| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andréa V Maglione, Bruna P P do Nascimento, Miriam O Ribeiro, Talytha J L de Souza, Renata E C da Silva, Monica A Sato, Carlos A A Penatti, Luiz R G Britto, Janaina S de Souza, Rui M B Maciel, Rodrigo Rodrigues da Conceição, Roberto Laureano-Melo, Gisele Giannocc. Triiodothyronine Treatment reverses Depression-Like Behavior in a triple-transgenic animal model of Alzheimer's Disease. Metabolic brain disease. 2022-08-11. PMID:35951206. |
when compared to control hippocampal samples, the t3 group exhibited attenuated glycogen synthase kinase-3 (gsk3), metalloproteinase 10 (adam10), amyloid-beta precursor-protein (app), serotonin transporter (sert), 5ht1a receptor, monocarboxylate transporter 8 (mct8) and bone morphogenetic protein 7 (bmp-7) gene expression, whereas augmented superoxide dismutase 2 (sod2) and hairless gene expression. |
2022-08-11 |
2023-08-14 |
mouse |
| Camilla Borgsted, Emma Hoegsted, Susanne Henningsson, Anja Pinborg, Melanie Ganz, Vibe G Frokjae. Hippocampal volume changes in a pharmacological sex-hormone manipulation risk model for depression in women. Hormones and behavior. vol 145. 2022-07-29. PMID:35905507. |
within this model, we here evaluated if gnrha, compared to placebo, reduced hippocampal volume, in a manner that depended on the magnitude of the estradiol decrease and sert binding, and if this decrease translated to the emergence of subclinical depressive symptoms. |
2022-07-29 |
2023-08-14 |
Not clear |
| Smriti Patodia, Alyma Somani, Joan Liu, Alice Cattaneo, Beatrice Paradiso, Maria Garcia, Muhammad Othman, Beate Diehl, Orrin Devinsky, James D Mills, Jackie Foong, Maria Tho. Serotonin transporter in the temporal lobe, hippocampus and amygdala in SUDEP. Brain pathology (Zurich, Switzerland). 2022-04-28. PMID:35478467. |
higher sert in hippocampal subfields in tle/hs cases with sudep risk factors and higher amygdala sert in post-mortem sudep cases than epilepsy controls supports a role for altered serotonergic networks involving limbic regions in sudep. |
2022-04-28 |
2023-08-13 |
Not clear |
| Bingqian Zhou, Ge Jin, Xiaoqi Pang, Qi Mo, Jie Bao, Tiaotiao Liu, Jingyi Wu, Runxiang Xie, Xiang Liu, Jinghua Liu, Hongwei Yang, Xin Xu, Bangmao Wang, Hailong Ca. Lactobacillus rhamnosus GG colonization in early life regulates gut-brain axis and relieves anxiety-like behavior in adulthood. Pharmacological research. 2022-01-22. PMID:35065201. |
mechanically, lgg colonization activated epithelial growth factor receptor (egfr) and enhanced serotonin transporter (sert) expression and modulated serotonergic system in the intestine, and increased brain-derived neurotrophic factor and γ-aminobutyric acid receptor levels in the hippocampus and amygdala. |
2022-01-22 |
2023-08-13 |
mouse |
| Tatiana de Queiroz Oliveira, Adriano José Maia Chaves Filho, Paloma Marinho Jucá, Michelle Verde Ramos Soares, Natássia Lopes Cunha, Charliene Freire Xavier Vieira, Carlos Venício Jataí Gadelha Filho, Glautemberg de Almeida Viana, Gabriela Mariângela Farias De Oliveira, Danielle Silveira Macedo, Silvânia Maria Mendes Vasconcelo. Lipoic acid prevents mirtazapine-induced weight gain in mice without impairs its antidepressant-like action in a neuroendocrine model of depression. Behavioural brain research. vol 419. 2021-12-10. PMID:34798169. |
also, hippocampus (hc) protein expression of the serotonin transporter (sert), synaptophysin, protein kinase b-akt (total and phosphorylated) and the cytokines il-4 and il-6 were investigated. |
2021-12-10 |
2023-08-13 |
mouse |
| Charlotte P Magee, BaoMinh D Le, Yasmeen H Siripathane, Diana G Wilkins, Glen R Hanson, Annette E Fleckenstei. Methcathinone decreases dopamine transporter function: Role of protein kinase C. Journal of neurochemistry. vol 159. issue 1. 2021-11-17. PMID:34320222. |
thus, effects of mcat on 1) striatal dopamine (da) transporter (dat); and 2) striatal and hippocampal serotonin transporter (sert) function, as determined in tissues from adult male rats, were assessed. |
2021-11-17 |
2023-08-13 |
rat |
| Héctor Miguel Mancha-Gutiérrez, Erika Estrada-Camarena, Lilian Mayagoitia-Novales, Elena López-Pacheco, Carolina López-Rubalcav. Chronic Social Defeat During Adolescence Induces Short- and Long-Term Behavioral and Neuroendocrine Effects in Male Swiss-Webster Mice. Frontiers in behavioral neuroscience. vol 15. 2021-10-22. PMID:34658806. |
