| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Francesca Calabrese, Rick H A van der Doelen, Gianluigi Guidotti, Giorgio Racagni, Tamas Kozicz, Judith R Homberg, Marco A Riv. Exposure to early life stress regulates Bdnf expression in SERT mutant rats in an anatomically selective fashion. Journal of neurochemistry. vol 132. issue 1. 2015-02-19. PMID:25087780. |
we found that both sert deletion and the ms led to an overall reduction in bdnf expression in the ventral hippocampus and the ventromedial pfc, whereas in the dorsal hippocampus and in the dorsomedial pfc, we observed a significant increase in the neurotrophin gene expression after ms exposure, specifically in the heterozygous sert rats. |
2015-02-19 |
2023-08-13 |
rat |
| Francesca Calabrese, Rick H A van der Doelen, Gianluigi Guidotti, Giorgio Racagni, Tamas Kozicz, Judith R Homberg, Marco A Riv. Exposure to early life stress regulates Bdnf expression in SERT mutant rats in an anatomically selective fashion. Journal of neurochemistry. vol 132. issue 1. 2015-02-19. PMID:25087780. |
in summary, we show that the modulation of bdnf expression in sert mutant rats exposed to ms reflects the complex functional consequences of this gene-environment interaction with a clear distinction between the ventral and the dorsal subfields of the hippocampus and of the pfc. |
2015-02-19 |
2023-08-13 |
rat |
| Francesca Calabrese, Rick H A van der Doelen, Gianluigi Guidotti, Giorgio Racagni, Tamas Kozicz, Judith R Homberg, Marco A Riv. Exposure to early life stress regulates Bdnf expression in SERT mutant rats in an anatomically selective fashion. Journal of neurochemistry. vol 132. issue 1. 2015-02-19. PMID:25087780. |
specifically, both sert deletion and the maternal separation (ms) led to an overall reduction in bdnf expression in the ventral hippocampus and in the ventromedial prefrontal cortex, whereas in the dorsal hippocampus and in the dorsomedial prefrontal cortex, we observed a significant increase in the neurotrophin gene expression after ms exposure specifically in the heterozygous sert rats. |
2015-02-19 |
2023-08-13 |
rat |
| Alonzo Whyte, Tammy Jessen, Seth Varney, Ana M D Carneir. Serotonin transporter and integrin beta 3 genes interact to modulate serotonin uptake in mouse brain. Neurochemistry international. vol 73. 2015-02-02. PMID:24083985. |
citalopram binding revealed significant slc6a4-driven reductions in sert expression in midbrain synapses, whereas no significant changes were observed in hippocampal or cortical projections. |
2015-02-02 |
2023-08-12 |
mouse |
| Sylvia Montañez, Jaclyn L Munn, W Anthony Owens, Rebecca E Horton, Lynette C Daw. 5-HT1B receptor modulation of the serotonin transporter in vivo: studies using KO mice. Neurochemistry international. vol 73. 2015-02-02. PMID:24246466. |
likewise, cyanopindolol was without effect on 5-ht clearance in sert-/- mice, demonstrating a requirement for the presence of both sert and 5-ht1b receptors in order for cyanopindolol to inhibit 5-ht clearance in ca3 region of hippocampus. |
2015-02-02 |
2023-08-12 |
mouse |
| Bruno P Guiard, Mostafa El Mansari, Dennis L Murphy, Pierre Blie. Altered response to the selective serotonin reuptake inhibitor escitalopram in mice heterozygous for the serotonin transporter: an electrophysiological and neurochemical study. The international journal of neuropsychopharmacology. vol 15. issue 3. 2015-01-22. PMID:21439106. |
nevertheless, the ability of microiontophoretically applied 5-ht to inhibit the firing rate of ca3 pyramidal neurons was not different between sert+/+ and sert+/- mice given escitalopram for 21 d. the data indicate that the poor response to ssris of depressive patients with short allele(s) of sert is not attributable to a lesser increase in 5-ht transmission in the hippocampus. |
