| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sheng-Jun Wang, Xiu-He Zhao, Wen Chen, Ning Bo, Xian-Jin Wang, Zhao-Fu Chi, Wei W. Sirtuin 1 activation enhances the PGC-1α/mitochondrial antioxidant system pathway in status epilepticus. Molecular medicine reports. vol 11. issue 1. 2015-06-26. PMID:25333348. |
the data demonstrated that sirt1 expression and activity were enhanced in the rat hippocampus following se. |
2015-06-26 |
2023-08-13 |
rat |
| Nady Braidy, Anne Poljak, Ross Grant, Tharusha Jayasena, Hussein Mansour, Tailoi Chan-Ling, Gilles J Guillemin, George Smythe, Perminder Sachde. Mapping NAD(+) metabolism in the brain of ageing Wistar rats: potential targets for influencing brain senescence. Biogerontology. vol 15. issue 2. 2015-02-19. PMID:24337988. |
hyperphosphorylation of h2ax levels was also observed together with increased parp-1 and parp-2 expression, and cd38 activity, concomitantly with reduced nad(+) and atp levels and sirt1 function in the cortex, brainstem, hippocampus and cerebellum. |
2015-02-19 |
2023-08-12 |
rat |
| Chen-Yan Ma, Mao-jin Yao, Qi-wei Zhai, Jian-wei Jiao, Xiao-bing Yuan, Mu-ming Po. SIRT1 suppresses self-renewal of adult hippocampal neural stem cells. Development (Cambridge, England). vol 141. issue 24. 2015-02-04. PMID:25468938. |
sirt1 suppresses self-renewal of adult hippocampal neural stem cells. |
2015-02-04 |
2023-08-13 |
mouse |
| Chen-Yan Ma, Mao-jin Yao, Qi-wei Zhai, Jian-wei Jiao, Xiao-bing Yuan, Mu-ming Po. SIRT1 suppresses self-renewal of adult hippocampal neural stem cells. Development (Cambridge, England). vol 141. issue 24. 2015-02-04. PMID:25468938. |
here, we investigate the role of sirt1, an important metabolic sensor and epigenetic repressor, in regulating adult hippocampal neurogenesis in mice. |
2015-02-04 |
2023-08-13 |
mouse |
| Jianguo Li, Li Feng, Yonghua Xing, Yan Wang, Liqing Du, Chang Xu, Jia Cao, Qin Wang, Saijun Fan, Qiang Liu, Feiyue Fa. Radioprotective and antioxidant effect of resveratrol in hippocampus by activating Sirt1. International journal of molecular sciences. vol 15. issue 4. 2015-01-19. PMID:24722566. |
radioprotective and antioxidant effect of resveratrol in hippocampus by activating sirt1. |
2015-01-19 |
2023-08-13 |
Not clear |
| Mirjam I Lutz, Ivan Milenkovic, Günther Regelsberger, Gabor G Kovac. Distinct patterns of sirtuin expression during progression of Alzheimer's disease. Neuromolecular medicine. vol 16. issue 2. 2015-01-05. PMID:24464653. |
to examine whether the expression levels of sirtuins associate with the progression of ad or not, we performed a comparative immunoblotting and immunohistochemical study of sirt1, 3, and 5 in the entorhinal cortex and hippocampal subregions and white matter in 45 cases grouped according to braak and braak stages of neurofibrillary degeneration. |
2015-01-05 |
2023-08-12 |
Not clear |
| Lai-Ling Du, Jia-Zhao Xie, Xiang-Shu Cheng, Xiao-Hong Li, Fan-Li Kong, Xia Jiang, Zhi-Wei Ma, Jian-Zhi Wang, Chen Chen, Xin-Wen Zho. Activation of sirtuin 1 attenuates cerebral ventricular streptozotocin-induced tau hyperphosphorylation and cognitive injuries in rat hippocampi. Age (Dordrecht, Netherlands). vol 36. issue 2. 2014-11-18. PMID:24142524. |
in conclusion, sirt1 protects hippocampus neurons from tau hyperphosphorylation and prevents cognitive impairment induced by icv-stz brain insulin resistance with decreased hippocampus erk1/2 activity. |
