| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jin-Xi Zuo, Min Li, Li Jiang, Fang Lan, Yi-Yun Tang, Xuan Kang, Wei Zou, Chun-Yan Wang, Ping Zhang, Xiao-Qing Tan. Hydrogen Sulfide Prevents Sleep Deprivation-Induced Hippocampal Damage by Upregulation of Sirt1 in the Hippocampus. Frontiers in neuroscience. vol 14. 2020-09-28. PMID:32218719. |
hydrogen sulfide prevents sleep deprivation-induced hippocampal damage by upregulation of sirt1 in the hippocampus. |
2020-09-28 |
2023-08-13 |
Not clear |
| Cuixia Li, Feng Wang, Pei Miao, Libo Yan, Silin Liu, Xian Wang, Zuolin Jin, Zexu G. miR-138 Increases Depressive-Like Behaviors by Targeting SIRT1 in Hippocampus. Neuropsychiatric disease and treatment. vol 16. 2020-09-28. PMID:32308399. |
mir-138 increases depressive-like behaviors by targeting sirt1 in hippocampus. |
2020-09-28 |
2023-08-13 |
Not clear |
| Lina Shi, Jing Zhang, Yan Wang, Qingfei Hao, Haoming Chen, Xiuyong Chen. Sirt1 Regulates Oxidative Stress in Oxygen-Glucose Deprived Hippocampal Neurons. Frontiers in pediatrics. vol 8. 2020-09-28. PMID:32923413. |
sirt1 regulates oxidative stress in oxygen-glucose deprived hippocampal neurons. |
2020-09-28 |
2023-08-13 |
Not clear |
| Sabrina Salberg, Himanthri Weerwardhena, Reid Collins, Raylene A Reimer, Richelle Mychasiu. The behavioural and pathophysiological effects of the ketogenic diet on mild traumatic brain injury in adolescent rats. Behavioural brain research. vol 376. 2020-09-22. PMID:31518660. |
the timing of kd administration also differentially modified expression of prefrontal cortex, hippocampus, and intestinal mrna for our genes of interest (fgf2, iba1, opa1, sirt1, claudin3, occ, and zo1) this study demonstrates the neuroprotective and therapeutic potential of the kd for mtbi and warrants further investigation. |
2020-09-22 |
2023-08-13 |
rat |
| Minmin Yao, Zhimeng Zhao, Lan Wei, Di Zhou, Zhanggang Xue, Shengjin G. HSF1/HSP pathway in the hippocampus is involved in SIRT1-mediated caloric restriction-induced neuroprotection after surgery in aged mice. Experimental gerontology. vol 119. 2020-07-15. PMID:30772489. |
cr increased hsp70 expression through the hsf1/hsp pathway in a sirt1-mediated manner, and inhibition of sirt1 in the hippocampus by lentivirus injection partially reduced the benefits of cr (increased hsp70, deacetylated hsf1, reduced er-stress, and improved memory). |
2020-07-15 |
2023-08-13 |
mouse |
| Weiming Li, Baolin Guo, Kai Tao, Fei Li, Zhenru Liu, Han Yao, Dayun Feng, Xufeng Li. Inhibition of SIRT1 in hippocampal CA1 ameliorates PTSD-like behaviors in mice by protections of neuronal plasticity and serotonin homeostasis via NHLH2/MAO-A pathway. Biochemical and biophysical research communications. vol 518. issue 2. 2020-06-15. PMID:31421827. |
hippocampal sirt1 dysfunction and gene variation have previously been found potentially involved in depressive and anxiety disorders. |
2020-06-15 |
2023-08-13 |
mouse |
| Weiming Li, Baolin Guo, Kai Tao, Fei Li, Zhenru Liu, Han Yao, Dayun Feng, Xufeng Li. Inhibition of SIRT1 in hippocampal CA1 ameliorates PTSD-like behaviors in mice by protections of neuronal plasticity and serotonin homeostasis via NHLH2/MAO-A pathway. Biochemical and biophysical research communications. vol 518. issue 2. 2020-06-15. PMID:31421827. |
moreover, the expression of sirt1 in the ventral ca1 (vca1) region of hippocampus showed no significant changes following sps induction, but the activity of sirt1 enzyme was significantly increased post-sps. |
