| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sumiti Saharan, Dhanisha J Jhaveri, Perry F Bartlet. SIRT1 regulates the neurogenic potential of neural precursors in the adult subventricular zone and hippocampus. Journal of neuroscience research. vol 91. issue 5. 2013-09-10. PMID:23404532. |
however, sirt1 knock down results in a significant increase in neuronal production in both the subventricular zone and the hippocampus. |
2013-09-10 |
2023-08-12 |
mouse |
| Sumiti Saharan, Dhanisha J Jhaveri, Perry F Bartlet. SIRT1 regulates the neurogenic potential of neural precursors in the adult subventricular zone and hippocampus. Journal of neuroscience research. vol 91. issue 5. 2013-09-10. PMID:23404532. |
importantly, knock down of sirt1 in hippocampal precursors in vivo, either through rnai or through genetic ablation, promotes their neurogenic potential. |
2013-09-10 |
2023-08-12 |
mouse |
| Sumiti Saharan, Dhanisha J Jhaveri, Perry F Bartlet. SIRT1 regulates the neurogenic potential of neural precursors in the adult subventricular zone and hippocampus. Journal of neuroscience research. vol 91. issue 5. 2013-09-10. PMID:23404532. |
these findings highlight sirt1 signaling as a negative regulator of neuronal differentiation of adult subventricular zone and hippocampal neural precursors. |
2013-09-10 |
2023-08-12 |
mouse |
| Tatiane Katsue Furuya, Patrícia Natália Oliveira da Silva, Spencer Luiz Marques Payão, Lucas Trevizani Rasmussen, Roger Willian de Labio, Paulo Henrique Ferreira Bertolucci, Ianna Lacerda Sampaio Braga, Elizabeth Suchi Chen, Gustavo Turecki, Naguib Mechawar, Jonathan Mill, Marília de Arruda Cardoso Smit. SORL1 and SIRT1 mRNA expression and promoter methylation levels in aging and Alzheimer's Disease. Neurochemistry international. vol 61. issue 7. 2013-06-05. PMID:22836009. |
as sorl1 (sortilin-related receptor) and sirt1 (sirtuin 1) genes have been linked to ad pathogenesis, we aimed to investigate their mrna expression and promoter dna methylation in post mortem brain tissues (entorhinal and auditory cortices and hippocampus) from healthy elderly subjects and ad patients. |
2013-06-05 |
2023-08-12 |
human |
| Juan F Codocedo, Claudio Allard, Juan A Godoy, Lorena Varela-Nallar, Nibaldo C Inestros. SIRT1 regulates dendritic development in hippocampal neurons. PloS one. vol 7. issue 10. 2013-05-31. PMID:23056585. |
sirt1 regulates dendritic development in hippocampal neurons. |
2013-05-31 |
2023-08-12 |
Not clear |
| Juan F Codocedo, Claudio Allard, Juan A Godoy, Lorena Varela-Nallar, Nibaldo C Inestros. SIRT1 regulates dendritic development in hippocampal neurons. PloS one. vol 7. issue 10. 2013-05-31. PMID:23056585. |
in the present study, the role of sirt1 in dendritic development was evaluated in cultured hippocampal neurons which were transfected at 3 days in vitro with a construct coding for sirt1 or for the dominant negative sirt1h363y, which lacks the catalytic activity. |
2013-05-31 |
2023-08-12 |
Not clear |
| Juan F Codocedo, Claudio Allard, Juan A Godoy, Lorena Varela-Nallar, Nibaldo C Inestros. SIRT1 regulates dendritic development in hippocampal neurons. PloS one. vol 7. issue 10. 2013-05-31. PMID:23056585. |
moreover, hippocampal neurons overexpressing sirt1 were resistant to dendritic dystrophy induced by aβ aggregates, an effect that was dependent on the deacetylase activity of sirt1. |
2013-05-31 |
