| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuanyuan Ma, Yelong Ji, Li Xu, Zheng Li, Shengjin G. Obesity aggravated hippocampal-dependent cognitive impairment after sleeve gastrectomy in C57/BL6J mice via SIRT1/CREB/BDNF pathway. Experimental brain research. 2022-09-17. PMID:36114835. |
expression of sirtuin1 (sirt1), phosphorylated camp-responsive element binding protein (p-creb), creb and brain-derived neurotrophic factor (bdnf) in the hippocampus were measured. |
2022-09-17 |
2023-08-14 |
mouse |
| Yuanyuan Ma, Yelong Ji, Li Xu, Zheng Li, Shengjin G. Obesity aggravated hippocampal-dependent cognitive impairment after sleeve gastrectomy in C57/BL6J mice via SIRT1/CREB/BDNF pathway. Experimental brain research. 2022-09-17. PMID:36114835. |
hippocampal expression of sirt1, p-creb, and bdnf in the hds group was significantly lower than that of the hdc group. |
2022-09-17 |
2023-08-14 |
mouse |
| Xi Fang, Qiang Han, Shiyong Li, Ailin Lu. Melatonin attenuates spatial learning and memory dysfunction in developing rats by suppressing isoflurane-induced endoplasmic reticulum stress via the SIRT1/Mfn2/PERK signaling pathway. Heliyon. vol 8. issue 9. 2022-09-12. PMID:36091956. |
the hippocampal tissue and serum were collected to determine the levels of sirt1, mfn2, perk, and other proteins or cytokines related to er stress, apoptosis, and neuroinflammation. |
2022-09-12 |
2023-08-14 |
rat |
| Nan Chen, Xin-Chen Wang, Ling-Ling Fan, Yu-Huang Zhu, Qi Wang, Yun-Bo Che. Berberine ameliorates lipopolysaccharide-induced cognitive impairment through Sirt1/Nrf2/NF-κB signaling pathway in C57BL/6J mice. Rejuvenation research. 2022-08-27. PMID:36029207. |
we found that berberine reduced neuronal damage in the hippocampus by nissl staining, and verified by western blot and immunofluorescence that berberine improved lps-induced cognitive impairment through the sirt1/nrf2/nf-κb signaling pathway.the results showed that berberine plays an anti-inflammatory and antioxidant role by targeting sirt1/nrf2/nfκb signaling pathway so as to reduce the cognitive impairment and neuronal damage caused by lipopolysaccharide in c57bl/6j mice.berberine pre-protection increased the expression of heme oxygenase-1 (ho-1) after activating nuclear factor e2 related factor 2 (nrf2), and inhibited the activation of nf-κb and the release of inos, which may be related to berberine activating sirt1. |
2022-08-27 |
2023-08-14 |
mouse |
| Jian Zhao, Wenqiang Li, Yue Wang, Yuanhe Jiang, Chunyan Ding, Huaibin Li, Jian Ding, Lin Wan. The effect of electroacupuncture on the expression of Sirt1 and STAT3 in hippocampus and amygdala of vascular dementia rats. Neuroreport. 2022-07-26. PMID:35882013. |
the effect of electroacupuncture on the expression of sirt1 and stat3 in hippocampus and amygdala of vascular dementia rats. |
2022-07-26 |
2023-08-14 |
rat |
| Xing-Yuan Zhao, Dong Yu, Xingjie Shi, Shiqiang Hou, Da Ten. Resveratrol reduces p38 mitogen-activated protein kinase phosphorylation by activating Sirtuin 1 to alleviate cognitive dysfunction after traumatic brain injury in mice. Neuroreport. vol 33. issue 11. 2022-07-01. PMID:35775323. |
two days after tbi, the hippocampus of mice was extracted, and western blot analysis was performed for sirtuin 1 (sirt1), synaptophysin (syp), p38 mitogen-activated protein kinase (mapk), and p-p38 mapk. |
2022-07-01 |
2023-08-14 |
mouse |
