| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hak-Su Kim, Sohee Moon, Sujin Kim, Min-Jae Lee, Min Hwa Suk, Dong-Ho Park, Dong Wun Shin, Chang-Shin Park, Ju-Hee Kan. Chronological changes in the expression of phosphorylated tau and 5‑AMP‑activated protein kinase in the brain of senescence‑accelerated P8 mice. Molecular medicine reports. vol 15. issue 5. 2018-01-22. PMID:28339060. |
however, in the hippocampus of samp8, the patterns of chronological changes and levels of p‑tau, p‑ampk, sirt1 and irs‑1 relative to samr1 were different from those in the cortex. |
2018-01-22 |
2023-08-13 |
mouse |
| Liang Liu, Qin Zhang, Yulong Cai, Dayu Sun, Xie He, Lian Wang, Dan Yu, Xin Li, Xiaoyi Xiong, Haiwei Xu, Qingwu Yang, Xiaotang Fa. Resveratrol counteracts lipopolysaccharide-induced depressive-like behaviors via enhanced hippocampal neurogenesis. Oncotarget. vol 7. issue 35. 2018-01-16. PMID:27517628. |
in addition, rsv ameliorated lps-induced nf-κb activation in the hippocampus coincides with the up-regulation levels of sirt1 and hes1. |
2018-01-16 |
2023-08-13 |
mouse |
| Jin Gao, Rui Zhou, Xintong You, Fen Luo, He He, Xiayun Chang, Lingpeng Zhu, Xuansheng Ding, Tianhua Ya. Salidroside suppresses inflammation in a D-galactose-induced rat model of Alzheimer's disease via SIRT1/NF-κB pathway. Metabolic brain disease. vol 31. issue 4. 2018-01-12. PMID:26909502. |
d-gal also activated nuclear factor kappa b (nf-κb) p65/rela by down-regulating the expression level of sirtuins 1 (sirt1) in the hippocampus. |
2018-01-12 |
2023-08-13 |
rat |
| Siew Ying Wong, Bor Luen Tan. SIRT1 as a therapeutic target for Alzheimer's disease. Reviews in the neurosciences. vol 27. issue 8. 2018-01-02. PMID:27497424. |
collectively, sirt1 activity could potentially affect multiple aspects of hippocampal and cortical neuron function and survival, thus modifying disease onset and progression. |
2018-01-02 |
2023-08-13 |
Not clear |
| YuanBo Cui, ShanShan Ma, ChunYan Zhang, Wei Cao, Min Liu, DongPeng Li, PengJu Lv, Qu Xing, RuiNa Qu, Ning Yao, Bo Yang, FangXia Gua. Human umbilical cord mesenchymal stem cells transplantation improves cognitive function in Alzheimer's disease mice by decreasing oxidative stress and promoting hippocampal neurogenesis. Behavioural brain research. vol 320. 2017-12-27. PMID:28007537. |
the mechanisms underlying the improved cognitive function may be linked to hippocampal neurogenesis and an up-regulation of neuronal synaptic plasticity related proteins levels including silent information regulator 1 (sirt1), brain-derived neurotrophic factor (bdnf) and synaptophysin (syn). |
2017-12-27 |
2023-08-13 |
mouse |
| Rui Wang, Yu Zhang, Jianguo Li, Ce Zhan. Resveratrol ameliorates spatial learning memory impairment induced by Aβ Neuroscience. vol 344. 2017-11-09. PMID:27600946. |
however, whether resveratrol can alleviate aβ-induced cognitive dysfunction, whether sirt1 expression and creb phosphorylation in the hippocampus are affected by aβ, and whether resveratrol influences these effects remain unknown. |
2017-11-09 |
2023-08-13 |
rat |
| Sabine Sellner, Ricardo Paricio-Montesinos, Alena Spieß, Annette Masuch, Daniel Erny, Laura A Harsan, Dominik V Elverfeldt, Marius Schwabenland, Knut Biber, Ori Staszewski, Sergio Lira, Steffen Jung, Marco Prinz, Thomas Blan. Microglial CX3CR1 promotes adult neurogenesis by inhibiting Sirt 1/p65 signaling independent of CX3CL1. Acta neuropathologica communications. vol 4. issue 1. 2017-10-25. PMID:27639555. |
the reverse condition was induced when sirt1 was inhibited in cx3cr1 (-/-) mice, causing reduced adult neurogenesis and lowered hippocampal cognitive abilities. |
2017-10-25 |
