| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Talita Tuon, Priscila S Souza, Marcela F Santos, Fernanda T Pereira, Giulia S Pedroso, Thais F Luciano, Claudio T De Souza, Rafael C Dutra, Paulo C L Silveira, Ricardo A Pinh. Physical Training Regulates Mitochondrial Parameters and Neuroinflammatory Mechanisms in an Experimental Model of Parkinson's Disease. Oxidative medicine and cellular longevity. vol 2015. 2016-05-18. PMID:26448816. |
str + 6-ohda mice had higher th levels and ci activity and lower nf-κb p65 and ifn-γ levels in the striatum compared to u + 6-ohda mice, while ttr + 6-ohda mice had higher sirt1 levels and ci activity in both the striatum and the hippocampus, compared to u + 6-ohda mice. |
2016-05-18 |
2023-08-13 |
mouse |
| N M Pathak, V Pathak, A M Lynch, N Irwin, V A Gault, P R Flat. Stable oxyntomodulin analogues exert positive effects on hippocampal neurogenesis and gene expression as well as improving glucose homeostasis in high fat fed mice. Molecular and cellular endocrinology. vol 412. 2016-05-17. PMID:26048772. |
furthermore, oxm analogues up-regulated hippocampal mrna expression of mash1, synaptophysin, sirt1, glut4 and irs1, and down-regulated expression of ldl-r and gsk3β. |
2016-05-17 |
2023-08-13 |
mouse |
| Haiqin Wu, Huqing Wang, Wenting Zhang, Xuanhui Wei, Jiaxin Zhao, Pu Yan, Chao Li. rhEPO affects apoptosis in hippocampus of aging rats by upregulating SIRT1. International journal of clinical and experimental pathology. vol 8. issue 6. 2016-05-16. PMID:26261574. |
rhepo affects apoptosis in hippocampus of aging rats by upregulating sirt1. |
2016-05-16 |
2023-08-13 |
human |
| Haiqin Wu, Huqing Wang, Wenting Zhang, Xuanhui Wei, Jiaxin Zhao, Pu Yan, Chao Li. rhEPO affects apoptosis in hippocampus of aging rats by upregulating SIRT1. International journal of clinical and experimental pathology. vol 8. issue 6. 2016-05-16. PMID:26261574. |
the aim of this study was to elucidate the signaling pathway involved in the anti-aging effect of erythropoietin (epo) and to clarify whether recombinant human epo (rhepo) affects apoptosis in the aging rat hippocampus by upregulating sirtuin 1 (sirt1). |
2016-05-16 |
2023-08-13 |
human |
| Haiqin Wu, Huqing Wang, Wenting Zhang, Xuanhui Wei, Jiaxin Zhao, Pu Yan, Chao Li. rhEPO affects apoptosis in hippocampus of aging rats by upregulating SIRT1. International journal of clinical and experimental pathology. vol 8. issue 6. 2016-05-16. PMID:26261574. |
using immunohistochemistry, we studied the expression of sirt1, b-cell lymphoma/leukemia-2 gene (bcl-2), and bcl-2 associated x protein (bax) expression, and apoptotic cells in the hippocampus of a rat model of aging in which rhepo was intraperitoneally injected. |
2016-05-16 |
2023-08-13 |
human |
| Haiqin Wu, Huqing Wang, Wenting Zhang, Xuanhui Wei, Jiaxin Zhao, Pu Yan, Chao Li. rhEPO affects apoptosis in hippocampus of aging rats by upregulating SIRT1. International journal of clinical and experimental pathology. vol 8. issue 6. 2016-05-16. PMID:26261574. |
compared to the d-gal group, in the epo group, the number of sirt1 and bcl-2-positive cells increased (p < 0.05), but the number of bax-positive cells and apoptotic cells decreased in the hippocampus of aging rats (p < 0.05). |
2016-05-16 |
2023-08-13 |
human |
| Zachary S Bailey, Venkata Silva Sai Sujith Sajja, W Brad Hubbard, Pamela J VandeVor. Blast Induced Neurotrauma Leads To Changes In The Epigenome. Biomedical sciences instrumentation. vol 51. 2016-02-18. PMID:25996748. |