| Xing-Yuan Zhao, Dong Yu, Xingjie Shi, Shiqiang Hou, Da Ten. Resveratrol reduces p38 mitogen-activated protein kinase phosphorylation by activating Sirtuin 1 to alleviate cognitive dysfunction after traumatic brain injury in mice. Neuroreport. vol 33. issue 11. 2022-07-01. PMID:35776938. |
two days after tbi, the hippocampus of mice was extracted, and western blot analysis was performed for sirtuin 1 (sirt1), synaptophysin (syp), p38 mitogen-activated protein kinase (mapk), and p-p38 mapk. |
2022-07-01 |
2023-08-14 |
mouse |
| Zuhao Sun, Shuang Zhao, Xinjun Suo, Yan Do. Sirt1 protects against hippocampal atrophy and its induced cognitive impairment in middle-aged mice. BMC neuroscience. vol 23. issue 1. 2022-06-06. PMID:35668361. |
sirt1 protects against hippocampal atrophy and its induced cognitive impairment in middle-aged mice. |
2022-06-06 |
2023-08-14 |
mouse |
| Zuhao Sun, Shuang Zhao, Xinjun Suo, Yan Do. Sirt1 protects against hippocampal atrophy and its induced cognitive impairment in middle-aged mice. BMC neuroscience. vol 23. issue 1. 2022-06-06. PMID:35668361. |
hippocampal volume is considered to be the most sensitive brain imaging phenotype for cognition, but the effect of sirt1 on hippocampal morphology during aging has not been reported. |
2022-06-06 |
2023-08-14 |
mouse |
| Ning Jiang, Yiwen Zhang, Caihong Yao, Hong Huang, Qiong Wang, Shuangxue Huang, Qinghu He, Xinmin Li. Ginsenosides Rb1 Attenuates Chronic Social Defeat Stress-Induced Depressive Behavior Frontiers in nutrition. vol 9. 2022-05-31. PMID:35634375. |
moreover, rb1 administration considerably reduced the protein expression of nlrp3 (inflammasome) and promoted the protein expressions of nrf2, ho-1 and sirtuin1(sirt1) activation in the hippocampus. |
2022-05-31 |
2023-08-13 |
mouse |
| Burak Ozaydin, Ela Bicki, Onur E Taparli, Temour Z Sheikh, Danielle K Schmidt, Sefer Yapici, Margarett B Hackett, Nida Karahan-Keles, Jens C Eickhoff, Karson Corcoran, Claudia Lagoa-Miguel, Jose Guerrero Gonzalez, Douglas C Dean Iii, Andre M M Sousa, Peter A Ferrazzano, Jon E Levine, Pelin Cengi. Novel injury scoring tool for assessing brain injury following neonatal hypoxia-ischemia in mice. Developmental neuroscience. 2022-05-25. PMID:35613558. |
the ipsilateral (il) hippocampal caspase-3 and sirt1 mrna expressions post-hi were significantly higher than sham il hippocampi, and positively correlated with the novel injury scores in both males and females. |
2022-05-25 |
2023-08-13 |
mouse |
| Xiang-Fei Guo, Xin-Hao Wang, Ya-Ling Fu, Qian Meng, Bo-Ya Huang, Rui Yang, Yi Guo, Yu-Ru Du, Xi Wang, Yuan Gao, Li Song, Miao Gong, Sheng Wang, You-Dong Li, Hai-Shui Shi, Yun Sh. Elevation of N-acetyltransferase 10 in hippocampal neurons mediates depression- and anxiety-like behaviors. Brain research bulletin. 2022-05-13. PMID:35550155. |
neuron-specific overexpression of nat10 in the hippocampus resulted in anxiety- and depression-like behaviors, accompanied by higher sirt1 protein levels, and lower dendritic spine densities. |
2022-05-13 |
2023-08-13 |
mouse |
| Xiaofang Wei, Juan Tan, Hui Ga. Role of sirtuin 1 in the brain development in congenital hypothyroidism rats via the regulation of p53 signaling pathway. Bioengineered. vol 13. issue 4. 2022-04-06. PMID:35383535. |
reverse transcription-quantitative polymerase chain reaction (rt-qpcr) and western blotting were used to detect the expression levels of sirt1, p53, b-cell lymphoma-extra-large (bcl-xl), bcl-2-associated x (bax), and cytochrome c in the hippocampal tissues and neuronal cells. |
2022-04-06 |
