| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Frankie D Heyward, R Grace Walton, Matthew S Carle, Mark A Coleman, W Timothy Garvey, J David Sweat. Adult mice maintained on a high-fat diet exhibit object location memory deficits and reduced hippocampal SIRT1 gene expression. Neurobiology of learning and memory. vol 98. issue 1. 2012-12-03. PMID:22542746. |
adult mice maintained on a high-fat diet exhibit object location memory deficits and reduced hippocampal sirt1 gene expression. |
2012-12-03 |
2023-08-12 |
mouse |
| Frankie D Heyward, R Grace Walton, Matthew S Carle, Mark A Coleman, W Timothy Garvey, J David Sweat. Adult mice maintained on a high-fat diet exhibit object location memory deficits and reduced hippocampal SIRT1 gene expression. Neurobiology of learning and memory. vol 98. issue 1. 2012-12-03. PMID:22542746. |
dio mice exhibited significant reductions in both sirt1 and pp1 mrna within the hippocampus. |
2012-12-03 |
2023-08-12 |
mouse |
| Erika Koltai, Zhongfu Zhao, Zsombor Lacza, Attila Cselenyak, Gabriella Vacz, Csaba Nyakas, Istvan Boldogh, Noriko Ichinoseki-Sekine, Zsolt Rada. Combined exercise and insulin-like growth factor-1 supplementation induces neurogenesis in old rats, but do not attenuate age-associated DNA damage. Rejuvenation research. vol 14. issue 6. 2012-04-17. PMID:21867412. |
sirtuin 1 (sirt1) and sirt3, as dna damage-associated lysine deacetylases, were measured, and sirt1 decreased with aging, resulting in a large increase in acetylated lysine residues in the hippocampus. |
2012-04-17 |
2023-08-12 |
rat |
| Erika Koltai, Zhongfu Zhao, Zsombor Lacza, Attila Cselenyak, Gabriella Vacz, Csaba Nyakas, Istvan Boldogh, Noriko Ichinoseki-Sekine, Zsolt Rada. Combined exercise and insulin-like growth factor-1 supplementation induces neurogenesis in old rats, but do not attenuate age-associated DNA damage. Rejuvenation research. vol 14. issue 6. 2012-04-17. PMID:21867412. |
age-associated decreases in sirt1 and the associated increase in lysine acetylation, in the hippocampus, could have significant impact on function and thus, could suggest a therapeutic target. |
2012-04-17 |
2023-08-12 |
rat |
| Ana Quintas, Alain J de Solís, F Javier Díez-Guerra, José M Carrascosa, Elena Bogóne. Age-associated decrease of SIRT1 expression in rat hippocampus: prevention by late onset caloric restriction. Experimental gerontology. vol 47. issue 2. 2012-03-21. PMID:22143179. |
age-associated decrease of sirt1 expression in rat hippocampus: prevention by late onset caloric restriction. |
2012-03-21 |
2023-08-12 |
rat |
| Ana Quintas, Alain J de Solís, F Javier Díez-Guerra, José M Carrascosa, Elena Bogóne. Age-associated decrease of SIRT1 expression in rat hippocampus: prevention by late onset caloric restriction. Experimental gerontology. vol 47. issue 2. 2012-03-21. PMID:22143179. |
we have studied the effect of aging and late onset caloric restriction (cr) on the expression of sirt1 in hippocampus and cerebral cortex of the rat. |
2012-03-21 |
2023-08-12 |
rat |
| Ana Quintas, Alain J de Solís, F Javier Díez-Guerra, José M Carrascosa, Elena Bogóne. Age-associated decrease of SIRT1 expression in rat hippocampus: prevention by late onset caloric restriction. Experimental gerontology. vol 47. issue 2. 2012-03-21. PMID:22143179. |
quantitative analysis showed that there is a significant reduction of sirt1 protein levels in hippocampus with aging. |
2012-03-21 |
2023-08-12 |
rat |
| Ana Quintas, Alain J de Solís, F Javier Díez-Guerra, José M Carrascosa, Elena Bogóne. Age-associated decrease of SIRT1 expression in rat hippocampus: prevention by late onset caloric restriction. Experimental gerontology. vol 47. issue 2. 2012-03-21. PMID:22143179. |
examination of sirt1 immunoreactivity in coronal sections from hippocampus supported these results, and confirmed that old animals are able to respond to the beneficial effects of cr by regulating sirt1 protein expression. |
2012-03-21 |
2023-08-12 |
rat |
| Wei-Hai Xu, Xiao-Ying Yao, Hao-Jie Yu, Ji-Wei Huang, Li-Ying Cu. Downregulation of miR-199a may play a role in 3-nitropropionic acid induced ischemic tolerance in rat brain. Brain research. vol 1429. 2012-03-20. PMID:22079324. |
the level of sirt1 protein, a putative target of mir-199a and a known mediator of neuroprotective effect in brain ischemic tolerance, decreased significantly in hippocampal neurons by overexpression of mir-199a, while it increased with knockdown of mir-199a. |
2012-03-20 |
2023-08-12 |
rat |
| P-S Huang, J-H Son, L C Abbott, U H Winzer-Serha. Regulated expression of neuronal SIRT1 and related genes by aging and neuronal β2-containing nicotinic cholinergic receptors. Neuroscience. vol 196. 2012-02-23. PMID:21939740. |
