| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P D Lisachev, V O Pustylnyak, M B Shtar. Sirt1 Regulates p53 Stability and Expression of Its Target S100B during Long-Term Potentiation in Rat Hippocampus. Bulletin of experimental biology and medicine. vol 160. issue 4. 2016-12-13. PMID:26902357. |
sirt1 regulates p53 stability and expression of its target s100b during long-term potentiation in rat hippocampus. |
2016-12-13 |
2023-08-13 |
rat |
| Weiguo Dong, Feng Wang, Wanqing Guo, Xuehua Zheng, Yue Chen, Wenguang Zhang, Hong Sh. Aβ25-35 Suppresses Mitochondrial Biogenesis in Primary Hippocampal Neurons. Cellular and molecular neurobiology. vol 36. issue 1. 2016-10-07. PMID:26055049. |
in primary hippocampal neurons, we found that 24-h incubation with aβ25-35 suppressed both phosphorylations of ampk and sirt1 expression and increased pgc-1α acetylation expression. |
2016-10-07 |
2023-08-13 |
Not clear |
| Mark F McCarty, James J DiNicolantonio, James H O'Keef. Ketosis may promote brain macroautophagy by activating Sirt1 and hypoxia-inducible factor-1. Medical hypotheses. vol 85. issue 5. 2016-09-09. PMID:26306884. |
another recent study has observed reduced activity of mtorc1 in the hippocampus of rats fed a ketogenic diet - an effect plausibly attributable to sirt1 activation. |
2016-09-09 |
2023-08-13 |
rat |
| Hak-Su Kim, Sohee Moon, Jin-Hwe Paik, Dong Wun Shin, Lindsay S Kim, Chang-Shin Park, Joohun Ha, Ju-Hee Kan. Activation of the 5'-AMP-Activated Protein Kinase in the Cerebral Cortex of Young Senescence-Accelerated P8 Mice and Association with GSK3β- and PP2A-Dependent Inhibition of p-tau₃₉₆ Expression. Journal of Alzheimer's disease : JAD. vol 46. issue 1. 2016-06-27. PMID:25737046. |
the hippocampal levels of p-ampk and p-tau396 in samp8 animals were not significantly different from those of samr1, whereas upregulation of p-gsk3βs9 and downregulation of sirt1 was observed in the hippocampus of samp8 mice. |
2016-06-27 |
2023-08-13 |
mouse |
| Frankie D Heyward, Daniel Gilliam, Mark A Coleman, Cristin F Gavin, Jing Wang, Garrett Kaas, Richard Trieu, John Lewis, Jerome Moulden, J David Sweat. Obesity Weighs down Memory through a Mechanism Involving the Neuroepigenetic Dysregulation of Sirt1. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 4. 2016-06-01. PMID:26818519. |
here we report evidence of obesity-induced alterations in dna methylation of memory-associated genes, including sirtuin 1 (sirt1), within the hippocampus, and thus offer a novel mechanism by which sirt1 expression within the hippocampus is suppressed during obesity. |
2016-06-01 |
2023-08-13 |
mouse |
| Frankie D Heyward, Daniel Gilliam, Mark A Coleman, Cristin F Gavin, Jing Wang, Garrett Kaas, Richard Trieu, John Lewis, Jerome Moulden, J David Sweat. Obesity Weighs down Memory through a Mechanism Involving the Neuroepigenetic Dysregulation of Sirt1. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 4. 2016-06-01. PMID:26818519. |
forebrain neuron-specific sirt1 knock-out closely recapitulated the memory deficits exhibited by obese mice, consistent with the hypothesis that the high-fat diet-mediated reduction of hippocampal sirt1 could be responsible for obesity-linked memory impairment. |
2016-06-01 |
2023-08-13 |
mouse |
| Frankie D Heyward, Daniel Gilliam, Mark A Coleman, Cristin F Gavin, Jing Wang, Garrett Kaas, Richard Trieu, John Lewis, Jerome Moulden, J David Sweat. Obesity Weighs down Memory through a Mechanism Involving the Neuroepigenetic Dysregulation of Sirt1. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 4. 2016-06-01. PMID:26818519. |
