| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| YuanBo Cui, ShanShan Ma, ChunYan Zhang, DongPeng Li, Bo Yang, PengJu Lv, Qu Xing, Tuanjie Huang, Greta Luyuan Yang, Wei Cao, FangXia Gua. Pharmacological activation of the Nrf2 pathway by 3H-1, 2-dithiole-3-thione is neuroprotective in a mouse model of Alzheimer disease. Behavioural brain research. vol 336. 2018-06-01. PMID:28887195. |
further mechanistic studies revealed that d3t significantly promoted hippocampal neurogenesis, and up-regulated levels of silent information regulator 1 (sirt1), nrf2 and heme oxygenase-1 (ho-1). |
2018-06-01 |
2023-08-13 |
mouse |
| Sohi Kang, Yeonghoon Son, Sueun Lee, Juhwan Kim, Jong-Choon Kim, Joong-Sun Kim, Uhee Jung, Sung-Ho Kim, Miyoung Yang, Changjong Moo. Changes in epigenetic markers, DNMT1 and HDAC1/2, in the adult mouse hippocampus after cranial irradiation. Neuroscience letters. vol 657. 2018-05-28. PMID:28780164. |
we assessed changes in the levels of enzymes associated with the epigenetic modification of gene expression, including dnmt1, hdac1, hdac2, sirtuin 1 (sirt1), and acetylated histone h3 (ace-h3) in the mouse hippocampus 1 and 30days after a single exposure to cranial irradiation (0 or 10gy). |
2018-05-28 |
2023-08-13 |
mouse |
| Sohi Kang, Yeonghoon Son, Sueun Lee, Juhwan Kim, Jong-Choon Kim, Joong-Sun Kim, Uhee Jung, Sung-Ho Kim, Miyoung Yang, Changjong Moo. Changes in epigenetic markers, DNMT1 and HDAC1/2, in the adult mouse hippocampus after cranial irradiation. Neuroscience letters. vol 657. 2018-05-28. PMID:28780164. |
furthermore, protein levels of sirt1 and ace-h3 were significantly downregulated in the mouse hippocampus 1 and 30days after cranial irradiation. |
2018-05-28 |
2023-08-13 |
mouse |
| Rubén Corpas, Susana Revilla, Suzanna Ursulet, Marco Castro-Freire, Perla Kaliman, Valérie Petegnief, Lydia Giménez-Llort, Chamsy Sarkis, Mercè Pallàs, Coral Sanfeli. SIRT1 Overexpression in Mouse Hippocampus Induces Cognitive Enhancement Through Proteostatic and Neurotrophic Mechanisms. Molecular neurobiology. vol 54. issue 7. 2018-05-18. PMID:27614878. |
sirt1 overexpression in mouse hippocampus induces cognitive enhancement through proteostatic and neurotrophic mechanisms. |
2018-05-18 |
2023-08-13 |
mouse |
| Rubén Corpas, Susana Revilla, Suzanna Ursulet, Marco Castro-Freire, Perla Kaliman, Valérie Petegnief, Lydia Giménez-Llort, Chamsy Sarkis, Mercè Pallàs, Coral Sanfeli. SIRT1 Overexpression in Mouse Hippocampus Induces Cognitive Enhancement Through Proteostatic and Neurotrophic Mechanisms. Molecular neurobiology. vol 54. issue 7. 2018-05-18. PMID:27614878. |
we aimed to investigate the benefits induced by sirt1 overexpression in the hippocampus of the ad mouse model 3xtg-ad and in control non-transgenic mice. |
2018-05-18 |
2023-08-13 |
mouse |
| Rubén Corpas, Susana Revilla, Suzanna Ursulet, Marco Castro-Freire, Perla Kaliman, Valérie Petegnief, Lydia Giménez-Llort, Chamsy Sarkis, Mercè Pallàs, Coral Sanfeli. SIRT1 Overexpression in Mouse Hippocampus Induces Cognitive Enhancement Through Proteostatic and Neurotrophic Mechanisms. Molecular neurobiology. vol 54. issue 7. 2018-05-18. PMID:27614878. |
a lentiviral vector encoding mouse sirt1 or gfp, selectively transducing neurons, was injected into the dorsal ca1 hippocampal area of 4-month-old mice. |
2018-05-18 |
2023-08-13 |
mouse |
| Vivek Kumar, Ankita Pandey, Sadaf Jahan, Rajendra Kumar Shukla, Dipak Kumar, Akriti Srivastava, Shripriya Singh, Chetan Singh Rajpurohit, Sanjay Yadav, Vinay Kumar Khanna, Aditya Bhushan Pan. Differential responses of Trans-Resveratrol on proliferation of neural progenitor cells and aged rat hippocampal neurogenesis. Scientific reports. vol 6. 2018-04-24. PMID:27334554. |