2023-08-13 |
mouse |
| Ying-Ying Chen, Li Zhang, Dong-Ling Shi, Xing-Hui Song, Yue-Liang Shen, Ming-Zhi Zheng, Lin-Lin Wan. Resveratrol Attenuates Subacute Systemic Inflammation-Induced Spatial Memory Impairment via Inhibition of Astrocyte Activation and Enhancement of Synaptophysin Expression in the Hippocampus. Annals of clinical and laboratory science. vol 47. issue 1. 2017-03-13. PMID:28249911. |
treatment with lps declined the sirt1 protein expression in the hippocampus, which could be prevented by resveratrol. |
2017-03-13 |
2023-08-13 |
mouse |
| Chang Feng, Junwang Gu, Fankun Zhou, Jiaoyang Li, Gaochun Zhu, Linfu Guan, Haizhen Liu, Guihua Du, Jiangao Feng, Dong Liu, Shuyun Zhang, Guangqin Fa. The effect of lead exposure on expression of SIRT1 in the rat hippocampus. Environmental toxicology and pharmacology. vol 44. 2017-02-08. PMID:27131751. |
the effect of lead exposure on expression of sirt1 in the rat hippocampus. |
2017-02-08 |
2023-08-13 |
rat |
| Chang Feng, Junwang Gu, Fankun Zhou, Jiaoyang Li, Gaochun Zhu, Linfu Guan, Haizhen Liu, Guihua Du, Jiangao Feng, Dong Liu, Shuyun Zhang, Guangqin Fa. The effect of lead exposure on expression of SIRT1 in the rat hippocampus. Environmental toxicology and pharmacology. vol 44. 2017-02-08. PMID:27131751. |
we examined the effects of maternal rat ingestion of pb in drinking water during gestation and lactation on the expression of sirt1 and creb in the hippocampus of their offspring at postnatal week 3 (pnw3) and 52 (pnw52), and then reexamined these effects in offspring after intragastric administration of resveratrol for 4 weeks. |
2017-02-08 |
2023-08-13 |
rat |
| Chang Feng, Junwang Gu, Fankun Zhou, Jiaoyang Li, Gaochun Zhu, Linfu Guan, Haizhen Liu, Guihua Du, Jiangao Feng, Dong Liu, Shuyun Zhang, Guangqin Fa. The effect of lead exposure on expression of SIRT1 in the rat hippocampus. Environmental toxicology and pharmacology. vol 44. 2017-02-08. PMID:27131751. |
pb exposure decreased sirt1 and creb phosphorylation in a dose-dependent manner in the rat hippocampus at both pnw3 and 52, and resveratrol reversed those losses. |
2017-02-08 |
2023-08-13 |
rat |
| P D Lisachev, V O Pustylnyak, M B Shtar. Sirt1 Regulates p53 Stability and Expression of Its Target S100B during Long-Term Potentiation in Rat Hippocampus. Bulletin of experimental biology and medicine. vol 160. issue 4. 2016-12-13. PMID:26902357. |
sirt1 regulates p53 stability and expression of its target s100b during long-term potentiation in rat hippocampus. |
2016-12-13 |
2023-08-13 |
rat |
| Weiguo Dong, Feng Wang, Wanqing Guo, Xuehua Zheng, Yue Chen, Wenguang Zhang, Hong Sh. Aβ25-35 Suppresses Mitochondrial Biogenesis in Primary Hippocampal Neurons. Cellular and molecular neurobiology. vol 36. issue 1. 2016-10-07. PMID:26055049. |
in primary hippocampal neurons, we found that 24-h incubation with aβ25-35 suppressed both phosphorylations of ampk and sirt1 expression and increased pgc-1α acetylation expression. |
2016-10-07 |
2023-08-13 |
Not clear |
| Mark F McCarty, James J DiNicolantonio, James H O'Keef. Ketosis may promote brain macroautophagy by activating Sirt1 and hypoxia-inducible factor-1. Medical hypotheses. vol 85. issue 5. 2016-09-09. PMID:26306884. |
another recent study has observed reduced activity of mtorc1 in the hippocampus of rats fed a ketogenic diet - an effect plausibly attributable to sirt1 activation. |
2016-09-09 |
2023-08-13 |
rat |
| Hak-Su Kim, Sohee Moon, Jin-Hwe Paik, Dong Wun Shin, Lindsay S Kim, Chang-Shin Park, Joohun Ha, Ju-Hee Kan. Activation of the 5'-AMP-Activated Protein Kinase in the Cerebral Cortex of Young Senescence-Accelerated P8 Mice and Association with GSK3β- and PP2A-Dependent Inhibition of p-tau₃₉₆ Expression. Journal of Alzheimer's disease : JAD. vol 46. issue 1. 2016-06-27. PMID:25737046. |
