| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anna Morozova, Eugene Zubkov, Tatyana Strekalova, Zurab Kekelidze, Zinaida Storozeva, Careen A Schroeter, Nataliia Bazhenova, Klaus-Peter Lesch, Brandon H Cline, Vladimir Chekhoni. Ultrasound of alternating frequencies and variable emotional impact evokes depressive syndrome in mice and rats. Progress in neuro-psychopharmacology & biological psychiatry. vol 68. 2017-01-02. PMID:27036099. |
rats showed an increased expression of sert and 5-ht2a receptor, a decreased expression of 5-ht1a receptor in the prefrontal cortex and hippocampus, diminished bdnf on gene and protein levels in the hippocampus. |
2017-01-02 |
2023-08-13 |
mouse |
| Golo Kronenberg, Valentina Mosienko, Karen Gertz, Natalia Alenina, Rainer Hellweg, Friederike Klempi. Increased brain-derived neurotrophic factor (BDNF) protein concentrations in mice lacking brain serotonin. European archives of psychiatry and clinical neuroscience. vol 266. issue 3. 2016-12-21. PMID:26100147. |
using a highly sensitive enzyme-linked immunosorbent assay, we studied bdnf concentrations in hippocampus and cortex of two mouse models of altered serotonin signaling: tryptophan hydroxylase (tph)2-deficient (tph2 (-/-)) mice lacking brain serotonin and serotonin transporter (sert)-deficient (sert(-/-)) mice lacking serotonin re-uptake. |
2016-12-21 |
2023-08-13 |
mouse |
| Golo Kronenberg, Valentina Mosienko, Karen Gertz, Natalia Alenina, Rainer Hellweg, Friederike Klempi. Increased brain-derived neurotrophic factor (BDNF) protein concentrations in mice lacking brain serotonin. European archives of psychiatry and clinical neuroscience. vol 266. issue 3. 2016-12-21. PMID:26100147. |
surprisingly, hippocampal bdnf was significantly elevated in tph2 (-/-) mice, whereas no significant changes were observed in sert(-/-) mice. |
2016-12-21 |
2023-08-13 |
mouse |
| K Berghauzen-Maciejewska, J Wardas, B Kosmowska, H Domin, M Śmiałowska, U Głowacka, K Ossowsk. Adaptive down-regulation of the serotonin transporter in the 6-hydroxydopamine-induced rat model of preclinical stages of Parkinson's disease and after chronic pramipexole treatment. Neuroscience. vol 314. 2016-10-13. PMID:26628402. |
intrastriatal 6-ohda injections decreased the number of dopaminergic, but not serotonergic neurons in the dr. 6-ohda reduced the dat binding in the cp, and sert binding in the nigrostriatal system (cp, substantia nigra (sn)), limbic system (ventral tegmental area (vta), nucleus accumbens (nac), amygdala, prefrontal cortex (pfcx), habenula, hippocampus) and dr. a significant positive correlation was found between dat and sert binding in the cp. |
2016-10-13 |
2023-08-13 |
rat |
| Anu Aonurm-Helm, Kaili Anier, Tamara Zharkovsky, Eero Castrén, Tomi Rantamäki, Vladimir Stepanov, Jaak Järv, Alexander Zharkovsk. NCAM-deficient mice show prominent abnormalities in serotonergic and BDNF systems in brain - Restoration by chronic amitriptyline. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 12. 2016-10-05. PMID:26499173. |
serotonergic nerve fiber density and sert (serotonin transporter) protein levels were robustly reduced in the hippocampus, prefrontal cortex and basolateral amygdala of adult ncam(-)(/-) mice. |
2016-10-05 |
2023-08-13 |
mouse |
| Zhong-Min Wu, Chun-Hua Zheng, Zhen-Hua Zhu, Feng-Tian Wu, Gui-Lian Ni, Yong Lian. SiRNA-mediated serotonin transporter knockdown in the dorsal raphe nucleus rescues single prolonged stress-induced hippocampal autophagy in rats. Journal of the neurological sciences. vol 360. 2016-10-05. PMID:26723990. |
therefore, we hypothesized that attenuation of sert gene expression in the hippocampus could prevent hippocampal autophagy and the development of ptsd-like behavior. |
