| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H M Haughey, A E Fleckenstein, R R Metzger, G R Hanso. The effects of methamphetamine on serotonin transporter activity: role of dopamine and hyperthermia. Journal of neurochemistry. vol 75. issue 4. 2000-10-05. PMID:10987842. |
a role for dopamine (da) was suggested by findings that pretreatment with the tyrosine hydroxylase inhibitor alpha-methyl-p-tyrosine, the d1 antagonist sch-23390, or the d2 antagonist eticlopride attenuated the meth-induced decrease in striatal, but not hippocampal, sert activity. |
2000-10-05 |
2023-08-12 |
rat |
| H M Haughey, A E Fleckenstein, R R Metzger, G R Hanso. The effects of methamphetamine on serotonin transporter activity: role of dopamine and hyperthermia. Journal of neurochemistry. vol 75. issue 4. 2000-10-05. PMID:10987842. |
these results suggest that da contributes to the decrease in sert function caused by multiple meth injections in the striatum, but not hippocampus, and that hyperthermia facilitates these deficits in sert function in both brain regions. |
2000-10-05 |
2023-08-12 |
rat |
| B Vollmayr, S Keck, F A Henn, P Schlos. Acute stress decreases serotonin transporter mRNA in the raphe pontis but not in other raphe nuclei of the rat. Neuroscience letters. vol 290. issue 2. 2000-09-21. PMID:10936689. |
acute stress led to a significant decrease of bdnf mrna in the hippocampus and of sert mrna in the raphe pontis, but not in other raphe nuclei investigated. |
2000-09-21 |
2023-08-12 |
rat |
| S Benmansour, M Cecchi, D A Morilak, G A Gerhardt, M A Javors, G G Gould, A Fraze. Effects of chronic antidepressant treatments on serotonin transporter function, density, and mRNA level. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 23. 1999-12-17. PMID:10575045. |
sert density in the ca3 region of the hippocampus of the same rats, assessed by quantitative autoradiography with tritiated cyanoimipramine ([(3)h]cn-imi), was decreased by 80-90% in ssri-treated rats but not in those treated with phenelzine or dmi. |
1999-12-17 |
2023-08-12 |
rat |
| S Benmansour, M Cecchi, D A Morilak, G A Gerhardt, M A Javors, G G Gould, A Fraze. Effects of chronic antidepressant treatments on serotonin transporter function, density, and mRNA level. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 23. 1999-12-17. PMID:10575045. |
the serotonin content of the hippocampus was unaffected by paroxetine or sertraline treatment, ruling out neurotoxicity as a possible explanation for the ssri-induced decrease in sert binding and alteration in 5-ht clearance. |
1999-12-17 |
2023-08-12 |
rat |
| A Vicentic, G Battaglia, F I Carroll, M J Kuha. Serotonin transporter production and degradation rates: studies with RTI-76. Brain research. vol 841. issue 1-2. 1999-11-17. PMID:10546982. |
following 6 h of in vivo intracerebroventricular injections of 100 nmol of rti-76, there was a dose- and time-dependent reduction (- 60%) of sert binding in hippocampus and striatum, without a change in the kd. |
1999-11-17 |
2023-08-12 |
rat |
| A Vicentic, G Battaglia, F I Carroll, M J Kuha. Serotonin transporter production and degradation rates: studies with RTI-76. Brain research. vol 841. issue 1-2. 1999-11-17. PMID:10546982. |
the turnover parameters of sert were determined in hippocampus and striatum, regions that receive serotonergic innervation from the dorsal and median midbrain raphe nuclei, respectively. |
1999-11-17 |
2023-08-12 |
rat |
| A Vicentic, G Battaglia, F I Carroll, M J Kuha. Serotonin transporter production and degradation rates: studies with RTI-76. Brain research. vol 841. issue 1-2. 1999-11-17. PMID:10546982. |
in the hippocampus, the production rate constant was 2.36 fmol mg protein (-1)h(-1); the degradation rate constant was 0.0077 h(-1); and the half-life of the sert recovery was 3.4 days. |
1999-11-17 |
2023-08-12 |
rat |