| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Burak Ozaydin, Ela Bicki, Onur E Taparli, Temour Z Sheikh, Danielle K Schmidt, Sefer Yapici, Margarett B Hackett, Nida Karahan-Keles, Jens C Eickhoff, Karson Corcoran, Claudia Lagoa-Miguel, Jose Guerrero Gonzalez, Douglas C Dean Iii, Andre M M Sousa, Peter A Ferrazzano, Jon E Levine, Pelin Cengi. Novel injury scoring tool for assessing brain injury following neonatal hypoxia-ischemia in mice. Developmental neuroscience. 2022-05-25. PMID:35613558. |
the ipsilateral (il) hippocampal caspase-3 and sirt1 mrna expressions post-hi were significantly higher than sham il hippocampi, and positively correlated with the novel injury scores in both males and females. |
2022-05-25 |
2023-08-13 |
mouse |
| Xiang-Fei Guo, Xin-Hao Wang, Ya-Ling Fu, Qian Meng, Bo-Ya Huang, Rui Yang, Yi Guo, Yu-Ru Du, Xi Wang, Yuan Gao, Li Song, Miao Gong, Sheng Wang, You-Dong Li, Hai-Shui Shi, Yun Sh. Elevation of N-acetyltransferase 10 in hippocampal neurons mediates depression- and anxiety-like behaviors. Brain research bulletin. 2022-05-13. PMID:35550155. |
neuron-specific overexpression of nat10 in the hippocampus resulted in anxiety- and depression-like behaviors, accompanied by higher sirt1 protein levels, and lower dendritic spine densities. |
2022-05-13 |
2023-08-13 |
mouse |
| Xiaofang Wei, Juan Tan, Hui Ga. Role of sirtuin 1 in the brain development in congenital hypothyroidism rats via the regulation of p53 signaling pathway. Bioengineered. vol 13. issue 4. 2022-04-06. PMID:35383535. |
reverse transcription-quantitative polymerase chain reaction (rt-qpcr) and western blotting were used to detect the expression levels of sirt1, p53, b-cell lymphoma-extra-large (bcl-xl), bcl-2-associated x (bax), and cytochrome c in the hippocampal tissues and neuronal cells. |
2022-04-06 |
2023-08-13 |
rat |
| Xiaofang Wei, Juan Tan, Hui Ga. Role of sirtuin 1 in the brain development in congenital hypothyroidism rats via the regulation of p53 signaling pathway. Bioengineered. vol 13. issue 4. 2022-04-06. PMID:35383535. |
the results revealed that sirt1 was expressed at low levels in the hippocampal tissues of rats with ch. |
2022-04-06 |
2023-08-13 |
rat |
| Xiaofang Wei, Juan Tan, Hui Ga. Role of sirtuin 1 in the brain development in congenital hypothyroidism rats via the regulation of p53 signaling pathway. Bioengineered. vol 13. issue 4. 2022-04-06. PMID:35383535. |
moreover, overexpression of sirt1 in the hippocampal tissues of rats with ch and improved rat behavior, while reducing the ch-induced nerve cell apoptosis. |
2022-04-06 |
2023-08-13 |
rat |
| Tharcila Quadros de Oliveira, Ana Carolina de Moura, Vanessa Feistauer, Roberto Damiani, Matheus Filipe Braga, Silvana Almeida, Renata Padilha Guedes, Márcia Giovenard. Caloric restriction in mice improves short-term recognition memory and modifies the neuroinflammatory response in the hippocampus of male adult offspring. Behavioural brain research. 2022-03-14. PMID:35283195. |
at 90 days old, short-term memory was assessed by the object recognition test (ort); the inflammatory state of the hippocampus was analyzed by gene expression of sirtuin-1 (sirt1) and inflammasome nlrp3; and by protein expression of toll-like receptor-4 (tlr-4) and zonula occludens-1 (zo-1). |
2022-03-14 |
2023-08-13 |
mouse |
| Juli Choi, Hyejin Kwon, Yoon-Keun Kim, Pyung-Lim Ha. Extracellular Vesicles from Gram-positive and Gram-negative Probiotics Remediate Stress-Induced Depressive Behavior in Mice. Molecular neurobiology. 2022-02-16. PMID:35171438. |
