| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A C Meyer, D B Horton, N M Neugebauer, T E Wooters, J R Nickell, L P Dwoskin, M T Bard. Tetrabenazine inhibition of monoamine uptake and methamphetamine behavioral effects: locomotor activity, drug discrimination and self-administration. Neuropharmacology. vol 61. issue 4. 2012-05-25. PMID:21669212. |
effects of tbz on function of the dopamine transporter (dat) and serotonin transporter (sert) in striatal and hippocampal synaptosomes, respectively, and on vmat2 function in isolated striatal synaptic vesicles were determined. |
2012-05-25 |
2023-08-12 |
rat |
| Akihiro Mouri, Aya Sasaki, Ken Watanabe, Chiharu Sogawa, Shigeo Kitayama, Takayoshi Mamiya, Yoshiaki Miyamoto, Kiyofumi Yamada, Yukihiro Noda, Toshitaka Nabeshim. MAGE-D1 regulates expression of depression-like behavior through serotonin transporter ubiquitylation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 13. 2012-05-18. PMID:22457503. |
in these mice, the serotonergic function in the prefrontal cortex and hippocampus was hypoactive, accompanied by hyperexpression of sert attributable to a decrease in ubiquitylation. |
2012-05-18 |
2023-08-12 |
mouse |
| H N Noristani, R S Meadows, M Olabarria, A Verkhratsky, J J Rodrígue. Increased hippocampal CA1 density of serotonergic terminals in a triple transgenic mouse model of Alzheimer's disease: an ultrastructural study. Cell death & disease. vol 2. 2011-11-28. PMID:21918544. |
here, we analyse the ultrastructural localisation, distribution and numerical density (n(v)) of hippocampal sert axons (sert-ax) and terminals (sert-te) and their relationship with sert fibre sprouting and altered synaptic n(v) in 3xtg-ad compared with non-transgenic control mice. |
2011-11-28 |
2023-08-12 |
mouse |
| Eduard Maron, Innar Tõru, Jussi Hirvonen, Lauri Tuominen, Ville Lumme, Veiko Vasar, Jakov Shlik, David J Nutt, Semi Helin, Kjell Någren, Jari Tiihonen, Jarmo Hietal. Gender differences in brain serotonin transporter availability in panic disorder. Journal of psychopharmacology (Oxford, England). vol 25. issue 7. 2011-11-14. PMID:21148024. |
sert bp (nd) were significantly higher in 13 of 20 studied brain regions, including several cortical and raphe areas, but lower in the hippocampus in males with pd as compared with healthy males. |
2011-11-14 |
2023-08-12 |
human |
| Masahiro Shibasaki, Kazuhiro Kurokawa, Seitaro Ohkum. [Functional homology between alcohol dependence and mood disorder]. Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence. vol 46. issue 3. 2011-09-22. PMID:21861331. |
that is, sert expression increased in the cingulate cortex, nucleus accumbens, hippocampal ca1-ca3 layers, and mediodorsal nucleus of the thalamus. |
2011-09-22 |
2023-08-12 |
mouse |
| Jantarima Charoenphandhu, Jarinthorn Teerapornpuntakit, Amporn Nuntapornsak, Nateetip Krishnamra, Narattaphol Charoenphandh. Anxiety-like behaviors and expression of SERT and TPH in the dorsal raphé of estrogen- and fluoxetine-treated ovariectomized rats. Pharmacology, biochemistry, and behavior. vol 98. issue 4. 2011-08-24. PMID:21382399. |
furthermore, e2 and e2+flx similarly upregulated the mrna expression of serotonin reuptake transporter (sert) and tryptophan hydroxylase-2 in the dorsal raphé of ovx rats, while having no effect on sert expression in the frontal cortex, hippocampus, septum, amygdala and periaqueductal gray. |
2011-08-24 |
2023-08-12 |
rat |
| Xiaojun Wu, Hung Hsuchou, Abba J Kastin, Yi He, Reas S Khan, Kirsten P Stone, Michael S Cash, Weihong Pa. Interleukin-15 affects serotonin system and exerts antidepressive effects through IL15Rα receptor. Psychoneuroendocrinology. vol 36. issue 2. 2011-06-02. PMID:20724079. |
the hippocampus of the il15rα knockout mice had decreased mrna for 5-ht(1a), increased mrna for 5-ht(2c), and region-specific changes of serotonin reuptake transporter (sert) immunoreactivity. |
2011-06-02 |
2023-08-12 |
mouse |