obese mice fed a diet supplemented with the sirt1-activating molecule resveratrol exhibited increased hippocampal sirt1 activity and preserved hippocampus-dependent memory, further strengthening this conclusion. |
2016-06-01 |
2023-08-13 |
mouse |
| Frankie D Heyward, Daniel Gilliam, Mark A Coleman, Cristin F Gavin, Jing Wang, Garrett Kaas, Richard Trieu, John Lewis, Jerome Moulden, J David Sweat. Obesity Weighs down Memory through a Mechanism Involving the Neuroepigenetic Dysregulation of Sirt1. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 4. 2016-06-01. PMID:26818519. |
thus, our findings suggest that the memory-impairing effects of diet-induced obesity may potentially be mediated by neuroepigenetic dysregulation of sirt1 within the hippocampus. |
2016-06-01 |
2023-08-13 |
mouse |
| Talita Tuon, Priscila S Souza, Marcela F Santos, Fernanda T Pereira, Giulia S Pedroso, Thais F Luciano, Claudio T De Souza, Rafael C Dutra, Paulo C L Silveira, Ricardo A Pinh. Physical Training Regulates Mitochondrial Parameters and Neuroinflammatory Mechanisms in an Experimental Model of Parkinson's Disease. Oxidative medicine and cellular longevity. vol 2015. 2016-05-18. PMID:26448816. |
mice were euthanized by cervical dislocation and the striatum and hippocampus were homogenized to determine levels of tyrosine hydroxylase (th), nuclear factor kappa b (nf-κb) p65, and sirtuin 1 (sirt1) by western blot; tumor necrosis factor-α (tnf-α), interleukin-1β (il-1β), il-17, interferon-γ (ifn-γ), and transforming growth factor β1 (tgf-β1) levels by elisa; no content; and complex i (ci) activity. |
2016-05-18 |
2023-08-13 |
mouse |
| Talita Tuon, Priscila S Souza, Marcela F Santos, Fernanda T Pereira, Giulia S Pedroso, Thais F Luciano, Claudio T De Souza, Rafael C Dutra, Paulo C L Silveira, Ricardo A Pinh. Physical Training Regulates Mitochondrial Parameters and Neuroinflammatory Mechanisms in an Experimental Model of Parkinson's Disease. Oxidative medicine and cellular longevity. vol 2015. 2016-05-18. PMID:26448816. |
str + 6-ohda mice had higher th levels and ci activity and lower nf-κb p65 and ifn-γ levels in the striatum compared to u + 6-ohda mice, while ttr + 6-ohda mice had higher sirt1 levels and ci activity in both the striatum and the hippocampus, compared to u + 6-ohda mice. |
2016-05-18 |
2023-08-13 |
mouse |
| N M Pathak, V Pathak, A M Lynch, N Irwin, V A Gault, P R Flat. Stable oxyntomodulin analogues exert positive effects on hippocampal neurogenesis and gene expression as well as improving glucose homeostasis in high fat fed mice. Molecular and cellular endocrinology. vol 412. 2016-05-17. PMID:26048772. |
furthermore, oxm analogues up-regulated hippocampal mrna expression of mash1, synaptophysin, sirt1, glut4 and irs1, and down-regulated expression of ldl-r and gsk3β. |
2016-05-17 |
2023-08-13 |
mouse |
| Haiqin Wu, Huqing Wang, Wenting Zhang, Xuanhui Wei, Jiaxin Zhao, Pu Yan, Chao Li. rhEPO affects apoptosis in hippocampus of aging rats by upregulating SIRT1. International journal of clinical and experimental pathology. vol 8. issue 6. 2016-05-16. PMID:26261574. |
rhepo affects apoptosis in hippocampus of aging rats by upregulating sirt1. |
2016-05-16 |
2023-08-13 |
human |
| Haiqin Wu, Huqing Wang, Wenting Zhang, Xuanhui Wei, Jiaxin Zhao, Pu Yan, Chao Li. rhEPO affects apoptosis in hippocampus of aging rats by upregulating SIRT1. International journal of clinical and experimental pathology. vol 8. issue 6. 2016-05-16. PMID:26261574. |
the aim of this study was to elucidate the signaling pathway involved in the anti-aging effect of erythropoietin (epo) and to clarify whether recombinant human epo (rhepo) affects apoptosis in the aging rat hippocampus by upregulating sirtuin 1 (sirt1). |
2016-05-16 |
2023-08-13 |
human |
