| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Seth D Norrholm, David B Horton, Linda P Dwoski. The promiscuity of the dopamine transporter: implications for the kinetic analysis of [3H]serotonin uptake in rat hippocampal and striatal synaptosomes. Neuropharmacology. vol 53. issue 8. 2008-03-21. PMID:18022203. |
we performed a kinetic analysis of [(3)h]serotonin uptake in rat striatal synaptosomes (expressing dat and sert) and hippocampal synaptosomes (expressing sert, but not dat). |
2008-03-21 |
2023-08-12 |
rat |
| Seth D Norrholm, David B Horton, Linda P Dwoski. The promiscuity of the dopamine transporter: implications for the kinetic analysis of [3H]serotonin uptake in rat hippocampal and striatal synaptosomes. Neuropharmacology. vol 53. issue 8. 2008-03-21. PMID:18022203. |
thus, when dat is inhibited by gbr 12909, kinetic parameters for serotonin uptake via sert in striatum are not different from those obtained in hippocampus. |
2008-03-21 |
2023-08-12 |
rat |
| Chong-Bin Zhu, Jennifer A Steiner, Jaclyn L Munn, Lynette C Daws, William A Hewlett, Randy D Blakel. Rapid stimulation of presynaptic serotonin transport by A(3) adenosine receptors. The Journal of pharmacology and experimental therapeutics. vol 322. issue 1. 2007-08-30. PMID:17460150. |
chronoamperometry studies in the anesthetized rat hippocampus support a role for a(3)ars in sert regulation in vivo. |
2007-08-30 |
2023-08-12 |
mouse |
| Paul D Callaghan, W Anthony Owens, Martin A Javors, Teresa A Sanchez, David J Jones, Rodney J Irvine, Lynette C Daw. In vivo analysis of serotonin clearance in rat hippocampus reveals that repeated administration of p-methoxyamphetamine (PMA), but not 3,4-methylenedioxymethamphetamine (MDMA), leads to long-lasting deficits in serotonin transporter function. Journal of neurochemistry. vol 100. issue 3. 2007-03-20. PMID:17181558. |
the aim of this study was to determine the effect of repeated pma administration on in vitro measures of neurodegeneration: serotonin (5-ht) uptake, 5-ht transporter (sert) density and 5-ht content in the hippocampus, and compare with effects on in vivo 5-ht clearance. |
2007-03-20 |
2023-08-12 |
rat |
| Robert A Whittington, László Virá. Isoflurane decreases extracellular serotonin in the mouse hippocampus. Anesthesia and analgesia. vol 103. issue 1. 2006-08-16. PMID:16790633. |
isoflurane produced a significant decrease in hippocampal 5-ht in sert +/+ and sert -/-, and this decrease was larger in sert -/- compared with sert +/+: to 22.4% +/- 8.5% versus 50.2% +/- 17.4% of the baseline 5-ht level, respectively. |
2006-08-16 |
2023-08-12 |
mouse |
| Robert A Whittington, László Virá. Isoflurane decreases extracellular serotonin in the mouse hippocampus. Anesthesia and analgesia. vol 103. issue 1. 2006-08-16. PMID:16790633. |
these data suggest that isoflurane produces a decrease in hippocampal 5-ht, independent of sert function. |
2006-08-16 |
2023-08-12 |
mouse |
| Masanori Ichise, Douglass C Vines, Tami Gura, George M Anderson, Stephen J Suomi, J Dee Higley, Robert B Inni. Effects of early life stress on [11C]DASB positron emission tomography imaging of serotonin transporters in adolescent peer- and mother-reared rhesus monkeys. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 17. 2006-05-23. PMID:16641244. |
for the pr group, sert bp was decreased by 10-23% across a range of brain areas consisting of the raphe, thalamus, hypothalamus, caudate and putamen, globus pallidum, anterior cingulate gyrus, and medial temporal regions, including amygdala and hippocampus (cluster-level corrected p = 0.002). |
2006-05-23 |
2023-08-12 |
monkey |
| Dong-Kyu Kim, Teresa J Tolliver, Su-Jan Huang, Bradley J Martin, Anne M Andrews, Christine Wichems, Andrew Holmes, Klaus-Peter Lesch, Dennis L Murph. Altered serotonin synthesis, turnover and dynamic regulation in multiple brain regions of mice lacking the serotonin transporter. Neuropharmacology. vol 49. issue 6. 2006-03-10. PMID:16183083. |
