| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mengyao Li, Xiangxiu Xu, Yifan Jia, Yuan Yuan, Guo Na, Ling Zhu, Xiaowei Xiao, Yamin Zhang, Haiqing Y. Transformation of mulberry polyphenols by Lactobacillus plantarum SC-5: Increasing phenolic acids and enhancement of anti-aging effect. Food research international (Ottawa, Ont.). vol 192. 2024-08-15. PMID:39147466. |
meanwhile, the expression of sirtuin 1 (sirt1) and brain-derived neurotrophic factor (bdnf) increased, which protected the integrity of hippocampal tissue. |
2024-08-15 |
2024-08-18 |
mouse |
| Limin Chen, Shuying Chen, Yanjie Bai, Yongchuang Zhang, Xiaoxiao Li, Yan Wang, Yuqian Xiao, Jun Wan, Kexin Su. Electroacupuncture improves cognitive impairment after ischemic stroke based on regulation of mitochondrial dynamics through SIRT1/PGC-1α pathway. Brain research. 2024-08-07. PMID:39111521. |
investigating the effects of ea on the expression of sirtuin1 (sirt1), peroxisome proliferator-activated receptor γ coactivator-1α (pgc-1α), optic atrophy 1r + (opa1) and dynamin-related protein 1 (drp1) in hippocampal neurons and on the morphology and function of hippocampal neurons and mitochondria. |
2024-08-07 |
2024-08-10 |
rat |
| Limin Chen, Shuying Chen, Yanjie Bai, Yongchuang Zhang, Xiaoxiao Li, Yan Wang, Yuqian Xiao, Jun Wan, Kexin Su. Electroacupuncture improves cognitive impairment after ischemic stroke based on regulation of mitochondrial dynamics through SIRT1/PGC-1α pathway. Brain research. 2024-08-07. PMID:39111521. |
moreover, ea increased the expression of sirt1, pgc-1α, and opa1 in hippocampal tissues, inhibited the expression of drp1, attenuated neuronal and mitochondrial damage, and reduced mitochondrial fragmentation. |
2024-08-07 |
2024-08-10 |
rat |
| Li-Hao Cheng, Chien-Chen Wu, Yu-Hsuan Wei, Pei-Jun Wen, Chih-Chieh Hsu, Ying-Chieh Tsai, Sabrina Wan. Anti-aging effects of Lacticaseibacillus paracasei PS117 on cognitive and intestinal health in naturally-aged mice: A focus on senescence-related proteins and microbiota composition. Experimental gerontology. 2024-07-30. PMID:39079652. |
furthermore, the level of senescence-related protein p16ink4a (p16) were reduced, while anti-senescence protein sirtuin 1 (sirt1) were increased in the hippocampus. |
2024-07-30 |
2024-08-02 |
mouse |
| Reham L Younis, Rehab M El-Gohary, Asmaa A Ghalwash, Islam Ibrahim Hegab, Maram M Ghabrial, Azza M Aboshanady, Raghad A Mostafa, Alaa H Abd El-Azeem, Eman E Farghal, Asmaa A E Belal, Haidy Khatta. Luteolin Mitigates D-Galactose-Induced Brain Ageing in Rats: SIRT1-Mediated Neuroprotection. Neurochemical research. 2024-07-10. PMID:38987448. |
additionally, luteolin treatment considerably attenuated neuronal apoptosis and upregulated hippocampal sirt1 mrna expression. |
2024-07-10 |
2024-07-13 |
rat |
| Reham L Younis, Rehab M El-Gohary, Asmaa A Ghalwash, Islam Ibrahim Hegab, Maram M Ghabrial, Azza M Aboshanady, Raghad A Mostafa, Alaa H Abd El-Azeem, Eman E Farghal, Asmaa A E Belal, Haidy Khatta. Luteolin Mitigates D-Galactose-Induced Brain Ageing in Rats: SIRT1-Mediated Neuroprotection. Neurochemical research. 2024-07-10. PMID:38987448. |
in conclusion, our findings revealed that luteolin administration attenuated d-gal-evoked brain senescence, improving mitochondrial function and enhancing hippocampal neuroregeneration in an ageing rat model through its antioxidant, senolytic, anti-inflammatory, and anti-apoptotic impacts, possibly due to upregulation of sirt1. |
2024-07-10 |
2024-07-13 |
rat |
| Yadong Wen, Weihua Zhang, Dingran Wang, Meijing L. Propofol ameliorates cognitive deficits following splenectomy in aged rats by inhibiting ferroptosis via the SIRT1/Nrf2/GPX4 pathway. Neuroreport. 2024-07-05. PMID:38968575. |