2014-11-18 |
2023-08-12 |
rat |
| Xiao-Min Li, Mai-Tao Zhou, Xing-Ming Wang, Mu-Huo Ji, Zhi-Qiang Zhou, Jian-Jun Yan. Resveratrol pretreatment attenuates the isoflurane-induced cognitive impairment through its anti-inflammation and -apoptosis actions in aged mice. Journal of molecular neuroscience : MN. vol 52. issue 2. 2014-10-06. PMID:24126892. |
however, the isoflurane anesthesia had no significant effect on the hippocampal sirt1. |
2014-10-06 |
2023-08-12 |
mouse |
| Sarah A Prins, Magdalena M Przybycien-Szymanska, Yathindar S Rao, Toni R Pa. Long-term effects of peripubertal binge EtOH exposure on hippocampal microRNA expression in the rat. PloS one. vol 9. issue 1. 2014-09-08. PMID:24416161. |
two genes important for regulating hippocampal functions include brain-derived neurotrophic factor (bdnf) and sirtuin-1 (sirt1), which we identified as putative gene targets of mir-10a-5p, mir-26a, mir-103, mir-495. |
2014-09-08 |
2023-08-12 |
rat |
| Sarah A Prins, Magdalena M Przybycien-Szymanska, Yathindar S Rao, Toni R Pa. Long-term effects of peripubertal binge EtOH exposure on hippocampal microRNA expression in the rat. PloS one. vol 9. issue 1. 2014-09-08. PMID:24416161. |
in addition, we measured the effects of binge etoh-exposure on hippocampal drosha and dicer mrna levels, as well as the putative mir target genes, bdnf and sirt1. |
2014-09-08 |
2023-08-12 |
rat |
| Xiao-Hong Li, Chong Chen, Yue Tu, Hong-Tao Sun, Ming-Liang Zhao, Shi-Xiang Cheng, Yang Qu, Sai Zhan. Sirt1 promotes axonogenesis by deacetylation of Akt and inactivation of GSK3. Molecular neurobiology. vol 48. issue 3. 2014-06-18. PMID:23475611. |
then, we found that genetic inhibition of sirt1 retarded axonal development in embryonic hippocampal neurons, whereas genetic and pharmacologic upregulation of sirt1 promoted not only the formation but also the elongation of axons. |
2014-06-18 |
2023-08-12 |
Not clear |
| L Sarga, N Hart, L G Koch, S L Britton, G Hajas, I Boldogh, X Ba, Z Rada. Aerobic endurance capacity affects spatial memory and SIRT1 is a potent modulator of 8-oxoguanine repair. Neuroscience. vol 252. 2014-06-11. PMID:23973402. |
these findings imply that high-running capacity is associated with increased hippocampal function, and sirt1 level/activity and inversely correlates with acogg1 levels and thereby the repair of genomic 8-oxog. |
2014-06-11 |
2023-08-12 |
rat |
| Jean-Louis Guéant, Jean-Luc Daval, Paul Vert, Jean-Pierre Nicola. [Folates and fetal programming: role of epigenetics and epigenomics]. Bulletin de l'Academie nationale de medecine. vol 196. issue 9. 2014-03-31. PMID:24552105. |
deficiency in folate and vitamin b12 produces impaired fatty acid oxidation in liver and heart through imbalanced methylation and acetylation of pgc1-alpha and decreased expression of sirt1, and long-lasting cognitive disabilities through impaired hippocampal cell proliferation, differentiation and plasticity and atrophy of hippocampal ca1. |
2014-03-31 |
2023-08-12 |
mouse |
| Sung Chung, Hee Jeong Kim, In Seon Yoon, Hyun Ju Kim, Sun Hye Choi, Yong Sik Kim, Kyung Ho Shi. Electroconvulsive shock increases SIRT1 immunoreactivity in the mouse hippocampus and hypothalamus. The journal of ECT. vol 29. issue 2. 2014-01-08. PMID:23519217. |
