| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Catherine E Hagan, Ross A McDevitt, Yusha Liu, Amy R Furay, John F Neumaie. 5-HT(1B) autoreceptor regulation of serotonin transporter activity in synaptosomes. Synapse (New York, N.Y.). vol 66. issue 12. 2013-02-21. PMID:22961814. |
furthermore, sert activity varies as a function of 5-ht(1b) receptor expression-specifically, genetic deletion of 5-ht(1b) decreased sert function, while viral-mediated overexpression of 5-ht(1b) autoreceptors in rat raphe neurons increased sert activity in rat hippocampal synaptosomes. |
2013-02-21 |
2023-08-12 |
mouse |
| Jia Zhang, Yan Fan, Ying Li, Hobart Zhu, Liang Wang, Meng-Yang Zh. Chronic social defeat up-regulates expression of the serotonin transporter in rat dorsal raphe nucleus and projection regions in a glucocorticoid-dependent manner. Journal of neurochemistry. vol 123. issue 6. 2013-02-14. PMID:23061525. |
protein levels of the serotonin transporter (sert) in the dorsal raphe nucleus (drn), hippocampus, frontal cortex, and amygdala were examined by western blotting or immunofluorescence staining. |
2013-02-14 |
2023-08-12 |
rat |
| Jia Zhang, Yan Fan, Ying Li, Hobart Zhu, Liang Wang, Meng-Yang Zh. Chronic social defeat up-regulates expression of the serotonin transporter in rat dorsal raphe nucleus and projection regions in a glucocorticoid-dependent manner. Journal of neurochemistry. vol 123. issue 6. 2013-02-14. PMID:23061525. |
the results showed that csd up-regulated sert protein levels in the drn, hippocampus, frontal cortex, and amygdala regions. |
2013-02-14 |
2023-08-12 |
rat |
| Valeria Paola Carlini, María Belén Poretti, Mathias Rask-Andersen, Rohit A Chavan, Marina F Ponzio, Rahul S Sawant, Susana Rubiales de Barioglio, Helgi B Schiöth, Marta Fiol de Cune. Differential effects of fluoxetine and venlafaxine on memory recognition: possible mechanisms of action. Progress in neuro-psychopharmacology & biological psychiatry. vol 38. issue 2. 2013-01-21. PMID:22449479. |
considering that the changes in gene expression involved in the action of antidepressant drugs on memory have not been identified, in this study we investigated the impact of chronic treatment with a ssri (fluoxetine) and a snri (venlafaxine) on the mrna expression of genes related to memory cascade in the mouse hippocampus, namely, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa), nitric oxide synthase 1 (nos1), neurotrophic tyrosine kinase receptor type 2 (trkb), mitogen-activated protein kinases (mapk/erk) and serotonin transporter (sert). |
2013-01-21 |
2023-08-12 |
mouse |
| Ruth Tellez, Leticia Gómez-Viquez, Gustavo Liy-Salmeron, Alfredo Menese. GABA, glutamate, dopamine and serotonin transporters expression on forgetting. Neurobiology of learning and memory. vol 98. issue 1. 2012-12-03. PMID:22633984. |
fluoxetine plus meth administration was also able to prevent forgetting, which was associated to hippocampal dat, prefrontal cortex sert and striatal gat1, dat or sert up-regulation, but prefrontal cortex gat1 down-regulation. |
2012-12-03 |
2023-08-12 |
rat |
| Susanne Nikolaus, Hubertus Hautzel, Alexander Heinzel, Hans-Wilhelm Mülle. Key players in major and bipolar depression--a retrospective analysis of in vivo imaging studies. Behavioural brain research. vol 232. issue 2. 2012-10-22. PMID:22483788. |
additionally, there is some evidence that ventrostriatal and hippocampal sert may be decreased in depression, whereas in remission and mania elevations of thalamic and midbrain sert, respectively, were observed. |
2012-10-22 |
2023-08-12 |
Not clear |
| E J Burnett, A T Davenport, K A Grant, D P Friedma. The effects of chronic ethanol self-administration on hippocampal serotonin transporter density in monkeys. Frontiers in psychiatry. vol 3. 2012-10-02. PMID:22557982. |
the current study investigated the effects of chronic ethanol self-administration on hippocampal sert in a layer and field specific manner using a monkey model of human alcohol consumption. |
2012-10-02 |
2023-08-12 |
human |
| E J Burnett, A T Davenport, K A Grant, D P Friedma. The effects of chronic ethanol self-administration on hippocampal serotonin transporter density in monkeys. Frontiers in psychiatry. vol 3. 2012-10-02. PMID:22557982. |
[(3)h]citalopram was used to measure hippocampal sert density in male cynomolgus macaques that voluntarily self-administered ethanol for 18 months. |
2012-10-02 |
2023-08-12 |
human |
| E J Burnett, A T Davenport, K A Grant, D P Friedma. The effects of chronic ethanol self-administration on hippocampal serotonin transporter density in monkeys. Frontiers in psychiatry. vol 3. 2012-10-02. PMID:22557982. |
the lower hippocampal sert density observed suggests that chronic ethanol consumption is associated with altered serotonergic modulation of hippocampal neurotransmission. |
2012-10-02 |
2023-08-12 |
human |
| Erica Y Shen, Syed F Ali, Jerrold S Meye. Chronic administration of THC prevents the behavioral effects of intermittent adolescent MDMA administration and attenuates MDMA-induced hyperthermia and neurotoxicity in rats. Neuropharmacology. vol 61. issue 8. 2012-08-01. PMID:21763331. |