utilizing the western blotting to assess the expression of sirtuin-1 (sirt1) in the hippocampus. |
2024-07-05 |
2024-07-08 |
rat |
| Miriam Rebekka Rühling, Hans Hartmann, Anibh Martin Da. Simplification of Dietary Treatment in Pharmacoresistant Epilepsy: Impact of C8 and C10 Fatty Acids on Sirtuins of Neuronal Cells In Vitro. Nutrients. vol 16. issue 11. 2024-06-19. PMID:38892612. |
the aim of the present study was to investigate whether ß-hydroxybutyrate (ßhb), c8 fatty acids, c10 fatty acids, or a combination of c8 and c10 (250/250 µm) fatty acids, which all increase under a kd, could up-regulate sirt1, -3, -4, and -5 in ht22 hippocampal murine neurons in vitro. |
2024-06-19 |
2024-06-21 |
Not clear |
| Xi Liu, Jia Gu, Cheng Wang, Min Peng, Jilin Zhou, Xiyun Fei, Zhijun Zhong, Bo L. Ginsenoside Rg3 attenuates neuroinflammation and hippocampal neuronal damage after traumatic brain injury in mice by inactivating the NF-kB pathway via SIRT1 activation. Cell cycle (Georgetown, Tex.). 2024-05-26. PMID:38796716. |
ginsenoside rg3 attenuates neuroinflammation and hippocampal neuronal damage after traumatic brain injury in mice by inactivating the nf-kb pathway via sirt1 activation. |
2024-05-26 |
2024-05-31 |
mouse |
| Xi Liu, Jia Gu, Cheng Wang, Min Peng, Jilin Zhou, Xiyun Fei, Zhijun Zhong, Bo L. Ginsenoside Rg3 attenuates neuroinflammation and hippocampal neuronal damage after traumatic brain injury in mice by inactivating the NF-kB pathway via SIRT1 activation. Cell cycle (Georgetown, Tex.). 2024-05-26. PMID:38796716. |
as a result, ginsenoside rg3 enhanced neurological and motor functions in mice post-tbi, reduced brain water content, alleviated hippocampal neuronal neuroinflammation and damage, activated sirt1, and deactivated the nf-kb pathway. |
2024-05-26 |
2024-05-31 |
mouse |
| Huan Li, Yan Liu, Xiangmeng Wang, Chaoqun Xu, Xiaoyu Zhang, Jing Zhang, Li Lin, Qiao Ni. miR-128-3p is involved in aluminum-induced cognitive impairment by regulating the Sirt1-Keap1/Nrf2 pathway. Ecotoxicology and environmental safety. vol 271. 2024-01-14. PMID:38219620. |
the relative expression levels of sirt1 and nrf2 in hippocampal tissues of all groups decreased gradually with increasing maltol aluminum exposure dose the relative expression levels of sirt1 and nrf2 in high-dose group (0.261 ± 0.094,0.325 ± 0.108) were significantly lower than those in control group (1.018 ± 0.222,1.009 ± 0.156)(p < 0.05). |
2024-01-14 |
2024-01-17 |
rat |
| Hagar M Shendy, Sarah S Mohamed, Enas A Abd El-Haleim, Omneya Galal, Walaa Wadie, Amr Helal, Mohamed T Khayya. Rice bran extract mitigates depressive-like behavior in dextran sulfate sodium-induced colitis: Involvement of the gut-brain axis and Sirt1 signaling pathway. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-12-20. PMID:38123053. |
treatment with rbe also led to a profound increase in the hippocampal levels of sirt1, pgc-1α, nrf2, and ho-1, which were drastically dropped by dss. |
2023-12-20 |
2023-12-23 |
rat |
| Huijuan Hu, Fan Li, Shaoli Cheng, Tingting Qu, Fanqi Shen, Jie Cheng, Lina Chen, Zhenghang Zhao, Hao H. Alternate-day fasting ameliorated anxiety-like behavior in high-fat diet-induced obese mice. The Journal of nutritional biochemistry. 2023-11-06. PMID:37931668. |
pathological changes in the hippocampus, the expression of sirt1 and its downstream protein monoamine oxidase a (mao-a) in the hippocampus, and the expression of 5-hydroxytryptamine (5-ht) were detected. |
2023-11-06 |
2023-11-08 |
mouse |
| Huijuan Hu, Fan Li, Shaoli Cheng, Tingting Qu, Fanqi Shen, Jie Cheng, Lina Chen, Zhenghang Zhao, Hao H. Alternate-day fasting ameliorated anxiety-like behavior in high-fat diet-induced obese mice. The Journal of nutritional biochemistry. 2023-11-06. PMID:37931668. |