2016-10-05 |
2023-08-13 |
rat |
| Zhong-Min Wu, Chun-Hua Zheng, Zhen-Hua Zhu, Feng-Tian Wu, Gui-Lian Ni, Yong Lian. SiRNA-mediated serotonin transporter knockdown in the dorsal raphe nucleus rescues single prolonged stress-induced hippocampal autophagy in rats. Journal of the neurological sciences. vol 360. 2016-10-05. PMID:26723990. |
these results indicated that sert may play a critical role in the pathogenesis of hippocampal autophagy, and is likely involved in the development of ptsd. |
2016-10-05 |
2023-08-13 |
rat |
| Hyun-Jung Park, Hyun-Soo Shim, Kyungeh An, Angela Starkweather, Kyung Soo Kim, Insop Shi. IL-4 Inhibits IL-1β-Induced Depressive-Like Behavior and Central Neurotransmitter Alterations. Mediators of inflammation. vol 2015. 2016-06-21. PMID:26417153. |
also, il-4 reduced il-1β-induced 5-ht levels by inhibiting tryptophan hydroxylase (tph) mrna and activating serotonin transporter (sert) in the hippocampus, and levels of ne were increased by activating tyrosine hydroxylase (th) mrna expression. |
2016-06-21 |
2023-08-13 |
rat |
| Stefanie C Altieri, Hongyan Yang, Hannah J O'Brien, Hannah M Redwine, Damla Senturk, Julie G Hensler, Anne M Andrew. Perinatal vs genetic programming of serotonin states associated with anxiety. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 6. 2016-03-29. PMID:25523893. |
adult behavioral changes resulting from early fluoxetine (prozac) exposure were different from those of esc and, although somewhat similar to sert deficiency, were not associated with changes in hippocampal serotonin transmission in late adulthood. |
2016-03-29 |
2023-08-13 |
mouse |
| Ran Ye, Meagan A Quinlan, Hideki Iwamoto, Hsiao-Huei Wu, Noah H Green, Christopher S Jetter, Douglas G McMahon, Jeremy Veestra-VanderWeele, Pat Levitt, Randy D Blakel. Physical Interactions and Functional Relationships of Neuroligin 2 and Midbrain Serotonin Transporters. Frontiers in synaptic neuroscience. vol 7. 2016-01-21. PMID:26793096. |
consistent with correlative mrna expression studies, loss of nlgn2 expression in nlgn2 null mice produced significant reductions in midbrain and hippocampal sert expression and function. |
2016-01-21 |
2023-08-13 |
mouse |
| Eryan Kong, Sonja Sucic, Francisco J Monje, Giorgia Savalli, Weifei Diao, Deeba Khan, Marianne Ronovsky, Maureen Cabatic, Florian Koban, Michael Freissmuth, Daniela D Polla. STAT3 controls IL6-dependent regulation of serotonin transporter function and depression-like behavior. Scientific reports. vol 5. 2015-10-16. PMID:25760924. |
similarly, sert expression was reduced upon il6 treatment in the mouse hippocampus. |
2015-10-16 |
2023-08-13 |
mouse |
| Eryan Kong, Sonja Sucic, Francisco J Monje, Giorgia Savalli, Weifei Diao, Deeba Khan, Marianne Ronovsky, Maureen Cabatic, Florian Koban, Michael Freissmuth, Daniela D Polla. STAT3 controls IL6-dependent regulation of serotonin transporter function and depression-like behavior. Scientific reports. vol 5. 2015-10-16. PMID:25760924. |
conversely, hippocampal tissue of il6-ko mice contained elevated levels of sert and il6-ko mice displayed a reduction in depression-like behavior and blunted response to acute antidepressant treatment. |
2015-10-16 |
2023-08-13 |
mouse |
| Xiaona Wang, Yuan Tan, Feng Zhan. Ameliorative effect of gastrodin on 3,3'-iminodipropionitrile-induced memory impairment in rats. Neuroscience letters. vol 594. 2015-09-14. PMID:25817367. |
gastrodin treatment prevented the increase of serotonin transporter (sert) and the decrease of serotonin 1a (5-ht1a) receptor expression in the hippocampus of idpn-treated rats. |
2015-09-14 |
2023-08-13 |
rat |