to evaluate the consequences of inactivation of the serotonin transporter (sert) gene on 5-ht homeostasis and function, 5-ht synthesis and turnover rates were measured using the decarboxylase inhibition method in multiple brain regions (frontal cortex, striatum, brainstem, hippocampus and hypothalamus) from mice with a genetic disruption of sert. |
2006-03-10 |
2023-08-12 |
mouse |
| Paul P Bertrand, Udeni T Paranavitane, Carolina Chavez, Andrea Gogos, Margaret Jones, Maarten van den Buus. The effect of low estrogen state on serotonin transporter function in mouse hippocampus: a behavioral and electrochemical study. Brain research. vol 1064. issue 1-2. 2006-03-07. PMID:16298349. |
the aim of the present study was to examine the effect of a low estrogen state in mice on the behavioral effect of drugs acting through the sert, serotonin uptake kinetics and sert density in the hippocampus. |
2006-03-07 |
2023-08-12 |
mouse |
| Paul P Bertrand, Udeni T Paranavitane, Carolina Chavez, Andrea Gogos, Margaret Jones, Maarten van den Buus. The effect of low estrogen state on serotonin transporter function in mouse hippocampus: a behavioral and electrochemical study. Brain research. vol 1064. issue 1-2. 2006-03-07. PMID:16298349. |
measurement of sert density by [3h]-citalopram autoradiography, revealed an 18% decrease in hippocampus of ovx mice compared to intact controls. |
2006-03-07 |
2023-08-12 |
mouse |
| Paul P Bertrand, Udeni T Paranavitane, Carolina Chavez, Andrea Gogos, Margaret Jones, Maarten van den Buus. The effect of low estrogen state on serotonin transporter function in mouse hippocampus: a behavioral and electrochemical study. Brain research. vol 1064. issue 1-2. 2006-03-07. PMID:16298349. |
together, these results suggest that a low estrogen state increases sert activity in the hippocampus despite an apparent reduction in sert density. |
2006-03-07 |
2023-08-12 |
mouse |
| Renee F Ren-Patterson, Dong-Kyu Kim, Xiu Zheng, Suzanne Sherrill, Su-Jan Huang, Teresa Tolliver, Dennis L Murph. Serotonergic-like progenitor cells propagated from neural stem cells in vitro: survival with SERT protein expression following implantation into brains of mice lacking SERT. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 19. issue 11. 2006-03-06. PMID:15972295. |
implantation of the serotonergic-like progenitors into the hippocampus of adult mice genetically lacking sert was followed by migration of these cells into adjacent brain regions, and survival of the cells at 8 weeks was accompanied by a gradual increase in density of sert protein expression, which was not found in vehicle-injected, control mice. |
2006-03-06 |
2023-08-12 |
mouse |
| Annabelle M Belcher, Steven J O'Dell, John F Marshal. Impaired object recognition memory following methamphetamine, but not p-chloroamphetamine- or d-amphetamine-induced neurotoxicity. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 30. issue 11. 2006-01-24. PMID:15900317. |
mamph-treated rats showed reductions in striatal dat and hippocampal (hc) and perirhinal (prh) sert, as well as degeneration of neurons in primary somatosensory cortex. |
2006-01-24 |
2023-08-12 |
rat |
| Silvia Racca, Angela Spaccamiglio, Paola Esculapio, Giuliana Abbadessa, Luigi Cangemi, Francesco DiCarlo, Paolo Portaleon. Effects of swim stress and alpha-MSH acute pre-treatment on brain 5-HT transporter and corticosterone receptor. Pharmacology, biochemistry, and behavior. vol 81. issue 4. 2005-11-28. PMID:16023186. |
taking all together these data, we investigated the effects of the fst exposure and the effects of pre-treatment with alpha-msh on cortical synaptosomal serotonin transporter (sert) activity, corticosterone (cort) plasma levels and on glucocorticoid receptor (gr) occupancy and expression in rat hippocampus. |
2005-11-28 |
2023-08-12 |
rat |