thc additionally attenuated mdma -induced decreases in 5-ht levels and in sert binding in the frontal cortex, parietal cortex, and striatum, but not in the hippocampus. |
2012-08-01 |
2023-08-12 |
rat |
| Carmela M Reichel, Lauren A Ramsey, Marek Schwendt, Jacqueline F McGinty, Ronald E Se. Methamphetamine-induced changes in the object recognition memory circuit. Neuropharmacology. vol 62. issue 2. 2012-07-27. PMID:22115899. |
subsequently, transporters for serotonin (sert) and norepinephrine (net) were quantified using western blot in tissue obtained from the hippocampus, perirhinal cortex, and prefrontal cortex. |
2012-07-27 |
2023-08-12 |
human |
| Carmela M Reichel, Lauren A Ramsey, Marek Schwendt, Jacqueline F McGinty, Ronald E Se. Methamphetamine-induced changes in the object recognition memory circuit. Neuropharmacology. vol 62. issue 2. 2012-07-27. PMID:22115899. |
while only acute meth binge produced signs of neurotoxicity, both meth regimens decreased sert in the perirhinal cortex and hippocampus. |
2012-07-27 |
2023-08-12 |
human |
| Gianluigi Guidotti, Francesca Calabrese, Francesca Auletta, Jocelien Olivier, Giorgio Racagni, Judith Homberg, Marco A Riv. Developmental influence of the serotonin transporter on the expression of npas4 and GABAergic markers: modulation by antidepressant treatment. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 3. 2012-07-19. PMID:22012473. |
on the basis of these premises, we investigated the expression of npas4 and gabaergic markers in the hippocampus and prefrontal cortex of homozygous (sert(-/-)) and heterozygous (sert(+/-)) knockout rats, and analyzed the effect of long-term duloxetine treatment on the expression of these targets. |
2012-07-19 |
2023-08-12 |
rat |
| Gianluigi Guidotti, Francesca Calabrese, Francesca Auletta, Jocelien Olivier, Giorgio Racagni, Judith Homberg, Marco A Riv. Developmental influence of the serotonin transporter on the expression of npas4 and GABAergic markers: modulation by antidepressant treatment. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 3. 2012-07-19. PMID:22012473. |
interestingly, chronic treatment with the antidepressant duloxetine was able to restore the physiological levels of npas4 and gabaergic markers in sert(-/-) rats, although some differences in the modulation of gabaergic genes exist between hippocampus and prefrontal cortex. |
2012-07-19 |
2023-08-12 |
rat |
| Ruth Tellez, Leticia Gómez-Víquez, Alfredo Menese. GABA, glutamate, dopamine and serotonin transporters expression on memory formation and amnesia. Neurobiology of learning and memory. vol 97. issue 2. 2012-07-05. PMID:22183017. |
thus, memory formation in a pavlovian/instrumental autoshaping was associated to up-regulation of prefrontal cortex gat1 and eaac1, striatal sert, dat and eacc1; while, hippocampal eacc1, gat1 and sert were down-regulated. |
2012-07-05 |
2023-08-12 |
rat |
| Ruth Tellez, Leticia Gómez-Víquez, Alfredo Menese. GABA, glutamate, dopamine and serotonin transporters expression on memory formation and amnesia. Neurobiology of learning and memory. vol 97. issue 2. 2012-07-05. PMID:22183017. |
the meth-induced amnesia down-regulated sert, dat, eacc1 and gat1 in hippocampus and the gat1 in striatum; no-changes were observed in prefrontal cortex. |
2012-07-05 |
2023-08-12 |
rat |
| Ruth Tellez, Leticia Gómez-Víquez, Alfredo Menese. GABA, glutamate, dopamine and serotonin transporters expression on memory formation and amnesia. Neurobiology of learning and memory. vol 97. issue 2. 2012-07-05. PMID:22183017. |
post-training administration of fluoxetine improved ltm (48h), which was associated to dat, gat1 (prefrontal cortex) up-regulation, but gat1 (striatum) and sert (hippocampus) down-regulation. |
2012-07-05 |
2023-08-12 |
rat |
| Ruth Tellez, Leticia Gómez-Víquez, Alfredo Menese. GABA, glutamate, dopamine and serotonin transporters expression on memory formation and amnesia. Neurobiology of learning and memory. vol 97. issue 2. 2012-07-05. PMID:22183017. |
fluoxetine plus meth administration was able to prevent amnesia, which was associated to dat, eacc1 and gat1 (prefrontal cortex), sert and dat (hippocampus) and eacc1 or dat (striatal) up-regulation. |
2012-07-05 |
2023-08-12 |
rat |
| Noah B Gross, Patrick C Duncker, John F Marshal. Striatal dopamine D1 and D2 receptors: widespread influences on methamphetamine-induced dopamine and serotonin neurotoxicity. Synapse (New York, N.Y.). vol 65. issue 11. 2012-06-18. PMID:21584865. |
striatal dat and cortical, hippocampal, and amygdalar sert were assessed as markers of mamph-induced neurotoxicity 1 week following binge mamph administration. |
2012-06-18 |
2023-08-12 |
Not clear |
| Noah B Gross, Patrick C Duncker, John F Marshal. Striatal dopamine D1 and D2 receptors: widespread influences on methamphetamine-induced dopamine and serotonin neurotoxicity. Synapse (New York, N.Y.). vol 65. issue 11. 2012-06-18. PMID:21584865. |
blockade of striatal dopamine d1 or d2 receptors during an otherwise neurotoxic binge mamph regimen produced widespread protection against mamph-induced striatal dat loss and cortical, hippocampal, and amygdalar sert loss. |
2012-06-18 |
2023-08-12 |
Not clear |