| Masahiro Shibasaki, Mariko Inoue, Kazuhiro Kurokawa, Satoru Ogou, Seitaro Ohkum. Expression of serotonin transporter in mice with ethanol physical dependency. Journal of pharmacological sciences. vol 114. issue 2. 2011-02-24. PMID:20838024. |
sert expression increased in the cingulate cortex, nucleus accumbens, hippocampal ca1-ca3 layers, and mediodorsal nucleus of the thalamus and decreased in the basolateral nucleus of the amygdala. |
2011-02-24 |
2023-08-12 |
mouse |
| Kristin J Weaver, Ian A Paul, Rick C S Lin, Kimberly L Simpso. Neonatal exposure to citalopram selectively alters the expression of the serotonin transporter in the hippocampus: dose-dependent effects. Anatomical record (Hoboken, N.J. : 2007). vol 293. issue 11. 2011-02-10. PMID:20830689. |
in the present investigation, we injected rat pups with citalopram (ctm: 5 mg/kg, 10 mg/kg, and 20 mg/kg) from postnatal days 8-21, and examined serotonin transporter (sert) labeling in the hippocampus, ventrobasal thalamic complex, and caudate-putamen when the subjects reached adulthood. |
2011-02-10 |
2023-08-12 |
human |
| Georgianna G Gould, Julie G Hensler, Teresa F Burke, Robert H Benno, Emmanuel S Onaivi, Lynette C Daw. Density and function of central serotonin (5-HT) transporters, 5-HT1A and 5-HT2A receptors, and effects of their targeting on BTBR T+tf/J mouse social behavior. Journal of neurochemistry. vol 116. issue 2. 2011-01-20. PMID:21070242. |
in hippocampal membrane homogenates, [(3) h] citalopram maximal binding (b(max) ) to sert was 95 ± 13 fmol/mg protein in btbr and 171 ± 20 fmol/mg protein in c57bl/6j mice, and the btbr dissociation constant (k(d) ) was 2.0 ± 0.3 nm versus 1.1 ± 0.2 in c57bl/6j mice. |
2011-01-20 |
2023-08-12 |
mouse |
| Georgianna G Gould, Julie G Hensler, Teresa F Burke, Robert H Benno, Emmanuel S Onaivi, Lynette C Daw. Density and function of central serotonin (5-HT) transporters, 5-HT1A and 5-HT2A receptors, and effects of their targeting on BTBR T+tf/J mouse social behavior. Journal of neurochemistry. vol 116. issue 2. 2011-01-20. PMID:21070242. |
overall, altered sert and/or 5-ht(1a) functionality in hippocampus could contribute to the relatively low sociability of btbr mice. |
2011-01-20 |
2023-08-12 |
mouse |
| H N Noristani, M Olabarria, A Verkhratsky, J J Rodrígue. Serotonin fibre sprouting and increase in serotonin transporter immunoreactivity in the CA1 area of hippocampus in a triple transgenic mouse model of Alzheimer's disease. The European journal of neuroscience. vol 32. issue 1. 2011-01-13. PMID:20576032. |
here, we studied hippocampal 5-ht innervation by analysing: (i) the expression, density and distribution of 5-ht transporter (sert)-immunoreactive fibres; (ii) the specific morphological characteristics of serotonergic fibres and their relation to amyloid plaques; and (iii) the total number of 5-ht neurons within the raphe nuclei in triple transgenic mouse model of ad. |
2011-01-13 |
2023-08-12 |
mouse |
| H N Noristani, M Olabarria, A Verkhratsky, J J Rodrígue. Serotonin fibre sprouting and increase in serotonin transporter immunoreactivity in the CA1 area of hippocampus in a triple transgenic mouse model of Alzheimer's disease. The European journal of neuroscience. vol 32. issue 1. 2011-01-13. PMID:20576032. |
the transgenic animals showed a significant increase in sert fibres in the hippocampus in a subfield-, strata- and age-specific manner. |
2011-01-13 |
2023-08-12 |
mouse |
| Ruth Tellez, Luisa Rocha, Carlos Castillo, Alfredo Menese. Autoradiographic study of serotonin transporter during memory formation. Behavioural brain research. vol 212. issue 1. 2010-11-12. PMID:20226815. |
in untrained and trained treated animals with the amnesic dose (1.0mg/kg) of meth sert binding in several areas including hippocampus and cortex decreased, more remarkably in the trained animals. |
2010-11-12 |
2023-08-12 |
Not clear |