2023-08-13 |
rat |
| Xiaofang Wei, Juan Tan, Hui Ga. Role of sirtuin 1 in the brain development in congenital hypothyroidism rats via the regulation of p53 signaling pathway. Bioengineered. vol 13. issue 4. 2022-04-06. PMID:35383535. |
the results revealed that sirt1 was expressed at low levels in the hippocampal tissues of rats with ch. |
2022-04-06 |
2023-08-13 |
rat |
| Xiaofang Wei, Juan Tan, Hui Ga. Role of sirtuin 1 in the brain development in congenital hypothyroidism rats via the regulation of p53 signaling pathway. Bioengineered. vol 13. issue 4. 2022-04-06. PMID:35383535. |
moreover, overexpression of sirt1 in the hippocampal tissues of rats with ch and improved rat behavior, while reducing the ch-induced nerve cell apoptosis. |
2022-04-06 |
2023-08-13 |
rat |
| Tharcila Quadros de Oliveira, Ana Carolina de Moura, Vanessa Feistauer, Roberto Damiani, Matheus Filipe Braga, Silvana Almeida, Renata Padilha Guedes, Márcia Giovenard. Caloric restriction in mice improves short-term recognition memory and modifies the neuroinflammatory response in the hippocampus of male adult offspring. Behavioural brain research. 2022-03-14. PMID:35283195. |
at 90 days old, short-term memory was assessed by the object recognition test (ort); the inflammatory state of the hippocampus was analyzed by gene expression of sirtuin-1 (sirt1) and inflammasome nlrp3; and by protein expression of toll-like receptor-4 (tlr-4) and zonula occludens-1 (zo-1). |
2022-03-14 |
2023-08-13 |
mouse |
| Juli Choi, Hyejin Kwon, Yoon-Keun Kim, Pyung-Lim Ha. Extracellular Vesicles from Gram-positive and Gram-negative Probiotics Remediate Stress-Induced Depressive Behavior in Mice. Molecular neurobiology. 2022-02-16. PMID:35171438. |
while chronic stress decreases the expression of mecp2, sirt1, and/or neurotrophic factors in the hippocampus, evs from the three selected probiotics differentially restore stress-induced changes of these factors. |
2022-02-16 |
2023-08-13 |
mouse |
| Lin-Hui Ma, Jie Wan, Jing Yan, Ning Wang, Yan-Ping Liu, Hai-Bi Wang, Cheng-Hua Zhou, Yu-Qing W. Hippocampal SIRT1-Mediated Synaptic Plasticity and Glutamatergic Neuronal Excitability Are Involved in Prolonged Cognitive Dysfunction of Neonatal Rats Exposed to Propofol. Molecular neurobiology. 2022-01-16. PMID:35034265. |
repeated neonatal propofol exposure reduced sirt1 expression, suppressed synaptic plasticity, decreased glutamatergic neuron excitability in the hippocampus, and damaged learning and memory abilities. |
2022-01-16 |
2023-08-13 |
rat |
| Guo-Liang Dai, Xin-Yi Yang, Shan-Shan Chen, Yi-Qing Wang, Mei-Chen Liu, Yang Cao, Fei-Ran Li, Cheng-Yao Ma, Wen-Zheng J. [Effects of Jiaotai Pills on CUMS-induced depression model in mice based on changes of SIRT1 expression in hippocampus]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 24. 2022-01-07. PMID:34994144. |
[effects of jiaotai pills on cums-induced depression model in mice based on changes of sirt1 expression in hippocampus]. |
2022-01-07 |
2023-08-13 |
mouse |
| Guo-Liang Dai, Xin-Yi Yang, Shan-Shan Chen, Yi-Qing Wang, Mei-Chen Liu, Yang Cao, Fei-Ran Li, Cheng-Yao Ma, Wen-Zheng J. [Effects of Jiaotai Pills on CUMS-induced depression model in mice based on changes of SIRT1 expression in hippocampus]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 24. 2022-01-07. PMID:34994144. |
immunohistochemical staining was used to detect the level of sirt1 in the hippocampus of mice. |
2022-01-07 |
2023-08-13 |
mouse |