| Haiqin Wu, Huqing Wang, Wenting Zhang, Xuanhui Wei, Jiaxin Zhao, Pu Yan, Chao Li. rhEPO affects apoptosis in hippocampus of aging rats by upregulating SIRT1. International journal of clinical and experimental pathology. vol 8. issue 6. 2016-05-16. PMID:26261574. |
using immunohistochemistry, we studied the expression of sirt1, b-cell lymphoma/leukemia-2 gene (bcl-2), and bcl-2 associated x protein (bax) expression, and apoptotic cells in the hippocampus of a rat model of aging in which rhepo was intraperitoneally injected. |
2016-05-16 |
2023-08-13 |
human |
| Haiqin Wu, Huqing Wang, Wenting Zhang, Xuanhui Wei, Jiaxin Zhao, Pu Yan, Chao Li. rhEPO affects apoptosis in hippocampus of aging rats by upregulating SIRT1. International journal of clinical and experimental pathology. vol 8. issue 6. 2016-05-16. PMID:26261574. |
compared to the d-gal group, in the epo group, the number of sirt1 and bcl-2-positive cells increased (p < 0.05), but the number of bax-positive cells and apoptotic cells decreased in the hippocampus of aging rats (p < 0.05). |
2016-05-16 |
2023-08-13 |
human |
| Zachary S Bailey, Venkata Silva Sai Sujith Sajja, W Brad Hubbard, Pamela J VandeVor. Blast Induced Neurotrauma Leads To Changes In The Epigenome. Biomedical sciences instrumentation. vol 51. 2016-02-18. PMID:25996748. |
sirt1, dnmt3a and dnmt3b levels were all reduced in the hippocampus. |
2016-02-18 |
2023-08-13 |
Not clear |
| Letizia Polito, Armando Chierchia, Marta Tunesi, Ihssane Bouybayoune, Patrick Gavin Kehoe, Diego Albani, Gianluigi Forlon. Environmental enrichment lessens cognitive decline in APP23 mice without affecting brain sirtuin expression. Journal of Alzheimer's disease : JAD. vol 42. issue 3. 2015-08-25. PMID:24961946. |
we also investigated the involvement of sirtuins (sirts) as a possible molecular mediator of ee, by assessing hippocampal and cortical mrna and protein levels of the sirt family members (sirt1 to sirt7). |
2015-08-25 |
2023-08-13 |
mouse |
| Virginia Torres-Lista, Cristina Parrado-Fernández, Ismael Alvarez-Montón, Javier Frontiñán-Rubio, Mario Durán-Prado, Juan Ramón Peinado, Björn Johansson, Francisco Javier Alcaín, Lydia Giménez-Llor. Neophobia, NQO1 and SIRT1 as premorbid and prodromal indicators of AD in 3xTg-AD mice. Behavioural brain research. vol 271. 2015-08-06. PMID:24837743. |
sirt1 levels showed opposite age-dependent changes in cortex (increase) and hippocampus (decrease) relative to controls. |
2015-08-06 |
2023-08-13 |
mouse |
| Virginia Torres-Lista, Cristina Parrado-Fernández, Ismael Alvarez-Montón, Javier Frontiñán-Rubio, Mario Durán-Prado, Juan Ramón Peinado, Björn Johansson, Francisco Javier Alcaín, Lydia Giménez-Llor. Neophobia, NQO1 and SIRT1 as premorbid and prodromal indicators of AD in 3xTg-AD mice. Behavioural brain research. vol 271. 2015-08-06. PMID:24837743. |
prodromal cognitive deficits emerged at 6 months of age, concomitantly to cortical overexpression of sirt1 but down-regulation of nqo1 and sirt1 in the hippocampus, suggesting inadequate antioxidative protection to prevent or delay the subjacent neuronal damage. |
2015-08-06 |
2023-08-13 |
mouse |
| Rachael Lennox, David W Porter, Peter R Flatt, Christian Holscher, Nigel Irwin, Victor A Gaul. Comparison of the independent and combined effects of sub-chronic therapy with metformin and a stable GLP-1 receptor agonist on cognitive function, hippocampal synaptic plasticity and metabolic control in high-fat fed mice. Neuropharmacology. vol 86. 2015-07-14. PMID:24998752. |
expression of fundamental hippocampal genes including mtor, vegf, ntrk2 and sirt1 was also increased significantly (p < 0.001) by all treatments. |
2015-07-14 |
2023-08-13 |
mouse |