2015-01-22 |
2023-08-12 |
mouse |
| Brian J Piper, Christina S Henderson, Jerrold S Meye. Adolescent MDMA exposure diminishes the physiological and neurotoxic consequences of an MDMA binge in female rats. Developmental psychobiology. vol 56. issue 5. 2015-01-13. PMID:24752593. |
similarly, mdma-pretreated animals were resistant to the binge-induced sert reductions, especially in the hippocampus. |
2015-01-13 |
2023-08-13 |
rat |
| A Yu Morozova, E A Zubkov, F A Koshkin, Z I Storozheva, V P Chekhoni. Expression of genes encoding serotonin receptors and SERT in various brain structures of stressed rats after chronic exposure to ultrasound. Bulletin of experimental biology and medicine. vol 156. issue 3. 2015-01-07. PMID:24771365. |
the hippocampus was characterized by an increased expression of genes encoding sert and 5-ht1a, 5-ht2a, and 5-ht2b receptors. |
2015-01-07 |
2023-08-13 |
rat |
| Michelle G Baladi, Amy H Newman, Shannon M Nielsen, Glen R Hanson, Annette E Fleckenstei. Dopamine D(3) receptors contribute to methamphetamine-induced alterations in dopaminergic neuronal function: role of hyperthermia. European journal of pharmacology. vol 732. 2014-12-09. PMID:24685638. |
results indicate that the dopamine d3 receptor selective antagonist, pg01037, attenuated methamphetamine-induced decreases in striatal dat, but not hippocampal serotonin (5ht) transporter (sert), function, as assessed 7 days after treatment. |
2014-12-09 |
2023-08-12 |
rat |
| Andrew C Parrot. MDMA, serotonergic neurotoxicity, and the diverse functional deficits of recreational 'Ecstasy' users. Neuroscience and biobehavioral reviews. vol 37. issue 8. 2014-05-08. PMID:23660456. |
neurocognitive deficits are associated with reduced sert in the hippocampus, parietal cortex, and prefrontal cortex. |
2014-05-08 |
2023-08-12 |
Not clear |
| Javier A Bravo, Timothy G Dinan, John F Crya. Early-life stress induces persistent alterations in 5-HT1A receptor and serotonin transporter mRNA expression in the adult rat brain. Frontiers in molecular neuroscience. vol 7. 2014-04-30. PMID:24782706. |
when animals reached adulthood (11-13 weeks) brain was extracted and mrna expression of 5-ht1a receptor in amygdala, hippocampus and dorsal raphé nucleus (drn) and sert in the drn was analyzed through in situ hybridisation. |
2014-04-30 |
2023-08-13 |
rat |
| Silvina L Diaz, Nicolas Narboux-Nême, Sara Trowbridge, Sophie Scotto-Lomassese, Felix B Kleine Borgmann, Sebastian Jessberger, Bruno Giros, Luc Maroteaux, Evan Deneris, Patricia Gaspa. Paradoxical increase in survival of newborn neurons in the dentate gyrus of mice with constitutive depletion of serotonin. The European journal of neuroscience. vol 38. issue 5. 2014-02-26. PMID:23841816. |
here, we analysed two genetic models of 5-ht depletion, the pet1(-/-) and the vmat2(f/f) ; sert(cre/+) mice, which have, respectively, 80 and 95% reductions in hippocampal 5-ht. |
2014-02-26 |
2023-08-12 |
mouse |
| Su-Xia Li, Jing Li, Xue Wang, Zu-Gui Peng, Wei-Hong Kuang, Ming-Sheng Huan. [Long-term neurotoxic effects of MDMA result in cortical and hippocampal structural changes]. Sheng li xue bao : [Acta physiologica Sinica]. vol 58. issue 1. 2013-12-12. PMID:16489401. |
the results showed that the expression of sert mrna in hippocampus decreased by 31.96%, while expression of dbi mrna in neocortex increased by 40.51%, compared with the control group (p<0.05). |
2013-12-12 |
2023-08-12 |
rat |
| Nathan C Mitchell, Georgianna G Gould, Corey M Smolik, Wouter Koek, Lynette C Daw. Antidepressant-like drug effects in juvenile and adolescent mice in the tail suspension test: Relationship with hippocampal serotonin and norepinephrine transporter expression and function. Frontiers in pharmacology. vol 4. 2013-11-05. PMID:24191152. |