2020-06-15 |
2023-08-13 |
mouse |
| Ning Jiang, Jingwei Lv, Haixia Wang, Hong Huang, Qiong Wang, Cong Lu, Guirong Zeng, Xin-Min Li. Ginsenoside Rg1 ameliorates chronic social defeat stress-induced depressive-like behaviors and hippocampal neuroinflammation. Life sciences. vol 252. 2020-06-01. PMID:32298740. |
meanwhile, rg1 regulated sirt1 and decreased the levels of acetylated p65 (ac-p65) in the hippocampus. |
2020-06-01 |
2023-08-13 |
mouse |
| Ning Jiang, Jingwei Lv, Haixia Wang, Hong Huang, Qiong Wang, Cong Lu, Guirong Zeng, Xin-Min Li. Ginsenoside Rg1 ameliorates chronic social defeat stress-induced depressive-like behaviors and hippocampal neuroinflammation. Life sciences. vol 252. 2020-06-01. PMID:32298740. |
in conclusion, our findings suggest that rg1 prevents depressive-like behavior in csds-exposed mice, partially through the downregulation of hippocampal neuroinflammation and the upregulation of adult hippocampal neurogenesis and that these changes presumably occur through increased anti-inflammatory effects and the inhibition of proinflammatory cytokine and neurotoxic mediator expression and microglial activation, which is partly mediated by the regulation of the mapk and sirt1 signaling pathways and results in the inhibition of nf-κb transcriptional activity. |
2020-06-01 |
2023-08-13 |
mouse |
| Krish Chandrasekaran, Mohammad Salimian, Sruthi R Konduru, Joungil Choi, Pranith Kumar, Aaron Long, Nina Klimova, Cheng-Ying Ho, Tibor Kristian, James W Russel. Overexpression of Sirtuin 1 protein in neurons prevents and reverses experimental diabetic neuropathy. Brain : a journal of neurology. vol 142. issue 12. 2020-05-21. PMID:31754701. |
higher levels of sirt1 protein were localized to cortical and hippocampal neuronal nuclei in the brain and in nuclei and cytoplasm of small to medium sized neurons in dorsal root ganglia. |
2020-05-21 |
2023-08-13 |
mouse |
| Mitra Ansari Dezfouli, Maryam Zahmatkesh, Maryam Farahmandfar, Fariba Khodaghol. Melatonin protective effect against amyloid β-induced neurotoxicity mediated by mitochondrial biogenesis; involvement of hippocampal Sirtuin-1 signaling pathway. Physiology & behavior. vol 204. 2020-05-05. PMID:30769106. |
hippocampal sirt1, transcription factor-a mitochondrial (tfam) and mitochondrial dna (mtdna) copy number were measured. |
2020-05-05 |
2023-08-13 |
rat |
| Mitra Ansari Dezfouli, Maryam Zahmatkesh, Maryam Farahmandfar, Fariba Khodaghol. Melatonin protective effect against amyloid β-induced neurotoxicity mediated by mitochondrial biogenesis; involvement of hippocampal Sirtuin-1 signaling pathway. Physiology & behavior. vol 204. 2020-05-05. PMID:30769106. |
we observed a decrease in hippocampal sirt1, which accompanied with reduction in tfam and mtdna copy number in the aβ-injected rats. |
2020-05-05 |
2023-08-13 |
rat |
| Mitra Ansari Dezfouli, Maryam Zahmatkesh, Maryam Farahmandfar, Fariba Khodaghol. Melatonin protective effect against amyloid β-induced neurotoxicity mediated by mitochondrial biogenesis; involvement of hippocampal Sirtuin-1 signaling pathway. Physiology & behavior. vol 204. 2020-05-05. PMID:30769106. |
melatonin treatment increased hippocampal sirt1 and tfam expression and enhanced mtdna copy number in the hippocampus. |
2020-05-05 |
2023-08-13 |
rat |