| Peter Holm, Anders Ettrup, Anders B Klein, Martin A Santini, Mona El-Sayed, Anders B Elvang, Tine B Stensbøl, Jens D Mikkelsen, Gitte M Knudsen, Susana Azna. Plaque deposition dependent decrease in 5-HT2A serotonin receptor in AbetaPPswe/PS1dE9 amyloid overexpressing mice. Journal of Alzheimer's disease : JAD. vol 20. issue 4. 2010-10-12. PMID:20413853. |
[3h]-mdl100907, [3h]-escitalopram, and [11c]-pib autoradiography was performed for measuring 5-ht2a receptor, serotonin transporter (sert), and abeta plaque levels in medial prefrontal cortex (mpfc), prefrontal cortex (pfc), frontoparietal cortex (fpc), dorsal and ventral hippocampus, and somatosensory cortex. |
2010-10-12 |
2023-08-12 |
mouse |
| Brian J Piper, Syed F Ali, Lauren G Daniels, Jerrold S Meye. Repeated intermittent methylenedioxymethamphetamine exposure protects against the behavioral and neurotoxic, but not hyperthermic, effects of an MDMA binge in adult rats. Synapse (New York, N.Y.). vol 64. issue 6. 2010-07-19. PMID:20169574. |
spontaneous motor activity was determined the next day, and cortical and hippocampal samples were collected at 1 week postbinge to measure serotonin (5-ht) and 5-hydroxyindoleacetic acid (5-hiaa) concentrations as well as [3h]citalopram binding to sert. |
2010-07-19 |
2023-08-12 |
rat |
| Raffaella Molteni, Annamaria Cattaneo, Francesca Calabrese, Flavia Macchi, Jocelien D A Olivier, Giorgio Racagni, Bart A Ellenbroek, Massimo Gennarelli, Marco A Riv. Reduced function of the serotonin transporter is associated with decreased expression of BDNF in rodents as well as in humans. Neurobiology of disease. vol 37. issue 3. 2010-06-08. PMID:20034565. |
we found that bdnf levels were significantly reduced in the hippocampus and prefrontal cortex of sert knockout rats, through transcriptional changes that affect different neurotrophin isoforms. |
2010-06-08 |
2023-08-12 |
human |
| Francesca Calabrese, Raffaella Molteni, Annamaria Cattaneo, Flavia Macchi, Giorgio Racagni, Massimo Gennarelli, Bart A Ellenbroek, Marco A Riv. Long-Term duloxetine treatment normalizes altered brain-derived neurotrophic factor expression in serotonin transporter knockout rats through the modulation of specific neurotrophin isoforms. Molecular pharmacology. vol 77. issue 5. 2010-05-28. PMID:20159945. |
we have demonstrated recently that sert knockout (ko) rats, generated by n-ethyl-n-nitrosourea-induced mutagenesis, show reduced expression of the neurotrophin brain-derived neurotrophic factor (bdnf) in the hippocampus and prefrontal cortex, suggesting that depression vulnerability can be associated with impaired neuronal plasticity. |
2010-05-28 |
2023-08-12 |
rat |
| Francesca Calabrese, Raffaella Molteni, Annamaria Cattaneo, Flavia Macchi, Giorgio Racagni, Massimo Gennarelli, Bart A Ellenbroek, Marco A Riv. Long-Term duloxetine treatment normalizes altered brain-derived neurotrophic factor expression in serotonin transporter knockout rats through the modulation of specific neurotrophin isoforms. Molecular pharmacology. vol 77. issue 5. 2010-05-28. PMID:20159945. |
in the present study, we demonstrate that chronic treatment with the antidepressant duloxetine (dlx) was able to normalize the expression of bdnf mrna-coding exon (ix) in the hippocampus and prefrontal cortex of sert ko rats through the modulation of selected neurotrophin transcripts, whose expression was up-regulated by dlx only in sert ko rats. |
2010-05-28 |
2023-08-12 |
rat |
| Dominik K Biezonski, Jerrold S Meye. Effects of 3,4-methylenedioxymethamphetamine (MDMA) on serotonin transporter and vesicular monoamine transporter 2 protein and gene expression in rats: implications for MDMA neurotoxicity. Journal of neurochemistry. vol 112. issue 4. 2010-03-08. PMID:20002520. |
experiment 1 investigated mdma-induced changes in levels of the serotonin transporter (sert) and the vesicular monoamine transporter 2 (vmat-2) in the hippocampus, a region with sparse dopaminergic innervation, after lesioning noradrenergic input with n-(2-chloroethyl)-n-ethyl-2-bromobenzylamine (dsp-4). |
2010-03-08 |
2023-08-12 |
rat |