| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dominik K Biezonski, Jerrold S Meye. Effects of 3,4-methylenedioxymethamphetamine (MDMA) on serotonin transporter and vesicular monoamine transporter 2 protein and gene expression in rats: implications for MDMA neurotoxicity. Journal of neurochemistry. vol 112. issue 4. 2010-03-08. PMID:20002520. |
two weeks following the binge treatment, the dsp-4/mdma group unexpectedly showed little change in hippocampal vmat-2 protein expression compared with dsp-4/saline controls, despite large reductions in sert levels in all regions examined in the mdma-treated animals. |
2010-03-08 |
2023-08-12 |
rat |
| Raffaella Molteni, Francesca Calabrese, Paola F Maj, Jocelien D A Olivier, Giorgio Racagni, Bart A Ellenbroek, Marco A Riv. Altered expression and modulation of activity-regulated cytoskeletal associated protein (Arc) in serotonin transporter knockout rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 19. issue 12. 2010-01-25. PMID:19576731. |
indeed an acute swim stress significantly up-regulated the levels of arc mrna in hippocampus and prefrontal cortex, as well as of zif-268 in frontal cortex, only in sert(+/-) and sert(-/-) rats. |
2010-01-25 |
2023-08-12 |
human |
| Simone Macrì, Oleg Granstrem, Maria Shumilina, Fernando João Antunes Gomes dos Santos, Alessandra Berry, Luciano Saso, Giovanni Laviol. Resilience and vulnerability are dose-dependently related to neonatal stressors in mice. Hormones and behavior. vol 56. issue 4. 2009-12-22. PMID:19632235. |
while low levels of neonatal corticosterone improved adult cognitive abilities and increased na-abs levels directed to sert, high doses of neonatal corticosterone reduced hippocampal bdnf levels and na-abs directed to dat. |
2009-12-22 |
2023-08-12 |
mouse |
| Jacobi I Cunningham, Jamie Raudensky, John Tonkiss, Bryan K Yamamot. MDMA pretreatment leads to mild chronic unpredictable stress-induced impairments in spatial learning. Behavioral neuroscience. vol 123. issue 5. 2009-11-17. PMID:19824774. |
mdma pretreatment was hypothesized to enhance the effects of cus leading to enhanced 5-ht transporter (sert) depletion in the hippocampus and increased anxiety and cognitive impairment. |
2009-11-17 |
2023-08-12 |
rat |
| Jacobi I Cunningham, Jamie Raudensky, John Tonkiss, Bryan K Yamamot. MDMA pretreatment leads to mild chronic unpredictable stress-induced impairments in spatial learning. Behavioral neuroscience. vol 123. issue 5. 2009-11-17. PMID:19824774. |
in contrast, mdma pretreatment led to cus-induced learning impairment in the morris water maze but not an enhanced depletion of hippocampal sert protein. |
2009-11-17 |
2023-08-12 |
rat |
| Jonathan G McEuen, Katharine A Semsar, Maria A Lim, Tracy L Bal. Influence of sex and corticotropin-releasing factor pathways as determinants in serotonin sensitivity. Endocrinology. vol 150. issue 8. 2009-08-05. PMID:19342454. |
mechanistically, females had decreased hippocampal 5-ht transporter (sert) levels, whereas r2ko mice showed reduced sert in the prefrontal cortex, supporting a possible intersection of sex and genotype where r2ko females would have the lowest sert to be blocked by the ssri. |
2009-08-05 |
2023-08-12 |
mouse |
| Zaorui Zhao, Han-Ting Zhang, Elianna Bootzin, Mark J Millan, James M O'Donnel. Association of changes in norepinephrine and serotonin transporter expression with the long-term behavioral effects of antidepressant drugs. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 6. 2009-06-17. PMID:18923402. |