2023-08-12 |
Not clear |
| Juan F Codocedo, Claudio Allard, Juan A Godoy, Lorena Varela-Nallar, Nibaldo C Inestros. SIRT1 regulates dendritic development in hippocampal neurons. PloS one. vol 7. issue 10. 2013-05-31. PMID:23056585. |
our findings indicate that sirt1 plays a role in the development and maintenance of dendritic branching in hippocampal neurons, and suggest that these effects are mediated by the rock signaling pathway. |
2013-05-31 |
2023-08-12 |
Not clear |
| Stefano Falone, Antonella D'Alessandro, Alessandro Mirabilio, Marisa Cacchio, Carmine Di Ilio, Silvia Di Loreto, Fernanda Amicarell. Late-onset running biphasically improves redox balance, energy- and methylglyoxal-related status, as well as SIRT1 expression in mouse hippocampus. PloS one. vol 7. issue 10. 2013-04-26. PMID:23110231. |
late-onset running biphasically improves redox balance, energy- and methylglyoxal-related status, as well as sirt1 expression in mouse hippocampus. |
2013-04-26 |
2023-08-12 |
mouse |
| Jennifer L Steiner, E Angela Murphy, Jamie L McClellan, Martin D Carmichael, J Mark Davi. Exercise training increases mitochondrial biogenesis in the brain. Journal of applied physiology (Bethesda, Md. : 1985). vol 111. issue 4. 2012-12-05. PMID:21817111. |
twenty-four hours after the last training bout a subgroup of mice (n = 9-11/group) were euthanized, and brain (brain stem, cerebellum, cortex, frontal lobe, hippocampus, hypothalamus, and midbrain) and muscle (soleus) tissues were isolated for analysis of mrna expression of peroxisome proliferator-activated receptor-gamma coactivator-1-alpha (pgc-1α), silent information regulator t1 (sirt1), citrate synthase (cs), and mitochondrial dna (mtdna) using rt-pcr. |
2012-12-05 |
2023-08-12 |
mouse |
| Frankie D Heyward, R Grace Walton, Matthew S Carle, Mark A Coleman, W Timothy Garvey, J David Sweat. Adult mice maintained on a high-fat diet exhibit object location memory deficits and reduced hippocampal SIRT1 gene expression. Neurobiology of learning and memory. vol 98. issue 1. 2012-12-03. PMID:22542746. |
adult mice maintained on a high-fat diet exhibit object location memory deficits and reduced hippocampal sirt1 gene expression. |
2012-12-03 |
2023-08-12 |
mouse |
| Frankie D Heyward, R Grace Walton, Matthew S Carle, Mark A Coleman, W Timothy Garvey, J David Sweat. Adult mice maintained on a high-fat diet exhibit object location memory deficits and reduced hippocampal SIRT1 gene expression. Neurobiology of learning and memory. vol 98. issue 1. 2012-12-03. PMID:22542746. |
dio mice exhibited significant reductions in both sirt1 and pp1 mrna within the hippocampus. |
2012-12-03 |
2023-08-12 |
mouse |
| Erika Koltai, Zhongfu Zhao, Zsombor Lacza, Attila Cselenyak, Gabriella Vacz, Csaba Nyakas, Istvan Boldogh, Noriko Ichinoseki-Sekine, Zsolt Rada. Combined exercise and insulin-like growth factor-1 supplementation induces neurogenesis in old rats, but do not attenuate age-associated DNA damage. Rejuvenation research. vol 14. issue 6. 2012-04-17. PMID:21867412. |
sirtuin 1 (sirt1) and sirt3, as dna damage-associated lysine deacetylases, were measured, and sirt1 decreased with aging, resulting in a large increase in acetylated lysine residues in the hippocampus. |
2012-04-17 |
2023-08-12 |
rat |