| Walid Tajeddinn, Torbjörn Persson, Silvia Maioli, Javier Calvo-Garrido, Cristina Parrado-Fernandez, Takashi Yoshitake, Jan Kehr, Paul Francis, Bengt Winblad, Kina Höglund, Angel Cedazo-Minguez, Dag Aarslan. 5-HT1B and other related serotonergic proteins are altered in APPswe mutation. Neuroscience letters. vol 594. 2015-09-14. PMID:25841787. |
in addition, hippocampal expressions of 5-ht1b and sert were assessed in wild type and transgenic mice expressing appswe mutation (tg2576) at different age groups. |
2015-09-14 |
2023-08-13 |
mouse |
| Tatyana Strekalova, Matthew Evans, Anton Chernopiatko, Yvonne Couch, João Costa-Nunes, Raymond Cespuglio, Lesley Chesson, Julie Vignisse, Harry W Steinbusch, Daniel C Anthony, Igor Pomytkin, Klaus-Peter Lesc. Deuterium content of water increases depression susceptibility: the potential role of a serotonin-related mechanism. Behavioural brain research. vol 277. 2015-09-08. PMID:25092571. |
next, we used a 10-day chronic stress paradigm to test whether 2-week deuterium-depleted water treatment (91 ppm) affects depressive-like behavior and hippocampal sert. |
2015-09-08 |
2023-08-13 |
mouse |
| José Jaime Herrera-Pérez, Alonso Fernández-Guasti, Lucía Martínez-Mot. Brain SERT Expression of Male Rats Is Reduced by Aging and Increased by Testosterone Restitution. Neuroscience journal. vol 2013. 2015-08-28. PMID:26317087. |
the identification of the brain sert expression was done by immunofluorescence in prefrontal cortex, lateral septum, hippocampus, and raphe nuclei. |
2015-08-28 |
2023-08-13 |
rat |
| Lisa M McFadden, Paula L Vieira-Brock, Glen R Hanson, Annette E Fleckenstei. Methamphetamine self-administration attenuates hippocampal serotonergic deficits: role of brain-derived neurotrophic factor. The international journal of neuropsychopharmacology. vol 17. issue 8. 2015-04-14. PMID:24650575. |
preclinical studies suggest that prior treatment with escalating doses of methamphetamine (meth) attenuates the persistent deficits in hippocampal serotonin (5-hydroxytryptamine; 5ht) transporter (sert) function resulting from a subsequent 'binge' meth exposure. |
2015-04-14 |
2023-08-12 |
rat |
| Lisa M McFadden, Paula L Vieira-Brock, Glen R Hanson, Annette E Fleckenstei. Methamphetamine self-administration attenuates hippocampal serotonergic deficits: role of brain-derived neurotrophic factor. The international journal of neuropsychopharmacology. vol 17. issue 8. 2015-04-14. PMID:24650575. |
the current study investigated changes in hippocampal bdnf protein and sert function in rats exposed to saline or meth self-administration prior to a binge exposure to meth or saline. |
2015-04-14 |
2023-08-12 |
rat |
| Lisa M McFadden, Paula L Vieira-Brock, Glen R Hanson, Annette E Fleckenstei. Methamphetamine self-administration attenuates hippocampal serotonergic deficits: role of brain-derived neurotrophic factor. The international journal of neuropsychopharmacology. vol 17. issue 8. 2015-04-14. PMID:24650575. |
these results suggest that prior exposure to contingent meth increases hippocampal mbdnf, and this may contribute to attenuated deficits in sert function. |
2015-04-14 |
2023-08-12 |
rat |
| Francesca Calabrese, Rick H A van der Doelen, Gianluigi Guidotti, Giorgio Racagni, Tamas Kozicz, Judith R Homberg, Marco A Riv. Exposure to early life stress regulates Bdnf expression in SERT mutant rats in an anatomically selective fashion. Journal of neurochemistry. vol 132. issue 1. 2015-02-19. PMID:25087780. |
in this study, we investigated the impact of chronic maternal separation (ms) on the expression of the neurotrophin brain-derived neurotrophic factor (bdnf) in serotonin transporter (sert) knockout rats in the ventral and dorsal hippocampus as well as the ventromedial and dorsomedial prefrontal cortex (pfc). |
2015-02-19 |
2023-08-13 |
rat |