treatment of rats for 14 days with 20 mg/kg per day protriptyline or 7.5 mg/kg per day sertraline reduced net and sert expression, respectively, in cerebral cortex and hippocampus; these treatments also induced a persistent antidepressant-like effect on forced-swim behavior. |
2009-06-17 |
2023-08-12 |
rat |
| Anja W Fjorback, Patrick Pla, Heidi K Müller, Ove Wiborg, Frédéric Saudou, Jens R Nyengaar. Serotonin transporter oligomerization documented in RN46A cells and neurons by sensitized acceptor emission FRET and fluorescence lifetime imaging microscopy. Biochemical and biophysical research communications. vol 380. issue 4. 2009-04-28. PMID:19338744. |
we have used sensitized acceptor emission fluorescence resonance energy transfer (fret) and fluorescence lifetime imaging microscopy (flim) to study the oligomerization of sert in hek-msr-239 cells, rn46a cells and in cultured hippocampal neurons. |
2009-04-28 |
2023-08-12 |
Not clear |
| T Deltheil, B P Guiard, J Cerdan, D J David, K F Tanaka, C Repérant, J-P Guilloux, F Coudoré, R Hen, A M Gardie. Behavioral and serotonergic consequences of decreasing or increasing hippocampus brain-derived neurotrophic factor protein levels in mice. Neuropharmacology. vol 55. issue 6. 2009-04-14. PMID:18761360. |
(1) in heterozygous bdnf+/- mice in which brain bdnf protein levels were decreased by half, an enhancement of basal extracellular 5-ht levels (5-htext) that induced a down-regulation of sert, i.e., a decrease in its capacity to reuptake 5-ht, was found in the hippocampus. |
2009-04-14 |
2023-08-12 |
mouse |
| T Deltheil, B P Guiard, J Cerdan, D J David, K F Tanaka, C Repérant, J-P Guilloux, F Coudoré, R Hen, A M Gardie. Behavioral and serotonergic consequences of decreasing or increasing hippocampus brain-derived neurotrophic factor protein levels in mice. Neuropharmacology. vol 55. issue 6. 2009-04-14. PMID:18761360. |
however, the decreased capacity of sert to reuptake 5-ht was not associated to an increase in basal 5-htext in the hippocampus of wt mice. |
2009-04-14 |
2023-08-12 |
mouse |
| Nicolas Narboux-Nême, Luigi Michele Pavone, Luigi Avallone, Xiaoxi Zhuang, Patricia Gaspa. Serotonin transporter transgenic (SERTcre) mouse line reveals developmental targets of serotonin specific reuptake inhibitors (SSRIs). Neuropharmacology. vol 55. issue 6. 2009-04-14. PMID:18789954. |
this fate map of serotonin transporter expressing cells emphasizes the broad expression of sert in non-serotonin neurons during development and clarifies the localization of sert expression in the hippocampus and limbic cortex. |
2009-04-14 |
2023-08-12 |
mouse |
| Subhash M Nadgir, Manish Malviy. In vivo effect of antidepressants on [3H]paroxetine binding to serotonin transporters in rat brain. Neurochemical research. vol 33. issue 11. 2008-12-12. PMID:18437564. |
density of sert was measured in cortex and hippocampus using [(3)h]paroxetine (0.03-1.0 nm) in presence and absence of 10 mum fluoxetine as displacer. |
2008-12-12 |
2023-08-12 |
rat |
| Subhash M Nadgir, Manish Malviy. In vivo effect of antidepressants on [3H]paroxetine binding to serotonin transporters in rat brain. Neurochemical research. vol 33. issue 11. 2008-12-12. PMID:18437564. |
the density of sert in hippocampus was also significantly decreased with flx (65%, p < 0.0001), cmi (54%, p < 0.0001), cit (52%, p < 0.0001) and ami (46%, p < 0.0001) treatment, when compared to the density of 74.0 +/- 2.6 fmol/mg protein in control rats, without altering the affinity of [(3)h]paroxetine to the transporters. |
2008-12-12 |
2023-08-12 |
rat |
| Subhash M Nadgir, Manish Malviy. In vivo effect of antidepressants on [3H]paroxetine binding to serotonin transporters in rat brain. Neurochemical research. vol 33. issue 11. 2008-12-12. PMID:18437564. |