| Silvia Racca, Angela Spaccamiglio, Paola Esculapio, Giuliana Abbadessa, Luigi Cangemi, Francesco DiCarlo, Paolo Portaleon. Effects of swim stress and alpha-MSH acute pre-treatment on brain 5-HT transporter and corticosterone receptor. Pharmacology, biochemistry, and behavior. vol 81. issue 4. 2005-11-28. PMID:16023186. |
our data show that fst increased cort secretion; gr levels in hippocampus decreased in density after stress without variations in affinity; gr redistributed from the cytosolic to the nuclear tissue fraction; finally, sert activity strongly increased. |
2005-11-28 |
2023-08-12 |
rat |
| Paul D Callaghan, Rodney J Irvine, Lynette C Daw. Differences in the in vivo dynamics of neurotransmitter release and serotonin uptake after acute para-methoxyamphetamine and 3,4-methylenedioxymethamphetamine revealed by chronoamperometry. Neurochemistry international. vol 47. issue 5. 2005-09-08. PMID:15979209. |
to study the effect of these amphetamines on clearance of 5-ht mediated specifically by the sert, clearance of exogenously applied 5-ht was measured in the ca3 region of the hippocampus. |
2005-09-08 |
2023-08-12 |
rat |
| Paul D Callaghan, Rodney J Irvine, Lynette C Daw. Differences in the in vivo dynamics of neurotransmitter release and serotonin uptake after acute para-methoxyamphetamine and 3,4-methylenedioxymethamphetamine revealed by chronoamperometry. Neurochemistry international. vol 47. issue 5. 2005-09-08. PMID:15979209. |
these data demonstrate in vivo (1) brain region variability in the ability of pma and mdma to evoke release of neurotransmitter; (2) that clearance of 5-ht in the striatum is mediated by both the sert and the dat; (3) distinct differences in the amount and nature of neurotransmitter released in the striatum after local application of pma and mdma and (4) that pma is a more efficacious inhibitor of 5-ht clearance in the hippocampus than mdma. |
2005-09-08 |
2023-08-12 |
rat |
| Michael T Williams, Tori L Schaefer, Lisa A Ehrman, Jessica A Able, Gary A Gudelsky, Renu Sah, Charles V Vorhee. 3,4-Methylenedioxymethamphetamine administration on postnatal day 11 in rats increases pituitary-adrenal output and reduces striatal and hippocampal serotonin without altering SERT activity. Brain research. vol 1039. issue 1-2. 2005-08-30. PMID:15781051. |
3,4-methylenedioxymethamphetamine administration on postnatal day 11 in rats increases pituitary-adrenal output and reduces striatal and hippocampal serotonin without altering sert activity. |
2005-08-30 |
2023-08-12 |
rat |
| Zhihong Zhu, Ningning Guo, Raj Narendran, David Erritzoe, Jesper Ekelund, Dah-Ren Hwang, Sung-A Bae, Marc Laruelle, Yiyun Huan. The new PET imaging agent [11C]AFE is a selective serotonin transporter ligand with fast brain uptake kinetics. Nuclear medicine and biology. vol 31. issue 8. 2005-07-05. PMID:15607480. |
imaging experiments in baboons indicated that the uptake pattern of [(11)c]afe is consistent with the known distribution of sert in the baboon brain, with high levels of radioactivity detected in the midbrain and thalamus, moderate levels in the hippocampus and striatum and low levels in the cortical regions. |
2005-07-05 |
2023-08-12 |
rat |
| Laurent Galineau, Catherine Belzung, Ercem Kodas, Sylvie Bodard, Denis Guilloteau, Sylvie Chalo. Prenatal 3,4-methylenedioxymethamphetamine (ecstasy) exposure induces long-term alterations in the dopaminergic and serotonergic functions in the rat. Brain research. Developmental brain research. vol 154. issue 2. 2005-06-27. PMID:15707670. |
prenatally mdma-exposed rats showed (i) a two-fold decrease of whole brain levels of 5-ht and 5-hiaa at p0; (ii) no effect on the dat and sert density; (iii) a strongly reduced pharmacologically induced release of da and 5-ht at p70 in the striatum and hippocampus; and (iv) a significant 20% decrease in sucrose preference at p70. |
2005-06-27 |
2023-08-12 |
rat |