while chronic stress decreases the expression of mecp2, sirt1, and/or neurotrophic factors in the hippocampus, evs from the three selected probiotics differentially restore stress-induced changes of these factors. |
2022-02-16 |
2023-08-13 |
mouse |
| Lin-Hui Ma, Jie Wan, Jing Yan, Ning Wang, Yan-Ping Liu, Hai-Bi Wang, Cheng-Hua Zhou, Yu-Qing W. Hippocampal SIRT1-Mediated Synaptic Plasticity and Glutamatergic Neuronal Excitability Are Involved in Prolonged Cognitive Dysfunction of Neonatal Rats Exposed to Propofol. Molecular neurobiology. 2022-01-16. PMID:35034265. |
repeated neonatal propofol exposure reduced sirt1 expression, suppressed synaptic plasticity, decreased glutamatergic neuron excitability in the hippocampus, and damaged learning and memory abilities. |
2022-01-16 |
2023-08-13 |
rat |
| Guo-Liang Dai, Xin-Yi Yang, Shan-Shan Chen, Yi-Qing Wang, Mei-Chen Liu, Yang Cao, Fei-Ran Li, Cheng-Yao Ma, Wen-Zheng J. [Effects of Jiaotai Pills on CUMS-induced depression model in mice based on changes of SIRT1 expression in hippocampus]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 24. 2022-01-07. PMID:34994144. |
[effects of jiaotai pills on cums-induced depression model in mice based on changes of sirt1 expression in hippocampus]. |
2022-01-07 |
2023-08-13 |
mouse |
| Guo-Liang Dai, Xin-Yi Yang, Shan-Shan Chen, Yi-Qing Wang, Mei-Chen Liu, Yang Cao, Fei-Ran Li, Cheng-Yao Ma, Wen-Zheng J. [Effects of Jiaotai Pills on CUMS-induced depression model in mice based on changes of SIRT1 expression in hippocampus]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 24. 2022-01-07. PMID:34994144. |
immunohistochemical staining was used to detect the level of sirt1 in the hippocampus of mice. |
2022-01-07 |
2023-08-13 |
mouse |
| Guo-Liang Dai, Xin-Yi Yang, Shan-Shan Chen, Yi-Qing Wang, Mei-Chen Liu, Yang Cao, Fei-Ran Li, Cheng-Yao Ma, Wen-Zheng J. [Effects of Jiaotai Pills on CUMS-induced depression model in mice based on changes of SIRT1 expression in hippocampus]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 24. 2022-01-07. PMID:34994144. |
western blot was used to detect the protein expression levels of sirt1, p-nf-κb p65, nf-κb p65, and foxo1 in the hippocampus of mice. |
2022-01-07 |
2023-08-13 |
mouse |
| Guo-Liang Dai, Xin-Yi Yang, Shan-Shan Chen, Yi-Qing Wang, Mei-Chen Liu, Yang Cao, Fei-Ran Li, Cheng-Yao Ma, Wen-Zheng J. [Effects of Jiaotai Pills on CUMS-induced depression model in mice based on changes of SIRT1 expression in hippocampus]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 24. 2022-01-07. PMID:34994144. |
in the hippocampus, the expression level of sirt1 was reduced(p<0.01), and the levels of p-nf-κb p65/nf-κb p65 and foxo1 were increased(p<0.01). |
2022-01-07 |
2023-08-13 |
mouse |
| Guo-Liang Dai, Xin-Yi Yang, Shan-Shan Chen, Yi-Qing Wang, Mei-Chen Liu, Yang Cao, Fei-Ran Li, Cheng-Yao Ma, Wen-Zheng J. [Effects of Jiaotai Pills on CUMS-induced depression model in mice based on changes of SIRT1 expression in hippocampus]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 24. 2022-01-07. PMID:34994144. |
the treatment with high-dose jiaotai pills increased the sucrose preference rate, movement distance, and the number of crossing centers(p<0.05), reduced tail suspension time and swimming immobility time(p<0.01), elevated hippocampal sirt1 expression level(p<0.01), decreased hippocampal and serum il-1β, il-6, tnf-α, and mda levels(p<0.01), potentiated sod activity, and up-regulated gsh, da, 5-ht, ne, and bdnf levels in the hippocampus and serum(p<0.05, p<0.01) in model mice. |
2022-01-07 |
2023-08-13 |
