| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Krish Chandrasekaran, Mohammad Salimian, Sruthi R Konduru, Joungil Choi, Pranith Kumar, Aaron Long, Nina Klimova, Cheng-Ying Ho, Tibor Kristian, James W Russel. Overexpression of Sirtuin 1 protein in neurons prevents and reverses experimental diabetic neuropathy. Brain : a journal of neurology. vol 142. issue 12. 2020-05-21. PMID:31754701. |
higher levels of sirt1 protein were localized to cortical and hippocampal neuronal nuclei in the brain and in nuclei and cytoplasm of small to medium sized neurons in dorsal root ganglia. |
2020-05-21 |
2023-08-13 |
mouse |
| Mitra Ansari Dezfouli, Maryam Zahmatkesh, Maryam Farahmandfar, Fariba Khodaghol. Melatonin protective effect against amyloid β-induced neurotoxicity mediated by mitochondrial biogenesis; involvement of hippocampal Sirtuin-1 signaling pathway. Physiology & behavior. vol 204. 2020-05-05. PMID:30769106. |
hippocampal sirt1, transcription factor-a mitochondrial (tfam) and mitochondrial dna (mtdna) copy number were measured. |
2020-05-05 |
2023-08-13 |
rat |
| Mitra Ansari Dezfouli, Maryam Zahmatkesh, Maryam Farahmandfar, Fariba Khodaghol. Melatonin protective effect against amyloid β-induced neurotoxicity mediated by mitochondrial biogenesis; involvement of hippocampal Sirtuin-1 signaling pathway. Physiology & behavior. vol 204. 2020-05-05. PMID:30769106. |
we observed a decrease in hippocampal sirt1, which accompanied with reduction in tfam and mtdna copy number in the aβ-injected rats. |
2020-05-05 |
2023-08-13 |
rat |
| Mitra Ansari Dezfouli, Maryam Zahmatkesh, Maryam Farahmandfar, Fariba Khodaghol. Melatonin protective effect against amyloid β-induced neurotoxicity mediated by mitochondrial biogenesis; involvement of hippocampal Sirtuin-1 signaling pathway. Physiology & behavior. vol 204. 2020-05-05. PMID:30769106. |
melatonin treatment increased hippocampal sirt1 and tfam expression and enhanced mtdna copy number in the hippocampus. |
2020-05-05 |
2023-08-13 |
rat |
| Fei Chen, Can-Can Zhou, Yin Yang, Jian-Wen Liu, Chong-Huai Ya. GM1 Ameliorates Lead-Induced Cognitive Deficits and Brain Damage Through Activating the SIRT1/CREB/BDNF Pathway in the Developing Male Rat Hippocampus. Biological trace element research. vol 190. issue 2. 2020-02-04. PMID:30414004. |
furthermore, we found that gm1 upregulated the expression of sirt1, creb phosphorylation, and bdnf, which underlie learning and memory in the lead-treated developing rat hippocampus. |
2020-02-04 |
2023-08-13 |
rat |
| Yao-Chung Chuang, Shang-Der Chen, Shuo-Bin Jou, Tsu-Kung Lin, Shu-Fang Chen, Nai-Ching Chen, Chung-Yao Hs. Sirtuin 1 Regulates Mitochondrial Biogenesis and Provides an Endogenous Neuroprotective Mechanism Against Seizure-Induced Neuronal Cell Death in the Hippocampus Following Status Epilepticus. International journal of molecular sciences. vol 20. issue 14. 2019-12-27. PMID:31340436. |
increased sirt1, pgc-1α, and mitochondrial biogenesis machinery were found in the hippocampus following experimental status epilepticus. |
2019-12-27 |
2023-08-13 |
rat |
| Yao-Chung Chuang, Shang-Der Chen, Shuo-Bin Jou, Tsu-Kung Lin, Shu-Fang Chen, Nai-Ching Chen, Chung-Yao Hs. Sirtuin 1 Regulates Mitochondrial Biogenesis and Provides an Endogenous Neuroprotective Mechanism Against Seizure-Induced Neuronal Cell Death in the Hippocampus Following Status Epilepticus. International journal of molecular sciences. vol 20. issue 14. 2019-12-27. PMID:31340436. |