sirt1, dnmt3a and dnmt3b levels were all reduced in the hippocampus. |
2016-02-18 |
2023-08-13 |
Not clear |
| Letizia Polito, Armando Chierchia, Marta Tunesi, Ihssane Bouybayoune, Patrick Gavin Kehoe, Diego Albani, Gianluigi Forlon. Environmental enrichment lessens cognitive decline in APP23 mice without affecting brain sirtuin expression. Journal of Alzheimer's disease : JAD. vol 42. issue 3. 2015-08-25. PMID:24961946. |
we also investigated the involvement of sirtuins (sirts) as a possible molecular mediator of ee, by assessing hippocampal and cortical mrna and protein levels of the sirt family members (sirt1 to sirt7). |
2015-08-25 |
2023-08-13 |
mouse |
| Virginia Torres-Lista, Cristina Parrado-Fernández, Ismael Alvarez-Montón, Javier Frontiñán-Rubio, Mario Durán-Prado, Juan Ramón Peinado, Björn Johansson, Francisco Javier Alcaín, Lydia Giménez-Llor. Neophobia, NQO1 and SIRT1 as premorbid and prodromal indicators of AD in 3xTg-AD mice. Behavioural brain research. vol 271. 2015-08-06. PMID:24837743. |
sirt1 levels showed opposite age-dependent changes in cortex (increase) and hippocampus (decrease) relative to controls. |
2015-08-06 |
2023-08-13 |
mouse |
| Virginia Torres-Lista, Cristina Parrado-Fernández, Ismael Alvarez-Montón, Javier Frontiñán-Rubio, Mario Durán-Prado, Juan Ramón Peinado, Björn Johansson, Francisco Javier Alcaín, Lydia Giménez-Llor. Neophobia, NQO1 and SIRT1 as premorbid and prodromal indicators of AD in 3xTg-AD mice. Behavioural brain research. vol 271. 2015-08-06. PMID:24837743. |
prodromal cognitive deficits emerged at 6 months of age, concomitantly to cortical overexpression of sirt1 but down-regulation of nqo1 and sirt1 in the hippocampus, suggesting inadequate antioxidative protection to prevent or delay the subjacent neuronal damage. |
2015-08-06 |
2023-08-13 |
mouse |
| Rachael Lennox, David W Porter, Peter R Flatt, Christian Holscher, Nigel Irwin, Victor A Gaul. Comparison of the independent and combined effects of sub-chronic therapy with metformin and a stable GLP-1 receptor agonist on cognitive function, hippocampal synaptic plasticity and metabolic control in high-fat fed mice. Neuropharmacology. vol 86. 2015-07-14. PMID:24998752. |
expression of fundamental hippocampal genes including mtor, vegf, ntrk2 and sirt1 was also increased significantly (p < 0.001) by all treatments. |
2015-07-14 |
2023-08-13 |
mouse |
| Sheng-Jun Wang, Xiu-He Zhao, Wen Chen, Ning Bo, Xian-Jin Wang, Zhao-Fu Chi, Wei W. Sirtuin 1 activation enhances the PGC-1α/mitochondrial antioxidant system pathway in status epilepticus. Molecular medicine reports. vol 11. issue 1. 2015-06-26. PMID:25333348. |
the data demonstrated that sirt1 expression and activity were enhanced in the rat hippocampus following se. |
2015-06-26 |
2023-08-13 |
rat |
| Nady Braidy, Anne Poljak, Ross Grant, Tharusha Jayasena, Hussein Mansour, Tailoi Chan-Ling, Gilles J Guillemin, George Smythe, Perminder Sachde. Mapping NAD(+) metabolism in the brain of ageing Wistar rats: potential targets for influencing brain senescence. Biogerontology. vol 15. issue 2. 2015-02-19. PMID:24337988. |
hyperphosphorylation of h2ax levels was also observed together with increased parp-1 and parp-2 expression, and cd38 activity, concomitantly with reduced nad(+) and atp levels and sirt1 function in the cortex, brainstem, hippocampus and cerebellum. |