compared with hfd-fed mice, hfd-fed mice subjected to adf for 16 weeks had a lower body weight but more brown adipose tissue (bat), less anxiety behavior, and less pathological damage in the hippocampus, and lower expression of sirt1 and mao-a protein and higher 5-ht levels in the hippocampus could be observed. |
2023-11-06 |
2023-11-08 |
mouse |
| Bataa M A El-Kafoury, Enas A Abdel-Hady, Wesam El Bakly, Wael M Elayat, Ghada Galal Hamam, Samar M M Abd El Rahman, Noha N Lashee. Lipoic acid inhibits cognitive impairment induced by multiple cell phones in young male rats: role of Sirt1 and Atg7 pathway. Scientific reports. vol 13. issue 1. 2023-10-30. PMID:37898621. |
correspondingly, there was an elevation of hippocampal ach, glutamate, and mda levels; accompanied by up-regulation of hippocampal sirt1 and atg7 gene expression. |
2023-10-30 |
2023-11-08 |
rat |
| Bataa M A El-Kafoury, Enas A Abdel-Hady, Wesam El Bakly, Wael M Elayat, Ghada Galal Hamam, Samar M M Abd El Rahman, Noha N Lashee. Lipoic acid inhibits cognitive impairment induced by multiple cell phones in young male rats: role of Sirt1 and Atg7 pathway. Scientific reports. vol 13. issue 1. 2023-10-30. PMID:37898621. |
compared to the emf-exposed group, la administration improved both learning and memory, this was proved by the significant decline in hippocampal mda and ach levels, the higher hippocampal glutamate, the downregulated hippocampal sirt1 gene expression and the upregulated atg7 gene expression. |
2023-10-30 |
2023-11-08 |
rat |
| Bataa M A El-Kafoury, Enas A Abdel-Hady, Wesam El Bakly, Wael M Elayat, Ghada Galal Hamam, Samar M M Abd El Rahman, Noha N Lashee. Lipoic acid inhibits cognitive impairment induced by multiple cell phones in young male rats: role of Sirt1 and Atg7 pathway. Scientific reports. vol 13. issue 1. 2023-10-30. PMID:37898621. |
lipoic acid treatment improved both learning and memory by enhancing autophagy and hippocampal glutamate level and by the reduced ach levels and sirt1 gene expression. |
2023-10-30 |
2023-11-08 |
rat |
| En-Long Zhao, Yong-Chang Diwu, Hu Zhang, Li-Qi Duan, Xin-Yue Han, Ya-Li Wang, Yuan Zho. [Xixin Decoction improves learning and memory ability of SAMP8 by enhancing neuroprotective effect and inhibiting neuroinflammation]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 18. 2023-10-06. PMID:37802845. |
western blot was employed to test the protein expression levels of silencing information regulator 2 related enzyme 1(sirt1), ager, tlr1, and tlr2 in the hippocampus of mice. |
2023-10-06 |
2023-10-15 |
mouse |
| En-Long Zhao, Yong-Chang Diwu, Hu Zhang, Li-Qi Duan, Xin-Yue Han, Ya-Li Wang, Yuan Zho. [Xixin Decoction improves learning and memory ability of SAMP8 by enhancing neuroprotective effect and inhibiting neuroinflammation]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 18. 2023-10-06. PMID:37802845. |
in particular, h-xxd significantly increased the expression of sirt1 in the hippocampus of mice, reduced the expression levels of nf-κb p65, nlrp3, tnf-α, and il-1β in the serum and hippocampus of mice, and decreased the expression of ager, tlr1, and tlr2 in the hippocampus of mice(p<0.05 or p<0.01). |
2023-10-06 |
2023-10-15 |
mouse |
| Zhao-Jun Wang, Xin-Ru Li, Shi-Fan Chai, Wei-Ran Li, Shuo Li, Meng Hou, Jia-Lei Li, Yu-Cai Ye, Hong-Yan Cai, Christian Hölscher, Mei-Na W. Semaglutide ameliorates cognition and glucose metabolism dysfunction in the 3xTg mouse model of Alzheimer's disease via the GLP-1R/SIRT1/GLUT4 pathway. Neuropharmacology. 2023-09-20. PMID:37730113. |
in this study, we found that sirt1 is closely related to expression of glp-1r in hippocampus of 3xtg mice. |
2023-09-20 |
2023-10-07 |
mouse |