administration of resveratrol (20 mg/kg body weight) to adult rats significantly increased the number of newly generated cells in the hippocampus, with upregulation of p-creb and sirt1 proteins implicated in neuronal survival and lifespan extension respectively. |
2018-04-24 |
2023-08-13 |
rat |
| Francesco Bellanti, Giuseppina Iannelli, Maria Blonda, Rosanna Tamborra, Rosanna Villani, Adele Romano, Silvio Calcagnini, Gianluigi Mazzoccoli, Manlio Vinciguerra, Silvana Gaetani, Anna Maria Giudetti, Gianluigi Vendemiale, Tommaso Cassano, Gaetano Serviddi. Alterations of Clock Gene RNA Expression in Brain Regions of a Triple Transgenic Model of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 59. issue 2. 2018-04-09. PMID:28671110. |
in other brain areas, age rather than genotype affected gene expression; the effect of genotype was observed on hippocampal sirt1 expression, while it modified the expression of genes regulating the negative feedback loop as well as rorα, csnk1ɛ and sirt1 in the brainstem. |
2018-04-09 |
2023-08-13 |
mouse |
| Dongying Yan, Cuihong Jin, Yang Cao, Lulu Wang, Xiaobo Lu, Jinghua Yang, Shengwen Wu, Yuan Ca. Effects of Aluminium on Long-Term Memory in Rats and on SIRT1 Mediating the Transcription of CREB-Dependent Gene in Hippocampus. Basic & clinical pharmacology & toxicology. vol 121. issue 4. 2018-01-30. PMID:28429887. |
effects of aluminium on long-term memory in rats and on sirt1 mediating the transcription of creb-dependent gene in hippocampus. |
2018-01-30 |
2023-08-13 |
rat |
| Hak-Su Kim, Sohee Moon, Sujin Kim, Min-Jae Lee, Min Hwa Suk, Dong-Ho Park, Dong Wun Shin, Chang-Shin Park, Ju-Hee Kan. Chronological changes in the expression of phosphorylated tau and 5‑AMP‑activated protein kinase in the brain of senescence‑accelerated P8 mice. Molecular medicine reports. vol 15. issue 5. 2018-01-22. PMID:28339060. |
however, in the hippocampus of samp8, the patterns of chronological changes and levels of p‑tau, p‑ampk, sirt1 and irs‑1 relative to samr1 were different from those in the cortex. |
2018-01-22 |
2023-08-13 |
mouse |
| Liang Liu, Qin Zhang, Yulong Cai, Dayu Sun, Xie He, Lian Wang, Dan Yu, Xin Li, Xiaoyi Xiong, Haiwei Xu, Qingwu Yang, Xiaotang Fa. Resveratrol counteracts lipopolysaccharide-induced depressive-like behaviors via enhanced hippocampal neurogenesis. Oncotarget. vol 7. issue 35. 2018-01-16. PMID:27517628. |
in addition, rsv ameliorated lps-induced nf-κb activation in the hippocampus coincides with the up-regulation levels of sirt1 and hes1. |
2018-01-16 |
2023-08-13 |
mouse |
| Jin Gao, Rui Zhou, Xintong You, Fen Luo, He He, Xiayun Chang, Lingpeng Zhu, Xuansheng Ding, Tianhua Ya. Salidroside suppresses inflammation in a D-galactose-induced rat model of Alzheimer's disease via SIRT1/NF-κB pathway. Metabolic brain disease. vol 31. issue 4. 2018-01-12. PMID:26909502. |
d-gal also activated nuclear factor kappa b (nf-κb) p65/rela by down-regulating the expression level of sirtuins 1 (sirt1) in the hippocampus. |
2018-01-12 |
2023-08-13 |
rat |
| Siew Ying Wong, Bor Luen Tan. SIRT1 as a therapeutic target for Alzheimer's disease. Reviews in the neurosciences. vol 27. issue 8. 2018-01-02. PMID:27497424. |
collectively, sirt1 activity could potentially affect multiple aspects of hippocampal and cortical neuron function and survival, thus modifying disease onset and progression. |
2018-01-02 |
2023-08-13 |
Not clear |
| YuanBo Cui, ShanShan Ma, ChunYan Zhang, Wei Cao, Min Liu, DongPeng Li, PengJu Lv, Qu Xing, RuiNa Qu, Ning Yao, Bo Yang, FangXia Gua. Human umbilical cord mesenchymal stem cells transplantation improves cognitive function in Alzheimer's disease mice by decreasing oxidative stress and promoting hippocampal neurogenesis. Behavioural brain research. vol 320. 2017-12-27. PMID:28007537. |