the results suggest that chronic antidepressant treatment significantly down-regulates both cortical and hippocampal sert in rat brain and ssris have high affinity for sert than tcas. |
2008-12-12 |
2023-08-12 |
rat |
| Brian A Hoshaw, Tiffany I Hill, James J Crowley, Jessica E Malberg, Xavier Khawaja, Sharon Rosenzweig-Lipson, Lee E Schechter, Irwin Luck. Antidepressant-like behavioral effects of IGF-I produced by enhanced serotonin transmission. European journal of pharmacology. vol 594. issue 1-3. 2008-11-25. PMID:18675266. |
in addition, igf-i did not alter the expression of mrna levels of tryptophan hydroxylase or sert in the brain stem, or [3h] citalopram binding in the hippocampus or cortex. |
2008-11-25 |
2023-08-12 |
rat |
| Donald R Gehlert, Linda K Thompson, Susan K Hemrick-Luecke, Janice Sha. Monoaminergic compensation in the neuropeptide Y deficient mouse brain. Neuropeptides. vol 42. issue 3. 2008-09-19. PMID:18329096. |
in contrast, more modest and regionally variable changes were observed in the sert binding with decreases in regions such as the accessory olfactory nucleus, glomerular layer of the olfactory bulb and the ca1 region of the hippocampus. |
2008-09-19 |
2023-08-12 |
mouse |
| Saloua Benmansour, Thierry Deltheil, Jonathan Piotrowski, Lorelei Nicolas, Christelle Reperant, Alain M Gardier, Alan Frazer, Denis J Davi. Influence of brain-derived neurotrophic factor (BDNF) on serotonin neurotransmission in the hippocampus of adult rodents. European journal of pharmacology. vol 587. issue 1-3. 2008-08-25. PMID:18474368. |
overall, it may be inferred that in the hippocampus, through trkb activation, a single injection of bdnf enhances sert function. |
2008-08-25 |
2023-08-12 |
mouse |
| Bruno P Guiard, Denis J P David, Thierry Deltheil, Franck Chenu, Erwan Le Maître, Thibault Renoir, Isabelle Leroux-Nicollet, Pierre Sokoloff, Laurence Lanfumey, Michel Hamon, Anne M Andrews, René Hen, Alain M Gardie. Brain-derived neurotrophic factor-deficient mice exhibit a hippocampal hyperserotonergic phenotype. The international journal of neuropsychopharmacology. vol 11. issue 1. 2008-04-15. PMID:17559709. |
heterozygous mutants bdnf +/- mice were utilized to investigate the influence of bdnf on the serotonin (5-ht) system and the activity of the serotonin transporter (sert) in the hippocampus. |
2008-04-15 |
2023-08-12 |
mouse |
| Bruno P Guiard, Denis J P David, Thierry Deltheil, Franck Chenu, Erwan Le Maître, Thibault Renoir, Isabelle Leroux-Nicollet, Pierre Sokoloff, Laurence Lanfumey, Michel Hamon, Anne M Andrews, René Hen, Alain M Gardie. Brain-derived neurotrophic factor-deficient mice exhibit a hippocampal hyperserotonergic phenotype. The international journal of neuropsychopharmacology. vol 11. issue 1. 2008-04-15. PMID:17559709. |
a significant decrease in [3h]citalopram-binding-site density in the ca3 subregion of the ventral hippocampus and a significant reduction in [3h]5-ht uptake in hippocampal synaptosomes, revealed mainly a decrease in sert function. |
2008-04-15 |
2023-08-12 |
mouse |
| Bruno P Guiard, Denis J P David, Thierry Deltheil, Franck Chenu, Erwan Le Maître, Thibault Renoir, Isabelle Leroux-Nicollet, Pierre Sokoloff, Laurence Lanfumey, Michel Hamon, Anne M Andrews, René Hen, Alain M Gardie. Brain-derived neurotrophic factor-deficient mice exhibit a hippocampal hyperserotonergic phenotype. The international journal of neuropsychopharmacology. vol 11. issue 1. 2008-04-15. PMID:17559709. |
these results provide evidence that constitutive reductions in bdnf modulate sert function reuptake in the hippocampus. |
2008-04-15 |
2023-08-12 |
mouse |