using in situ hybridization, the expression of sirt1, ku70, nampt, p53, forkhead box o3 (foxo3), and mitochondria uncoupling protein 5 (ucp5) was determined in neocortex and hippocampus of young adult 3-month and middle-aged 18-month-old wild-type (wt), and age-matched mice lacking β2* heteromeric nachrs (β2-/-). |
2012-02-23 |
2023-08-12 |
mouse |
| P-S Huang, J-H Son, L C Abbott, U H Winzer-Serha. Regulated expression of neuronal SIRT1 and related genes by aging and neuronal β2-containing nicotinic cholinergic receptors. Neuroscience. vol 196. 2012-02-23. PMID:21939740. |
genotype had no effect on expression in young adults in either cortex or mhb, but increased mrna expression of sirt1, nampt, and ku70 was detected in cortex, hippocampus, and mhb of aged β2-/- mice compared with wt mice. |
2012-02-23 |
2023-08-12 |
mouse |
| Dongmei Wu, Yifu Qiu, Xiang Gao, Xiao-Bing Yuan, Qiwei Zha. Overexpression of SIRT1 in mouse forebrain impairs lipid/glucose metabolism and motor function. PloS one. vol 6. issue 6. 2011-12-01. PMID:21738790. |
here we created transgenic mice overexpressing sirt1 in striatum and hippocampus under the control of camkiiα promoter. |
2011-12-01 |
2023-08-12 |
mouse |
| G Torres, J N Dileo, B H Hallas, J M Horowitz, J R Lehest. Silent information regulator 1 mediates hippocampal plasticity through presenilin1. Neuroscience. vol 179. 2011-07-13. PMID:21277951. |
our findings reveal a strong link between resveratrol-dependent sirt1 signaling and hippocampal plasticity in the mammalian brain. |
2011-07-13 |
2023-08-12 |
human |
| Sherry M Zakhary, Diana Ayubcha, Jeffery N Dileo, Riya Jose, Joerg R Leheste, Judith M Horowitz, German Torre. Distribution analysis of deacetylase SIRT1 in rodent and human nervous systems. Anatomical record (Hoboken, N.J. : 2007). vol 293. issue 6. 2010-12-13. PMID:20225204. |
sirt1 is ubiquitously present in areas of the brain especially susceptible to age-related neurodegenerative states (e.g., the prefrontal cortex, hippocampus and basal ganglia). |
2010-12-13 |
2023-08-12 |
mouse |
| Shaday Michán, Ying Li, Maggie Meng-Hsiu Chou, Edoardo Parrella, Huanying Ge, Jeffrey M Long, Joanne S Allard, Kaitlyn Lewis, Marshall Miller, Wei Xu, Ronald F Mervis, Jing Chen, Karen I Guerin, Lois E H Smith, Michael W McBurney, David A Sinclair, Michel Baudry, Rafael de Cabo, Valter D Long. SIRT1 is essential for normal cognitive function and synaptic plasticity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 29. 2010-08-13. PMID:20660252. |
here we show that sirt1 is expressed in neurons of the hippocampus, a key structure in learning and memory. |
2010-08-13 |
2023-08-12 |
mouse |
| D Della-Morte, K R Dave, R A DeFazio, Y C Bao, A P Raval, M A Perez-Pinzo. Resveratrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1-uncoupling protein 2 pathway. Neuroscience. vol 159. issue 3. 2009-09-21. PMID:19356683. |
ipc increased sirt1 activity at 48 h, while rpc increased sirt1 activity at 1 h but not 48 h after treatment in hippocampus. |
2009-09-21 |
2023-08-12 |
rat |
| Ami P Raval, Hung Wen Lin, Kunjan R Dave, R Anthony Defazio, David Della Morte, Eun Joo Kim, Miguel A Perez-Pinzo. Resveratrol and ischemic preconditioning in the brain. Current medicinal chemistry. vol 15. issue 15. 2008-09-03. PMID:18537630. |
inhibition of sirt1 abolished ischemic preconditioning-induced neuroprotection in ca1 region of the hippocampus. |
2008-09-03 |
2023-08-12 |
Not clear |
| Dohoon Kim, Minh Dang Nguyen, Matthew M Dobbin, Andre Fischer, Farahnaz Sananbenesi, Joseph T Rodgers, Ivana Delalle, Joseph A Baur, Guangchao Sui, Sean M Armour, Pere Puigserver, David A Sinclair, Li-Huei Tsa. SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. The EMBO journal. vol 26. issue 13. 2007-11-27. PMID:17581637. |
in the inducible p25 transgenic mouse, a model of ad and tauopathies, resveratrol reduced neurodegeneration in the hippocampus, prevented learning impairment, and decreased the acetylation of the known sirt1 substrates pgc-1alpha and p53. |
2007-11-27 |
2023-08-12 |
mouse |
| Dohoon Kim, Minh Dang Nguyen, Matthew M Dobbin, Andre Fischer, Farahnaz Sananbenesi, Joseph T Rodgers, Ivana Delalle, Joseph A Baur, Guangchao Sui, Sean M Armour, Pere Puigserver, David A Sinclair, Li-Huei Tsa. SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. The EMBO journal. vol 26. issue 13. 2007-11-27. PMID:17581637. |
furthermore, injection of sirt1 lentivirus in the hippocampus of p25 transgenic mice conferred significant protection against neurodegeneration. |
2007-11-27 |
2023-08-12 |
mouse |
| Ami P Raval, Kunjan R Dave, Miguel A Pérez-Pinzó. Resveratrol mimics ischemic preconditioning in the brain. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 26. issue 9. 2006-09-20. PMID:16395277. |
employing an in vitro model of cerebral ischemia, the organotypic hippocampal slice culture, we report that resveratrol pretreatment mimics ipc via the sirt1 pathway. |
2006-09-20 |
2023-08-12 |
Not clear |