the mechanisms underlying the improved cognitive function may be linked to hippocampal neurogenesis and an up-regulation of neuronal synaptic plasticity related proteins levels including silent information regulator 1 (sirt1), brain-derived neurotrophic factor (bdnf) and synaptophysin (syn). |
2017-12-27 |
2023-08-13 |
mouse |
| Rui Wang, Yu Zhang, Jianguo Li, Ce Zhan. Resveratrol ameliorates spatial learning memory impairment induced by Aβ Neuroscience. vol 344. 2017-11-09. PMID:27600946. |
however, whether resveratrol can alleviate aβ-induced cognitive dysfunction, whether sirt1 expression and creb phosphorylation in the hippocampus are affected by aβ, and whether resveratrol influences these effects remain unknown. |
2017-11-09 |
2023-08-13 |
rat |
| Sabine Sellner, Ricardo Paricio-Montesinos, Alena Spieß, Annette Masuch, Daniel Erny, Laura A Harsan, Dominik V Elverfeldt, Marius Schwabenland, Knut Biber, Ori Staszewski, Sergio Lira, Steffen Jung, Marco Prinz, Thomas Blan. Microglial CX3CR1 promotes adult neurogenesis by inhibiting Sirt 1/p65 signaling independent of CX3CL1. Acta neuropathologica communications. vol 4. issue 1. 2017-10-25. PMID:27639555. |
the reverse condition was induced when sirt1 was inhibited in cx3cr1 (-/-) mice, causing reduced adult neurogenesis and lowered hippocampal cognitive abilities. |
2017-10-25 |
2023-08-13 |
mouse |
| Ying-Ying Chen, Li Zhang, Dong-Ling Shi, Xing-Hui Song, Yue-Liang Shen, Ming-Zhi Zheng, Lin-Lin Wan. Resveratrol Attenuates Subacute Systemic Inflammation-Induced Spatial Memory Impairment via Inhibition of Astrocyte Activation and Enhancement of Synaptophysin Expression in the Hippocampus. Annals of clinical and laboratory science. vol 47. issue 1. 2017-03-13. PMID:28249911. |
treatment with lps declined the sirt1 protein expression in the hippocampus, which could be prevented by resveratrol. |
2017-03-13 |
2023-08-13 |
mouse |
| Chang Feng, Junwang Gu, Fankun Zhou, Jiaoyang Li, Gaochun Zhu, Linfu Guan, Haizhen Liu, Guihua Du, Jiangao Feng, Dong Liu, Shuyun Zhang, Guangqin Fa. The effect of lead exposure on expression of SIRT1 in the rat hippocampus. Environmental toxicology and pharmacology. vol 44. 2017-02-08. PMID:27131751. |
the effect of lead exposure on expression of sirt1 in the rat hippocampus. |
2017-02-08 |
2023-08-13 |
rat |
| Chang Feng, Junwang Gu, Fankun Zhou, Jiaoyang Li, Gaochun Zhu, Linfu Guan, Haizhen Liu, Guihua Du, Jiangao Feng, Dong Liu, Shuyun Zhang, Guangqin Fa. The effect of lead exposure on expression of SIRT1 in the rat hippocampus. Environmental toxicology and pharmacology. vol 44. 2017-02-08. PMID:27131751. |
we examined the effects of maternal rat ingestion of pb in drinking water during gestation and lactation on the expression of sirt1 and creb in the hippocampus of their offspring at postnatal week 3 (pnw3) and 52 (pnw52), and then reexamined these effects in offspring after intragastric administration of resveratrol for 4 weeks. |
2017-02-08 |
2023-08-13 |
rat |
| Chang Feng, Junwang Gu, Fankun Zhou, Jiaoyang Li, Gaochun Zhu, Linfu Guan, Haizhen Liu, Guihua Du, Jiangao Feng, Dong Liu, Shuyun Zhang, Guangqin Fa. The effect of lead exposure on expression of SIRT1 in the rat hippocampus. Environmental toxicology and pharmacology. vol 44. 2017-02-08. PMID:27131751. |
pb exposure decreased sirt1 and creb phosphorylation in a dose-dependent manner in the rat hippocampus at both pnw3 and 52, and resveratrol reversed those losses. |
2017-02-08 |
2023-08-13 |
rat |