electroconvulsive shock increases sirt1 immunoreactivity in the mouse hippocampus and hypothalamus. |
2014-01-08 |
2023-08-12 |
mouse |
| Sung Chung, Hee Jeong Kim, In Seon Yoon, Hyun Ju Kim, Sun Hye Choi, Yong Sik Kim, Kyung Ho Shi. Electroconvulsive shock increases SIRT1 immunoreactivity in the mouse hippocampus and hypothalamus. The journal of ECT. vol 29. issue 2. 2014-01-08. PMID:23519217. |
the present study was designed to observe whether ecs dynamically regulates sirt1 levels in the hippocampus and hypothalamus; both of these regions have been implicated in the pathophysiology of depression. |
2014-01-08 |
2023-08-12 |
mouse |
| Jean-Louis Guéant, Fares Namour, Rosa-Maria Guéant-Rodriguez, Jean-Luc Dava. Folate and fetal programming: a play in epigenomics? Trends in endocrinology and metabolism: TEM. vol 24. issue 6. 2013-12-31. PMID:23474063. |
deficiency in folate and other methyl donors increases birth defects and produces visceral manifestations of fetal programming, including liver and heart steatosis, through imbalanced methylation and acetylation of pgc1-α and decreased sirt1 expression, and produces persistent cognitive and learning disabilities through impaired plasticity and hippocampal atrophy. |
2013-12-31 |
2023-08-12 |
Not clear |
| Amrita Datta Chaudhuri, Sowmya V Yelamanchili, Maria Cecilia G Marcondes, Howard S Fo. Up-regulation of microRNA-142 in simian immunodeficiency virus encephalitis leads to repression of sirtuin1. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 27. issue 9. 2013-11-12. PMID:23752207. |
sirtuin1 (sirt1) was predicted as a potential mir-142 target by analysis of its 3'-utr and bioinformatic analysis of factors linked to altered hippocampal gene expression profile in sive. |
2013-11-12 |
2023-08-12 |
human |
| Dae-Won Kim, Young-Mi Kim, Sung-Don Kang, Young-Min Han, Hyun-Ock Pa. Effects of Resveratrol and trans-3,5,4'-Trimethoxystilbene on Glutamate-Induced Cytotoxicity, Heme Oxygenase-1, and Sirtuin 1 in HT22 Neuronal Cells. Biomolecules & therapeutics. vol 20. issue 3. 2013-10-16. PMID:24130928. |
in this study, the effects of resveratrol and trans-3,5,4'-trimethoxystilbene (tms), a resveratrol derivative, on cytotoxicity caused by glutamate-induced oxidative stress, ho-1 expression, and sirt1 activation have been investigated by using murine hippocampal ht22 cells, which have been widely used as an in vitro model for investigating glutamate-induced neurotoxicity. |
2013-10-16 |
2023-08-12 |
Not clear |
| Sumiti Saharan, Dhanisha J Jhaveri, Perry F Bartlet. SIRT1 regulates the neurogenic potential of neural precursors in the adult subventricular zone and hippocampus. Journal of neuroscience research. vol 91. issue 5. 2013-09-10. PMID:23404532. |
sirt1 regulates the neurogenic potential of neural precursors in the adult subventricular zone and hippocampus. |
2013-09-10 |
2023-08-12 |
mouse |
| Sumiti Saharan, Dhanisha J Jhaveri, Perry F Bartlet. SIRT1 regulates the neurogenic potential of neural precursors in the adult subventricular zone and hippocampus. Journal of neuroscience research. vol 91. issue 5. 2013-09-10. PMID:23404532. |
we show that sirt1 is expressed by proliferating adult subventricular zone and hippocampal neural precursors, although its transcript and protein levels are dramatically reduced during neural precursor differentiation. |
2013-09-10 |
2023-08-12 |
mouse |