the hippocampal levels of p-ampk and p-tau396 in samp8 animals were not significantly different from those of samr1, whereas upregulation of p-gsk3βs9 and downregulation of sirt1 was observed in the hippocampus of samp8 mice. |
2016-06-27 |
2023-08-13 |
mouse |
| Frankie D Heyward, Daniel Gilliam, Mark A Coleman, Cristin F Gavin, Jing Wang, Garrett Kaas, Richard Trieu, John Lewis, Jerome Moulden, J David Sweat. Obesity Weighs down Memory through a Mechanism Involving the Neuroepigenetic Dysregulation of Sirt1. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 4. 2016-06-01. PMID:26818519. |
here we report evidence of obesity-induced alterations in dna methylation of memory-associated genes, including sirtuin 1 (sirt1), within the hippocampus, and thus offer a novel mechanism by which sirt1 expression within the hippocampus is suppressed during obesity. |
2016-06-01 |
2023-08-13 |
mouse |
| Frankie D Heyward, Daniel Gilliam, Mark A Coleman, Cristin F Gavin, Jing Wang, Garrett Kaas, Richard Trieu, John Lewis, Jerome Moulden, J David Sweat. Obesity Weighs down Memory through a Mechanism Involving the Neuroepigenetic Dysregulation of Sirt1. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 4. 2016-06-01. PMID:26818519. |
forebrain neuron-specific sirt1 knock-out closely recapitulated the memory deficits exhibited by obese mice, consistent with the hypothesis that the high-fat diet-mediated reduction of hippocampal sirt1 could be responsible for obesity-linked memory impairment. |
2016-06-01 |
2023-08-13 |
mouse |
| Frankie D Heyward, Daniel Gilliam, Mark A Coleman, Cristin F Gavin, Jing Wang, Garrett Kaas, Richard Trieu, John Lewis, Jerome Moulden, J David Sweat. Obesity Weighs down Memory through a Mechanism Involving the Neuroepigenetic Dysregulation of Sirt1. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 4. 2016-06-01. PMID:26818519. |
obese mice fed a diet supplemented with the sirt1-activating molecule resveratrol exhibited increased hippocampal sirt1 activity and preserved hippocampus-dependent memory, further strengthening this conclusion. |
2016-06-01 |
2023-08-13 |
mouse |
| Frankie D Heyward, Daniel Gilliam, Mark A Coleman, Cristin F Gavin, Jing Wang, Garrett Kaas, Richard Trieu, John Lewis, Jerome Moulden, J David Sweat. Obesity Weighs down Memory through a Mechanism Involving the Neuroepigenetic Dysregulation of Sirt1. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 4. 2016-06-01. PMID:26818519. |
thus, our findings suggest that the memory-impairing effects of diet-induced obesity may potentially be mediated by neuroepigenetic dysregulation of sirt1 within the hippocampus. |
2016-06-01 |
2023-08-13 |
mouse |
| Talita Tuon, Priscila S Souza, Marcela F Santos, Fernanda T Pereira, Giulia S Pedroso, Thais F Luciano, Claudio T De Souza, Rafael C Dutra, Paulo C L Silveira, Ricardo A Pinh. Physical Training Regulates Mitochondrial Parameters and Neuroinflammatory Mechanisms in an Experimental Model of Parkinson's Disease. Oxidative medicine and cellular longevity. vol 2015. 2016-05-18. PMID:26448816. |
mice were euthanized by cervical dislocation and the striatum and hippocampus were homogenized to determine levels of tyrosine hydroxylase (th), nuclear factor kappa b (nf-κb) p65, and sirtuin 1 (sirt1) by western blot; tumor necrosis factor-α (tnf-α), interleukin-1β (il-1β), il-17, interferon-γ (ifn-γ), and transforming growth factor β1 (tgf-β1) levels by elisa; no content; and complex i (ci) activity. |
2016-05-18 |
2023-08-13 |
mouse |