2015-02-19 |
2023-08-12 |
rat |
| Chen-Yan Ma, Mao-jin Yao, Qi-wei Zhai, Jian-wei Jiao, Xiao-bing Yuan, Mu-ming Po. SIRT1 suppresses self-renewal of adult hippocampal neural stem cells. Development (Cambridge, England). vol 141. issue 24. 2015-02-04. PMID:25468938. |
sirt1 suppresses self-renewal of adult hippocampal neural stem cells. |
2015-02-04 |
2023-08-13 |
mouse |
| Chen-Yan Ma, Mao-jin Yao, Qi-wei Zhai, Jian-wei Jiao, Xiao-bing Yuan, Mu-ming Po. SIRT1 suppresses self-renewal of adult hippocampal neural stem cells. Development (Cambridge, England). vol 141. issue 24. 2015-02-04. PMID:25468938. |
here, we investigate the role of sirt1, an important metabolic sensor and epigenetic repressor, in regulating adult hippocampal neurogenesis in mice. |
2015-02-04 |
2023-08-13 |
mouse |
| Jianguo Li, Li Feng, Yonghua Xing, Yan Wang, Liqing Du, Chang Xu, Jia Cao, Qin Wang, Saijun Fan, Qiang Liu, Feiyue Fa. Radioprotective and antioxidant effect of resveratrol in hippocampus by activating Sirt1. International journal of molecular sciences. vol 15. issue 4. 2015-01-19. PMID:24722566. |
radioprotective and antioxidant effect of resveratrol in hippocampus by activating sirt1. |
2015-01-19 |
2023-08-13 |
Not clear |
| Mirjam I Lutz, Ivan Milenkovic, Günther Regelsberger, Gabor G Kovac. Distinct patterns of sirtuin expression during progression of Alzheimer's disease. Neuromolecular medicine. vol 16. issue 2. 2015-01-05. PMID:24464653. |
to examine whether the expression levels of sirtuins associate with the progression of ad or not, we performed a comparative immunoblotting and immunohistochemical study of sirt1, 3, and 5 in the entorhinal cortex and hippocampal subregions and white matter in 45 cases grouped according to braak and braak stages of neurofibrillary degeneration. |
2015-01-05 |
2023-08-12 |
Not clear |
| Lai-Ling Du, Jia-Zhao Xie, Xiang-Shu Cheng, Xiao-Hong Li, Fan-Li Kong, Xia Jiang, Zhi-Wei Ma, Jian-Zhi Wang, Chen Chen, Xin-Wen Zho. Activation of sirtuin 1 attenuates cerebral ventricular streptozotocin-induced tau hyperphosphorylation and cognitive injuries in rat hippocampi. Age (Dordrecht, Netherlands). vol 36. issue 2. 2014-11-18. PMID:24142524. |
in conclusion, sirt1 protects hippocampus neurons from tau hyperphosphorylation and prevents cognitive impairment induced by icv-stz brain insulin resistance with decreased hippocampus erk1/2 activity. |
2014-11-18 |
2023-08-12 |
rat |
| Xiao-Min Li, Mai-Tao Zhou, Xing-Ming Wang, Mu-Huo Ji, Zhi-Qiang Zhou, Jian-Jun Yan. Resveratrol pretreatment attenuates the isoflurane-induced cognitive impairment through its anti-inflammation and -apoptosis actions in aged mice. Journal of molecular neuroscience : MN. vol 52. issue 2. 2014-10-06. PMID:24126892. |
however, the isoflurane anesthesia had no significant effect on the hippocampal sirt1. |
2014-10-06 |
2023-08-12 |
mouse |
| Sarah A Prins, Magdalena M Przybycien-Szymanska, Yathindar S Rao, Toni R Pa. Long-term effects of peripubertal binge EtOH exposure on hippocampal microRNA expression in the rat. PloS one. vol 9. issue 1. 2014-09-08. PMID:24416161. |
two genes important for regulating hippocampal functions include brain-derived neurotrophic factor (bdnf) and sirtuin-1 (sirt1), which we identified as putative gene targets of mir-10a-5p, mir-26a, mir-103, mir-495. |
2014-09-08 |
2023-08-12 |
rat |