downregulation of sirt1 decreased pgc-1α expression and mitochondrial biogenesis machinery, increased complex i dysfunction, augmented the level of oxidized proteins, raised activated caspase-3 expression, and promoted neuronal cell damage in the hippocampus. |
2019-12-27 |
2023-08-13 |
rat |
| Sara Nikseresht, Fariba Khodagholi, Abolhassan Ahmadian. Protective effects of ex-527 on cerebral ischemia-reperfusion injury through necroptosis signaling pathway attenuation. Journal of cellular physiology. vol 234. issue 2. 2019-12-10. PMID:30067864. |
our data showed different patterns of sirt1 and necroptosis critical regulators, including receptor-interacting protein kinase 3 and mixed lineage kinase domain-like protein gene expressions in the prefrontal cortex and the hippocampus after ischemia-reperfusion. |
2019-12-10 |
2023-08-13 |
Not clear |
| Juncao Chen, Xiaoyun Gong, Li Huang, Pingyang Chen, Tao Wang, Wei Zhou, Kaiju Luo, Jing Wan. MiR-199a-5p regulates sirtuin1 and PI3K in the rat hippocampus with intrauterine growth restriction. Scientific reports. vol 8. issue 1. 2019-12-06. PMID:30217997. |
changes in pi3k, sirt1 and caspase-3 protein expressions levels in the hippocampus were confirmed by western blot analysis (all p < 0.05). |
2019-12-06 |
2023-08-13 |
rat |
| Xiao-Na Li, Lei Chen, Bang Luo, Xiang Li, Chun-Yan Wang, Wei Zou, Ping Zhang, Yong You, Xiao-Qing Tan. Hydrogen sulfide attenuates chronic restrain stress-induced cognitive impairment by upreglulation of Sirt1 in hippocampus. Oncotarget. vol 8. issue 59. 2019-11-20. PMID:29245987. |
hydrogen sulfide attenuates chronic restrain stress-induced cognitive impairment by upreglulation of sirt1 in hippocampus. |
2019-11-20 |
2023-08-13 |
Not clear |
| Xiajie Shi, Linhua Pi, Shanlei Zhou, Xin Li, Fangyuan Min, Shan Wang, Zhenqi Liu, Jing W. Activation of Sirtuin 1 Attenuates High Glucose-Induced Neuronal Apoptosis by Deacetylating p53. Frontiers in endocrinology. vol 9. 2019-11-20. PMID:29892266. |
to address this issue, we examined the possible role of sirt1 in hippocampal neuronal apoptosis in streptozotocin |
2019-11-20 |
2023-08-13 |
Not clear |
| Wen-Jun Yan, Da-Bin Wang, Dong-Qing Ren, Ling-Kai Wang, Zhong-Yuan Hu, Ya-Bing Ma, Jin-Wen Huang, Shao-Li Din. AMPKα1 overexpression improves postoperative cognitive dysfunction in aged rats through AMPK-Sirt1 and autophagy signaling. Journal of cellular biochemistry. 2019-11-20. PMID:30775803. |
furthermore, overexpression of ampkα1 could upregulate the expression of p-ampk and sirt1 in the hippocampus of rats with pocd. |
2019-11-20 |
2023-08-13 |
rat |
| Jesus Campagna, Patricia Spilman, Barbara Jagodzinska, Dongsheng Bai, Asa Hatami, Chunni Zhu, Tina Bilousova, Michael Jun, Chris Jean Elias, Johnny Pham, Gregory Cole, Mary Jo LaDu, Michael E Jung, Dale E Bredesen, Varghese Joh. A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer's disease mouse model. Scientific reports. vol 8. issue 1. 2019-10-25. PMID:30514854. |
in vivo, a03 treatment increased sirt1 levels in the hippocampus of 5xfad-apoe4 (e4fad) alzheimer's disease (ad) model mice and elicited cognitive improvement while inducing no observed toxicity. |
2019-10-25 |
2023-08-13 |
mouse |
| Peng Yao, Yong Chen, Guo-Hai X. [Effect of triptolide on cognitive dysfunction in vascular dementia rats through SIRT1/NF-κB signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 44. issue 16. 2019-10-21. PMID:31602904. |