mouse |
| Guo-Liang Dai, Xin-Yi Yang, Shan-Shan Chen, Yi-Qing Wang, Mei-Chen Liu, Yang Cao, Fei-Ran Li, Cheng-Yao Ma, Wen-Zheng J. [Effects of Jiaotai Pills on CUMS-induced depression model in mice based on changes of SIRT1 expression in hippocampus]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 24. 2022-01-07. PMID:34994144. |
in conclusion, the results showed that jiaotai pills could improve the depression behaviors of model mice with cums-induced depression, and the underlying mechanism was related to the up-regulation of sirt1 in the hippocampus of mice to exert anti-inflammatory and anti-oxidative stress effects. |
2022-01-07 |
2023-08-13 |
mouse |
| Naihao Shi, Yuwen Lin, Binbin Yan, Xiaowei Jiao, Xiaobao Ding, Yuqing Wu, Chenghua Zho. Hippocampal SIRT1 improves cognitive impairment by deacetylating tau protein in diabetic models. European journal of pharmacology. vol 914. 2021-12-11. PMID:34861210. |
hippocampal sirt1 improves cognitive impairment by deacetylating tau protein in diabetic models. |
2021-12-11 |
2023-08-13 |
rat |
| Naihao Shi, Yuwen Lin, Binbin Yan, Xiaowei Jiao, Xiaobao Ding, Yuqing Wu, Chenghua Zho. Hippocampal SIRT1 improves cognitive impairment by deacetylating tau protein in diabetic models. European journal of pharmacology. vol 914. 2021-12-11. PMID:34861210. |
in this study, we found that the expression of sirtuin 1 (sirt1), a nicotinamide adenine dinucleotide (nad+)-dependent histone deacetylase, was downregulated significantly in the hippocampus of streptozotocin (stz)-induced diabetic cognitive impairment rats. |
2021-12-11 |
2023-08-13 |
rat |
| Naihao Shi, Yuwen Lin, Binbin Yan, Xiaowei Jiao, Xiaobao Ding, Yuqing Wu, Chenghua Zho. Hippocampal SIRT1 improves cognitive impairment by deacetylating tau protein in diabetic models. European journal of pharmacology. vol 914. 2021-12-11. PMID:34861210. |
viral overexpression of hippocampal sirt1 ameliorated cognitive impairment in diabetic rats, but viral knockdown of hippocampal sirt1 mimicked the diabetic effect, eliciting the cognitive decline in normal animals. |
2021-12-11 |
2023-08-13 |
rat |
| Naihao Shi, Yuwen Lin, Binbin Yan, Xiaowei Jiao, Xiaobao Ding, Yuqing Wu, Chenghua Zho. Hippocampal SIRT1 improves cognitive impairment by deacetylating tau protein in diabetic models. European journal of pharmacology. vol 914. 2021-12-11. PMID:34861210. |
further study showed that the decreased level of sirt1 may result in the increase of acetylated tau protein in the hippocampus, which may mediate the development of diabetic cognitive impairment. |
2021-12-11 |
2023-08-13 |
rat |
| Ruike Wang, Zuntao Wu, Mengchen Liu, Yingying Wu, Qiong Li, Yue Ba, Huizhen Zhang, Xuemin Cheng, Guoyu Zhou, Hui Huan. Resveratrol reverses hippocampal synaptic markers injury and SIRT1 inhibition against developmental Pb exposure. Brain research. vol 1767. 2021-12-09. PMID:34175265. |
resveratrol reverses hippocampal synaptic markers injury and sirt1 inhibition against developmental pb exposure. |
2021-12-09 |
2023-08-13 |
rat |
| Gen-Lin He, Ze-Ze Wang, Xue-Ting Yu, Ting-Ting Shen, Zhen Luo, Ping Li, Xue Luo, Yu-Long Tan, Peng Gao, Xue-Sen Yan. The involvement of microglial CX3CR1 in heat acclimation-induced amelioration of adult hippocampal neurogenesis impairment in EMF-exposed mice. Brain research bulletin. vol 177. 2021-11-18. PMID:34555433. |
moreover, pharmacological inhibition of cx3cr1 and sirt1 failed to restore cx3cr1 expression and ameliorate hippocampal neurogenesis impairment following ha plus emf stimulation. |
2021-11-18 |
2023-08-13 |
mouse |