuejiao Li, Chuanning Sun, Xianliang Zhan. Treadmill exercise mitigates neuroinflammation and increases BDNF via activation of SIRT1 signaling in a mouse model of T2DM. Brain research bulletin. vol 165. 2021-10-26. PMID:32987101. |
our results showed that long-term moderate intensity treadmill exercise can alleviate inflammatory response in the hippocampus and increase bdnf expression in t2dm mice by activating sirt1. |
2021-10-26 |
2023-08-13 |
mouse |
| Li-Ling He, Yun-Cui Wang, Ya-Ting Ai, Ling Wang, Si-Meng Gu, Ping Wang, Qing-Hua Long, Hui H. Qiangji Decoction Alleviates Neurodegenerative Changes and Hippocampal Neuron Apoptosis Induced by D-Galactose Frontiers in pharmacology. vol 12. 2021-10-12. PMID:34630111. |
besides, the protein expression levels of bcl-2, bax, caspase-3, cleaved caspase-3, ampkα, p-ampkα-thr172, sirt1, iκbα, nf-κb p65, p-iκbα-ser32, and p-nf-κb p65-ser536 in the hippocampus of different groups were detected by western blot (wb). |
2021-10-12 |
2023-08-13 |
mouse |
| Ning Jiang, Lv Jingwei, Haixia Wang, Hong Huang, Qiong Wang, Guirong Zeng, Shanshan Li, Xinmin Li. Ginsenoside 20(S)-protopanaxadiol attenuates depressive-like behaviour and neuroinflammation in chronic unpredictable mild stress-induced depressive rats. Behavioural brain research. vol 393. 2021-10-04. PMID:32464121. |
furthermore, our results suggested that rats treated with ppd displayed decreased inos, cox2, cleaved-caspase3, cleaved-caspase9, bax, bcl-2, and ac-p65 levels and increased sirt1 levels in the hippocampus. |
2021-10-04 |
2023-08-13 |
rat |
| Lin Cong, Meng-Yu Lei, Zhi-Qi Liu, Zhuo-Fan Liu, Zhuo Ma, Kuan Liu, Jing Li, Yu Deng, Wei Liu, Bin X. Resveratrol attenuates manganese-induced oxidative stress and neuroinflammation through SIRT1 signaling in mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 153. 2021-10-04. PMID:34029668. |
to evaluate whether rsv treatment relieves the oxidative stress and neuroinflammation in the hippocampus after mn exposure through sirt1 signaling, c57bl/6 adult mice were exposed to mncl |
2021-10-04 |
2023-08-13 |
mouse |
| Xi Jiang, Ziwei Chen, Xuefeng Yu, Jin Chen, Chonglu Sun, Changfeng Jing, Lexing Xu, Fuhe Liu, Wenjuan Ni, Lei Che. Lipopolysaccharide-induced depression is associated with estrogen receptor-α/SIRT1/NF-κB signaling pathway in old female mice. Neurochemistry international. vol 148. 2021-09-08. PMID:34119591. |
in the experiments of mechanism exploration in old female mice, e2 improved lps-induced depressive-like behavior, and simultaneously elevated sirt1 levels and downregulated expressions of nf-κb and inflammatory cytokines in the hippocampus and frontal cortex. |
2021-09-08 |
2023-08-13 |
mouse |
| Juan He, Zhuo Chen, Xuan Kang, Lin Wu, Jia-Mei Jiang, Su-Mei Liu, Hai-Jun Wei, Yong-Jun Chen, Wei Zou, Chun-Yan Wang, Ping Zhan. SIRT1 Mediates H Neurochemical research. vol 46. issue 3. 2021-09-07. PMID:33534060. |
sirt1 mediates h diabetes-associated cognitive dysfunction (dacd) characterized by hippocampal injury increases the risk of major cerebrovascular events and death. |
2021-09-07 |
2023-08-13 |
Not clear |
| Rundong Liu, Yawei Wang, Lin Bai, Ruike Wang, Yingying Wu, Mengchen Liu, Qiong Li, Yue Ba, Huizhen Zhang, Guoyu Zhou, Xuemin Cheng, Hui Huan. Time-course miRNA alterations and SIRT1 inhibition triggered by adolescent lead exposure in mice. Toxicology research. vol 10. issue 4. 2021-09-07. PMID:34484659. |
in this study, we found that the protein level of sirt1 was inhibited in the hippocampus and cortex of 16-month-old aged mice exposed to pb. |
2021-09-07 |
2023-08-13 |
mouse |