| Fei Chen, Can-Can Zhou, Yin Yang, Jian-Wen Liu, Chong-Huai Ya. GM1 Ameliorates Lead-Induced Cognitive Deficits and Brain Damage Through Activating the SIRT1/CREB/BDNF Pathway in the Developing Male Rat Hippocampus. Biological trace element research. vol 190. issue 2. 2020-02-04. PMID:30414004. |
furthermore, we found that gm1 upregulated the expression of sirt1, creb phosphorylation, and bdnf, which underlie learning and memory in the lead-treated developing rat hippocampus. |
2020-02-04 |
2023-08-13 |
rat |
| Yao-Chung Chuang, Shang-Der Chen, Shuo-Bin Jou, Tsu-Kung Lin, Shu-Fang Chen, Nai-Ching Chen, Chung-Yao Hs. Sirtuin 1 Regulates Mitochondrial Biogenesis and Provides an Endogenous Neuroprotective Mechanism Against Seizure-Induced Neuronal Cell Death in the Hippocampus Following Status Epilepticus. International journal of molecular sciences. vol 20. issue 14. 2019-12-27. PMID:31340436. |
increased sirt1, pgc-1α, and mitochondrial biogenesis machinery were found in the hippocampus following experimental status epilepticus. |
2019-12-27 |
2023-08-13 |
rat |
| Yao-Chung Chuang, Shang-Der Chen, Shuo-Bin Jou, Tsu-Kung Lin, Shu-Fang Chen, Nai-Ching Chen, Chung-Yao Hs. Sirtuin 1 Regulates Mitochondrial Biogenesis and Provides an Endogenous Neuroprotective Mechanism Against Seizure-Induced Neuronal Cell Death in the Hippocampus Following Status Epilepticus. International journal of molecular sciences. vol 20. issue 14. 2019-12-27. PMID:31340436. |
downregulation of sirt1 decreased pgc-1α expression and mitochondrial biogenesis machinery, increased complex i dysfunction, augmented the level of oxidized proteins, raised activated caspase-3 expression, and promoted neuronal cell damage in the hippocampus. |
2019-12-27 |
2023-08-13 |
rat |
| Sara Nikseresht, Fariba Khodagholi, Abolhassan Ahmadian. Protective effects of ex-527 on cerebral ischemia-reperfusion injury through necroptosis signaling pathway attenuation. Journal of cellular physiology. vol 234. issue 2. 2019-12-10. PMID:30067864. |
our data showed different patterns of sirt1 and necroptosis critical regulators, including receptor-interacting protein kinase 3 and mixed lineage kinase domain-like protein gene expressions in the prefrontal cortex and the hippocampus after ischemia-reperfusion. |
2019-12-10 |
2023-08-13 |
Not clear |
| Juncao Chen, Xiaoyun Gong, Li Huang, Pingyang Chen, Tao Wang, Wei Zhou, Kaiju Luo, Jing Wan. MiR-199a-5p regulates sirtuin1 and PI3K in the rat hippocampus with intrauterine growth restriction. Scientific reports. vol 8. issue 1. 2019-12-06. PMID:30217997. |
changes in pi3k, sirt1 and caspase-3 protein expressions levels in the hippocampus were confirmed by western blot analysis (all p < 0.05). |
2019-12-06 |
2023-08-13 |
rat |
| Xiao-Na Li, Lei Chen, Bang Luo, Xiang Li, Chun-Yan Wang, Wei Zou, Ping Zhang, Yong You, Xiao-Qing Tan. Hydrogen sulfide attenuates chronic restrain stress-induced cognitive impairment by upreglulation of Sirt1 in hippocampus. Oncotarget. vol 8. issue 59. 2019-11-20. PMID:29245987. |
hydrogen sulfide attenuates chronic restrain stress-induced cognitive impairment by upreglulation of sirt1 in hippocampus. |
2019-11-20 |
2023-08-13 |
Not clear |
| Xiajie Shi, Linhua Pi, Shanlei Zhou, Xin Li, Fangyuan Min, Shan Wang, Zhenqi Liu, Jing W. Activation of Sirtuin 1 Attenuates High Glucose-Induced Neuronal Apoptosis by Deacetylating p53. Frontiers in endocrinology. vol 9. 2019-11-20. PMID:29892266. |
to address this issue, we examined the possible role of sirt1 in hippocampal neuronal apoptosis in streptozotocin |
2019-11-20 |
2023-08-13 |
Not clear |