csd during early adolescence induced enduring depression-like behaviors as inferred from increased social avoidance and immobility behavior in the sit and fst, respectively, which correlated in an age-dependent manner with sert binding in the hippocampus; csd during early adolescence also induced long-lasting learning and memory impairments in the barnes maze (bm). |
2021-10-22 |
2023-08-13 |
mouse |
| Rodrigo Campos-Cardoso, Carla P B Silva, Ruither O G Carolino, Janete A Anselmo-Franci, Carlos R Tirapelli, Cláudia M Padova. Imipramine attenuates anxiety- and depressive-like effects of acute and prolonged ethanol-abstinence in male rats by modulating SERT and GR expression in the dorsal hippocampus. Behavioural brain research. vol 408. 2021-09-02. PMID:33839161. |
imipramine attenuates anxiety- and depressive-like effects of acute and prolonged ethanol-abstinence in male rats by modulating sert and gr expression in the dorsal hippocampus. |
2021-09-02 |
2023-08-13 |
rat |
| Janak R Awasthi, Kota Tamada, Eric T N Overton, Toru Takum. Comprehensive topographical map of the serotonergic fibers in the male mouse brain. The Journal of comparative neurology. vol 529. issue 7. 2021-08-16. PMID:32892368. |
our findings include: (a) sert fibers distribute abundantly in the thalamic nuclei close to the midline and dorsolateral areas, in most of the hypothalamic nuclei with few exceptions such as the median eminence and arcuate nuclei, and within the basal amygdaloid complex and lateral septal nuclei, (b) the source fibers of innervation of the hippocampus traverse through the septal nuclei before reaching its destination, (c) unique, filamentous type of straight terminal fibers within the nucleus accumbens, (d) laminar pattern of innervation in the hippocampus, olfactory bulb and cortex with heterogenicity in innervation density among the layers, (e) cortical labeling density gradually decreases rostro-caudally, (f) fibers traverse and distribute mostly within the gray matter, leaving the white fiber bundles uninnervated, and (g) most of the highly labeled nuclei and cortical areas have predominant anatomical connection to limbic structures. |
2021-08-16 |
2023-08-13 |
mouse |
| Clarissa Tavares Dias, Haidar Tafner Curi, Tanyara Baliani Payolla, Simone Ferreira Lemes, Isadora Carolina Betim Pavan, Marcio Alberto Torsoni, Fernando Moreira Simabuco, Rafael Herling Lambertucci, Cristiano Mendes da Silv. Maternal high-fat diet stimulates proinflammatory pathway and increases the expression of Tryptophan Hydroxylase 2 (TPH2) and brain-derived neurotrophic factor (BDNF) in adolescent mice hippocampus. Neurochemistry international. vol 139. 2021-08-11. PMID:32652271. |
this study aims to evaluate maternal hfd effects, during pregnancy and lactation, upon dams/mice offspring nutritional status, protein and gene expression of inflammatory pathway (jnk, pjnk and tnf-α), serotonin system molecules (tryptophan hydroxylase 2 (tph2), key-enzyme of serotonin synthesis, serotonin transporter (sert); 5-ht1a serotonergic receptor (5-ht1a)) and brain derived neurotrophic factor (bdnf) on recently weaned mice offspring hippocampus. |
2021-08-11 |
2023-08-13 |
mouse |
| Francesca Zoratto, Clelia Buccheri, Romina Mura, Luisa Altabella, Marion Vanneste, Marie Villotte, Giovanni Laviola, Francois Dauphin, Eleni Paizanis, Walter Adriani, Rossella Canes. Anatomical and behavioral impact of a lentiviral tool tapping onto hippocampal serotonin reuptake in rats. Synapse (New York, N.Y.). vol 74. issue 4. 2021-08-10. PMID:31587367. |
we aimed at the further characterization of rats in which sert gene silencing was achieved by hippocampal injection of a lentiviral vector, carrying three si-rna to block sert mrna at 66% of normal levels. |
2021-08-10 |
2023-08-13 |
rat |
| Francesca Zoratto, Clelia Buccheri, Romina Mura, Luisa Altabella, Marion Vanneste, Marie Villotte, Giovanni Laviola, Francois Dauphin, Eleni Paizanis, Walter Adriani, Rossella Canes. Anatomical and behavioral impact of a lentiviral tool tapping onto hippocampal serotonin reuptake in rats. Synapse (New York, N.Y.). vol 74. issue 4. 2021-08-10. PMID:31587367. |
while all rats had a widespread modification within dorsal/ventral striatum, amygdala, and hypothalamus, only the former subgroup showed an involvement of raphé medialis, while, for the latter subgroup, an increase of sert within hippocampus was unexpectedly caused. |
2021-08-10 |
2023-08-13 |
rat |