| Erika Koltai, Zhongfu Zhao, Zsombor Lacza, Attila Cselenyak, Gabriella Vacz, Csaba Nyakas, Istvan Boldogh, Noriko Ichinoseki-Sekine, Zsolt Rada. Combined exercise and insulin-like growth factor-1 supplementation induces neurogenesis in old rats, but do not attenuate age-associated DNA damage. Rejuvenation research. vol 14. issue 6. 2012-04-17. PMID:21867412. |
age-associated decreases in sirt1 and the associated increase in lysine acetylation, in the hippocampus, could have significant impact on function and thus, could suggest a therapeutic target. |
2012-04-17 |
2023-08-12 |
rat |
| Ana Quintas, Alain J de Solís, F Javier Díez-Guerra, José M Carrascosa, Elena Bogóne. Age-associated decrease of SIRT1 expression in rat hippocampus: prevention by late onset caloric restriction. Experimental gerontology. vol 47. issue 2. 2012-03-21. PMID:22143179. |
age-associated decrease of sirt1 expression in rat hippocampus: prevention by late onset caloric restriction. |
2012-03-21 |
2023-08-12 |
rat |
| Ana Quintas, Alain J de Solís, F Javier Díez-Guerra, José M Carrascosa, Elena Bogóne. Age-associated decrease of SIRT1 expression in rat hippocampus: prevention by late onset caloric restriction. Experimental gerontology. vol 47. issue 2. 2012-03-21. PMID:22143179. |
we have studied the effect of aging and late onset caloric restriction (cr) on the expression of sirt1 in hippocampus and cerebral cortex of the rat. |
2012-03-21 |
2023-08-12 |
rat |
| Ana Quintas, Alain J de Solís, F Javier Díez-Guerra, José M Carrascosa, Elena Bogóne. Age-associated decrease of SIRT1 expression in rat hippocampus: prevention by late onset caloric restriction. Experimental gerontology. vol 47. issue 2. 2012-03-21. PMID:22143179. |
quantitative analysis showed that there is a significant reduction of sirt1 protein levels in hippocampus with aging. |
2012-03-21 |
2023-08-12 |
rat |
| Ana Quintas, Alain J de Solís, F Javier Díez-Guerra, José M Carrascosa, Elena Bogóne. Age-associated decrease of SIRT1 expression in rat hippocampus: prevention by late onset caloric restriction. Experimental gerontology. vol 47. issue 2. 2012-03-21. PMID:22143179. |
examination of sirt1 immunoreactivity in coronal sections from hippocampus supported these results, and confirmed that old animals are able to respond to the beneficial effects of cr by regulating sirt1 protein expression. |
2012-03-21 |
2023-08-12 |
rat |
| Wei-Hai Xu, Xiao-Ying Yao, Hao-Jie Yu, Ji-Wei Huang, Li-Ying Cu. Downregulation of miR-199a may play a role in 3-nitropropionic acid induced ischemic tolerance in rat brain. Brain research. vol 1429. 2012-03-20. PMID:22079324. |
the level of sirt1 protein, a putative target of mir-199a and a known mediator of neuroprotective effect in brain ischemic tolerance, decreased significantly in hippocampal neurons by overexpression of mir-199a, while it increased with knockdown of mir-199a. |
2012-03-20 |
2023-08-12 |
rat |
| P-S Huang, J-H Son, L C Abbott, U H Winzer-Serha. Regulated expression of neuronal SIRT1 and related genes by aging and neuronal β2-containing nicotinic cholinergic receptors. Neuroscience. vol 196. 2012-02-23. PMID:21939740. |
using in situ hybridization, the expression of sirt1, ku70, nampt, p53, forkhead box o3 (foxo3), and mitochondria uncoupling protein 5 (ucp5) was determined in neocortex and hippocampus of young adult 3-month and middle-aged 18-month-old wild-type (wt), and age-matched mice lacking β2* heteromeric nachrs (β2-/-). |
2012-02-23 |
2023-08-12 |
mouse |