the smaller antidepressant response of juveniles was not related to either maximal binding (b max) or affinity (k d) for [(3)h]citalopram binding to the serotonin transporter (sert) in hippocampus, which did not vary significantly among ages. |
2013-11-05 |
2023-08-12 |
mouse |
| Nathan C Mitchell, Georgianna G Gould, Corey M Smolik, Wouter Koek, Lynette C Daw. Antidepressant-like drug effects in juvenile and adolescent mice in the tail suspension test: Relationship with hippocampal serotonin and norepinephrine transporter expression and function. Frontiers in pharmacology. vol 4. 2013-11-05. PMID:24191152. |
together, these findings suggest that juvenile mice are less responsive to the antidepressant-like effects of escitalopram than adults, but that this effect is not due to delayed maturation of sert in hippocampus. |
2013-11-05 |
2023-08-12 |
mouse |
| Darrick T Balu, Jill R Turner, Bethany R Brookshire, Tiffany E Hill-Smith, Julie A Blendy, Irwin Luck. Brain monoamines and antidepressant-like responses in MRL/MpJ versus C57BL/6J mice. Neuropharmacology. vol 67. 2013-11-04. PMID:23220293. |
in addition, the expression of 5-ht(1a) mrna was lower in the hippocampus, 5-ht(1b) mrna was higher in the hippocampus and brainstem and sert mrna was higher in the brain stem of mrl/mpj mice. |
2013-11-04 |
2023-08-12 |
mouse |
| Courtney Huff, Nirmal Bhide, Allen Schroering, Bryan K Yamamoto, Gary A Gudelsk. Effect of repeated exposure to MDMA on the function of the 5-HT transporter as assessed by synaptosomal 5-HT uptake. Brain research bulletin. vol 91. 2013-08-12. PMID:23318273. |
the distribution of sert immunoreactivity (ir) in membrane and endosomal fractions of the hippocampus also was evaluated following the preconditioning regimen of mdma. |
2013-08-12 |
2023-08-12 |
rat |
| Narattaphol Charoenphandhu, Amporn Nuntapornsak, Kannikar Wongdee, Nateetip Krishnamra, Jantarima Charoenphandh. Upregulated mRNA levels of SERT, NET, MAOB, and BDNF in various brain regions of ovariectomized rats exposed to chronic aversive stimuli. Molecular and cellular biochemistry. vol 375. issue 1-2. 2013-07-26. PMID:23208077. |
after cas exposure, mrna levels of sert and net were upregulated in the frontal cortex, hippocampus, amygdala, and periaqueductal gray. |
2013-07-26 |
2023-08-12 |
rat |
| Abigail G Schindler, Daniel I Messinger, Jeffrey S Smith, Haripriya Shankar, Richard M Gustin, Selena S Schattauer, Julia C Lemos, Nicholas W Chavkin, Catherine E Hagan, John F Neumaier, Charles Chavki. Stress produces aversion and potentiates cocaine reward by releasing endogenous dynorphins in the ventral striatum to locally stimulate serotonin reuptake. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 49. 2013-04-11. PMID:23223282. |
although the serotonergic neurons in the dorsal raphe project throughout the forebrain, a significant stress-induced increase in cell-surface sert expression was only evident in the ventral striatum, and not in the dorsal striatum, hippocampus, prefrontal cortex, amygdala, or dorsal raphe. |
2013-04-11 |
2023-08-12 |
mouse |
| J M Launay, S Mouillet-Richard, A Baudry, M Pietri, O Kellerman. Raphe-mediated signals control the hippocampal response to SRI antidepressants via miR-16. Translational psychiatry. vol 1. 2013-04-04. PMID:22833211. |
fluoxetine, acting on serotonergic raphe neurons, decreases the amount of mir-16 in the hippocampus, which in turn increases the levels of the serotonin transporter (sert), the target of sri, and that of bcl-2 and the number of cells positive for doublecortin, a marker of neuronal maturation. |
2013-04-04 |
2023-08-12 |
mouse |