western blot was used to detect the expression of sirt1,nf-κb,iκbα and caspase 3 in hippocampus. |
2019-10-21 |
2023-08-13 |
rat |
| Peng Yao, Yong Chen, Guo-Hai X. [Effect of triptolide on cognitive dysfunction in vascular dementia rats through SIRT1/NF-κB signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 44. issue 16. 2019-10-21. PMID:31602904. |
the results showed that compared with the sham group,the learning and memory ability of the vascular dementia model rats was reduced,the sod activity in the hippocampus was decreased,the mda activity and il-6 level were increased,the neuronal degeneration changed significantly,the expression of sirt1 and iκbα was decreased and the expression of caspase 3 and nf-κb was significantly increased. |
2019-10-21 |
2023-08-13 |
rat |
| Peng Yao, Yong Chen, Guo-Hai X. [Effect of triptolide on cognitive dysfunction in vascular dementia rats through SIRT1/NF-κB signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 44. issue 16. 2019-10-21. PMID:31602904. |
while,after intervention by triptolide and ex527,the expression of sirt1 was decreased,the levels of oxidative stress and neuronal degeneration in the hippocampus were aggravated,and the learning and memory ability was reduced. |
2019-10-21 |
2023-08-13 |
rat |
| A Hadar, E Milanesi, M Walczak, M Puzianowska-Kuźnicka, J Kuźnicki, A Squassina, P Niola, C Chillotti, J Attems, I Gozes, D Gurwit. SIRT1, miR-132 and miR-212 link human longevity to Alzheimer's Disease. Scientific reports. vol 8. issue 1. 2019-10-08. PMID:29855513. |
here, we studied the expression of sirt1 along with mir-132 and mir-212, two micrornas known to regulate sirt1, in lymphoblastoid cell lines (lcls) from 45 healthy donors aged 21 to 105 years and 24 ad patients, and in postmortem olfactory bulb and hippocampus tissues from 14 ad patients and 20 age-matched non-demented individuals. |
2019-10-08 |
2023-08-13 |
human |
| A Hadar, E Milanesi, M Walczak, M Puzianowska-Kuźnicka, J Kuźnicki, A Squassina, P Niola, C Chillotti, J Attems, I Gozes, D Gurwit. SIRT1, miR-132 and miR-212 link human longevity to Alzheimer's Disease. Scientific reports. vol 8. issue 1. 2019-10-08. PMID:29855513. |
correlations of sirt1, mir-132 and mir-212 expression with cognitive scores were observed for ad patient-derived lcls and postmortem ad olfactory bulb and hippocampus tissues, suggesting that higher sirt1 expression, possibly mediated by lower mir-132 and mir-212, may protect aged individuals from dementia and is reflected in their peripheral tissues. |
2019-10-08 |
2023-08-13 |
human |
| Shuhu Zhou, Baojun Qiao, Xu Chu, Qingxia Kon. Oxymatrine attenuates cognitive deficits through SIRT1-mediated autophagy in ischemic stroke. Journal of neuroimmunology. vol 323. 2019-10-03. PMID:30196826. |
oxymatrine may attenuate hippocampus ischemia/reperfusion injury through upregulation sirt1, further influencing the processes of apoptosis and autophagy. |
2019-10-03 |
2023-08-13 |
rat |
| F Sarubbo, M R Ramis, C Kienzer, S Aparicio, S Esteban, A Miralles, D Morant. Chronic Silymarin, Quercetin and Naringenin Treatments Increase Monoamines Synthesis and Hippocampal Sirt1 Levels Improving Cognition in Aged Rats. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 13. issue 1. 2019-10-02. PMID:28808887. |
chronic silymarin, quercetin and naringenin treatments increase monoamines synthesis and hippocampal sirt1 levels improving cognition in aged rats. |
2019-10-02 |
2023-08-13 |
rat |