| Jing Yan, Ailin Luo, Rao Sun, Xiaole Tang, Yilin Zhao, Jie Zhang, Biyun Zhou, Hua Zheng, Honghui Yu, Shiyong L. Resveratrol Mitigates Hippocampal Tau Acetylation and Cognitive Deficit by Activation SIRT1 in Aged Rats following Anesthesia and Surgery. Oxidative medicine and cellular longevity. vol 2020. 2021-09-02. PMID:33381265. |
resveratrol mitigates hippocampal tau acetylation and cognitive deficit by activation sirt1 in aged rats following anesthesia and surgery. |
2021-09-02 |
2023-08-13 |
rat |
| Jing Yan, Ailin Luo, Rao Sun, Xiaole Tang, Yilin Zhao, Jie Zhang, Biyun Zhou, Hua Zheng, Honghui Yu, Shiyong L. Resveratrol Mitigates Hippocampal Tau Acetylation and Cognitive Deficit by Activation SIRT1 in Aged Rats following Anesthesia and Surgery. Oxidative medicine and cellular longevity. vol 2020. 2021-09-02. PMID:33381265. |
in the present study, our findings showed that tau acetylation mediated by sirt1 deficiency resulted in tau hyperphosphorylation in the hippocampus of the aged pocd model and consequently contributed to cognitive impairment. |
2021-09-02 |
2023-08-13 |
rat |
| Jing Yan, Ailin Luo, Rao Sun, Xiaole Tang, Yilin Zhao, Jie Zhang, Biyun Zhou, Hua Zheng, Honghui Yu, Shiyong L. Resveratrol Mitigates Hippocampal Tau Acetylation and Cognitive Deficit by Activation SIRT1 in Aged Rats following Anesthesia and Surgery. Oxidative medicine and cellular longevity. vol 2020. 2021-09-02. PMID:33381265. |
interestingly, pretreatment with resveratrol almost restored the expression of sirt1, reduced the levels of acetylated tau and hyperphosphorylated tau in the hippocampus, and improved the cognitive performance in the behavioral tests. |
2021-09-02 |
2023-08-13 |
rat |
| Margarita R Ramis, Fiorella Sarubbo, David Moranta, Silvia Tejada, Jerònia Lladó, Antoni Miralles, Susana Esteba. Cognitive and Neurochemical Changes Following Polyphenol-Enriched Diet in Rats. Nutrients. vol 13. issue 1. 2021-09-01. PMID:33375450. |
in addition, hippocampal sirt1 protein which has an important role in regulating normal brain function was evaluated. |
2021-09-01 |
2023-08-13 |
rat |
| Margarita R Ramis, Fiorella Sarubbo, David Moranta, Silvia Tejada, Jerònia Lladó, Antoni Miralles, Susana Esteba. Cognitive and Neurochemical Changes Following Polyphenol-Enriched Diet in Rats. Nutrients. vol 13. issue 1. 2021-09-01. PMID:33375450. |
the results show that long-term intake of polyphenol-enriched diet improves memory and learning, correlating with restoration of brain monoaminergic neurotransmitters and hippocampal sirt1 levels in aged rats. |
2021-09-01 |
2023-08-13 |
rat |
| A E Pukhalskaia, A S Dyatlova, N S Linkova, K L Kozlov, T V Kvetnaia, M V Koroleva, I M Kvetno. Sirtuins as Possible Predictors of Aging and Alzheimer's Disease Development: Verification in the Hippocampus and Saliva. Bulletin of experimental biology and medicine. vol 169. issue 6. 2021-08-23. PMID:33098511. |
we studied the expression of sirt1, sirt3, sirt5, and sirt6 in the hippocampus and saliva of humans without neurological pathologies and in patients with alzheimer's disease of elderly and senile age. |
2021-08-23 |
2023-08-13 |
Not clear |
| A E Pukhalskaia, A S Dyatlova, N S Linkova, K L Kozlov, T V Kvetnaia, M V Koroleva, I M Kvetno. Sirtuins as Possible Predictors of Aging and Alzheimer's Disease Development: Verification in the Hippocampus and Saliva. Bulletin of experimental biology and medicine. vol 169. issue 6. 2021-08-23. PMID:33098511. |
in elderly and senile patients, the expression of sirt1, sirt3, and sirt6 in the hippocampus and saliva was 1.5-4.9-fold reduced in comparison with healthy individuals of the corresponding age. |
2021-08-23 |
2023-08-13 |
Not clear |