| Francesca Zoratto, Clelia Buccheri, Romina Mura, Luisa Altabella, Marion Vanneste, Marie Villotte, Giovanni Laviola, Francois Dauphin, Eleni Paizanis, Walter Adriani, Rossella Canes. Anatomical and behavioral impact of a lentiviral tool tapping onto hippocampal serotonin reuptake in rats. Synapse (New York, N.Y.). vol 74. issue 4. 2021-08-10. PMID:31587367. |
overall, tapping hippocampal sert affected the balance between habits versus strategies of coping by promoting morphogenetic processes indicative of a serotonergic fiber plasticity. |
2021-08-10 |
2023-08-13 |
rat |
| Melinda Hersey, Jennifer L Woodruff, Nicholas Maxwell, Alia T Sadek, Maria K Bykalo, Ian Bain, Claudia A Grillo, Gerardo G Piroli, Parastoo Hashemi, Lawrence P Reaga. High-fat diet induces neuroinflammation and reduces the serotonergic response to escitalopram in the hippocampus of obese rats. Brain, behavior, and immunity. vol 96. 2021-08-06. PMID:34010713. |
further studies revealed that these neurochemical observations could be explained by increases in serotonin transporter (sert) expression in the hippocampus driven by elevated neuroinflammation. |
2021-08-06 |
2023-08-13 |
human |
| Melinda Hersey, Jennifer L Woodruff, Nicholas Maxwell, Alia T Sadek, Maria K Bykalo, Ian Bain, Claudia A Grillo, Gerardo G Piroli, Parastoo Hashemi, Lawrence P Reaga. High-fat diet induces neuroinflammation and reduces the serotonergic response to escitalopram in the hippocampus of obese rats. Brain, behavior, and immunity. vol 96. 2021-08-06. PMID:34010713. |
collectively, these results demonstrate that obesity-induced increases in neuroinflammation adversely affect sert expression in the hippocampus of obese rats, thereby providing a potential synaptic mechanism for reduced ssri responsiveness in obese subjects with co-morbid depressive illness. |
2021-08-06 |
2023-08-13 |
human |
| Frederick S Barrett, Clifford I Workman, Haris I Sair, Alena V Savonenko, Michael A Kraut, Devin J Sodums, Jin J Joo, Najlla Nassery, Christopher M Marano, Cynthia A Munro, Jason Brandt, Yun Zhou, Dean F Wong, Gwenn S Smit. Association between serotonin denervation and resting-state functional connectivity in mild cognitive impairment. Human brain mapping. vol 38. issue 7. 2021-07-03. PMID:28379618. |
decreased sert in drn was associated with lower hippocampal resting-state connectivity in mci participants compared to controls. |
2021-07-03 |
2023-08-13 |
human |
| Ashkan Divanbeigi, Mohammad Nasehi, Salar Vaseghi, Sepideh Amiri, Mohammad-Reza Zarrindas. Tropisetron But Not Granisetron Ameliorates Spatial Memory Impairment Induced by Chronic Cerebral Hypoperfusion. Neurochemical research. vol 45. issue 11. 2021-06-02. PMID:32797381. |
dorsal hippocampal (ca1) neurons count, interleukin 6 (il-6) serum level, and serotonin-reuptake transporter (sert) gene expression were also evaluated. |
2021-06-02 |
2023-08-13 |
rat |
| Carina Meinke, Meagan A Quinlan, Krista C Paffenroth, Fiona E Harrison, Cristina Fenollar-Ferrer, Rania M Katamish, Isabel Stillman, Sammanda Ramamoorthy, Randy D Blakel. Serotonin Transporter Ala276 Mouse: Novel Model to Assess the Neurochemical and Behavioral Impact of Thr276 Phosphorylation In Vivo. Neurochemical research. 2021-04-08. PMID:33830406. |
similarly, no genotype differences were evident in midbrain or hippocampal 5-ht levels, midbrain and hippocampal sert mrna or midbrain protein levels, nor in midbrain synaptosomal 5-ht uptake kinetics. |
2021-04-08 |
2023-08-13 |
mouse |
| Melodi A Bowman, Melissa Vitela, Kyra M Clarke, Wouter Koek, Lynette C Daw. Serotonin Transporter and Plasma Membrane Monoamine Transporter Are Necessary for the Antidepressant-Like Effects of Ketamine in Mice. International journal of molecular sciences. vol 21. issue 20. 2021-02-25. PMID:33066466. |
using high-speed chronoamperometry to measure real-time clearance of serotonin from ca3 region of hippocampus in vivo, we found ketamine robustly inhibited serotonin clearance in wild-type mice, an effect that was lost in mice constitutively lacking sert or pmat. |
2021-02-25 |
2023-08-13 |
mouse |
| Yang Yang, Zhiying Hu, Xiaoxue Du, Henry Davies, Xue Huo, Marong Fan. miR-16 and Fluoxetine Both Reverse Autophagic and Apoptotic Change in Chronic Unpredictable Mild Stress Model Rats. Frontiers in neuroscience. vol 11. 2020-10-01. PMID:28790887. |
it has been suggested that mir-16 regulates serotonin transporters (sert) via raphe nuclei and hippocampal responses to antidepressants. |
2020-10-01 |
2023-08-13 |
rat |